{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:21:15Z","timestamp":1773760875578,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics & Neonatology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.pedneo.2022.12.004","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T19:17:11Z","timestamp":1672687031000},"page":"411-419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical outcomes of different patent ductus arteriosus treatment in preterm infants born between 28 and 32 weeks in Taiwan"],"prefix":"10.1016","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5159-1427","authenticated-orcid":false,"given":"Hao-Wei","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-037X","authenticated-orcid":false,"given":"Fu-Wen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0565-4631","authenticated-orcid":false,"given":"Hsiu-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2022.12.004_bib1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-4258","article-title":"Spontaneous closure of patent ductus arteriosus in infants \u22641500 g","volume":"140","author":"Semberova","year":"2017","journal-title":"Pediatrics"},{"issue":"Suppl 1","key":"10.1016\/j.pedneo.2022.12.004_bib2","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.3346\/jkms.2015.30.S1.S59","article-title":"Current status of therapeutic strategies for patent ductus arteriosus in very-low-birth-weight infants in Korea","volume":"30","author":"Lee","year":"2015","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.pedneo.2022.12.004_bib3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/bmj.1.5115.134","article-title":"The cardiac murmur in relation to symptoms in the newborn","volume":"1","author":"Burnard","year":"1959","journal-title":"Br Med J"},{"key":"10.1016\/j.pedneo.2022.12.004_bib4","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1542\/peds.2009-3506","article-title":"Patent ductus arteriosus of the preterm infant","volume":"125","author":"Hamrick","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2022.12.004_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13052-021-00956-2","article-title":"Morbidity associated with patent ductus arteriosus in preterm newborns: a retrospective case-control study","volume":"47","author":"Terrin","year":"2021","journal-title":"Ital J Pediatr"},{"key":"10.1016\/j.pedneo.2022.12.004_bib6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/jp.2010.3","article-title":"Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?","volume":"30","author":"Benitz","year":"2010","journal-title":"J Perinatol"},{"key":"10.1016\/j.pedneo.2022.12.004_bib7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/adc.55.2.106","article-title":"Patent ductus arteriosus: current clinical status","volume":"55","author":"Kitterman","year":"1980","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.pedneo.2022.12.004_bib8","doi-asserted-by":"crossref","first-page":"F498","DOI":"10.1136\/adc.2005.092734","article-title":"Patent ductus arteriosus: lack of evidence for common treatments","volume":"92","author":"Bose","year":"2007","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.pedneo.2022.12.004_bib9","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-3730","article-title":"American Academy of Pediatrics, Patent ductus arteriosus in preterm infants","volume":"137","author":"Benitz","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2022.12.004_bib10","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1001\/jama.2018.1896","article-title":"Association of Placebo, indomethacin, ibuprofen, and acetaminophen with closure of hemodynamically significant patent ductus arteriosus in preterm infants: a systematic review and meta-analysis","volume":"319","author":"Mitra","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.pedneo.2022.12.004_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jpeds.2018.09.012","article-title":"PDA-TOLERATE trial: an exploratory randomized controlled trial of treatment of moderate-to-large patent ductus arteriosus at 1 Week of age","volume":"205","author":"Clyman","year":"2019","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2022.12.004_bib12","doi-asserted-by":"crossref","first-page":"e1024","DOI":"10.1542\/peds.2013-3431","article-title":"PDA ligation and health outcomes: a meta-analysis","volume":"133","author":"Weisz","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2022.12.004_bib13","first-page":"CD003481","article-title":"Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants","volume":"2","author":"Ohlsson","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.pedneo.2022.12.004_bib14","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-2390","article-title":"Trends in patent ductus arteriosus diagnosis and management for very low birth weight infants","volume":"139","author":"Ngo","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2022.12.004_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.626261","article-title":"Conservative management of patent ductus arteriosus in preterm infants-A systematic review and meta-analyses assessing differences in outcome measures between randomized controlled trials and cohort studies","volume":"9","author":"Hundscheid","year":"2021","journal-title":"Front Pediatr"},{"key":"10.1016\/j.pedneo.2022.12.004_bib16","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.pedneo.2014.05.002","article-title":"Neonatal outcomes of extremely preterm infants from Taiwan: comparison with Canada, Japan, and the USA","volume":"56","author":"Su","year":"2015","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.pedneo.2022.12.004_bib17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm","volume":"92","author":"Papile","year":"1978","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2022.12.004_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging","volume":"187","author":"Bell","year":"1978","journal-title":"Ann Surg"},{"key":"10.1016\/j.pedneo.2022.12.004_bib19","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","article-title":"Bronchopulmonary dysplasia","volume":"163","author":"Jobe","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pedneo.2022.12.004_bib20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jpeds.2021.12.071","article-title":"International variation in the management of patent ductus arteriosus and its association with infant outcomes: a survey and linked cohort study","volume":"244","author":"Isayama","year":"2022","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2022.12.004_bib21","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2021-052874","article-title":"Variation of patent ductus arteriosus treatment in very low birth weight infants","volume":"148","author":"Runte","year":"2021","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2022.12.004_bib22","article-title":"Patent ductus arteriosus treatment trends and associated morbidities in neonates","volume":"11","author":"Park","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.pedneo.2022.12.004_bib23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1159\/000454798","article-title":"Patent ductus arteriosus treatment in very preterm infants: a European Population-based cohort study (EPICE) on variation and outcomes","volume":"111","author":"Edstedt Bonamy","year":"2017","journal-title":"Neonatology"},{"key":"10.1016\/j.pedneo.2022.12.004_bib24","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2020-1209","article-title":"Patent ductus arteriosus of the preterm infant","volume":"146","author":"Hamrick","year":"2020","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2022.12.004_bib25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/j.semperi.2011.09.022","article-title":"Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?","volume":"36","author":"Clyman","year":"2012","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.pedneo.2022.12.004_bib26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pedneo.2019.10.002","article-title":"Therapeutic strategy of patent ductus arteriosus in extremely preterm infants","volume":"61","author":"Su","year":"2020","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.pedneo.2022.12.004_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12887-015-0480-y","article-title":"Lung function in very preterm infants with patent ductus arteriosus under conservative management: an observational study","volume":"15","author":"Chen","year":"2015","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.pedneo.2022.12.004_bib28","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jpeds.2012.05.007","article-title":"Treatment of patent ductus arteriosus and neonatal mortality\/morbidities: adjustment for treatment selection bias","volume":"161","author":"Mirea","year":"2012","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2022.12.004_bib29","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jpeds.2017.11.029","article-title":"Outcomes of surgical ligation after unsuccessful Pharmacotherapy for patent ductus arteriosus in neonates born extremely preterm","volume":"195","author":"Weisz","year":"2018","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2022.12.004_bib30","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1203\/PDR.0b013e318163a8e4","article-title":"Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus","volume":"63","author":"Chang","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pedneo.2022.12.004_bib31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jpeds.2017.03.021","article-title":"Prophylactic indomethacin compared with delayed conservative management of the patent ductus arteriosus in extremely preterm infants: effects on neonatal outcomes","volume":"187","author":"Liebowitz","year":"2017","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2022.12.004_bib32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1055\/s-0039-1697672","article-title":"Relationship between duration of infant exposure to a moderate-to-large patent ductus arteriosus shunt and the risk of developing bronchopulmonary dysplasia or death before 36 weeks","volume":"37","author":"Clyman","year":"2020","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.pedneo.2022.12.004_bib33","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1080\/14767058.2017.1347921","article-title":"Morbidities associated with patent ductus arteriosus in preterm infants. Nationwide cohort study","volume":"31","author":"H\u00e4rkin","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.pedneo.2022.12.004_bib34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.pedneo.2020.03.009","article-title":"Ligation of patent ductus arteriosus in very low birth weight premature infants","volume":"61","author":"Othman","year":"2020","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.pedneo.2022.12.004_bib35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1053\/j.semperi.2008.01.003","article-title":"The neonatal intestinal vasculature: contributing factors to necrotizing enterocolitis","volume":"32","author":"Nankervis","year":"2008","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.pedneo.2022.12.004_bib36","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13019-020-01191-2","article-title":"Surgical ligation of patent ductus arteriosus in preterm neonates weighing less than 1500g: a 9-year single center experience","volume":"15","author":"Lee","year":"2020","journal-title":"J Cardiothorac Surg"},{"key":"10.1016\/j.pedneo.2022.12.004_bib37","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1001\/jamapediatrics.2016.5143","article-title":"Association of patent ductus arteriosus ligation with death or neurodevelopmental impairment among extremely preterm infants","volume":"171","author":"Weisz","year":"2017","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.pedneo.2022.12.004_bib38","article-title":"The optimal timing of surgical ligation of patent ductus arteriosus in preterm or very-low-birth-weight infants: a systematic review and meta-analysis","volume":"99","author":"Yan","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.pedneo.2022.12.004_bib39","first-page":"21","article-title":"What is a hemodynamically significant PDA in preterm infants?","volume":"14","author":"Shepherd","year":"2019","journal-title":"Congenit Heart Dis"}],"container-title":["Pediatrics & Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957222002741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957222002741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:56:37Z","timestamp":1761749797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957222002741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S1875957222002741"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2022.12.004","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical outcomes of different patent ductus arteriosus treatment in preterm infants born between 28 and 32 weeks in Taiwan","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2022.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}