{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:45:19Z","timestamp":1790801119604,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics & Neonatology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.pedneo.2023.12.007","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T06:59:56Z","timestamp":1716361196000},"page":"44-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-blinded non-inferiority parallel clinical trial"],"prefix":"10.1016","volume":"66","author":[{"given":"Mandana","family":"Kashaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Mohazzab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Radgoudarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Bordbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sama","family":"Dabbagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2023.12.007_bib1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1067\/mpd.2002.122730","article-title":"Neurodevelopmental and medical outcomes of persistent pulmonary hypertension in term newborns treated with nitric oxide","volume":"140","author":"Lipkin","year":"2002","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2023.12.007_bib2","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-1165","article-title":"Persistent pulmonary hypertension of the newborn in late preterm and term infants in California","volume":"139","author":"Steurer","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2023.12.007_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1542\/peds.105.1.14","article-title":"Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes","volume":"105","author":"Walsh-Sukys","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2023.12.007_bib4","doi-asserted-by":"crossref","DOI":"10.1177\/2045894020979503","article-title":"Macitentan in infants and children with pulmonary hypertensive vascular disease. Feasibility, tolerability and practical issues - a single-centre experience","volume":"11","author":"Albinni","year":"2021","journal-title":"Pulm Circ"},{"key":"10.1016\/j.pedneo.2023.12.007_bib5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1517\/17425255.2015.1000859","article-title":"Pharmacokinetic and pharmacodynamic evaluation of macitentan , a novel endothelin receptor antagonist for the treatment of pulmonary arterial hypertension","volume":"11","author":"Sidharta","year":"2015","journal-title":"Expet Opin Drug Metab Toxicol"},{"key":"10.1016\/j.pedneo.2023.12.007_bib6","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1056\/NEJM199702273360901","article-title":"Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure","volume":"336","year":"1997","journal-title":"N Engl J Med"},{"issue":"1 Suppl","key":"10.1016\/j.pedneo.2023.12.007_bib7","doi-asserted-by":"crossref","first-page":"65S","DOI":"10.1378\/chest.114.1_Supplement.65S","article-title":"Chronic intrauterine pulmonary hypertension increases preproendothelin-1 and decreases endothelin B receptor mRNA expression in the ovine fetal lung","volume":"114","author":"Ivy","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.pedneo.2023.12.007_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00000542-199907000-00041","article-title":"Sildenafil ameliorates effects of inhaled nitric oxide withdrawal","volume":"91","author":"Atz","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pedneo.2023.12.007_bib9","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1542\/peds.2005-0523","article-title":"Oral sildenafil in infants with persistent pulmonary hypertension of the newborn: a pilot randomized blinded study","volume":"117","author":"Baquero","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2023.12.007_bib10","first-page":"L931","article-title":"Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity","volume":"275","author":"Hanson","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pedneo.2023.12.007_bib11","first-page":"333","article-title":"Comparison of the efficacy of sildenafil Alone versus sildenafil Plus bosentan in newborns with persistent pulmonary hypertension","volume":"30","author":"Fatima","year":"2018","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"10.1016\/j.pedneo.2023.12.007_bib12","first-page":"77","article-title":"Hepatotoxicity by bosentan in a patient with portopulmonary hypertension: a case-report and review of the literature","volume":"20","author":"Eriksson","year":"2011","journal-title":"J Gastrointestin Liver Dis"},{"key":"10.1016\/j.pedneo.2023.12.007_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4070\/kcj.2009.39.3.105","article-title":"Beneficial and adverse effects of bosentan treatment in Korean patients with pulmonary artery hypertension","volume":"39","author":"Sohn","year":"2009","journal-title":"Korean Circ J"},{"key":"10.1016\/j.pedneo.2023.12.007_bib14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4103\/jcn.JCN_5_20","article-title":"Comparison of the effects of bosentan and sildenafil in the treatment of persistent pulmonary arterial hypertension in infants","volume":"9","author":"Farhangdoust","year":"2020","journal-title":"Journal of Clinical Neonatology"},{"key":"10.1016\/j.pedneo.2023.12.007_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1086\/685051","article-title":"Transthoracic echocardiography in the evaluation of pediatric pulmonary hypertension and ventricular dysfunction","volume":"6","author":"Koestenberger","year":"2016","journal-title":"Pulm Circ"},{"key":"10.1016\/j.pedneo.2023.12.007_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/818971","article-title":"Persistent pulmonary hypertension of non cardiac cause in a neonatal intensive care unit","volume":"2012","author":"Rocha","year":"2012","journal-title":"Pulm Med"},{"key":"10.1016\/j.pedneo.2023.12.007_bib17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/jcecho.jcecho_31_18","article-title":"Reference values of Longitudinal systolic right and left ventricular function measured by M-mode echocardiography in Healthy preterm and term neonates","volume":"28","author":"Ghandi","year":"2018","journal-title":"J Cardiovasc Echogr"},{"key":"10.1016\/j.pedneo.2023.12.007_bib18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fped.2017.00201","article-title":"Echocardiographic evaluation of Hemodynamics in neonates and children","volume":"5","author":"Singh","year":"2017","journal-title":"Front Pediatr"},{"key":"10.1016\/j.pedneo.2023.12.007_bib19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1542\/peds.101.3.325","article-title":"Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. The I-NO\/PPHN Study Group","volume":"101","author":"Davidson","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2023.12.007_bib20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.lfs.2014.02.018","article-title":"Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension","volume":"118","author":"Iglarz","year":"2014","journal-title":"Life Sci"},{"key":"10.1016\/j.pedneo.2023.12.007_bib21","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1124\/jpet.116.234930","article-title":"Endothelin ET(A) receptor Blockade, by Activating ET(B) receptors, increases vascular Permeability and Induces Exaggerated Fluid Retention","volume":"361","author":"Vercauteren","year":"2017","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pedneo.2023.12.007_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003896","article-title":"Clinical adverse effects of endothelin receptor antagonists: Insights from the Meta-analysis of 4894 patients from 24 randomized double-Blind placebo-controlled clinical trials","volume":"5","author":"Wei","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.pedneo.2023.12.007_bib23","first-page":"1675","article-title":"Safety, efficacy, and clinical utility of macitentan in the treatment of pulmonary arterial hypertension","volume":"10","author":"Monaco","year":"2016","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.pedneo.2023.12.007_bib24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/bcpt.13033","article-title":"A focus on macitentan in the treatment of pulmonary arterial hypertension","volume":"123","author":"Bedan","year":"2018","journal-title":"Basic Clin Pharmacol Toxicol"}],"container-title":["Pediatrics & Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957224000779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957224000779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T16:33:45Z","timestamp":1737650025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957224000779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1875957224000779"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2023.12.007","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-blinded non-inferiority parallel clinical trial","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2023.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}