{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:38:29Z","timestamp":1777621109166,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 111\\u20132314-B-182A-104"],"award-info":[{"award-number":["MOST 111\\u20132314-B-182A-104"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112-2314-B-182A-073"],"award-info":[{"award-number":["112-2314-B-182A-073"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["NMRPG3M0081"],"award-info":[{"award-number":["NMRPG3M0081"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["NMRPG3N0141"],"award-info":[{"award-number":["NMRPG3N0141"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Linkou Chang Gung Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics & Neonatology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.pedneo.2024.08.005","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T06:21:19Z","timestamp":1737526879000},"page":"454-461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biologics promote catch-up growth in young Juvenile idiopathic arthritis patients with lower body height"],"prefix":"10.1016","volume":"66","author":[{"given":"Jr-Lin","family":"Hsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Chih","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Han","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Hsin-Yi Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Long","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2024.08.005_bib1","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/S0140-6736(11)60244-4","article-title":"Juvenile idiopathic arthritis","volume":"377","author":"Prakken","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.pedneo.2024.08.005_bib2","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.berh.2018.10.004","article-title":"Update on the epidemiology, risk factors and disease outcomes of Juvenile idiopathic arthritis","volume":"32","author":"Palman","year":"2018","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib4","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s00296-014-3022-2","article-title":"Growth abnormalities in children and adolescents with juvenile idiopathic arthritis","volume":"34","author":"Bechtold","year":"2014","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.pedneo.2024.08.005_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.semarthrit.2017.11.002","article-title":"Growth patterns in early juvenile idiopathic arthritis: results from the Childhood Arthritis Prospective Study (CAPS)","volume":"48","author":"McErlane","year":"2018","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.pedneo.2024.08.005_bib6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3899\/jrheum.130311","article-title":"Effect of biologic treatments on growth in children with juvenile idiopathic arthritis","volume":"41","author":"Uettwiller","year":"2014","journal-title":"J Rheumatol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib7","first-page":"367","article-title":"Juvenile arthritis--who gets it, where and when? A review of current data on incidence and prevalence","volume":"17","author":"Andersson G\u00e4re","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib8","doi-asserted-by":"crossref","first-page":"936","DOI":"10.3899\/jrheum.121147","article-title":"Race, ethnicity, and disease outcomes in juvenile idiopathic arthritis: a cross-sectional analysis of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry","volume":"40","author":"Ringold","year":"2013","journal-title":"J Rheumatol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12969-021-00650-x","article-title":"Epidemiology and demographics of juvenile idiopathic arthritis in Africa and Middle East","volume":"19","author":"Al-Mayouf","year":"2021","journal-title":"Pediatr Rheumatol Online J"},{"key":"10.1016\/j.pedneo.2024.08.005_bib10","article-title":"Juvenile idiopathic arthritis-associated uveitis: a nationwide population-based study in Taiwan","volume":"8","author":"Yu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pedneo.2024.08.005_bib11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jbspin.2013.09.003","article-title":"Prevalence and incidence of juvenile idiopathic arthritis: a systematic review","volume":"81","author":"Thierry","year":"2014","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.pedneo.2024.08.005_bib12","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1007\/s10067-020-05081-9","article-title":"Juvenile idiopathic arthritis in Southeast Asia: the Singapore experience over two decades","volume":"39","author":"Tanya","year":"2020","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1442-200X.1997.tb03593.x","article-title":"Clinical analysis of 570 cases with juvenile rheumatoid arthritis: results of a nationwide retrospective survey in Japan","volume":"39","author":"Fujikawa","year":"1997","journal-title":"Acta Paediatr Jpn"},{"key":"10.1016\/j.pedneo.2024.08.005_bib14","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jmii.2012.03.006","article-title":"Clinical features of children with juvenile idiopathic arthritis using the ILAR classification criteria: a community-based cohort study in Taiwan","volume":"46","author":"Shen","year":"2013","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.pedneo.2024.08.005_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12969-019-0363-0","article-title":"Enthesitis-related arthritis is the most common category of juvenile idiopathic arthritis in Taiwan and presents persistent active disease","volume":"17","author":"Shih","year":"2019","journal-title":"Pediatr Rheumatol Online J"},{"key":"10.1016\/j.pedneo.2024.08.005_bib16","unstructured":"World Health Organization, Child growth standards. 2007. Available at https:\/\/www.who.int\/tools\/child-growth-standards. Accessed November 6, 2023."},{"key":"10.1016\/j.pedneo.2024.08.005_bib17","unstructured":"World Health Organization , Growth reference data for 5-19 years ; 2007. Available at https:\/\/www.who.int\/tools\/growth-reference-data-for-5to19-years. Accessed November 6, 2023."},{"key":"10.1016\/j.pedneo.2024.08.005_bib18","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/acr.20497","article-title":"American College of Rheumatology provisional criteria for defining clinical inactive disease in select categories of juvenile idiopathic arthritis","volume":"63","author":"Wallace","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.pedneo.2024.08.005_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1875-9572(10)60014-9","article-title":"New growth charts for Taiwanese children and adolescents based on World Health Organization standards and health-related physical fitness","volume":"51","author":"Chen","year":"2010","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib20","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/acr.20460","article-title":"American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features","volume":"63","author":"Beukelman","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.pedneo.2024.08.005_bib21","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1002\/art.38092","volume":"65","author":"Ringold","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.pedneo.2024.08.005_bib22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/17571472.2010.11493315","article-title":"An overview of the healthcare system in Taiwan","volume":"3","author":"Wu","year":"2010","journal-title":"London J Prim Care (Abingdon)"},{"key":"10.1016\/j.pedneo.2024.08.005_bib23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12969-017-0196-7","article-title":"Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort","volume":"15","author":"Guzman","year":"2017","journal-title":"Pediatr Rheumatol Online J"},{"key":"10.1016\/j.pedneo.2024.08.005_bib24","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/rheumatology\/keu489","article-title":"Growth in children and adolescents with juvenile idiopathic arthritis over 2 years of treatment with etanercept: results from the British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study","volume":"54","author":"Kearsley-Fleet","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.pedneo.2024.08.005_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12969-021-00521-5","article-title":"Growth and puberty in children with juvenile idiopathic arthritis","volume":"19","author":"d\u2019Angelo","year":"2021","journal-title":"Pediatr Rheumatol Online J"},{"key":"10.1016\/j.pedneo.2024.08.005_bib26","first-page":"104","article-title":"Growth in juvenile idiopathic arthritis: the role of inflammation","volume":"29","author":"Gaspari","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib27","first-page":"1296","article-title":"Linear growth and final height in patients with systemic juvenile idiopathic arthritis treated with longterm glucocorticoids","volume":"29","author":"Simon","year":"2002","journal-title":"J Rheumatol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib28","first-page":"2481","article-title":"Etanercept treatment improves longitudinal growth in prepubertal children with juvenile idiopathic arthritis","volume":"34","author":"Vojvodich","year":"2007","journal-title":"J Rheumatol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib29","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3899\/jrheum.170326","article-title":"Growth during tocilizumab therapy for polyarticular-course juvenile idiopathic arthritis: 2-year data from a phase III clinical trial","volume":"45","author":"Bharucha","year":"2018","journal-title":"J Rheumatol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib30","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/art.38984","article-title":"Catch-up growth during tocilizumab therapy for systemic juvenile idiopathic arthritis: results from a phase III trial","volume":"67","author":"De Benedetti","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib31","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1002\/art.27682","article-title":"Effects of long-term etanercept treatment on growth in children with selected categories of juvenile idiopathic arthritis","volume":"62","author":"Giannini","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.pedneo.2024.08.005_bib32","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1136\/ard.2005.047225","article-title":"Impact of anti-TNF treatment on growth in severe juvenile idiopathic arthritis","volume":"65","author":"Tynj\u00e4l\u00e4","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.pedneo.2024.08.005_bib33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mce.2006.06.002","article-title":"Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levels","volume":"256","author":"Gore","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.pedneo.2024.08.005_bib34","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1007\/s00296-013-2683-6","article-title":"Sexual maturation in Egyptian boys and girls with juvenile rheumatoid arthritis","volume":"33","author":"Maher","year":"2013","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.pedneo.2024.08.005_bib35","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0929-6646(08)60165-5","article-title":"Relationship between age at menarche and skeletal maturation stages in Taiwanese female orthodontic patients","volume":"107","author":"Lai","year":"2008","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.pedneo.2024.08.005_bib36","first-page":"1","article-title":"A cross-sectional study on the skeletal development of the hand and wrist from preadolescence to early adulthood among Chinese in Taiwan","volume":"9","author":"Chang","year":"1990","journal-title":"Zhonghua Ya Yi Xue Hui Za Zhi"},{"key":"10.1016\/j.pedneo.2024.08.005_bib37","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0929-6646(08)60093-5","article-title":"Radiographic assessment of skeletal maturation stages for orthodontic patients: hand-wrist bones or cervical vertebrae?","volume":"107","author":"Lai","year":"2008","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.pedneo.2024.08.005_bib38","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/art.22882","article-title":"Delay in access to appropriate care for children presenting with musculoskeletal symptoms and ultimately diagnosed with juvenile idiopathic arthritis","volume":"57","author":"Foster","year":"2007","journal-title":"Arthritis Rheum"}],"container-title":["Pediatrics & Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957225000208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957225000208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T23:51:39Z","timestamp":1762559499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957225000208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1875957225000208"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2024.08.005","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biologics promote catch-up growth in young Juvenile idiopathic arthritis patients with lower body height","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2024.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}