{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:46:25Z","timestamp":1782733585613,"version":"3.54.5"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 110-T05"],"award-info":[{"award-number":["NTUH 110-T05"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["111-T0009"],"award-info":[{"award-number":["111-T0009"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["112-E0009"],"award-info":[{"award-number":["112-E0009"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics & Neonatology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.pedneo.2025.07.004","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T02:42:05Z","timestamp":1763347325000},"page":"360-365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship between lymphocyte subtypes distribution and biliary cirrhosis in biliary atresia patients"],"prefix":"10.1016","volume":"67","author":[{"given":"Chieh-Jung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Chiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Hao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Chi","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6828-8809","authenticated-orcid":false,"given":"Chi-San","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1158-5249","authenticated-orcid":false,"given":"Yen-Hsuan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3648-9261","authenticated-orcid":false,"given":"Mei-Hwei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6343-1658","authenticated-orcid":false,"given":"Jia-Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2025.07.004_bib1","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/S0140-6736(09)60946-6","article-title":"Biliary atresia","volume":"374","author":"Hartley","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.pedneo.2025.07.004_bib2","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/hep.29905","article-title":"Biliary atresia: clinical and research challenges for the twenty-first century","volume":"68","author":"Bezerra","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.pedneo.2025.07.004_bib3","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/MPG.0000000000000676","article-title":"Use of Lactobacillus casei rhamnosus to prevent cholangitis in biliary atresia after Kasai operation","volume":"60","author":"Lien","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2025.07.004_bib4","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/SLA.0000000000006273","article-title":"The outcome of a centralization program in biliary atresia: twenty years and beyond","volume":"281","author":"Davenport","year":"2025","journal-title":"Ann Surg"},{"key":"10.1016\/j.pedneo.2025.07.004_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-90860-w","article-title":"Life long follow up and management strategies of patients living with native livers after Kasai portoenterostomy","volume":"11","author":"Chung","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.pedneo.2025.07.004_bib6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jcmgh.2015.04.001","article-title":"What causes biliary atresia? Unique aspects of the neonatal immune system provide clues to disease pathogenesis","volume":"1","author":"Mack","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.pedneo.2025.07.004_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1055\/s-2007-985068","article-title":"The pathogenesis of biliary atresia: evidence for a virus-induced autoimmune disease","volume":"27","author":"Mack","year":"2007","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.pedneo.2025.07.004_bib8","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.cell.2020.10.048","article-title":"Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia","volume":"183","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.pedneo.2025.07.004_bib9","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s13258-021-01153-5","article-title":"RRV-induced biliary atresia in neonatal mice involves CD8 + T lymphocyte killer cells and the Notch signaling pathway","volume":"43","author":"Si","year":"2021","journal-title":"Genes Genomics"},{"key":"10.1016\/j.pedneo.2025.07.004_bib10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3748\/wjg.v24.i3.387","article-title":"Autoimmune liver disease-related autoantibodies in patients with biliary atresia","volume":"24","author":"Pang","year":"2018","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.pedneo.2025.07.004_bib11","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/hep4.1672","article-title":"Diagnostic performance of transient elastography in biliary atresia among infants with cholestasis","volume":"5","author":"Boo","year":"2021","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.pedneo.2025.07.004_bib12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/gut.2005.069153","article-title":"Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study","volume":"55","author":"Foucher","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.pedneo.2025.07.004_bib13","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/hep.29856","article-title":"Transient elastography is useful in diagnosing biliary atresia and predicting prognosis after hepatoportoenterostomy","volume":"68","author":"Wu","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.pedneo.2025.07.004_bib14","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno VII - Renewing consensus in portal hypertension","volume":"76","author":"de Franchis","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.pedneo.2025.07.004_bib15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/jpn3.12278","article-title":"Performance of Baveno VII criteria for the screening of varices needing treatment in patients with biliary atresia","volume":"79","author":"Ling","year":"2024","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2025.07.004_bib16","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.2147\/JIR.S430730","article-title":"The role of inflammation in cholestatic liver injury","volume":"16","author":"Chen","year":"2023","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.pedneo.2025.07.004_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.867940","article-title":"Hepatic stellate cell-immune interactions in NASH","volume":"13","author":"Carter","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.pedneo.2025.07.004_bib18","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1016\/j.vaccine.2009.02.094","article-title":"Humoral immunogenicity to measles, rubella, and varicella-zoster vaccines in biliary atresia children","volume":"27","author":"Wu","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.pedneo.2025.07.004_bib19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1203\/PDR.0b013e3181732908","article-title":"Inadequate humoral immunogenicity to recombinant hepatitis B virus vaccine in biliary atresia children","volume":"64","author":"Wu","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pedneo.2025.07.004_bib20","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3389\/fimmu.2019.00477","article-title":"\u03b3\u03b4T cells suppress liver fibrosis via strong cytolysis and enhanced NK cell-mediated cytotoxicity against hepatic stellate cells","volume":"10","author":"Liu","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.pedneo.2025.07.004_bib21","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/hep.22413","article-title":"Activation of hepatic stellate cells after phagocytosis of lymphocytes: a novel pathway of fibrogenesis","volume":"48","author":"Muhanna","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.pedneo.2025.07.004_bib22","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/hep.510230538","article-title":"Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis","volume":"23","author":"Baroni","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.pedneo.2025.07.004_bib23","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/376594a0","article-title":"An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection","volume":"376","author":"Wynn","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.pedneo.2025.07.004_bib24","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/S0140-6736(02)11603-5","article-title":"Genetic induction of proinflammatory immunity in children with biliary atresia","volume":"360","author":"Bezerra","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.pedneo.2025.07.004_bib25","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1172\/JCI200421153","article-title":"Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia","volume":"114","author":"Shivakumar","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pedneo.2025.07.004_bib26","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s12519-015-0023-5","article-title":"The correlation between plasma cytokine levels in jaundice-free children with biliary atresia","volume":"11","author":"Jian","year":"2015","journal-title":"World J Pediatr"},{"key":"10.1016\/j.pedneo.2025.07.004_bib27","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41419-018-0605-y","article-title":"MicroRNA-29b\/142-5p contribute to the pathogenesis of biliary atresia by regulating the IFN-\u03b3 gene","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pedneo.2025.07.004_bib28","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/cvr\/cvu062","article-title":"Crosstalk between fibroblasts and inflammatory cells","volume":"102","author":"Van Linthout","year":"2014","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pedneo.2025.07.004_bib29","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190418","article-title":"Biology and therapeutic potential of interleukin-10","volume":"217","author":"Saraiva","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.pedneo.2025.07.004_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111341","article-title":"Interleukin-10 gene intervention ameliorates liver fibrosis by enhancing the immune function of natural killer cells in liver tissue","volume":"127","author":"Chen","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.pedneo.2025.07.004_bib31","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1053\/j.gastro.2009.11.051","article-title":"Effect of puberty onset on spontaneous hepatitis B virus e antigen seroconversion in men","volume":"138","author":"Wu","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pedneo.2025.07.004_bib32","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s00535-013-0831-0","article-title":"Role of serum dehydroepiandrosterone sulfate level on the clearance of chronic hepatitis B virus infection","volume":"49","author":"Wu","year":"2014","journal-title":"J Gastroenterol"}],"container-title":["Pediatrics & Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957225002049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957225002049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:16:57Z","timestamp":1782731817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957225002049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S1875957225002049"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2025.07.004","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The relationship between lymphocyte subtypes distribution and biliary cirrhosis in biliary atresia patients","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2025.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}