{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:12:45Z","timestamp":1788901965895,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics &amp; Neonatology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.pedneo.2026.02.010","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:22:09Z","timestamp":1785885729000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanisms of A\u03b21-42-mediated oxidative stress-induced neuronal apoptosis in neonatal hypoxic-ischemic brain injury"],"prefix":"10.1016","author":[{"given":"Lixuan","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2026.02.010_bib1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1651-2227.1995.tb13794.x","article-title":"Birth asphyxia: incidence, clinical course and outcome in a Swedish population","volume":"84","author":"Thornberg","year":"1995","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.pedneo.2026.02.010_bib2","first-page":"65","article-title":"Low 5-minute Apgar score: a population-based register study of 1 million term births","volume":"98","author":"Thorngren-Jerneck","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.pedneo.2026.02.010_bib3","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jconrel.2020.12.056","article-title":"Drug delivery platforms for neonatal brain injury","volume":"330","author":"Narayanamurthy","year":"2021","journal-title":"J Contr Release"},{"key":"10.1016\/j.pedneo.2026.02.010_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/AOG.0000000000005392","article-title":"Neonatal hypoxic-ischemic encephalopathy and hypothermia treatment","volume":"143","author":"Arnautovic","year":"2024","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.pedneo.2026.02.010_bib5","doi-asserted-by":"crossref","first-page":"228.e1","DOI":"10.1016\/j.anpedi.2017.05.005","article-title":"[Oxidative stress in perinatal asphyxia and hypoxic-ischaemic encephalopathy]","volume":"88","author":"Nu\u00f1ez","year":"2018","journal-title":"An Pediatr (Engl Ed)"},{"key":"10.1016\/j.pedneo.2026.02.010_bib6","first-page":"929","article-title":"Treatment and new progress of neonatal hypoxic-ischemic brain damage","volume":"35","author":"Yang","year":"2020","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.pedneo.2026.02.010_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s13760-020-01308-3","article-title":"Pathophysiology of hypoxic-ischemic encephalopathy: a review of the past and a view on the future","volume":"120","author":"Greco","year":"2020","journal-title":"Acta Neurol Belg"},{"key":"10.1016\/j.pedneo.2026.02.010_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122078","article-title":"Oxidative stress in hypoxic-ischemic encephalopathy: molecular mechanisms and therapeutic strategies","volume":"17","author":"Zhao","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.pedneo.2026.02.010_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12974-021-02084-4","article-title":"The role of G-CSF neuroprotective effects in neonatal hypoxic-ischemic encephalopathy (HIE): current status","volume":"18","author":"Dumbuya","year":"2021","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.pedneo.2026.02.010_bib10","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.freeradbiomed.2024.09.025","article-title":"Detection of lipid radicals generated via cerebral ischemia\/reperfusion injury using a radiolabeled nitroxide probe","volume":"224","author":"Azuma","year":"2024","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.pedneo.2026.02.010_bib11","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/brain\/awad330","article-title":"Longitudinal associations of serum biomarkers with early cognitive, amyloid and grey matter changes","volume":"147","author":"De Meyer","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.pedneo.2026.02.010_bib12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13195-021-00874-9","article-title":"A cross-sectional study in healthy elderly subjects aimed at development of an algorithm to increase identification of Alzheimer pathology for the purpose of clinical trial participation","volume":"13","author":"Prins","year":"2021","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.pedneo.2026.02.010_bib13","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.4103\/1673-5374.369117","article-title":"Reperfusion after hypoxia-ischemia exacerbates brain injury with compensatory activation of the anti- ferroptosis system: based on a novel rat model","volume":"18","author":"Zhang","year":"2023","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.pedneo.2026.02.010_bib14","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1038\/s41380-022-01676-7","article-title":"Hypoxia inducible Factor-1\u03b1 binds and activates \u03b3-secretase for A\u03b2 production under hypoxia and cerebral hypoperfusion","volume":"27","author":"Alexander","year":"2022","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.pedneo.2026.02.010_bib15","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.freeradbiomed.2024.09.051","article-title":"Free radicals in Alzheimer's disease: from pathophysiology to clinical trial results","volume":"225","author":"Vi\u00f1a","year":"2024","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.pedneo.2026.02.010_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41398-020-01137-1","article-title":"Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer's disease","volume":"11","author":"Chatterjee","year":"2021","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.pedneo.2026.02.010_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13437","article-title":"Knockdown of astrocytic Grin2a aggravates \u03b2-amyloid-induced memory and cognitive deficits through regulating nerve growth factor","volume":"20","author":"Du","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.pedneo.2026.02.010_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252313020","article-title":"The detection of toxic amyloid-\u03b2 fibril fragments through a surface plasmon resonance immunoassay","volume":"25","author":"Beeg","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.pedneo.2026.02.010_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110029","article-title":"Chlorpyrifos oxon crosslinking of amyloid beta 42 peptides is a new route for generation of self-aggregating amyloidogenic oligomers that promote Alzheimer's disease","volume":"363","author":"Onder","year":"2022","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.pedneo.2026.02.010_bib20","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1021\/acs.chemrev.8b00626","article-title":"Reactive oxygen species (ROS)-based nanomedicine","volume":"119","author":"Yang","year":"2019","journal-title":"Chem Rev"},{"key":"10.1016\/j.pedneo.2026.02.010_bib21","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.cell.2015.10.001","article-title":"Mitochondrial ROS signaling in organismal homeostasis","volume":"163","author":"Shadel","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.pedneo.2026.02.010_bib22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00249-007-0234-3","article-title":"Copper binding to the Alzheimer's disease amyloid precursor protein","volume":"37","author":"Kong","year":"2008","journal-title":"Eur Biophys J"},{"key":"10.1016\/j.pedneo.2026.02.010_bib23","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1126\/science.271.5254.1406","article-title":"The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)","volume":"271","author":"Multhaup","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.pedneo.2026.02.010_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103101","article-title":"Aerobic exercise attenuates LPS-induced cognitive dysfunction by reducing oxidative stress, glial activation, and neuroinflammation","volume":"71","author":"Choi","year":"2024","journal-title":"Redox Biol"},{"key":"10.1016\/j.pedneo.2026.02.010_bib25","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1471-4159.2007.05072.x","article-title":"Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein","volume":"104","author":"Tamagno","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.pedneo.2026.02.010_bib26","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/nm1295-1291","article-title":"The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway","volume":"1","author":"Haass","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.pedneo.2026.02.010_bib27","first-page":"3493","article-title":"Sestrin2 aggravates oxidative stress of neurons by decreasing the expression of Nrf2","volume":"22","author":"Zhang","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.pedneo.2026.02.010_bib28","doi-asserted-by":"crossref","first-page":"783","DOI":"10.4103\/1673-5374.249226","article-title":"Shuxuetong injection protects cerebral microvascular endothelial cells against oxygen-glucose deprivation reperfusion","volume":"14","author":"Sun","year":"2019","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.pedneo.2026.02.010_bib29","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s12035-014-8661-5","article-title":"Lipid integration in neurodegeneration: an overview of Alzheimer's disease","volume":"50","author":"Yadav","year":"2014","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.pedneo.2026.02.010_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2018.05.004","article-title":"Neural stem cell therapies and hypoxic-ischemic brain injury","volume":"173","author":"Huang","year":"2019","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.pedneo.2026.02.010_bib33","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4103\/1673-5374.350203","article-title":"Chlorogenic acid alleviates hypoxic-ischemic brain injury in neonatal mice","volume":"18","author":"Li","year":"2023","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.pedneo.2026.02.010_bib30","first-page":"2523","article-title":"DHA protects PC12 cells against oxidative stress and apoptotic signals through the activation of the NFE2L2\/HO-1 axis","volume":"43","author":"Clementi","year":"2019","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.pedneo.2026.02.010_bib31","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s40478-025-02062-4","article-title":"Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus","volume":"13","author":"Ianevski","year":"2025","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.pedneo.2026.02.010_bib34","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jgr.2022.12.006","article-title":"Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC-CN-NFAT1 signaling in T2DM mice","volume":"47","author":"Dong","year":"2023","journal-title":"J Ginseng Res"}],"container-title":["Pediatrics &amp; Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957226001178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957226001178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:53:16Z","timestamp":1788900796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957226001178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":34,"alternative-id":["S1875957226001178"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2026.02.010","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of A\u03b21-42-mediated oxidative stress-induced neuronal apoptosis in neonatal hypoxic-ischemic brain injury","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2026.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}