{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T13:26:45Z","timestamp":1759411605246},"reference-count":63,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Protein Expression and Purification"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.pep.2010.04.021","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T06:21:11Z","timestamp":1272867671000},"page":"16-23","source":"Crossref","is-referenced-by-count":7,"title":["Purification and characterization of Yersinia enterocolitica and Yersinia pestis LcrV\u2013cholera toxin A2\/B chimeras"],"prefix":"10.1016","volume":"74","author":[{"given":"Juliette K.","family":"Tinker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chadwick T.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britni M.","family":"Arlian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pep.2010.04.021_bib1","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0140-6736(07)60566-2","article-title":"Plague","volume":"369","author":"Prentice","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.pep.2010.04.021_bib2","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1001\/jama.283.17.2281","article-title":"Plague as a biological weapon: medical and public health management. Working group on civilian biodefense","volume":"283","author":"Inglesby","year":"2000","journal-title":"Jama"},{"key":"10.1016\/j.pep.2010.04.021_bib3","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1517\/14712598.4.6.965","article-title":"Yersinia pestis (plague) vaccines","volume":"4","author":"Titball","year":"2004","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.pep.2010.04.021_bib4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1001\/jama.1967.03130170165036","article-title":"Pneumonic plague in an untreated plague-vaccinated individual","volume":"202","author":"Cohen","year":"1967","journal-title":"Jama"},{"issue":"Suppl.","key":"10.1016\/j.pep.2010.04.021_bib5","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1093\/infdis\/129.Supplement_1.S85","article-title":"Live, attenuated Yersinia pestis vaccine: virulent in nonhuman primates, harmless to guinea pigs","volume":"129","author":"Meyer","year":"1974","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pep.2010.04.021_bib6","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1016\/S0264-410X(01)00163-3","article-title":"Vaccination against bubonic and pneumonic plague","volume":"19","author":"Titball","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.pep.2010.04.021_bib7","first-page":"75","article-title":"Antigen F1 from Yersinia pestis forms aqueous channels in lipid bilayer membranes","volume":"25","author":"Rodrigues","year":"1992","journal-title":"Br. J. Med. Biol. Res."},{"key":"10.1016\/j.pep.2010.04.021_bib8","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1046\/j.1365-2958.2001.02259.x","article-title":"LcrV is a channel size-determining component of the Yop effector translocon of Yersinia","volume":"39","author":"Holmstrom","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pep.2010.04.021_bib9","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1046\/j.1365-2958.1999.01408.x","article-title":"The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation","volume":"32","author":"Pettersson","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pep.2010.04.021_bib10","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1128\/IAI.73.6.3598-3608.2005","article-title":"Human immune response to a plague vaccine comprising recombinant F1 and V antigens","volume":"73","author":"Williamson","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pep.2006.12.018","article-title":"Purification and protective efficacy of monomeric and modified Yersinia pestis capsular F1\u2013V antigen fusion proteins for vaccination against plague","volume":"53","author":"Goodin","year":"2007","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.pep.2010.04.021_bib12","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1021\/bp050098r","article-title":"Design and testing for a nontagged F1\u2013V fusion protein as vaccine antigen against bubonic and pneumonic plague","volume":"21","author":"Powell","year":"2005","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.pep.2010.04.021_bib13","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0264-410X(98)80110-2","article-title":"Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1\u2013V antigen fusion protein vaccine","volume":"16","author":"Heath","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.pep.2010.04.021_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1586\/14760584.7.2.209","article-title":"Current challenges in the development of vaccines for pneumonic plague","volume":"7","author":"Smiley","year":"2008","journal-title":"Expert. Rev. Vaccines"},{"key":"10.1016\/j.pep.2010.04.021_bib15","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.vaccine.2005.09.052","article-title":"Intranasal Protollin\/F1\u2013V vaccine elicits respiratory and serum antibody responses and protects mice against lethal aerosolized plague infection","volume":"24","author":"Jones","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.pep.2010.04.021_bib16","series-title":"Yersinia enterocolitica","author":"Robins-Browne","year":"1997"},{"key":"10.1016\/j.pep.2010.04.021_bib17","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0167-5699(99)01523-6","article-title":"Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins","volume":"20","author":"Rappuoli","year":"1999","journal-title":"Immunol. Today"},{"key":"10.1016\/j.pep.2010.04.021_bib18","first-page":"42","article-title":"Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant","volume":"50","author":"Holmgren","year":"1994","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pep.2010.04.021_bib19","first-page":"301","article-title":"Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens","volume":"59","author":"Lycke","year":"1986","journal-title":"Immunology"},{"key":"10.1016\/j.pep.2010.04.021_bib20","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1016\/S0264-410X(00)00553-3","article-title":"Giudice, mucosal vaccines: nontoxic derivatives of LT and CT as mucosal adjuvants","volume":"19","author":"Pizza","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.pep.2010.04.021_bib21","first-page":"1","article-title":"Immune modulation by the cholera-like enterotoxins","volume":"2002","author":"Salmond","year":"2002","journal-title":"Expert. Rev. Mol. Med."},{"key":"10.1016\/j.pep.2010.04.021_bib22","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1177\/154405910508401205","article-title":"Immunomodulation with enterotoxins for the generation of secretory immunity or tolerance. applications for oral infections","volume":"84","author":"Hajishengallis","year":"2005","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.pep.2010.04.021_bib23","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1128\/IAI.00581-06","article-title":"Induction of cell signaling events by the cholera toxin B subunit in antigen-presenting cells","volume":"75","author":"Schnitzler","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib24","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1016\/j.vaccine.2007.09.030","article-title":"Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens","volume":"25","author":"Uddowla","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.pep.2010.04.021_bib25","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1016\/j.vaccine.2004.02.049","article-title":"Immunisation against plague by transcutaneous and intradermal application of subunit antigens","volume":"22","author":"Eyles","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.pep.2010.04.021_bib26","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00018-008-7496-5","article-title":"Cholera toxin structure, gene regulation and pathophysiological and immunological aspects","volume":"65","author":"Sanchez","year":"2008","journal-title":"Cell Mol, Life Sci,"},{"key":"10.1016\/j.pep.2010.04.021_bib27","series-title":"Vaccines","author":"Plotkin","year":"2008"},{"key":"10.1016\/j.pep.2010.04.021_bib28","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.1128\/IAI.60.11.4915-4924.1992","article-title":"Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras","volume":"60","author":"Jobling","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib29","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/plas.1997.1309","article-title":"Construction and characterization of versatile cloning vectors for efficient delivery of native foreign proteins to the periplasm of Escherichia coli","volume":"38","author":"Jobling","year":"1997","journal-title":"Plasmid"},{"key":"10.1016\/j.pep.2010.04.021_bib30","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/IAI.66.2.462-468.1998","article-title":"Mucosal immunogenicity of a holotoxin-like molecule containing the serine-rich Entamoeba histolytica protein (SREHP) fused to the A2 domain of cholera toxin","volume":"66","author":"Sultan","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib31","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1128\/IAI.72.12.7306-7310.2004","article-title":"Use of translational fusion of the MrpH fimbrial adhesin-binding domain with the cholera toxin A2 domain, coexpressed with the cholera toxin B subunit, as an intranasal vaccine to prevent experimental urinary tract infection by Proteus mirabilis","volume":"72","author":"Li","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib32","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1128\/IAI.73.9.5654-5665.2005","article-title":"Heteropentameric cholera toxin B subunit chimeric molecules genetically fused to a vaccine antigen induce systemic and mucosal immune responses: a potential new strategy to target recombinant vaccine antigens to mucosal immune systems","volume":"73","author":"Harakuni","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib33","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1365-2567.2005.02246.x","article-title":"Induction and recall of immune memory by mucosal immunization with a non-toxic recombinant enterotoxin-based chimeric protein","volume":"116","author":"Gockel","year":"2005","journal-title":"Immunology"},{"key":"10.1016\/j.pep.2010.04.021_bib34","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.4049\/jimmunol.154.9.4322","article-title":"Mucosal immunization with a bacterial protein antigen genetically coupled to cholera toxin A2\/B subunits","volume":"154","author":"Hajishengallis","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.pep.2010.04.021_bib35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/abio.2001.5084","article-title":"In vitro assembly of novel cholera toxin-like complexes","volume":"292","author":"Hatic","year":"2001","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.pep.2010.04.021_bib36","doi-asserted-by":"crossref","first-page":"33369","DOI":"10.1074\/jbc.M112337200","article-title":"Detoxification of cholera toxin without removal of its immunoadjuvanticity by the addition of (STa-related) peptides to the catalytic subunit. A potential new strategy to generate immunostimulants for vaccination","volume":"277","author":"Sanchez","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pep.2010.04.021_bib37","doi-asserted-by":"crossref","first-page":"12140","DOI":"10.1073\/pnas.89.24.12140","article-title":"Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo","volume":"89","author":"Streatfield","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.pep.2010.04.021_bib38","doi-asserted-by":"crossref","first-page":"7109","DOI":"10.1073\/pnas.85.19.7109","article-title":"Coordinated assembly of multisubunit proteins: oligomerization of bacterial enterotoxins in vivo and in vitro","volume":"85","author":"Hardy","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.pep.2010.04.021_bib39","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1128\/jb.177.14.4121-4130.1995","article-title":"Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter","volume":"177","author":"Guzman","year":"1995","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.pep.2010.04.021_bib40","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1128\/JCM.28.10.2175-2177.1990","article-title":"Recombinant fusion protein for simple detection of Escherichia coli heat-stable enterotoxin by GM1 enzyme-linked immunosorbent assay","volume":"28","author":"Sanchez","year":"1990","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.pep.2010.04.021_bib41","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1074\/jbc.274.7.3962","article-title":"Structural basis for the differential toxicity of cholera toxin and Escherichia coli heat-labile enterotoxin. Construction of hybrid toxins identifies the A2-domain as the determinant of differential toxicity","volume":"274","author":"Rodighiero","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pep.2010.04.021_bib42","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1128\/IAI.73.6.3627-3635.2005","article-title":"Characterization of fluorescent chimeras of cholera toxin and Escherichia coli heat-labile enterotoxins produced by use of the twin arginine translocation system","volume":"73","author":"Tinker","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib43","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1128\/IAI.65.11.4476-4482.1997","article-title":"Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunization","volume":"65","author":"Hill","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1128\/IAI.66.2.521-527.1998","article-title":"Analysis of the Yersinia pestis V protein for the presence of linear antibody epitopes","volume":"66","author":"Pullen","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib45","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.vaccine.2009.11.076","article-title":"Amino acid residues 196\u2013225 of LcrV represent a plague protective epitope","volume":"28","author":"Quenee","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.pep.2010.04.021_bib46","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.1128\/IAI.73.8.5152-5159.2005","article-title":"LcrV plague vaccine with altered immunomodulatory properties","volume":"73","author":"Overheim","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib47","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/978-0-387-72124-8_36","article-title":"Oral vaccination with different antigens from Yersinia pestis KIM delivered by live attenuated Salmonella typhimurium elicits a protective immune response against plague","volume":"603","author":"Branger","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.pep.2010.04.021_bib48","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1016\/j.vaccine.2009.06.078","article-title":"Oral vaccination with LcrV from Yersinia pestis KIM delivered by live attenuated Salmonella enterica serovar Typhimurium elicits a protective immune response against challenge with Yersinia pseudotuberculosis and Yersinia enterocolitica","volume":"27","author":"Branger","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.pep.2010.04.021_bib49","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.meegid.2009.10.003","article-title":"Amino acid and structural variability of Yersinia pestis LcrV protein","volume":"10","author":"Anisimov","year":"2009","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.pep.2010.04.021_bib50","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/IAI.65.2.446-451.1997","article-title":"Passive immunity to infection with Yersinia spp. mediated by anti-recombinant V antigen is dependent on polymorphism of V antigen","volume":"65","author":"Roggenkamp","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib51","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1002\/j.1460-2075.1996.tb00799.x","article-title":"Imaging the intracellular trafficking and state of the AB5 quaternary structure of cholera toxin","volume":"15","author":"Bastiaens","year":"1996","journal-title":"Embo J."},{"key":"10.1016\/j.pep.2010.04.021_bib52","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1083\/jcb.133.4.777","article-title":"Transport of an external Lys-Asp-Glu-Leu (KDEL) protein from the plasma membrane to the endoplasmic reticulum: studies with cholera toxin in Vero cells","volume":"133","author":"Majoul","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.pep.2010.04.021_bib53","doi-asserted-by":"crossref","DOI":"10.4161\/hv.9866","article-title":"Plague vaccines and the molecular basis of immunity against Yersinia pestis","volume":"5","author":"Quenee","year":"2009","journal-title":"Hum. Vaccine"},{"key":"10.1016\/j.pep.2010.04.021_bib54","doi-asserted-by":"crossref","first-page":"6994","DOI":"10.1128\/jb.179.22.6994-7003.1997","article-title":"General secretion pathway (eps) genes required for toxin secretion and outer membrane biogenesis in Vibrio cholerae","volume":"179","author":"Sandkvist","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.pep.2010.04.021_bib55","doi-asserted-by":"crossref","first-page":"7066","DOI":"10.1073\/pnas.092152899","article-title":"Identification of a protein secretory pathway for the secretion of heat-labile enterotoxin by an enterotoxigenic strain of Escherichia coli","volume":"99","author":"Tauschek","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.pep.2010.04.021_bib56","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1128\/IAI.70.6.3249-3258.2002","article-title":"Enhanced delivery of exogenous peptides into the class I antigen processing and presentation pathway","volume":"70","author":"De Haan","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib57","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1189\/jlb.1103534","article-title":"Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent","volume":"75","author":"Lavelle","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.pep.2010.04.021_bib58","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1128\/IAI.71.4.1740-1747.2003","article-title":"Cholera toxin and its B subunit promote dendritic cell vaccination with different influences on Th1 and Th2 development","volume":"71","author":"Eriksson","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pep.2010.04.021_bib59","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1051\/vetres:2006014","article-title":"Adjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa","volume":"37","author":"Cox","year":"2006","journal-title":"Vet. Res."},{"key":"10.1016\/j.pep.2010.04.021_bib60","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1038\/nm1213","article-title":"Mucosal immunity and vaccines","volume":"11","author":"Holmgren","year":"2005","journal-title":"Nat. Med."},{"issue":"Suppl. 2","key":"10.1016\/j.pep.2010.04.021_bib61","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1016\/S0264-410X(03)00206-8","article-title":"Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges","volume":"21","author":"Holmgren","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.pep.2010.04.021_bib62","doi-asserted-by":"crossref","first-page":"e206","DOI":"10.1371\/journal.pgen.0020206","article-title":"The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081","volume":"2","author":"Thomson","year":"2006","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pep.2010.04.021_bib63","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.1128\/JB.180.19.5192-5202.1998","article-title":"Structural organization of virulence-associated plasmids of Yersinia pestis","volume":"180","author":"Hu","year":"1998","journal-title":"J. Bacteriol."}],"container-title":["Protein Expression and Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104659281000135X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104659281000135X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T10:43:58Z","timestamp":1711449838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104659281000135X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S104659281000135X"],"URL":"https:\/\/doi.org\/10.1016\/j.pep.2010.04.021","relation":{},"ISSN":["1046-5928"],"issn-type":[{"value":"1046-5928","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}