{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T22:39:59Z","timestamp":1772923199536,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1016\/j.peptides.2004.03.015","type":"journal-article","created":{"date-parts":[[2004,5,11]],"date-time":"2004-05-11T07:57:10Z","timestamp":1084262230000},"page":"1013-1020","source":"Crossref","is-referenced-by-count":25,"title":["Gastrointestinal effects of intracerebroventricularly injected nociceptin\/orphaninFQ in rats"],"prefix":"10.1016","volume":"25","author":[{"given":"Maria","family":"Broccardo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remo","family":"Guerrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Petrella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Improta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2004.03.015_BIB1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/(SICI)1096-9861(19960429)368:2<229::AID-CNE5>3.0.CO;2-5","article-title":"Immunohistochemical localization of ORL-1 in the central nervous system of the rat","volume":"368","author":"Anton","year":"1996","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.peptides.2004.03.015_BIB2","first-page":"R200","article-title":"Topography of efferent vagal innervation of the rat gastrointestinal tract","volume":"260","author":"Berthoud","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1016\/j.peptides.2004.03.015_BIB3","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0014-5793(94)00561-3","article-title":"Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type","volume":"347","author":"Bunzow","year":"1994","journal-title":"FEBS Lett"},{"key":"10.1016\/j.peptides.2004.03.015_BIB4","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/sj.bjp.0703169","article-title":"Characterization of [NPhe1]nociceptin(1\u201313)-NH2, a new selective nociceptin antagonist","volume":"129","author":"Cal\u00f2","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.peptides.2004.03.015_BIB5","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/sj.bjp.0703219","article-title":"Pharmacology of nociceptin and its receptor: a novel therapeutic target","volume":"129","author":"Cal\u00f2","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.peptides.2004.03.015_BIB6","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/BF02532380","article-title":"Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ","volume":"21","author":"Devine","year":"1996","journal-title":"Neurochem Res"},{"key":"10.1016\/j.peptides.2004.03.015_BIB7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0006-8993(00)02669-X","article-title":"Autoradiographic localization of [H3]nociceptin binding sites in the rat brain","volume":"880","author":"Florin","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.peptides.2004.03.015_BIB8","first-page":"456","article-title":"Roles of central and peripheral mu, delta and kappa receptors in the mediation of gastric motor and secretory effects in the rat","volume":"244","author":"Fox","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.peptides.2004.03.015_BIB9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0167-0115(82)90130-6","article-title":"Neural regulation of gastric acid secretion in rats: influence of dermorphin","volume":"3","author":"Improta","year":"1982","journal-title":"Regul Pept"},{"key":"10.1016\/j.peptides.2004.03.015_BIB10","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0028-3908(94)90155-4","article-title":"Effect of selective mu1, mu2 and delta2 opioid receptor agonists on gastric functions in the rat","volume":"33","author":"Improta","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.peptides.2004.03.015_BIB11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0014-2999(02)01451-6","article-title":"Gastric acid secretion stimulated by centrally injected nociceptin in urethane-anesthetized rats","volume":"44","author":"Ishihara","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.peptides.2004.03.015_BIB12","first-page":"551","article-title":"A method for the evaluation of colonic propulsive motility in the mouse after icv administered compounds","volume":"29","author":"Jacoby","year":"1984","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.peptides.2004.03.015_BIB13","first-page":"173","article-title":"Central administration of [Phe1\u03a8(CH2\u2013NH) Gly2]nociceptin(1\u201313)-NH2 and orphanin FQ\/nociceptin produce similar cardiovascular and renal responses in conscious rats","volume":"289","author":"Kapusta","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.peptides.2004.03.015_BIB14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0006-8993(98)00075-4","article-title":"Modification of dopamine release by nociceptin in conscious rat striatum","volume":"788","author":"Konya","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.peptides.2004.03.015_BIB15","first-page":"429","article-title":"Excitatory gastric motor and cardiovascular effects of nociceptin in the dorsal vagal complex of the rat","volume":"23","author":"Krowicki","year":"1997","journal-title":"Soc Neurosc Abstr"},{"key":"10.1016\/j.peptides.2004.03.015_BIB16","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/sj.bjp.0703463","article-title":"Orphanin FQ\/nociceptin and [Phe1\u03a8(CH2\u2013NH)Gly2]nociceptin(1\u201313)-NH2 stimulate gastric motor function in anaesthetized rats","volume":"130","author":"Krowicki","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.peptides.2004.03.015_BIB17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-2999(99)00700-1","article-title":"In vitro agonist effects of nociceptin and [Phe1\u03a8(CH2\u2013NH)Gly2]nociceptin(1\u201313)-NH2 in the mouse and rat colon and the mouse vas deferens","volume":"385","author":"Menzies","year":"1999","journal-title":"Eur J Phrmacol"},{"key":"10.1016\/j.peptides.2004.03.015_BIB18","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/377532a0","article-title":"Isolation and structure of the endogenous agonist of opioid-receptor like ORL-1 receptor","volume":"377","author":"Meunier","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2004.03.015_BIB19","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/BF01303214","article-title":"Effects of morphine and naloxone on esophageal motility and gastric emptying in man","volume":"31","author":"Mittal","year":"1986","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.peptides.2004.03.015_BIB20","first-page":"381","article-title":"The molecular and behavioral pharmacology of the orphanin FQ\/nociceptin peptide receptor family","volume":"53","author":"Mogil","year":"2001","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.peptides.2004.03.015_BIB21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0014-5793(94)80235-1","article-title":"ORL-1, a novel member of the opioid receptor family. Cloning, functional expression and localization","volume":"341","author":"Mollerau","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.peptides.2004.03.015_BIB22","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0196-9781(00)00227-8","article-title":"Tissue distribution of the opioid receptor-like (ORL-1) receptor","volume":"21","author":"Mollerau","year":"2000","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2004.03.015_BIB23","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/(SICI)1096-9861(19991004)412:4<563::AID-CNE2>3.0.CO;2-Z","article-title":"Opioid receptor-like (ORL-1) receptor distribution in the rat central nervous system: comparison of ORL-1 receptor mRNA expression with 125I 14 Tyr-orphanin FQ binding","volume":"412","author":"Neal","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.peptides.2004.03.015_BIB24","doi-asserted-by":"crossref","first-page":"G125","DOI":"10.1152\/ajpgi.1999.276.1.G125","article-title":"Peripheral and central actions of orphanin FQ (nociceptin) on murine colon","volume":"276","author":"Osinski","year":"1999","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.peptides.2004.03.015_BIB25","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0196-9781(00)00240-0","article-title":"Orphanin FQ\/nociceptin: a novel neuromodulator of gastrointestinal function","volume":"21","author":"Osinski","year":"2000","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2004.03.015_BIB26","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0196-9781(00)00243-6","article-title":"The hyperphagic effect of nociceptin\/orphanin FQ in rats","volume":"21","author":"Polidori","year":"2000","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2004.03.015_BIB27","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00001756-199612200-00072","article-title":"Agonist of orphan opioid receptor ORL-1, stimulates feeding in rats","volume":"8","author":"Pomonis","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.peptides.2004.03.015_BIB28","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/0024-3205(87)90520-0","article-title":"Colonic bead expulsion time in normal and mu-opioid deficient mice following central administration of mu- and delta-opiod agonists","volume":"41","author":"Raffa","year":"1987","journal-title":"Life Sci"},{"key":"10.1016\/j.peptides.2004.03.015_BIB29","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1126\/science.270.5237.792","article-title":"Orphanin FQ: a neuropeptide that activates an opioid-like G-protein-coupled receptor","volume":"270","author":"Reinscheid","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.peptides.2004.03.015_BIB30","doi-asserted-by":"crossref","first-page":"R3","DOI":"10.1016\/S0014-2999(99)00730-X","article-title":"[NPhe1]nociceptin(1\u201313)NH2 antagonizes nociceptin effects in the mouse colon","volume":"385","author":"Rizzi","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.peptides.2004.03.015_BIB31","first-page":"286","article-title":"Action of caerulein on gastric emptying of the conscious rat","volume":"246","author":"Scarpignato","year":"1980","journal-title":"Arch Int Pharmacod Ther"},{"key":"10.1016\/j.peptides.2004.03.015_BIB32","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0196-9781(00)00233-3","article-title":"Nociceptin\/orphanin FQ and neurotransmitter release in the central nervous system","volume":"21","author":"Schlicker","year":"2000","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2004.03.015_BIB33","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF00501390","article-title":"Centrally and peripherally mediated inhibition of intestinal motility by opioids","volume":"308","author":"Schulz","year":"1979","journal-title":"NS Arch Pharmacol"},{"key":"10.1016\/j.peptides.2004.03.015_BIB34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0014-2999(98)00411-7","article-title":"The effect of nociceptin, an endogenous ligand for the ORL-1 receptor","volume":"353","author":"Taniguchi","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.peptides.2004.03.015_BIB35","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0016-5085(99)70234-9","article-title":"Functional significance of a newly discovered neuropeptide, orphanin FQ, in rat gastrointestinal motility","volume":"116","author":"Yazdani","year":"1999","journal-title":"Gastroenterology"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978104001482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978104001482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T09:29:31Z","timestamp":1549704571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978104001482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["S0196978104001482"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2004.03.015","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}