{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:42:03Z","timestamp":1791042123541,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.peptides.2005.01.026","type":"journal-article","created":{"date-parts":[[2005,11,8]],"date-time":"2005-11-08T12:12:12Z","timestamp":1131451932000},"page":"438-443","source":"Crossref","is-referenced-by-count":18,"title":["Cardiovascular responses to melanocortin 4-receptor stimulation in conscious unrestrained normotensive rats"],"prefix":"10.1016","volume":"27","author":[{"given":"Ulrich","family":"Nordheim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet R.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Dokladny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Dunant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl G.","family":"Hofbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2005.01.026_bib1","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMoa021423","article-title":"Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults","volume":"348","author":"Calle","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.peptides.2005.01.026_bib2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0014-2999(93)90362-L","article-title":"The hemodynamic effects of 2-melanocyte-stimulating hormone and related melanotropins depend on the arousal potential of the rat","volume":"233","author":"De Wildt","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.peptides.2005.01.026_bib3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0196-9781(99)00192-8","article-title":"Proopiomelanocortin (POMC) products in the central regulation of sympathetic and cardiovascular dynamics: studies on melanocortin and opioid interactions","volume":"21","author":"Dunbar","year":"2000","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2005.01.026_bib4","first-page":"R824","article-title":"Central sympathoinhibition and peripheral neuronal uptake blockade after desipramine in rabbits","volume":"260","author":"Eisenhofer","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1016\/j.peptides.2005.01.026_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/385165a0","article-title":"Role of melanocortinergic neurons in feeding and the agouti obesity syndrome","volume":"385","author":"Fan","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2005.01.026_bib6","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1210\/jc.86.3.1144","article-title":"The melanocortin melanocyte-stimulating hormone\/adrenocorticotropin 4\u201310 decreases body fat in humans","volume":"86","author":"Fehm","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.peptides.2005.01.026_bib7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0006-8993(98)00837-3","article-title":"Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands","volume":"809","author":"Giraudo","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.peptides.2005.01.026_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0014-2999(00)00216-8","article-title":"Enantioselective behavioral effects of sibutramine metabolites","volume":"397","author":"Glick","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.peptides.2005.01.026_bib9","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1126\/science.299.5608.849","article-title":"Obesity drug pipeline not so fat","volume":"299","author":"Gura","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.peptides.2005.01.026_bib10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00000441-200209000-00003","article-title":"Mechanisms of obesity-associated cardiovascular and renal disease","volume":"324","author":"Hall","year":"2002","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.peptides.2005.01.026_bib11","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1126\/science.1072327","article-title":"Activation of central melanocortin pathways by fenfluramine","volume":"297","author":"Heisler","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.peptides.2005.01.026_bib12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1749-6632.1993.tb19674.x","article-title":"Design, synthesis, and conformation of superpotent and prolonged acting melanotropins","volume":"680","author":"Hruby","year":"1993","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.peptides.2005.01.026_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0092-8674(00)81865-6","article-title":"Targeted disruption of the melanocortin-4 receptor results in obesity in mice","volume":"88","author":"Huszar","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.peptides.2005.01.026_bib14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1152\/physiolgenomics.00164.2002","article-title":"Evaluation and applications of radiotelemetry in small laboratory animals","volume":"13","author":"Kramer","year":"2003","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.peptides.2005.01.026_bib15","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1161\/01.HYP.0000048194.97428.1A","article-title":"Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function","volume":"41","author":"Kuo","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2005.01.026_bib16","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1161\/01.HYP.0000111836.54204.93","article-title":"Role of adrenergic activity in pressor responses to chronic melanocortin activation","volume":"43","author":"Kuo","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2005.01.026_bib17","first-page":"R389","article-title":"Reduced norepinephrine turnover in organs and brains of obesity-prone rats","volume":"268","author":"Levin","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.peptides.2005.01.026_bib18","doi-asserted-by":"crossref","first-page":"5182","DOI":"10.1523\/JNEUROSCI.16-16-05182.1996","article-title":"Melanocortin antagonists define two distinct pathways of cardiovascular control by alpha- and gamma-melanocyte-stimulating hormones","volume":"16","author":"Li","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.peptides.2005.01.026_bib19","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1345\/aph.18319","article-title":"Sibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity","volume":"33","author":"Luque","year":"1999","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.peptides.2005.01.026_bib20","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0140-6736(90)90878-9","article-title":"Blood pressure, stroke, and coronary heart disease. Part 1. Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias","volume":"335","author":"MacMahon","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.peptides.2005.01.026_bib21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0006-8993(02)03045-7","article-title":"Central alpha-melanocyte-stimulating hormone acts at melanocortin-4 receptor to activate sympathetic nervous system in conscious rabbits","volume":"948","author":"Matsumura","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.peptides.2005.01.026_bib22","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1152\/jappl.1989.66.3.1506","article-title":"Sympathetic response to exercise in various tissues with advancing age","volume":"66","author":"Mazzeo","year":"1989","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.peptides.2005.01.026_bib23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/sj.ijir.3901200","article-title":"Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra","volume":"16","author":"Rosen","year":"2004","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.peptides.2005.01.026_bib24","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1021\/jm025539h","article-title":"Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist","volume":"45","author":"Sebhat","year":"2002","journal-title":"J Med Chem"},{"key":"10.1016\/j.peptides.2005.01.026_bib25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/153537020422900303","article-title":"Hypothalamic melanocortin system regulates sympathetic nerve activity in brown adipose tissue","volume":"229","author":"Yasuda","year":"2004","journal-title":"Exp Biol Med"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978105004572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978105004572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T12:34:02Z","timestamp":1554381242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978105004572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0196978105004572"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2005.01.026","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}