{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:00:38Z","timestamp":1777442438957,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.peptides.2007.05.007","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T20:23:17Z","timestamp":1179606197000},"page":"1424-1432","source":"Crossref","is-referenced-by-count":40,"title":["Copper complexing decreases the ability of amyloid beta peptide to cross the BBB and enter brain parenchyma"],"prefix":"10.1016","volume":"28","author":[{"given":"Suneetha","family":"Mare","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suman","family":"Penugonda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra M.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Dohgu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Banks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuran","family":"Ercal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2007.05.007_bib1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1046\/j.1471-4159.2000.0751219.x","article-title":"Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42","volume":"75","author":"Atwood","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.peptides.2007.05.007_bib2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/10611860290031831","article-title":"Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy","volume":"10","author":"Bading","year":"2002","journal-title":"J Drug Target"},{"key":"10.1016\/j.peptides.2007.05.007_bib3","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0196-9781(99)00139-4","article-title":"Impaired transport of leptin across the blood\u2013brain barrier in obesity","volume":"20","author":"Banks","year":"1999","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.peptides.2007.05.007_bib4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.brainres.2006.07.112","article-title":"Aluminum complexing enhances amyloid beta protein penetration of blood\u2013brain barrier","volume":"1116","author":"Banks","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.peptides.2007.05.007_bib5","doi-asserted-by":"crossref","first-page":"14187","DOI":"10.1073\/pnas.2332818100","article-title":"Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice","volume":"100","author":"Bayer","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.peptides.2007.05.007_bib6","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1073\/pnas.122249699","article-title":"The galvanization of beta-amyloid in Alzheimer's disease","volume":"99","author":"Bush","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.peptides.2007.05.007_bib7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3727\/095535491820873191","article-title":"Use of an aqueous soluble tetrazolium\/formazan assay for cell growth assays in culture","volume":"3","author":"Cory","year":"1991","journal-title":"Cancer Commun"},{"key":"10.1016\/j.peptides.2007.05.007_bib8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuron.2004.07.017","article-title":"LRP\/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms","volume":"43","author":"Deane","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.peptides.2007.05.007_bib9","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1111\/j.1471-4159.1992.tb10055.x","article-title":"Drug transfer across the blood\u2013brain barrier: correlation between in vitro and in vivo models","volume":"58","author":"Dehouck","year":"1992","journal-title":"J Neurochem"},{"key":"10.1016\/j.peptides.2007.05.007_bib10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1471-4159.2001.00384.x","article-title":"Homocysteine potentiates beta-amyloid neurotoxicity: role of oxidative stress","volume":"78","author":"Ho","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.peptides.2007.05.007_bib11","doi-asserted-by":"crossref","first-page":"37111","DOI":"10.1074\/jbc.274.52.37111","article-title":"Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction","volume":"274","author":"Huang","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2007.05.007_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1196\/annals.1306.012","article-title":"Redox-active metals, oxidative stress, and Alzheimer's disease pathology","volume":"1012","author":"Huang","year":"2004","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.peptides.2007.05.007_bib13","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0891-5849(99)00112-4","article-title":"Transendothelial permeability changes induced by free radicals in an in vitro model of the blood\u2013brain barrier","volume":"27","author":"Lagrange","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.peptides.2007.05.007_bib14","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/0024-3205(94)00331-9","article-title":"Passage of human amyloid beta-protein 1-40 across the murine blood\u2013brain barrier","volume":"55","author":"Maness","year":"1994","journal-title":"Life Sci"},{"key":"10.1016\/j.peptides.2007.05.007_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0196-9781(95)02135-3","article-title":"Periventricular penetration and disappearance of ICV Tyr-MIF-1, DAMGO, tyrosine, and albumin","volume":"17","author":"Maness","year":"1996","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2007.05.007_bib16","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1210\/en.139.11.4556","article-title":"Fate of leptin after intracerebroventricular injection into the mouse brain","volume":"139","author":"Maness","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2007.05.007_bib17","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0006-3223(02)01451-8","article-title":"Alzheimer's disease and total plasma aminothiols","volume":"53","author":"McCaddon","year":"2003","journal-title":"Biol Psychiatr"},{"key":"10.1016\/j.peptides.2007.05.007_bib18","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/01.jnen.0000228136.58062.bf","article-title":"Involvement of oxidative stress in Alzheimer disease","volume":"65","author":"Nunomura","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.peptides.2007.05.007_bib19","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.nbd.2006.01.005","article-title":"Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels","volume":"22","author":"Pacheco-Quinto","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.peptides.2007.05.007_bib20","first-page":"621","article-title":"Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease","volume":"140","author":"Pappolla","year":"1992","journal-title":"Am J Pathol"},{"key":"10.1016\/j.peptides.2007.05.007_bib21","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1172\/JCI23610","article-title":"Alzheimer disease beta-amyloid activity mimics cholesterol oxidase","volume":"115","author":"Puglielli","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.peptides.2007.05.007_bib22","doi-asserted-by":"crossref","first-page":"16157","DOI":"10.1074\/jbc.M500309200","article-title":"Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide","volume":"280","author":"Raman","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2007.05.007_bib23","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1007\/s00018-005-5141-0","article-title":"Aluminum-triggered structural modifications and aggregation of beta-amyloids","volume":"62","author":"Ricchelli","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.peptides.2007.05.007_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10571-004-1376-9","article-title":"Rat brain endothelial cell lines for the study of blood\u2013brain barrier permeability and transport functions","volume":"25","author":"Roux","year":"2005","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.peptides.2007.05.007_bib25","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMoa011613","article-title":"Plasma homocysteine as a risk factor for dementia and Alzheimer's disease","volume":"346","author":"Seshadri","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.peptides.2007.05.007_bib26","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI10498","article-title":"Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood\u2013brain barrier","volume":"106","author":"Shibata","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.peptides.2007.05.007_bib27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1126\/science.1439760","article-title":"Production of the Alzheimer amyloid beta protein by normal proteolytic processing","volume":"258","author":"Shoji","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.peptides.2007.05.007_bib28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0896-6273(04)00533-1","article-title":"Clearance of Alzheimer's Abeta peptide: the many roads to perdition","volume":"43","author":"Tanzi","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.peptides.2007.05.007_bib29","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0197-4580(03)00005-8","article-title":"Combination of serum markers related to several mechanisms in Alzheimer's disease","volume":"24","author":"Teunissen","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.peptides.2007.05.007_bib30","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1111\/j.1471-4159.1993.tb09841.x","article-title":"Characterization of beta-amyloid peptide from human cerebrospinal fluid","volume":"61","author":"Vigo-Pelfrey","year":"1993","journal-title":"J Neurochem"},{"key":"10.1016\/j.peptides.2007.05.007_bib31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/abio.1995.1246","article-title":"Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1-pyrenyl)maleimide","volume":"227","author":"Winters","year":"1995","journal-title":"Anal Biochem"},{"key":"10.1016\/j.peptides.2007.05.007_bib32","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1006\/bbrc.1993.2582","article-title":"Blood\u2013brain barrier transport of circulating Alzheimer's amyloid beta","volume":"197","author":"Zlokovic","year":"1993","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978107001684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978107001684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T05:45:21Z","timestamp":1556430321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978107001684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0196978107001684"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2007.05.007","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}