{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:11:31Z","timestamp":1769202691378,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.peptides.2009.09.003","type":"journal-article","created":{"date-parts":[[2009,9,11]],"date-time":"2009-09-11T09:43:41Z","timestamp":1252662221000},"page":"2242-2249","source":"Crossref","is-referenced-by-count":18,"title":["Islet neogenesis-associated protein-related pentadecapeptide enhances the differentiation of islet-like clusters from human pancreatic duct cells"],"prefix":"10.1016","volume":"30","author":[{"given":"Juan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xirong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2009.09.003_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.regpep.2006.04.015","article-title":"Islet Neogenesis Associated Protein (INGAP) modulates gene expression in cultured neonatal rat islets","volume":"136","author":"Barbosa","year":"2006","journal-title":"Regul Pept"},{"key":"10.1016\/j.peptides.2009.09.003_bib2","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1073\/pnas.97.14.7999","article-title":"In vitro cultivation of human islets from expanded ductal tissue","volume":"97","author":"Bonner-Weir","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.peptides.2009.09.003_bib3","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.regpep.2006.12.028","article-title":"Transcription, expression and tissue binding in vivo of INGAP and INGAP-related peptide in normal hamsters","volume":"140","author":"Borelli","year":"2007","journal-title":"Regul Pept"},{"key":"10.1016\/j.peptides.2009.09.003_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.regpep.2005.07.003","article-title":"INGAP-related pentadecapeptide: its modulatory effect upon insulin secretion","volume":"131","author":"Borelli","year":"2005","journal-title":"Regul Pept"},{"key":"10.1016\/j.peptides.2009.09.003_bib5","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1007\/s001250100012","article-title":"Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice","volume":"44","author":"Castaing","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.peptides.2009.09.003_bib6","doi-asserted-by":"crossref","first-page":"14843","DOI":"10.1074\/jbc.270.25.14843","article-title":"How MAP kinases are regulated","volume":"270","author":"Cobb","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2009.09.003_bib7","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.2337\/diabetes.40.8.1041","article-title":"Induction of islet cytodifferentiation by fetal mesenchyme in adult pancreatic ductal epithelium","volume":"40","author":"Dudek","year":"1991","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2009.09.003_bib8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1677\/joe.0.1770249","article-title":"Pancreatic duodenal homeobox-1 and islet neogenesis-associated protein: a possible combined marker of activateable pancreatic cell precursors","volume":"177","author":"Gagliardino","year":"2003","journal-title":"J Endocrinol"},{"key":"10.1016\/j.peptides.2009.09.003_bib9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mce.2006.10.007","article-title":"Maturation of in vitro-generated human islets after transplantation in nude mice","volume":"264","author":"Gao","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.peptides.2009.09.003_bib10","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1210\/jc.86.3.984","article-title":"Using beta-cell growth factors to enhance human pancreatic Islet transplantation","volume":"86","author":"Garcia-Ocana","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.peptides.2009.09.003_bib11","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1210\/jc.82.8.2471","article-title":"Experimental transplantation of human fetal and adult pancreatic islets","volume":"82","author":"Hayek","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.peptides.2009.09.003_bib12","doi-asserted-by":"crossref","DOI":"10.1634\/stemcells.2006-0761","article-title":"Generation of insulin-producing islet-like clusters from human embryonic stem cells","author":"Jiang","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.peptides.2009.09.003_bib13","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.bbrc.2004.12.043","article-title":"Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue","volume":"327","author":"Lechner","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.peptides.2009.09.003_bib14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1677\/joe.1.05703","article-title":"Co-localization of nestin and insulin and expression of islet cell markers in long-term human pancreatic nestin-positive cell cultures","volume":"183","author":"Maria-Engler","year":"2004","journal-title":"J Endocrinol"},{"key":"10.1016\/j.peptides.2009.09.003_bib15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/01.mpa.0000240609.56806.43","article-title":"Intramuscular injection of islet neogenesis-associated protein peptide stimulates pancreatic islet neogenesis in healthy dogs","volume":"34","author":"Pittenger","year":"2007","journal-title":"Pancreas"},{"key":"10.1016\/j.peptides.2009.09.003_bib16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-4615-3448-8_13","article-title":"The partial isolation and characterization of ilotropin, a novel islet-specific growth factor","volume":"321","author":"Pittenger","year":"1992","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.peptides.2009.09.003_bib17","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0963-6897(95)00020-X","article-title":"In vivo cell transformation: neogenesis of beta cells from pancreatic ductal cells","volume":"4","author":"Rosenberg","year":"1995","journal-title":"Cell Transplant"},{"key":"10.1016\/j.peptides.2009.09.003_bib18","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1097\/01.sla.0000143270.99191.10","article-title":"A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL\/6J mice","volume":"240","author":"Rosenberg","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.peptides.2009.09.003_bib19","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.2337\/diabetes.51.7.2148","article-title":"Successful islet transplantation: continued insulin reserve provides long-term glycemic control","volume":"51","author":"Ryan","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2009.09.003_bib20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/labinvest.3700377","article-title":"Expansion of mesenchymal stem cells from human pancreatic ductal epithelium","volume":"86","author":"Seeberger","year":"2006","journal-title":"Lab Invest"},{"key":"10.1016\/j.peptides.2009.09.003_bib21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.peptides.2009.09.003_bib22","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1900\/RDS.2004.1.66","article-title":"Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently","volume":"1","author":"Street","year":"2004","journal-title":"Rev Diabet Stud"},{"key":"10.1016\/j.peptides.2009.09.003_bib23","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1096\/fj.04-1894fje","article-title":"INGAP peptide improves nerve function and enhances regeneration in streptozotocin-induced diabetic C57BL\/6 mice","volume":"18","author":"Tam","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.peptides.2009.09.003_bib24","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1677\/joe.1.06698","article-title":"Islet neogenesis associated protein transgenic mice are resistant to hyperglycemia induced by streptozotocin","volume":"190","author":"Taylor-Fishwick","year":"2006","journal-title":"J Endocrinol"},{"key":"10.1016\/j.peptides.2009.09.003_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0925-4439(03)00042-5","article-title":"Cloning genomic INGAP: a Reg-related family member with distinct transcriptional regulation sites","volume":"1638","author":"Taylor-Fishwick","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.peptides.2009.09.003_bib26","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1242\/dev.118.4.1031","article-title":"Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide","volume":"118","author":"Teitelman","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.peptides.2009.09.003_bib27","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1055\/s-2007-979037","article-title":"Induction of pancreatic islet neogenesis","volume":"29","author":"Vinik","year":"1997","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.peptides.2009.09.003_bib28","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.2337\/db06-1670","article-title":"Differentiation of affinity-purified human pancreatic duct cells to beta-cells","volume":"56","author":"Yatoh","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2009.09.003_bib29","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2337\/diabetes.50.3.521","article-title":"Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes","volume":"50","author":"Zulewski","year":"2001","journal-title":"Diabetes"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978109003593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978109003593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T15:28:27Z","timestamp":1633879707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978109003593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0196978109003593"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2009.09.003","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}