{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:27:22Z","timestamp":1789424842047,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.peptides.2010.04.002","type":"journal-article","created":{"date-parts":[[2010,4,11]],"date-time":"2010-04-11T04:24:23Z","timestamp":1270959863000},"page":"1292-1300","source":"Crossref","is-referenced-by-count":18,"title":["An unusual peptide from Conus villepinii: Synthesis, solution structure, and cardioactivity"],"prefix":"10.1016","volume":"31","author":[{"given":"Alesia","family":"Miloslavina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tietze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Ohlenschl\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Englert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"G\u00f6rlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Imhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2010.04.002_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1359-0278(96)00013-2","article-title":"Unfolded BPTI variants with a single disulfide bond have diminished non-native structure distant from the crosslink 1","volume":"1","author":"Barbar","year":"1996","journal-title":"Fold Des"},{"key":"10.1016\/j.peptides.2010.04.002_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00417486","article-title":"The program XEASY for computer-supported NMR spectral analysis of biological macromolecules","volume":"5","author":"Bartels","year":"1995","journal-title":"J Biomol NMR"},{"key":"10.1016\/j.peptides.2010.04.002_bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.aquatox.2006.06.010","article-title":"Cadmium accumulation in zebrafish (Danio rerio) eggs is modulated by dissolved organic matter (DOM)","volume":"79","author":"Burnison","year":"2006","journal-title":"Aquat Toxicol (Amsterdam, Netherlands)"},{"key":"10.1016\/j.peptides.2010.04.002_bib4","doi-asserted-by":"crossref","first-page":"8887","DOI":"10.1002\/anie.200702295","article-title":"Protein denaturation by ionic liquids and the Hofmeister series: a case study of aqueous solutions of ribonuclease A","volume":"46","author":"Constantinescu","year":"2007","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.peptides.2010.04.002_bib5","doi-asserted-by":"crossref","first-page":"13752","DOI":"10.1074\/jbc.274.20.13752","article-title":"Contulakin-G, an O-glycosylated invertebrate neurotensin","volume":"274","author":"Craig","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2010.04.002_bib6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1034\/j.1399-3011.2003.t01-1-00048.x","article-title":"Detergent-assisted oxidative folding of delta-conotoxins","volume":"61","author":"DeLa Cruz","year":"2002","journal-title":"J Pept Res"},{"key":"10.1016\/j.peptides.2010.04.002_bib7","series-title":"Recent advances in arthropod endocrinology","first-page":"302","article-title":"Conserved crustacean cardioactive peptide (CCAP) neuronal networks and functions in arthropod evolution","author":"Dircksen","year":"1998"},{"key":"10.1016\/j.peptides.2010.04.002_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/neu.20136","article-title":"Role of the neuropeptide CCAP in Drosophila cardiac function","volume":"64","author":"Dulcis","year":"2005","journal-title":"J Neurobiol"},{"key":"10.1016\/j.peptides.2010.04.002_bib9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0003-9861(58)90014-6","article-title":"A colorimetric method for determining low concentrations of mercaptans","volume":"74","author":"Ellman","year":"1958","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.peptides.2010.04.002_bib10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.peptides.2010.04.002_bib11","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1016\/S0043-1354(01)00084-7","article-title":"Effect of age on the susceptibility of zebrafish eggs to industrial wastewater","volume":"35","author":"Gellert","year":"2001","journal-title":"Water Res"},{"key":"10.1016\/j.peptides.2010.04.002_bib12","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1023\/A:1008391403193","article-title":"Conformation analysis of protein and nucleic acid fragments with the new grid search algorithm FOUND","volume":"12","author":"G\u00fcntert","year":"1998","journal-title":"J Biomol NMR"},{"key":"10.1016\/j.peptides.2010.04.002_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1021614115432","article-title":"Protein NMR structure determination with automated NOE-identification in the NOESY spectra using the new software ATNOS","volume":"24","author":"Herrmann","year":"2002","journal-title":"J Biomol NMR"},{"key":"10.1016\/j.peptides.2010.04.002_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF01918191","article-title":"Zur Lehre von der Wirkung der Salze. Zweite Mittheilung","volume":"24","author":"Hofmeister","year":"1888","journal-title":"Arch Exp Pathol Pharmakol"},{"key":"10.1016\/j.peptides.2010.04.002_bib15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.peptides.2008.11.014","article-title":"Solution conformations of an insect neuropeptide: crustacean cardioactive peptide (CCAP)","volume":"30","author":"Jackson","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2010.04.002_bib16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev Dyn"},{"key":"10.1016\/j.peptides.2010.04.002_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/0263-7855(96)00009-4","article-title":"MOLMOL: a program for display and analysis of macromolecular structures","volume":"14","author":"Koradi","year":"1996","journal-title":"J Mol Graph"},{"key":"10.1016\/j.peptides.2010.04.002_bib18","doi-asserted-by":"crossref","first-page":"12108","DOI":"10.1073\/pnas.0803147105","article-title":"Localizing organomercury uptake and accumulation in zebrafish larvae at the tissue and cellular level","volume":"105","author":"Korbas","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.peptides.2010.04.002_bib19","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1073\/pnas.69.12.3629","article-title":"Conformational energy studies of oxytocin and its cyclic moiety","volume":"69","author":"Kotelchuck","year":"1972","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.peptides.2010.04.002_bib20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0005-2795(73)90350-4","article-title":"Chain reversals in proteins","volume":"303","author":"Lewis","year":"1973","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.peptides.2010.04.002_bib21","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1242\/jeb.204.16.2803","article-title":"Identification, sequence and expression of a crustacean cardioactive peptide (CCAP) gene in the moth Manduca sexta","volume":"204","author":"Loi","year":"2001","journal-title":"J Exp Biol"},{"key":"10.1016\/j.peptides.2010.04.002_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/BF00211160","article-title":"The new program OPAL for molecular dynamics simulations and energy refinements of biological macromolecules","volume":"8","author":"Luginbuhl","year":"1996","journal-title":"J Biomol NMR"},{"key":"10.1016\/j.peptides.2010.04.002_bib23","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1039\/b714629a","article-title":"A hydrogen bond accepting (HBA) scale of anions, including room temperature ionic liquids","volume":"32","author":"Lungwitz","year":"2008","journal-title":"New J Chem"},{"key":"10.1016\/j.peptides.2010.04.002_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/(SICI)1097-0177(199805)212:1<133::AID-AJA12>3.0.CO;2-8","article-title":"Isolation of the zebrafish homologues for the tie-1 and tie-2 endothelium-specific receptor tyrosine kinases","volume":"212","author":"Lyons","year":"1998","journal-title":"Dev Dyn"},{"key":"10.1016\/j.peptides.2010.04.002_bib25","first-page":"43","article-title":"Conopeptides: unique pharmacological agents that challenge current peptide methodologies","volume":"21","author":"Mari","year":"2003","journal-title":"Chimica Oggi"},{"key":"10.1016\/j.peptides.2010.04.002_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00301650","article-title":"Peptidergic modulation of cardiovascular dynamics in the Dungeness crab, Cancer magister","volume":"164","author":"McGaw","year":"1994","journal-title":"J Comp Physiol B"},{"key":"10.1016\/j.peptides.2010.04.002_bib27","doi-asserted-by":"crossref","first-page":"16796","DOI":"10.1074\/jbc.270.28.16796","article-title":"A new family of conotoxins that blocks voltage-gated sodium-channels","volume":"270","author":"McIntosh","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2010.04.002_bib28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/psc.1106","article-title":"A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides 1","volume":"15","author":"Miloslavina","year":"2009","journal-title":"J Pept Sci"},{"key":"10.1016\/j.peptides.2010.04.002_bib29","first-page":"19","volume":"14","author":"Moller","year":"2008","journal-title":"J Pept Sci Suppl"},{"key":"10.1016\/j.peptides.2010.04.002_bib30","doi-asserted-by":"crossref","first-page":"15986","DOI":"10.1021\/bi0511181","article-title":"A novel conotoxin framework with a helix-loop-helix (Cs alpha\/alpha) fold","volume":"44","author":"Moller","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.peptides.2010.04.002_bib31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0304-3940(94)90423-5","article-title":"Periodic maternal deprivation-induced potentiation of the negative feedback sensitivity to glucocorticoids to inhibit stress-induced adrenocortical-response persists throughout the animals life-span 6","volume":"168","author":"Muneoka","year":"1994","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.peptides.2010.04.002_bib32","first-page":"441","article-title":"Cardioacceleratory peptide (CCAP) of the fruit fly Drosophila melanogaster: solution structure analysis and docking simulation to the receptor CG6111","volume":"41","author":"Nagata","year":"2005","journal-title":"Pept Sci"},{"key":"10.1016\/j.peptides.2010.04.002_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ab.2007.12.004","article-title":"Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pK(a) values by matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry","volume":"375","author":"Nelson","year":"2008","journal-title":"Anal Biochem"},{"key":"10.1016\/j.peptides.2010.04.002_bib34","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.toxicon.2006.07.022","article-title":"Conotoxins down under","volume":"48","author":"Norton","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.peptides.2010.04.002_bib35","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/j.saa.2004.09.012","article-title":"l-Cysteine: neutron spectroscopy, Raman, IR and ab initio study","volume":"61","author":"Pawlukojc","year":"2005","journal-title":"Spectrochim Acta"},{"key":"10.1016\/j.peptides.2010.04.002_bib36","doi-asserted-by":"crossref","first-page":"14350","DOI":"10.1021\/ja046079f","article-title":"Dissolution and regeneration of Bombyx mori silk fibroin using ionic liquids","volume":"126","author":"Phillips","year":"2004","journal-title":"JACS"},{"key":"10.1016\/j.peptides.2010.04.002_bib37","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0269-7491(02)00118-5","article-title":"Sensitivity of the zebrafish (Danio rerio) early life stage test for compounds with different modes of action","volume":"120","author":"Roex","year":"2002","journal-title":"Environ Pollut"},{"key":"10.1016\/j.peptides.2010.04.002_bib38","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/bip.20515","article-title":"Conformational differences in protein disulfide linkages between normal hair and hair from subjects with trichothiodystrophy: a quantitative analysis by Raman microspectroscopy","volume":"82","author":"Schlucker","year":"2006","journal-title":"Biopolymers"},{"key":"10.1016\/j.peptides.2010.04.002_bib39","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1432-1033.1991.tb16293.x","article-title":"Conformation of [8-arginine]vasopressin and V1 antagonists in dimethyl sulfoxide solution derived from two-dimensional NMR spectroscopy and molecular dynamics simulation","volume":"201","author":"Schmidt","year":"1991","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.peptides.2010.04.002_bib40","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/arch.20131","article-title":"Effect of corazonin and crustacean cardioactive peptide on heartbeat in the adult American cockroach (Periplaneta americana)","volume":"62","author":"Slama","year":"2006","journal-title":"Arch Insect Biochem Physiol"},{"key":"10.1016\/j.peptides.2010.04.002_bib41","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1073\/pnas.84.2.575","article-title":"Unusual cardioactive peptide (CCAP) from pericardial organs of the shore crab Carcinus maenas","volume":"84","author":"Stangier","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.peptides.2010.04.002_bib42","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1021\/ja025790m","article-title":"Dissolution of cellose with ionic liquids","volume":"124","author":"Swatloski","year":"2002","journal-title":"JACS"},{"key":"10.1016\/j.peptides.2010.04.002_bib43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1152\/physrev.00020.2003","article-title":"Conus venoms: a rich source of novel ion channel-targeted peptides","volume":"84","author":"Terlau","year":"2004","journal-title":"Physiol Rev"},{"key":"10.1016\/j.peptides.2010.04.002_bib44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.2042-7158.1976.tb04112.x","article-title":"Some pharmacological properties of the venom, venom fractions and pure toxin of the yellow-bellied sea snake Pelamis platurus","volume":"28","author":"Tu","year":"1976","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.peptides.2010.04.002_bib45","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neulet.2004.10.020","article-title":"Crustacean cardioactive peptide (CCAP)-related molluscan peptides (M-CCAPs) are potential extrinsic modulators of the buccal feeding network in the pond snail Lymnaea stagnalis 2","volume":"373","author":"Vehovszky","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.peptides.2010.04.002_bib46","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/abbs\/36.11.713","article-title":"Conus peptides\u2014a rich pharmaceutical treasure","volume":"36","author":"Wang","year":"2004","journal-title":"Acta Biochim Biophys Sin"},{"key":"10.1016\/j.peptides.2010.04.002_bib47","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00360-008-0276-6","article-title":"Pleiotropic effects of the neuropeptides CCAP and myosuppressin in the beetle, Tenebrio molitor L.","volume":"178","author":"Wasielewski","year":"2008","journal-title":"J Comp Physiol"},{"key":"10.1016\/j.peptides.2010.04.002_bib48","series-title":"The zebrafish book; a guide for the laboratory use of zebrafish (Brachydanio rerio)","author":"Westerfield","year":"1993"},{"key":"10.1016\/j.peptides.2010.04.002_bib49","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0022-2836(85)90347-X","article-title":"Solution conformation of proteinase inhibitor IIA from bull seminal plasma by 1H nuclear magnetic resonance and distance geometry","volume":"182","author":"Williamson","year":"1985","journal-title":"J Mol Biol"},{"key":"10.1016\/j.peptides.2010.04.002_bib50","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.molcatb.2005.08.007","article-title":"Effect of ions and other compatible solutes on enzyme activity, and its implication for biocatalysis using ionic liquids","volume":"37","author":"Zhao","year":"2005","journal-title":"J Mol Catal B: Enzym"},{"key":"10.1016\/j.peptides.2010.04.002_bib51","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.tetasy.2006.01.015","article-title":"Hofmeister series of ionic liquids: kosmotropic effect of ionic liquids on the enzymatic hydrolysis of enantiomeric phenylalanine methyl ester","volume":"17","author":"Zhao","year":"2006","journal-title":"Tetrahedr: Asymm"},{"key":"10.1016\/j.peptides.2010.04.002_bib52","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bioorg.2005.10.004","article-title":"Effect of kosmotropicity of ionic liquids on the enzyme stability in aqueous solutions","volume":"34","author":"Zhao","year":"2006","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.peptides.2010.04.002_bib53","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.febslet.2006.01.057","article-title":"The mu O-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3","volume":"580","author":"Zorn","year":"2006","journal-title":"FEBS Lett"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978110001543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978110001543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T15:53:51Z","timestamp":1635177231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978110001543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0196978110001543"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2010.04.002","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}