{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T18:57:08Z","timestamp":1774897028293,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.peptides.2010.11.022","type":"journal-article","created":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T09:22:29Z","timestamp":1291195349000},"page":"286-292","source":"Crossref","is-referenced-by-count":28,"title":["Investigation of gastrin-releasing peptide as a mediator for 5\u2032-guanidinonaltrindole-induced compulsive scratching in mice"],"prefix":"10.1016","volume":"32","author":[{"given":"Saadet","family":"Inan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nae J.","family":"Dun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2010.11.022_bib0005","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/cne.20350","article-title":"Kiss-1 expression and metastatin-like immunoreactivity in the rat brain","volume":"481","author":"Brailoiu","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.peptides.2010.11.022_bib0010","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0024-3205(85)90416-3","article-title":"Effects of bombesin on behavior","volume":"37","author":"Cowan","year":"1985","journal-title":"Life Sci"},{"key":"10.1016\/j.peptides.2010.11.022_bib0015","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1749-6632.1988.tb23888.x","article-title":"Behavioral effects of bombesin","volume":"547","author":"Cowan","year":"1988","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.peptides.2010.11.022_bib0020","series-title":"Opioid receptors and antagonists: from bench to clinic","first-page":"533","article-title":"Kappa-opioid antagonists as pruritogenic agents","author":"Cowan","year":"2009"},{"key":"10.1016\/j.peptides.2010.11.022_bib0025","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/1040-8428(96)00220-X","article-title":"Bombesin receptor antagonists","volume":"24","author":"De Castiglione","year":"1996","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.peptides.2010.11.022_bib0030","doi-asserted-by":"crossref","first-page":"11330","DOI":"10.1073\/pnas.0905605106","article-title":"TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms","volume":"106","author":"Imamachi","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.peptides.2010.11.022_bib0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejphar.2004.09.010","article-title":"Kappa opioid agonists suppress choloroquine-induced scratching in mice","volume":"502","author":"Inan","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.peptides.2010.11.022_bib0040","first-page":"38","article-title":"Agmatine-induced stereotyped scratching in mice is antagonized by nalfurafine, a kappa opioid agonist","volume":"48","author":"Inan","year":"2006","journal-title":"Pharmacologist"},{"key":"10.1016\/j.peptides.2010.11.022_bib0045","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pbb.2006.07.004","article-title":"a kappa opioid receptor agonist, inhibits scratching behavior secondary to cholestasis induced by chronic ethynylestradiol injections in rats","volume":"85","author":"Inan","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.peptides.2010.11.022_bib0050","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuroscience.2009.06.016","article-title":"Nalfurafine prevents 5\u2032-guanidinonaltrindole- and compound 48\/80-induced spinal c-fos expression and attenuates 5\u2032-guanidinonaltrindole-elicited scratching behavior in mice","volume":"163","author":"Inan","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.peptides.2010.11.022_bib0055","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ejphar.2009.06.026","article-title":"Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5\u2032-guanidinonaltrindole-induced scratching models in mice: behavioral and neuroanatomical evidence","volume":"616","author":"Inan","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.peptides.2010.11.022_bib0060","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainres.2004.10.068","article-title":"Immunohistochemical localization of gastrin-releasing peptide receptor in the mouse brain","volume":"1032","author":"Kamichi","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.peptides.2010.11.022_bib0065","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1124\/jpet.108.143925","article-title":"Effects of atypical kappa-opioid receptor agonists on inrathecal morphine-induced itch and analgesia in primates","volume":"328","author":"Ko","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.peptides.2010.11.022_bib0070","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/ndt\/gfp588","article-title":"Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a Phase III, randomized, double-blind, placebo-controlled study","volume":"25","author":"Kumagai","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.peptides.2010.11.022_bib0075","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/intimm\/9.3.461","article-title":"Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC\/Nga mice","volume":"9","author":"Matsuda","year":"1997","journal-title":"Int Immunol"},{"key":"10.1016\/j.peptides.2010.11.022_bib0080","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.peptides.2004.01.003","article-title":"The bombesin\/gastrin releasing peptide receptor antagonist RC-3095 blocks apomorphine but not MK-801-induced stereotypy in mice","volume":"25","author":"Meller","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2010.11.022_bib0085","first-page":"75","article-title":"Effect of TRK-820, a selective kappa opioid receptor agonist, on scratching behavior in an animal model of atopic dermatitis","volume":"28","author":"Nakao","year":"2008","journal-title":"Nihon Shinkei Seishin Yakurigaku Zasshi"},{"key":"10.1016\/j.peptides.2010.11.022_bib0090","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00213-002-1038-x","article-title":"Levine AS kappa opipid antagonist effects of the novel kappa antagonist 5\u2032-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys","volume":"163","author":"Negus","year":"2002","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.peptides.2010.11.022_bib0095","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0167-0115(92)90112-8","article-title":"High potency of a new bombesin antagonist (RC-3095) in inhibiting serum gastrin levels; comparison of different routes of administration","volume":"41","author":"Pinski","year":"1992","journal-title":"Regul Pept"},{"key":"10.1016\/j.peptides.2010.11.022_bib0100","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10637-006-6886-5","article-title":"A Phase I trial of the bombesin\/gastrin-releasing peptide (BN\/GRP) antagonist RC3095 in patients with advanced solid malignancies","volume":"24","author":"Schwartsmann","year":"2006","journal-title":"Invest New Drugs"},{"key":"10.1016\/j.peptides.2010.11.022_bib0105","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1021\/jm0000665","article-title":"Potent and selective indolomorphinan antagonists of the kappa-opioid receptor","volume":"43","author":"Stevens","year":"2000","journal-title":"J Med Chem"},{"key":"10.1016\/j.peptides.2010.11.022_bib0110","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0091-3057(94)00319-E","article-title":"Fourth ventricular injection of the bombesin receptor antagonist [d-Phe6]bombesin(6-13) methyl esther, but not BW2258U89, increases food intake in rats","volume":"50","author":"Stratford","year":"1995","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.peptides.2010.11.022_bib0115","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nature06029","article-title":"A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord","volume":"448","author":"Sun","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2010.11.022_bib0120","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.1174868","article-title":"Cellular basis of itch sensation","volume":"325","author":"Sun","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.peptides.2010.11.022_bib0125","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1600-0625.2006.00540.x","article-title":"Role of scratch-induced cutaneous prostaglandin D2 production on atopic-like scratching behavior in mice","volume":"16","author":"Takaoka","year":"2007","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.peptides.2010.11.022_bib0130","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejphar.2006.08.041","article-title":"Specific down-regulation of spinal mu-opioid receptor and reduced analgesic effects of morphine in mice with postherpetic pain","volume":"550","author":"Takasaki","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.peptides.2010.11.022_bib0135","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1038\/jid.2009.188","article-title":"Histological characterization of cutaneous nerve fibers containing gastrin-releasing peptide in NC\/Nga mice: an atopic dermatitis model","volume":"129","author":"Tominaga","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.peptides.2010.11.022_bib0140","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1016\/j.lfs.2004.05.033","article-title":"Inhibitory effects of TRK-820 on systemic skin scratching induced by morphine in rhesus monkeys","volume":"75","author":"Wakasa","year":"2004","journal-title":"Life Sci"},{"key":"10.1016\/j.peptides.2010.11.022_bib0145","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1124\/jpet.104.073668","article-title":"Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo","volume":"312","author":"Wang","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.peptides.2010.11.022_bib0150","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1681\/ASN.2005020152","article-title":"Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies","volume":"16","author":"Wikstr\u00f6m","year":"2005","journal-title":"J Am Soc Nephrol"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978110005085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978110005085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T13:52:40Z","timestamp":1544104360000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978110005085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0196978110005085"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2010.11.022","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}