{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:07:01Z","timestamp":1785928021158,"version":"3.56.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30870791"],"award-info":[{"award-number":["30870791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["07JCZDJC08100"],"award-info":[{"award-number":["07JCZDJC08100"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.peptides.2012.02.003","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T03:38:47Z","timestamp":1332387527000},"page":"23-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Diet-induced obese rats exhibit impaired LKB1\u2013AMPK signaling in hypothalamus and adipose tissue"],"prefix":"10.1016","volume":"35","author":[{"family":"Fei-Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Run","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Tso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Sheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2012.02.003_bib0005","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1074\/jbc.C300557200","article-title":"AMP-activated protein kinase plays a role in the control of food intake","volume":"279","author":"Andersson","year":"2004","journal-title":"J Biol Chem"},{"issue":"Suppl. 1","key":"10.1016\/j.peptides.2012.02.003_bib0010","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1017\/S0007114500000891","article-title":"Obesity\u2014a genetic disease of adipose tissue?","volume":"83","author":"Arner","year":"2000","journal-title":"Br J Nutr"},{"key":"10.1016\/j.peptides.2012.02.003_bib0015","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0006-8993(99)02186-1","article-title":"Resistance to diet-induced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus","volume":"851","author":"Bergen","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.peptides.2012.02.003_bib0020","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.2337\/diabetes.51.7.2199","article-title":"Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome","volume":"51","author":"Buhl","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2012.02.003_bib0025","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.biochem.67.1.821","article-title":"The AMP-activated\/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell","volume":"67","author":"Hardie","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.peptides.2012.02.003_bib0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1475-4924-2-28","article-title":"Complexes between the LKB1 tumor suppressor, STRAD alpha\/beta and MO25 alpha\/beta are upstream kinases in the AMP-activated protein kinase cascade","volume":"2","author":"Hawley","year":"2003","journal-title":"J Biol"},{"key":"10.1016\/j.peptides.2012.02.003_bib0035","doi-asserted-by":"crossref","first-page":"27879","DOI":"10.1074\/jbc.271.44.27879","article-title":"Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase","volume":"271","author":"Hawley","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2012.02.003_bib0040","doi-asserted-by":"crossref","first-page":"E239","DOI":"10.1152\/ajpendo.00326.2003","article-title":"AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes","volume":"286","author":"Hojlund","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.peptides.2012.02.003_bib0045","doi-asserted-by":"crossref","first-page":"8839","DOI":"10.1073\/pnas.1533136100","article-title":"Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases","volume":"100","author":"Hong","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.peptides.2012.02.003_bib0050","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism","volume":"1","author":"Kahn","year":"2005","journal-title":"Cell Metab"},{"key":"10.1016\/j.peptides.2012.02.003_bib0055","doi-asserted-by":"crossref","first-page":"19970","DOI":"10.1074\/jbc.M402165200","article-title":"C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase","volume":"279","author":"Kim","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2012.02.003_bib0060","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nm1061","article-title":"Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase","volume":"10","author":"Kim","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.peptides.2012.02.003_bib0065","first-page":"227","article-title":"LKB1 and AMPK and the regulation of skeletal muscle metabolism","volume":"11","author":"Koh","year":"2008","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.peptides.2012.02.003_bib0070","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neulet.2011.05.060","article-title":"AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats","volume":"499","author":"Kohno","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.peptides.2012.02.003_bib0075","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2337\/diabetes.52.5.1066","article-title":"5-Amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes","volume":"52","author":"Koistinen","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2012.02.003_bib0080","doi-asserted-by":"crossref","first-page":"25196","DOI":"10.1074\/jbc.C500175200","article-title":"Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase","volume":"280","author":"Kola","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2012.02.003_bib0085","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1042\/bst0290791","article-title":"Mitochondrial uncoupling and lipid metabolism in adipocytes","volume":"29","author":"Kopecky","year":"2001","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.peptides.2012.02.003_bib0090","doi-asserted-by":"crossref","first-page":"R231","DOI":"10.1152\/ajpregu.2000.278.1.R231","article-title":"Defense of body weight against chronic caloric restriction in obesity-prone and -resistant rats","volume":"278","author":"Levin","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.peptides.2012.02.003_bib0095","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.bbrc.2004.02.139","article-title":"AICAR stimulates adiponectin and inhibits cytokines in adipose tissue","volume":"316","author":"Lihn","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.peptides.2012.02.003_bib0100","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/sj.emboj.7600110","article-title":"LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK\/PAR-1","volume":"23","author":"Lizcano","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.peptides.2012.02.003_bib0105","doi-asserted-by":"crossref","first-page":"18933","DOI":"10.1074\/jbc.M512831200","article-title":"Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle","volume":"281","author":"Martin","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2012.02.003_bib0110","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.febslet.2004.06.002","article-title":"Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat","volume":"569","author":"Matejkova","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.peptides.2012.02.003_bib0115","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0022-2275(20)38029-9","article-title":"A microfluorometric method for the determination of free fatty acids in plasma","volume":"24","author":"Miles","year":"1983","journal-title":"J Lipid Res"},{"key":"10.1016\/j.peptides.2012.02.003_bib0120","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature02440","article-title":"AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus","volume":"428","author":"Minokoshi","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2012.02.003_bib0125","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2337\/diabetes.50.5.921","article-title":"AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise","volume":"50","author":"Musi","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2012.02.003_bib0130","doi-asserted-by":"crossref","first-page":"E310","DOI":"10.1152\/ajpendo.00074.2004","article-title":"Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR","volume":"287","author":"Sakamoto","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.peptides.2012.02.003_bib0135","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1038\/sj.emboj.7600667","article-title":"Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction","volume":"24","author":"Sakamoto","year":"2005","journal-title":"EMBO J"},{"key":"10.1016\/j.peptides.2012.02.003_bib0140","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.2337\/diabetes.49.10.1649","article-title":"5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes","volume":"49","author":"Salt","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2012.02.003_bib0145","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1073\/pnas.0308061100","article-title":"The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress","volume":"101","author":"Shaw","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.peptides.2012.02.003_bib0150","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1126\/science.1120781","article-title":"The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin","volume":"310","author":"Shaw","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.peptides.2012.02.003_bib0155","doi-asserted-by":"crossref","first-page":"E925","DOI":"10.1152\/ajpendo.00429.2005","article-title":"LKB1\u2013AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training","volume":"290","author":"Sriwijitkamol","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.peptides.2012.02.003_bib0160","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/physrev.00011.2008","article-title":"AMPK in health and disease","volume":"89","author":"Steinberg","year":"2009","journal-title":"Physiol Rev"},{"key":"10.1016\/j.peptides.2012.02.003_bib0165","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1210\/jc.2004-0308","article-title":"AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females","volume":"89","author":"Steinberg","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.peptides.2012.02.003_bib0170","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.2337\/diab.46.9.1516","article-title":"Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice","volume":"46","author":"Surwit","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2012.02.003_bib0175","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0960-9822(03)00459-7","article-title":"Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex","volume":"13","author":"Sutherland","year":"2003","journal-title":"Curr Biol"},{"key":"10.1016\/j.peptides.2012.02.003_bib0180","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.peptides.2004.08.009","article-title":"Changes of hypothalamic alpha-MSH and CART peptide expression in diet-induced obese rats","volume":"25","author":"Tian","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2012.02.003_bib0185","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0196-9781(02)00030-X","article-title":"Diet-induced changes in hypothalamic pro-opio-melanocortin mRNA in the rat hypothalamus","volume":"23","author":"Torri","year":"2002","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2012.02.003_bib0190","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.2337\/diabetes.53.9.2242","article-title":"Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit","volume":"53","author":"Villena","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2012.02.003_bib0195","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1152\/jappl.2000.88.6.2219","article-title":"Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle","volume":"88","author":"Winder","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.peptides.2012.02.003_bib0200","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.cub.2003.10.031","article-title":"LKB1 is the upstream kinase in the AMP-activated protein kinase cascade","volume":"13","author":"Woods","year":"2003","journal-title":"Curr Biol"},{"key":"10.1016\/j.peptides.2012.02.003_bib0205","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/12506","article-title":"Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin","volume":"5","author":"Yaswen","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.peptides.2012.02.003_bib0210","doi-asserted-by":"crossref","first-page":"C283","DOI":"10.1152\/ajpcell.00319.2003","article-title":"Cloning and characterization of mouse 5\u2032-AMP-activated protein kinase gamma3 subunit","volume":"286","author":"Yu","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.peptides.2012.02.003_bib0215","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1753-4887.2000.tb01857.x","article-title":"Pro-opiomelanocortin (POMC) deficiency and peripheral melanocortins in obesity","volume":"58","author":"Zemel","year":"2000","journal-title":"Nutr Rev"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978112000630?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978112000630?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:21:49Z","timestamp":1759310509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978112000630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0196978112000630"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2012.02.003","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diet-induced obese rats exhibit impaired LKB1\u2013AMPK signaling in hypothalamus and adipose tissue","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2012.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}