{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:57:18Z","timestamp":1792097838097,"version":"4.4.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"China National 973 Research Project, Basic Research and Clinical Application of Venom Peptides from Toxic Animals","award":["2010CB529800"],"award-info":[{"award-number":["2010CB529800"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Fund for the Central Universities","doi-asserted-by":"crossref","award":["CUGL100613"],"award-info":[{"award-number":["CUGL100613"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.peptides.2012.06.002","type":"journal-article","created":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T02:19:05Z","timestamp":1339726745000},"page":"150-156","source":"Crossref","is-referenced-by-count":11,"title":["Tremendous intron length differences of the BmKBT and a novel BmKBT-like peptide genes provide a mechanical basis for the rapid or constitutive expression of the peptides"],"prefix":"10.1016","volume":"37","author":[{"given":"Yao","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Chun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.peptides.2012.06.002_bib0005","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1093\/nar\/gkq023","article-title":"Intronic elements in the Na+\/I\u2212 symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription","volume":"38","author":"Alotaibi","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"Pt 3","key":"10.1016\/j.peptides.2012.06.002_bib0010","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1042\/bj3130753","article-title":"Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus","volume":"313","author":"Becerril","year":"1996","journal-title":"Biochem J"},{"issue":"24","key":"10.1016\/j.peptides.2012.06.002_bib0015","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.2174\/138161208785777423","article-title":"Animal peptides targeting voltage-activated sodium channels","volume":"14","author":"Billen","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.peptides.2012.06.002_bib0020","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/j.1432-1033.1997.01118.x","article-title":"1H-NMR-derived secondary structure and overall fold of a natural anatoxin from the scorpion Androctonus australis hector","volume":"247","author":"Blanc","year":"1997","journal-title":"Eur J Biochem"},{"issue":"3\u20134","key":"10.1016\/j.peptides.2012.06.002_bib0025","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cbpc.2005.10.011","article-title":"Diversity of long-chain toxins in Tityus zulianus and Tityus discrepans venoms (Scorpiones, Buthidae): molecular, immunological, and mass spectral analyses","volume":"142","author":"Borges","year":"2006","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"issue":"1","key":"10.1016\/j.peptides.2012.06.002_bib0030","doi-asserted-by":"crossref","first-page":"e1000573","DOI":"10.1371\/journal.pbio.1000573","article-title":"The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing","volume":"9","author":"Brody","year":"2011","journal-title":"PLoS Biol"},{"issue":"4","key":"10.1016\/j.peptides.2012.06.002_bib0035","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng940","article-title":"Selection for short introns in highly expressed genes","volume":"31","author":"Castillo-Davis","year":"2002","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.peptides.2012.06.002_bib0040","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1042\/BJ20060035","article-title":"Chinese-scorpion (Buthus martensii Karsch) toxin BmK \u03b1IV, a novel modulator of sodium channels: from genomic organization to functional analysis","volume":"399","author":"Chai","year":"2006","journal-title":"Biochem J"},{"issue":"4","key":"10.1016\/j.peptides.2012.06.002_bib0045","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.tig.2005.02.003","article-title":"Human antisense genes have unusually short introns: evidence for selection for rapid transcription","volume":"21","author":"Chen","year":"2005","journal-title":"Trends Genet"},{"issue":"3","key":"10.1016\/j.peptides.2012.06.002_bib0050","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/genetics\/156.3.1175","article-title":"The correlation between intron length and recombination in Drosophila. Dynamic equilibrium between mutational and selective forces","volume":"156","author":"Comeron","year":"2000","journal-title":"Genetics"},{"issue":"3","key":"10.1016\/j.peptides.2012.06.002_bib0055","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.toxicon.2010.04.012","article-title":"Genomic cloning, characterization and statistical analysis of an antitumor-analgesic peptide from Chinese scorpion Buthus martensii Karsch","volume":"56","author":"Cui","year":"2010","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.peptides.2012.06.002_bib0060","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.toxicon.2011.02.006","article-title":"Isolation and molecular cloning of beta-neurotoxins from the venom of the scorpion Centruroides suffusus suffusus","volume":"57","author":"Espino-Solis","year":"2011","journal-title":"Toxicon"},{"issue":"11","key":"10.1016\/j.peptides.2012.06.002_bib0065","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1128\/AAC.00369-11","article-title":"Ctriporin, a new anti-methicillin-resistant Staphylococcus aureus Peptide from the Venom of the Scorpion Chaerilus tricostatus","volume":"55","author":"Fan","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"10.1016\/j.peptides.2012.06.002_bib0070","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/psc.578","article-title":"Arthropod defensins illuminate the divergence of scorpion neurotoxins","volume":"10","author":"Froy","year":"2004","journal-title":"J Pept Sci"},{"issue":"2","key":"10.1016\/j.peptides.2012.06.002_bib0075","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/PL00006457","article-title":"Dynamic diversification from a putative common ancestor of scorpion toxins affecting sodium, potassium, and chloride channels","volume":"48","author":"Froy","year":"1999","journal-title":"J Mol Evol"},{"issue":"1","key":"10.1016\/j.peptides.2012.06.002_bib0080","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.toxicon.2011.04.011","article-title":"Biochemical and molecular characterization of the venom from the Cuban scorpion Rhopalurus junceus","volume":"58","author":"Garc\u00eda-G\u00f3mez","year":"2011","journal-title":"Toxicon"},{"issue":"13","key":"10.1016\/j.peptides.2012.06.002_bib0085","doi-asserted-by":"crossref","first-page":"8320","DOI":"10.1074\/jbc.272.13.8320","article-title":"Makatoxin I, a novel toxin isolated from the venom of the scorpion Buthus martensii Karsch, exhibits nitrergic actions","volume":"272","author":"Gong","year":"1997","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.peptides.2012.06.002_bib0090","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1046\/j.1432-1033.2003.03643.x","article-title":"An \u2018Old World\u2019 scorpion beta-toxin that recognizes both insect and mammalian sodium channels","volume":"270","author":"Gordon","year":"2003","journal-title":"Eur J Biochem"},{"issue":"4","key":"10.1016\/j.peptides.2012.06.002_bib0095","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.toxicon.2006.11.015","article-title":"The insecticidal potential of scorpion beta-toxins","volume":"49","author":"Gurevitz","year":"2007","journal-title":"Toxicon"},{"issue":"9","key":"10.1016\/j.peptides.2012.06.002_bib0100","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0041-0101(02)00142-3","article-title":"An overview of toxins and genes from the venom of the Asian scorpion Buthus martensii Karsch","volume":"40","author":"Goudet","year":"2002","journal-title":"Toxicon"},{"issue":"1\u20132","key":"10.1016\/j.peptides.2012.06.002_bib0105","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0014-5793(01)02365-1","article-title":"Electrophysiological characterization of BmK M1, an alpha-like toxin from Buthus martensii Karsch venom","volume":"495","author":"Goudet","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.peptides.2012.06.002_bib0110","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.toxicon.2010.12.015","article-title":"ImKTx88, a novel selective Kv1.3 channel blocker derived from the scorpion Isometrus maculates","volume":"57","author":"Han","year":"2011","journal-title":"Toxicon"},{"key":"10.1016\/j.peptides.2012.06.002_bib0115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0014-5793(98)01710-4","article-title":"Aah VI, a novel, N-glycosylated anti-insect toxin from Androctonus australis hector scorpion venom: isolation, characterisation, and glycan structure determination","volume":"443","author":"Hassani","year":"1999","journal-title":"FEBS Lett"},{"issue":"10","key":"10.1016\/j.peptides.2012.06.002_bib0120","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.tig.2008.05.006","article-title":"Rapidly regulated genes are intron poor","volume":"24","author":"Jeffares","year":"2008","journal-title":"Trends Genet"},{"issue":"2","key":"10.1016\/j.peptides.2012.06.002_bib0125","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-5793(85)80262-3","article-title":"Primary structure of toxin IV of Leiurus quinquestriatus quinquestriatus: characterization of a new group of scorpion toxins","volume":"181","author":"Kopeyan","year":"1985","journal-title":"FEBS Lett"},{"key":"10.1016\/j.peptides.2012.06.002_bib0130","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/1471-2148-8-333","article-title":"Assembling an arsenal, the scorpion way","volume":"8","author":"Kozminsky-Atias","year":"2008","journal-title":"BMC Evol Biol"},{"key":"10.1016\/j.peptides.2012.06.002_bib0135","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1021\/bi00217a007","article-title":"An anti-insect toxin purified from the scorpion Androctonus australis Hector also acts on the alpha- and beta-sites of the mammalian sodium channel: sequence and circular dichroism study","volume":"30","author":"Loret","year":"1991","journal-title":"Biochemistry-US"},{"key":"10.1016\/j.peptides.2012.06.002_bib0140","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1016\/S0021-9258(18)61214-1","article-title":"Purification and chemical and biological characterizations of seven toxins from the Mexican scorpion, Centruroides suffusus suffusus","volume":"262","author":"Martin","year":"1987","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.peptides.2012.06.002_bib0145","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.toxicon.2011.02.001","article-title":"The tale of a resting gland: transcriptome of a replete venom gland from the scorpion Hottentotta judaicus","volume":"57","author":"Morgenstern","year":"2011","journal-title":"Toxicon"},{"issue":"24","key":"10.1016\/j.peptides.2012.06.002_bib0150","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.2174\/138161208785777478","article-title":"Peptides targeting voltage-gated calcium channels","volume":"14","author":"Norton","year":"2008","journal-title":"Curr Pharm Des"},{"issue":"13","key":"10.1016\/j.peptides.2012.06.002_bib0155","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.1093\/nar\/gkr043","article-title":"Comparative and functional analysis of intron-mediated enhancement signals reveals conserved features among plants","volume":"39","author":"Parra","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.peptides.2012.06.002_bib0160","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0041-0101(00)00240-3","article-title":"Purification, amino-acid sequence and partial characterization of two toxins with anti-insect activity from the venom of the South American scorpion Tityus bahiensis (Buthidae)","volume":"39","author":"Pimenta","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.peptides.2012.06.002_bib0165","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/jmbi.1999.2868","article-title":"Crystal structure of neurotoxin Ts1 from Tityus serrulatus provides insights into the specificity and toxicity of scorpion toxins","volume":"290","author":"Polikarpov","year":"1999","journal-title":"J Mol Biol"},{"issue":"2","key":"10.1016\/j.peptides.2012.06.002_bib0170","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1432-1327.1999.00625.x","article-title":"Scorpion toxins specific for Na+-channels","volume":"264","author":"Possani","year":"1999","journal-title":"Eur J Biochem"},{"issue":"1","key":"10.1016\/j.peptides.2012.06.002_bib0175","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/BJ20101488","article-title":"The pancreatic islet beta-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer","volume":"433","author":"Pound","year":"2011","journal-title":"Biochem J"},{"issue":"4","key":"10.1016\/j.peptides.2012.06.002_bib0180","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.peptides.2011.01.015","article-title":"Purification, synthesis and characterization of AaCtx, the first chlorotoxin-like peptide from Androctonus australis scorpion venom","volume":"32","author":"Rjeibi","year":"2011","journal-title":"Peptides"},{"issue":"8","key":"10.1016\/j.peptides.2012.06.002_bib0185","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.toxicon.2004.03.022","article-title":"Current views on scorpion toxins specific for K+-channels","volume":"43","author":"Rodriguez de la","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.peptides.2012.06.002_bib0190","first-page":"277","article-title":"Intron-mediated regulation of gene expression","volume":"326","author":"Rose","year":"2008","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.peptides.2012.06.002_bib0195","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1471-2164-8-119","article-title":"Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones)","volume":"8","author":"Schwartz","year":"2007","journal-title":"BMC Genomics"},{"issue":"8","key":"10.1016\/j.peptides.2012.06.002_bib0200","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/molbev\/msq086","article-title":"Distinct patterns of expression and evolution of intronless and intron-containing mammalian genes","volume":"27","author":"Shabalina","year":"2010","journal-title":"Mol Biol Evol"},{"issue":"11","key":"10.1016\/j.peptides.2012.06.002_bib0205","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0165-6147(99)01398-X","article-title":"A unified nomenclature for short-chain peptides isolated from scorpion venoms: \u03b1-KTx molecular subfamilies","volume":"20","author":"Tytgat","year":"1999","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"10.1016\/j.peptides.2012.06.002_bib0210","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.toxicon.2006.09.003","article-title":"Purification and characterization of Heteroscorpine-1 (HS-1) toxin from Heterometrus laoticus scorpion venom","volume":"49","author":"Uawonggul","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.peptides.2012.06.002_bib0215","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0041-0101(82)90167-2","article-title":"Neurotoxins from the venoms of two scorpions: Buthus occitanus tunetanus and Buthus occitanus mardochei","volume":"20","author":"Vargas","year":"1982","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.peptides.2012.06.002_bib0220","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbrc.2006.12.184","article-title":"Relationship between mRNA stability and intron presence","volume":"354","author":"Wang","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.peptides.2012.06.002_bib0225","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0041-0101(02)00242-8","article-title":"Three polymorphic genes encoding a depressant toxin from the Egyptian scorpion Leiurus quinquestriatus quinquestriatus","volume":"41","author":"Zaki","year":"2003","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.peptides.2012.06.002_bib0230","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/15216540500058899","article-title":"Scorpion venom peptides without disulfide bridges","volume":"57","author":"Zeng","year":"2005","journal-title":"IUBMB Life"},{"issue":"2\u20133","key":"10.1016\/j.peptides.2012.06.002_bib0235","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0041-0101(00)00119-7","article-title":"Molecular cloning and sequence analysis of cDNAs encoding a beta-toxin-like peptide and two MkTx I homologues from scorpion Buthus martensii Karsch","volume":"39","author":"Zeng","year":"2001","journal-title":"Toxicon"},{"issue":"9","key":"10.1016\/j.peptides.2012.06.002_bib0240","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(01)01326-8","article-title":"Molecular cloning and characterization of four scorpion K(+)-toxin-like peptides: a new subfamily of venom peptides (alpha-KTx14) and genomic analysis of a member","volume":"83","author":"Zeng","year":"2001","journal-title":"Biochimie"},{"issue":"1","key":"10.1016\/j.peptides.2012.06.002_bib0245","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.peptides.2011.11.012","article-title":"Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides","volume":"33","author":"Zeng","year":"2012","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.peptides.2012.06.002_bib0250","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.peptides.2003.12.003","article-title":"Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch","volume":"25","author":"Zeng","year":"2004","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.peptides.2012.06.002_bib0255","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.peptides.2011.12.012","article-title":"Identification and molecular characterization of three new K(+)-channel specific toxins from the Chinese scorpion Mesobuthus martensii Karsch revealing intronic number polymorphism and alternative splicing in duplicated genes","volume":"34","author":"Zeng","year":"2012","journal-title":"Peptides"},{"issue":"25","key":"10.1016\/j.peptides.2012.06.002_bib0260","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.1016\/j.febslet.2006.09.071","article-title":"Molecular characterization of a possible progenitor sodium channel toxin from the Old World scorpion Mesobuthus martensii","volume":"580","author":"Zhu","year":"2006","journal-title":"FEBS Lett"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019697811200263X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019697811200263X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:05:50Z","timestamp":1642464350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019697811200263X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S019697811200263X"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2012.06.002","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}