{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:31:55Z","timestamp":1767961915665,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.peptides.2012.07.003","type":"journal-article","created":{"date-parts":[[2012,7,7]],"date-time":"2012-07-07T12:37:24Z","timestamp":1341664644000},"page":"69-78","source":"Crossref","is-referenced-by-count":24,"title":["Multiple sites of the cleavage of 17- and 19-mer encephalytogenic oligopeptides corresponding to human myelin basic protein (MBP) by specific anti-MBP antibodies from patients with systemic lupus erythematosus"],"prefix":"10.1016","volume":"37","author":[{"given":"Anna M.","family":"Bezuglova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel S.","family":"Dmitrenok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila P.","family":"Konenkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina N.","family":"Buneva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgy A.","family":"Nevinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2012.07.003_bib0005","first-page":"460","article-title":"Catalytic heterogeneity of polyclonal RNA-hydrolyzing IgM from sera of patients with lupus erythematosus","volume":"6","author":"Andrievskaya","year":"2000","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.peptides.2012.07.003_bib0010","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0165-2478(02)00006-8","article-title":"Catalytic diversity of polyclonal RNA-hydrolyzing IgG antibodies from the sera of patients with systemic lupus erythematosus","volume":"81","author":"Andrievskaya","year":"2002","journal-title":"Immunol Lett"},{"key":"10.1016\/j.peptides.2012.07.003_bib0015","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/1531-8249(200006)47:6<694::AID-ANA2>3.0.CO;2-W","article-title":"The role of B cells and autoantibodies in multiple sclerosis","volume":"47","author":"Archelos","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.peptides.2012.07.003_bib0020","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.biochi.2009.06.018","article-title":"HIV-1 integrase-hydrolyzing antibodies from sera of HIV-infected patients","volume":"91","author":"Baranova","year":"2009","journal-title":"Biochimie"},{"key":"10.1016\/j.peptides.2012.07.003_bib0025","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/intimm\/dxq051","article-title":"HIV-1 integrase-hydrolyzing IgM antibodies from sera of HIV-infected patients","volume":"22","author":"Baranova","year":"2010","journal-title":"Int Immunol"},{"key":"10.1016\/j.peptides.2012.07.003_bib0030","first-page":"1239","article-title":"Polyclonal antibodies from blood and cerebrospinal fluid of patients with multiple sclerosis effectively hydrolyze DNA and RNA","volume":"63","author":"Baranovskii","year":"1998","journal-title":"Biochemistry (Moscow)"},{"key":"10.1016\/j.peptides.2012.07.003_bib0035","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0165-2478(01)00185-7","article-title":"Catalytic heterogeneity of polyclonal DNA-hydrolyzing antibodies from the sera of patients with multiple sclerosis","volume":"76","author":"Baranovskii","year":"2001","journal-title":"Immunol Lett"},{"key":"10.1016\/j.peptides.2012.07.003_bib0040","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.4049\/jimmunol.180.2.1258","article-title":"Recognition and degradation of myelin basic protein peptides by serum autoantibodies: novel biomarker for multiple sclerosis","volume":"180","author":"Belogurov","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.peptides.2012.07.003_bib0045","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/jmr.1143","article-title":"Affinity and catalytic heterogeneity and metal-dependence of polyclonal myelin basic protein-hydrolyzing IgGs from sera of patients with systemic lupus erythematosus","volume":"24","author":"Bezuglova","year":"2011","journal-title":"J Mol Recognit"},{"key":"10.1016\/j.peptides.2012.07.003_bib0050","first-page":"727","article-title":"Multiple sclerosis: molecular and cellular mechanisms","volume":"29","author":"Boiko","year":"1995","journal-title":"Mol Biol (Mosk)"},{"key":"10.1016\/j.peptides.2012.07.003_bib0055","series-title":"Enzyme Structure and Mechanism","author":"Fersht","year":"1985"},{"key":"10.1016\/j.peptides.2012.07.003_bib0060","doi-asserted-by":"crossref","first-page":"32389","DOI":"10.1016\/S0021-9258(18)31647-8","article-title":"Molecular cloning of a proteolytic antibody light chain","volume":"269","author":"Gao","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2012.07.003_bib0065","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nrn784","article-title":"New concepts in the immunopathogenesis of multiple sclerosis","volume":"3","author":"Hemmer","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.peptides.2012.07.003_bib0070","series-title":"Internal diseases","first-page":"407","article-title":"Systemic lipus erythematosus","author":"Hhachn","year":"1996"},{"key":"10.1016\/j.peptides.2012.07.003_bib0075","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.4049\/jimmunol.155.5.2695","article-title":"Unexpected presence of polyreactive catalytic antibodies in IgG from unimmunized donors and decreased levels in rheumatoid arthritis","volume":"155","author":"Kalaga","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.peptides.2012.07.003_bib0080","series-title":"Catalytic antibodies","year":"2005"},{"key":"10.1016\/j.peptides.2012.07.003_bib0085","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02787708","article-title":"Novel functional activities of anti-DNA autoantibodies from sera of patients with lymphoproliferative and autoimmune diseases","volume":"75","author":"Kozyr","year":"1998","journal-title":"Appl Biochem Biotechnol"},{"key":"10.1016\/j.peptides.2012.07.003_bib0090","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1582-4934.2009.00738.x","article-title":"Affinity and catalytic heterogeneity of polyclonal myelin basic protein-hydrolyzing IgGs from sera of patients with multiple sclerosis","volume":"14","author":"Legostaeva","year":"2010","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.peptides.2012.07.003_bib0095","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.4049\/jimmunol.154.7.3328","article-title":"Catalytic activity of anti-thyroglobulin antibodies","volume":"154","author":"Li","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.peptides.2012.07.003_bib0100","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0022-1759(02)00234-X","article-title":"Human catalytic RNA- and DNA-hydrolyzing antibodies","volume":"269","author":"Nevinsky","year":"2002","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.peptides.2012.07.003_bib0105","series-title":"Protein\u2013protein interactions: a molecular cloning manual","first-page":"1","article-title":"Natural catalytic antibodies\u2014new characters in the protein repertoire","author":"Nevinsky","year":"2002"},{"key":"10.1016\/j.peptides.2012.07.003_bib0110","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1582-4934.2003.tb00227.x","article-title":"Catalytic antibodies in healthy humans and patients with autoimmune and viral pathologies","volume":"7","author":"Nevinsky","year":"2003","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.peptides.2012.07.003_bib0115","series-title":"Catalytic antibodies","first-page":"1","article-title":"Natural catalytic antibodies\u2014abzymes","author":"Nevinsky","year":"2004"},{"key":"10.1016\/j.peptides.2012.07.003_bib0120","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1100\/tsw.2010.98","article-title":"Natural catalytic antibodies in norm, autoimmune, viral, and bacterial diseases","volume":"10","author":"Nevinsky","year":"2010","journal-title":"Scientific World J"},{"key":"10.1016\/j.peptides.2012.07.003_bib0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1011064007686","article-title":"Neuroimmunology of multiple sclerosis","volume":"21","author":"O\u2019Connor","year":"2001","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.peptides.2012.07.003_bib0130","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/jmr.2159","article-title":"Anti-integrase abzymes from the sera of HIV-infected patients specifically hydrolyze integrase but nonspecifically cleave short oligopeptides","volume":"25","author":"Odintsova","year":"2012","journal-title":"J Mol Recognit"},{"key":"10.1016\/j.peptides.2012.07.003_bib0135","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/intimm\/dxr065","article-title":"Antibodies to HIV integrase catalyze site-specific degradation of their antigen","volume":"23","author":"Odintsova","year":"2011","journal-title":"Int Immunol"},{"key":"10.1016\/j.peptides.2012.07.003_bib0140","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.biochi.2010.01.022","article-title":"DNA-hydrolyzing activity of IgG antibodies from the sera of patients with tick-borne encephalitis","volume":"92","author":"Parkhomenko","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.peptides.2012.07.003_bib0145","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.4049\/jimmunol.159.3.1530","article-title":"Chacterization of thyroglobulin-directed and polyreactive catalytic antibodies in autoimmune disease","volume":"159","author":"Paul","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.peptides.2012.07.003_bib0150","doi-asserted-by":"crossref","first-page":"15257","DOI":"10.1074\/jbc.270.25.15257","article-title":"Natural catalytic antibodies: peptide-hydrolyzing activities of Bence Jones proteins and VL fragment","volume":"270","author":"Paul","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2012.07.003_bib0155","first-page":"850","article-title":"Immune response to DNA in systemic lupus erythematosus","volume":"3","author":"Pisetsky","year":"2001","journal-title":"Isr Med Ass J"},{"key":"10.1016\/j.peptides.2012.07.003_bib0160","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1582-4934.2004.tb00325.x","article-title":"Hydrolysis of myelin basic protein by polyclonal catalytic IgGs from the sera of patients with multiple sclerosis","volume":"8","author":"Polosukhina","year":"2004","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.peptides.2012.07.003_bib0165","first-page":"BR266","article-title":"Hydrolysis of myelin basic protein by IgM and IgA antibodies from the sera of patients with multiple sclerosis","volume":"11","author":"Polosukhina","year":"2005","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.peptides.2012.07.003_bib0170","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.imlet.2005.10.018","article-title":"Metal-dependent hydrolysis of myelin basic protein by IgGs from the sera of patients with multiple sclerosis","volume":"103","author":"Polosukhina","year":"2006","journal-title":"Immunol Lett"},{"key":"10.1016\/j.peptides.2012.07.003_bib0175","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1073\/pnas.0509849103","article-title":"Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen","volume":"103","author":"Ponomarenko","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.peptides.2012.07.003_bib0180","series-title":"The diagnosis of multiple sclerosis","author":"Poser","year":"1984"},{"key":"10.1016\/j.peptides.2012.07.003_bib0185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4052\/tigg.16.17","article-title":"Human antibodies with amylolytic activity","volume":"16","author":"Savel\u2019ev","year":"2004","journal-title":"Trends Glycosci Glycotechnol"},{"key":"10.1016\/j.peptides.2012.07.003_bib0190","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0165-2478(03)00042-7","article-title":"Amylolytic activity of IgM and IgG antibodies from patients with multiple sclerosis","volume":"86","author":"Saveliev","year":"2003","journal-title":"Immunol Lett"},{"key":"10.1016\/j.peptides.2012.07.003_bib0195","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.1585181","article-title":"DNA hydrolyzing autoantibodies","volume":"256","author":"Shuster","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.peptides.2012.07.003_bib0200","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1021\/bi992588w","article-title":"Monoclonal antibody light chain with prothrombinase activity","volume":"39","author":"Thiagarajan","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.peptides.2012.07.003_bib0205","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1073\/pnas.98.4.1793","article-title":"Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis","volume":"98","author":"Williamson","year":"2001","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978112003026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978112003026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T15:35:29Z","timestamp":1714145729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978112003026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0196978112003026"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2012.07.003","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}