{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:50:50Z","timestamp":1760298650607,"version":"3.40.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National S&T Major Project of China","award":["2011ZX08006-005"],"award-info":[{"award-number":["2011ZX08006-005"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["30901018"],"award-info":[{"award-number":["30901018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"China Agriculture Research System"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.peptides.2013.01.004","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T19:39:40Z","timestamp":1357760380000},"page":"8-14","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Peripheral administration of TAT-obestatin can influence the expression of liporegulatory genes but fails to affect food intake in mice"],"prefix":"10.1016","volume":"42","author":[{"given":"Guangcai","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuyong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiqing","family":"Cong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxue","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenwei","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaosheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2013.01.004_bib0005","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.peptides.2010.12.005","article-title":"Chronic treatment with a stable obestatin analog significantly alters plasma triglyceride levels but fails to influence food intake; fluid intake; body weight; or body composition in rats","volume":"32","author":"Agnew","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2013.01.004_bib0010","doi-asserted-by":"crossref","first-page":"G1210","DOI":"10.1152\/ajpgi.00549.2007","article-title":"Obestatin inhibits motor activity in the antrum and duodenum in the fed state of conscious rats","volume":"294","author":"Ataka","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.peptides.2013.01.004_bib0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.regpep.2007.08.027","article-title":"The blood-brain barrier: connecting the gut and the brain","volume":"149","author":"Banks","year":"2008","journal-title":"Regul Pept"},{"key":"10.1016\/j.peptides.2013.01.004_bib0020","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0196-9781(97)00231-3","article-title":"Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin","volume":"18","author":"Banks","year":"1997","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2013.01.004_bib0025","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0196-9781(96)00025-3","article-title":"Leptin enters the brain by a saturable system independent of insulin","volume":"17","author":"Banks","year":"1996","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2013.01.004_bib0030","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1124\/jpet.102.034827","article-title":"Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure","volume":"302","author":"Banks","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.peptides.2013.01.004_bib0035","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/sj.bjp.0706969","article-title":"Little or no ability of obestatin to interact with ghrelin or modify motility in the rat gastrointestinal tract","volume":"150","author":"Bassil","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.peptides.2013.01.004_bib0040","doi-asserted-by":"crossref","first-page":"RC16","DOI":"10.1007\/BF03344175","article-title":"Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat","volume":"29","author":"Bresciani","year":"2006","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.peptides.2013.01.004_bib0045","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.peptides.2009.04.011","article-title":"Effects of obestatin on feeding and body weight after standard or cafeteria diet in the rat","volume":"30","author":"Brunetti","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2013.01.004_bib0050","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.bbrc.2006.11.112","article-title":"Obestatin improves memory performance and causes anxiolytic effects in rats","volume":"352","author":"Carlini","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.peptides.2013.01.004_bib0055","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1749-6632.1995.tb44724.x","article-title":"The neural network that regulates energy balance is responsive to glucocorticoids and insulin and also regulates HPA axis responsivity at a proximal to CRF neurons","volume":"771","author":"Dallman","year":"1995","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.peptides.2013.01.004_bib0060","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.nbd.2010.05.033","article-title":"Transplantation of TAT-Bcl-xL-transduced neural precursor cells: long-term neuroprotection after stroke","volume":"40","author":"Doeppner","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.peptides.2013.01.004_bib0065","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.regpep.2008.08.003","article-title":"Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas","volume":"152","author":"Egido","year":"2009","journal-title":"Regul Pept"},{"key":"10.1016\/j.peptides.2013.01.004_bib0070","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/0092-8674(88)90263-2","article-title":"Cellular uptake of the tat protein from human immunodeficiency virus","volume":"55","author":"Frankel","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.peptides.2013.01.004_bib0075","doi-asserted-by":"crossref","first-page":"97","DOI":"10.14712\/fb2007053030097","article-title":"Growth-inhibiting activity of transcription factor C\/EBPalpha, its role in haematopoiesis and its tumour suppressor or oncogenic properties in leukaemias","volume":"53","author":"Fuchs","year":"2007","journal-title":"Folia Biol (Praha)"},{"key":"10.1016\/j.peptides.2013.01.004_bib0080","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.3748\/wjg.14.6318","article-title":"Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats","volume":"14","author":"Fujimiya","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.peptides.2013.01.004_bib0085","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.domaniend.2010.02.004","article-title":"Expression analysis of key somatotropic axis and liporegulatory genes in ghrelin- and obestatin-infused dairy cows","volume":"39","author":"Grala","year":"2010","journal-title":"Domest Anim Endocrinol"},{"key":"10.1016\/j.peptides.2013.01.004_bib0090","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1096\/fj.11-201343","article-title":"Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation","volume":"26","author":"Granata","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.peptides.2013.01.004_bib0095","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.peptides.2007.02.003","article-title":"Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice","volume":"28","author":"Green","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2013.01.004_bib0100","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/0092-8674(88)90262-0","article-title":"Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein","volume":"55","author":"Green","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.peptides.2013.01.004_bib0105","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1111\/j.1582-4934.2010.01192.x","article-title":"Obestatin as a regulator of adipocyte metabolism and adipogenesis","volume":"15","author":"Gurriaran-Rodriguez","year":"2011","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.peptides.2013.01.004_bib0110","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1210\/en.2009-1039","article-title":"Corticotropin-releasing hormone receptor-1 in cerebral microvessels changes during development and influences urocortin transport across the blood-brain barrier","volume":"151","author":"Hsuchou","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2013.01.004_bib0115","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/ana.10356","article-title":"Intravenous TAT-Bcl-Xl is protective after middle cerebral artery occlusion in mice","volume":"52","author":"Kilic","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.peptides.2013.01.004_bib0120","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1527-3458.2005.tb00054.x","article-title":"TAT-GDNF in neurodegeneration and ischemic stroke","volume":"11","author":"Kilic","year":"2005","journal-title":"CNS Drug Rev"},{"key":"10.1016\/j.peptides.2013.01.004_bib0125","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1161\/01.STR.0000066869.45310.50","article-title":"Intravenous TAT-GDNF is protective after focal cerebral ischemia in mice","volume":"34","author":"Kilic","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.peptides.2013.01.004_bib0130","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbrc.2006.09.141","article-title":"Obestatin does not activate orphan G protein-coupled receptor GPR39","volume":"351","author":"Lauwers","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.peptides.2013.01.004_bib0135","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1021\/bc970058b","article-title":"99mTc labeling of highly potent small peptides","volume":"8","author":"Liu","year":"1997","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.peptides.2013.01.004_bib0140","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/jcb.22983","article-title":"Effect of desacyl ghrelin, obestatin and related peptides on triglyceride storage, metabolism and GHSR signaling in 3T3-L1 adipocytes","volume":"112","author":"Miegueu","year":"2011","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.peptides.2013.01.004_bib0145","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nature05026","article-title":"Central nervous system control of food intake and body weight","volume":"443","author":"Morton","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2013.01.004_bib0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.regpep.2009.08.008","article-title":"Fragment analogs as better mimics of obestatin","volume":"158","author":"Nagaraj","year":"2009","journal-title":"Regul Pept"},{"key":"10.1016\/j.peptides.2013.01.004_bib0155","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2013.01.004_bib0160","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1210\/en.2006-0915","article-title":"Effects of obestatin on energy balance and growth hormone secretion in rodents","volume":"148","author":"Nogueiras","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2013.01.004_bib0165","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.peptides.2005.12.014","article-title":"Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin","volume":"27","author":"Pan","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2013.01.004_bib0170","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.bbrc.2009.10.163","article-title":"Role of obestatin on growth hormone secretion: an in vitro approach","volume":"390","author":"Pazos","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.peptides.2013.01.004_bib0175","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.bbrc.2008.02.146","article-title":"Inhibitory effect of obestatin on glucose-induced insulin secretion in rats","volume":"369","author":"Ren","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.peptides.2013.01.004_bib0180","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2013.01.004_bib0185","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1038\/sj.emboj.7601784","article-title":"Foxo1 links insulin signaling to C\/EBPalpha and regulates gluconeogenesis during liver development","volume":"26","author":"Sekine","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.peptides.2013.01.004_bib0190","doi-asserted-by":"crossref","first-page":"RC13","DOI":"10.1007\/BF03344174","article-title":"Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats","volume":"29","author":"Seoane","year":"2006","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.peptides.2013.01.004_bib0195","doi-asserted-by":"crossref","first-page":"RC31","DOI":"10.1007\/BF03349204","article-title":"Intracerebroventricular acute and chronic administration of obestatin minimally affect food intake but not weight gain in the rat","volume":"29","author":"Sibilia","year":"2006","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.peptides.2013.01.004_bib0200","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1093\/clinchem\/41.10.1421","article-title":"National Cholesterol Education Program recommendations for triglyceride measurement: executive summary. The National Cholesterol Education Program Working Group on Lipoprotein Measurement","volume":"41","author":"Stein","year":"1995","journal-title":"Clin Chem"},{"key":"10.1016\/j.peptides.2013.01.004_bib0205","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Tschop","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2013.01.004_bib0210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.regpep.2009.04.014","article-title":"Central administration of obestatin fails to show inhibitory effects on food and water intake in mice","volume":"156","author":"Van Dijck","year":"2009","journal-title":"Regul Pept"},{"key":"10.1016\/j.peptides.2013.01.004_bib0215","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.peptides.2008.05.018","article-title":"In vitro metabolic stability of obestatin: kinetics and identification of cleavage products","volume":"29","author":"Vergote","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2013.01.004_bib0220","doi-asserted-by":"crossref","first-page":"26169","DOI":"10.1074\/jbc.M803544200","article-title":"HDAC1 cooperates with C\/EBPalpha in the inhibition of liver proliferation in old mice","volume":"283","author":"Wang","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2013.01.004_bib0225","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1387\/ijdb.062146aw","article-title":"C\/EBPbeta are markers of early liver development","volume":"50","author":"Westmacott","year":"2006","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.peptides.2013.01.004_bib0230","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.2337\/diabetes.50.11.2540","article-title":"Ghrelin causes hyperphagia and obesity in rats","volume":"50","author":"Wren","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2013.01.004_bib0235","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1210\/me.2007-0569","article-title":"Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39","volume":"22","author":"Zhang","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.peptides.2013.01.004_bib0240","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.1117255","article-title":"Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake","volume":"310","author":"Zhang","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.peptides.2013.01.004_bib0245","first-page":"486","article-title":"A new method for the direct determination of serum cholesterol","volume":"41","author":"Zlatkis","year":"1953","journal-title":"J Lab Clin Med"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978113000053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978113000053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T16:40:31Z","timestamp":1745944831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978113000053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":49,"alternative-id":["S0196978113000053"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2013.01.004","relation":{},"ISSN":["0196-9781"],"issn-type":[{"type":"print","value":"0196-9781"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}