{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:14:03Z","timestamp":1759565643611},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"crossref","award":["349\/07","101\/11"],"award-info":[{"award-number":["349\/07","101\/11"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.peptides.2013.01.006","type":"journal-article","created":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T07:46:15Z","timestamp":1358667975000},"page":"133-140","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Bradykinin decreases nitric oxide release from microglia via inhibition of cyclic adenosine monophosphate signaling"],"prefix":"10.1016","volume":"40","author":[{"given":"Sarit","family":"Ben-Shmuel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Danon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigal","family":"Fleisher-Berkovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2013.01.006_bib0005","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-2567.2009.03225.x","article-title":"Inflammation in neurodegenerative diseases","volume":"129","author":"Amor","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.peptides.2013.01.006_bib0010","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pneurobio.2005.06.004","article-title":"Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism","volume":"76","author":"Block","year":"2005","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.peptides.2013.01.006_bib0015","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jcp.21933","article-title":"Bradykinin protects against brain microvascular endothelial cell death induced by pathophysiological stimuli","volume":"222","author":"Bovenzi","year":"2010","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.peptides.2013.01.006_bib0020","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1042\/BST0351119","article-title":"Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase","volume":"35","author":"Brown","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.peptides.2013.01.006_bib0025","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.cellsig.2005.10.005","article-title":"Lipoteichoic acid-induced nitric oxide synthase expression in RAW 264.7 macrophages is mediated by cyclooxygenase-2, prostaglandin E2, protein kinase A, p38 MAPK, and nuclear factor-kappaB pathways","volume":"18","author":"Chang","year":"2006","journal-title":"Cell Signal"},{"key":"10.1016\/j.peptides.2013.01.006_bib0030","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/jcp.22849","article-title":"Bradykinin-mediated cell proliferation depends on transactivation of EGF receptor in corneal fibroblasts","volume":"227","author":"Cheng","year":"2012","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.peptides.2013.01.006_bib0035","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cellsig.2003.10.003","article-title":"PKA-dependent activation of PKC, p38 MAPK and IKK in macrophage: implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP","volume":"16","author":"Chio","year":"2004","journal-title":"Cell Signal"},{"key":"10.1016\/j.peptides.2013.01.006_bib0040","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/1098-1136(20010315)33:4<324::AID-GLIA1031>3.0.CO;2-M","article-title":"Repression of proinflammatory cytokine and inducible nitric oxide synthase (NOS2) gene expression in activated microglia by N-acetyl-O-methyldopamine: protein kinase A-dependent mechanism","volume":"33","author":"Cho","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.peptides.2013.01.006_bib0045","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.intimp.2007.08.003","article-title":"Participation of kallikrein-kinin system in different pathologies","volume":"8","author":"Costa-Neto","year":"2008","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.peptides.2013.01.006_bib0050","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pbb.2010.12.005","article-title":"The role of NOS in the impairment of spatial memory and damaged neurons in rats injected with amyloid beta 25\u201335 into the temporal cortex","volume":"98","author":"Diaz","year":"2011","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.peptides.2013.01.006_bib0055","first-page":"L553","article-title":"IL-1beta, BK, and TGF-beta1 attenuate PGI2-mediated cAMP formation in human pulmonary artery smooth muscle cells by multiple mechanisms involving p38 MAP kinase and PKA","volume":"294","author":"El-Haroun","year":"2008","journal-title":"Am J Physiol"},{"key":"10.1016\/j.peptides.2013.01.006_bib0060","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.neurobiolaging.2011.01.007","article-title":"Intracellular Abeta-oligomers and early inflammation in a model of Alzheimer's disease","volume":"33","author":"Ferretti","year":"2011","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.peptides.2013.01.006_bib0065","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.peptides.2009.12.006","article-title":"Protein synthesis dependent effects of kinins on astrocyte prostaglandin synthesis","volume":"31","author":"Filipovich-Rimon","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2013.01.006_bib0070","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1742-2094-7-61","article-title":"Distinct modulation of microglial amyloid beta phagocytosis and migration by neuropeptides","volume":"7","author":"Fleisher-Berkovich","year":"2010","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.peptides.2013.01.006_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.02.032","article-title":"Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide","volume":"1084","author":"Gibbons","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.peptides.2013.01.006_bib0080","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0924-977X(95)00038-Q","article-title":"Neuropeptides and Alzheimer's disease","volume":"5","author":"Gottfries","year":"1995","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.peptides.2013.01.006_bib0085","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/sj.jcbfm.9600096","article-title":"Release of bradykinin and expression of kinin B2 receptors in the brain: role for cell death and brain edema formation after focal cerebral ischemia in mice","volume":"25","author":"Groger","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.peptides.2013.01.006_bib0090","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pneurobio.2005.06.001","article-title":"The physiology and pathophysiology of nitric oxide in the brain","volume":"76","author":"Guix","year":"2005","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.peptides.2013.01.006_bib0095","first-page":"469","article-title":"Nitric oxide and superoxide in inflammation and immune regulation","volume":"54","author":"Guzik","year":"2003","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.peptides.2013.01.006_bib0100","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1097\/00001813-199707000-00010","article-title":"Cytotoxic effect of dibutyryl cAMP, phorbol-12-myristate-13-acetate and lipopolysaccharide, but not interferon-gamma, on promonocytic cell lines in vitro","volume":"8","author":"Hetland","year":"1997","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.peptides.2013.01.006_bib0105","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.taap.2012.02.011","article-title":"YC-1 potentiates cAMP-induced CREB activation and nitric oxide production in alveolar macrophages","volume":"260","author":"Hwang","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.peptides.2013.01.006_bib0110","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1016\/j.peptides.2006.08.012","article-title":"Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease","volume":"27","author":"Iores-Marcal","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2013.01.006_bib0115","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1111\/j.1471-4159.2010.07075.x","article-title":"Anti-inflammatory mechanism of ginsenoside Rh1 in lipopolysaccharide-stimulated microglia: critical role of the protein kinase A pathway and hemeoxygenase-1 expression","volume":"115","author":"Jung","year":"2010","journal-title":"J Neurochem"},{"key":"10.1016\/j.peptides.2013.01.006_bib0120","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0197-0186(01)00050-X","article-title":"Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses","volume":"39","author":"LaDu","year":"2001","journal-title":"Neurochem Int"},{"key":"10.1016\/j.peptides.2013.01.006_bib0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/pr.57.1.2","article-title":"International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences","volume":"57","author":"Leeb-Lundberg","year":"2005","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.peptides.2013.01.006_bib0130","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejphar.2006.06.074","article-title":"Kinins and neuroinflammation: dual effect on prostaglandin synthesis","volume":"546","author":"Levant","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.peptides.2013.01.006_bib0135","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1172\/JCI116818","article-title":"The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium-derived relaxing factor","volume":"92","author":"Liao","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.peptides.2013.01.006_bib0140","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.peptides.2011.06.010","article-title":"Role of vascular kinin B1 and B2 receptors in endothelial nitric oxide metabolism","volume":"32","author":"Loiola","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2013.01.006_bib0145","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1074\/jbc.M110.135244","article-title":"Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity","volume":"286","author":"Maezawa","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2013.01.006_bib0150","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1254\/jphs.SRJ05001X","article-title":"The kallikrein-kinin system: current and future pharmacological targets","volume":"99","author":"Moreau","year":"2005","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.peptides.2013.01.006_bib0155","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/cdd.2011.65","article-title":"Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases","volume":"18","author":"Nakamura","year":"2011","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.peptides.2013.01.006_bib0160","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1471-4159.2006.04339.x","article-title":"Neuroprotective role of bradykinin because of the attenuation of pro-inflammatory cytokine release from activated microglia","volume":"101","author":"Noda","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.peptides.2013.01.006_bib0165","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuint.2006.04.010","article-title":"Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms","volume":"49","author":"Pannu","year":"2006","journal-title":"Neurochem Int"},{"key":"10.1016\/j.peptides.2013.01.006_bib0170","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00001756-199901180-00007","article-title":"cAMP potentiates beta-amyloid-induced nitric oxide release from microglia","volume":"10","author":"Pyo","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.peptides.2013.01.006_bib0175","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0163-7258(98)00011-4","article-title":"Pathophysiology of the kallikrein-kinin system in mammalian nervous tissue","volume":"79","author":"Raidoo","year":"1998","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.peptides.2013.01.006_bib0180","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.peptides.2012.03.026","article-title":"Inhibitory role of kinins on microglial nitric oxide and tumor necrosis factor-alpha production","volume":"35","author":"Sarit","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2013.01.006_bib0185","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nm.1980","article-title":"Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system","volume":"15","author":"Schulze-Topphoff","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.peptides.2013.01.006_bib0190","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1165\/rcmb.2008-0091TR","article-title":"Cyclic AMP: master regulator of innate immune cell function","volume":"39","author":"Serezani","year":"2000","journal-title":"Am J Resp Cell Mol Biol"},{"key":"10.1016\/j.peptides.2013.01.006_bib0195","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0006-8993(98)00954-8","article-title":"Differential regulation of microglial activation by propentofylline via cAMP signaling","volume":"812","author":"Si","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.peptides.2013.01.006_bib0200","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1021\/ar800201v","article-title":"Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases","volume":"42","author":"Silverman","year":"2009","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.peptides.2013.01.006_bib0205","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.npep.2009.12.004","article-title":"Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors","volume":"44","author":"Kuhr","year":"2010","journal-title":"Neuropeptides"},{"key":"10.1016\/j.peptides.2013.01.006_bib0210","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.neulet.2008.01.072","article-title":"Lipopolysaccharide activates the kallikrein-kinin system in mouse choroid plexus cell line ECPC4","volume":"434","author":"Takano","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.peptides.2013.01.006_bib0215","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.neurobiolaging.2007.04.019","article-title":"Increases of kinin B1 and B2 receptors binding sites after brain infusion of amyloid-beta 1-40 peptide in rats","volume":"29","author":"Viel","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.peptides.2013.01.006_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-0186(94)00114-A","article-title":"Kinins and kinin receptors in the nervous system","volume":"26","author":"Walker","year":"1995","journal-title":"Neuroch Int"},{"key":"10.1016\/j.peptides.2013.01.006_bib0225","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.4049\/jimmunol.1001829","article-title":"The role of the transcription factor CREB in immune function","volume":"185","author":"Wen","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.peptides.2013.01.006_bib0230","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neulet.2003.11.056","article-title":"Differential regulation of inducible nitric oxide synthase and cytokine gene expression by forskolin and dibutyryl-cAMP in lipopolysaccharide-stimulated murine BV2 microglial cells","volume":"356","author":"Woo","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.peptides.2013.01.006_bib0235","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/mcbr.1999.0136","article-title":"Effect of the G-protein, G alpha(i2), and G alpha(i3) subunit knockdown on bradykinin-induced signal transduction in rat-1 cells","volume":"1","author":"Yang","year":"1999","journal-title":"Mol Cell Biol Res Commun"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978113000077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978113000077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T07:26:09Z","timestamp":1539933969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978113000077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":47,"alternative-id":["S0196978113000077"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2013.01.006","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}