{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:56:08Z","timestamp":1761155768938},"reference-count":30,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.peptides.2014.01.019","type":"journal-article","created":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T16:15:43Z","timestamp":1391271343000},"page":"47-51","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Opiorphin increases blood pressure of conscious rats through renin-angiotensin system (RAS)"],"prefix":"10.1016","volume":"55","author":[{"given":"Yuan","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huabin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangyu","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2014.01.019_bib0005","doi-asserted-by":"crossref","first-page":"H1353","DOI":"10.1152\/ajpheart.00383.2011","article-title":"Reversal of diabetic vasculopathy in a rat model of type 1 diabetes by opiorphin-related peptides","volume":"301","author":"Calenda","year":"2011","journal-title":"American Journal of Physiology \u2013 Heart and Circulatory Physiology"},{"key":"10.1016\/j.peptides.2014.01.019_bib0010","series-title":"Role of renal aminopeptidases and angiotensin type-2 (at(2)) receptors in sodium excretion and hypertension, Local Cardiac Renin-Angiotensin Aldosterone System","author":"Carey","year":"2009"},{"key":"10.1016\/j.peptides.2014.01.019_bib0015","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/TA.0b013e3181637a6c","article-title":"Regional and local brain oxygenation during hemorrhagic shock: a prospective experimental study on the effects of small-volume resuscitation with norepinephrine","volume":"64","author":"Cavus","year":"2008","journal-title":"Journal of Trauma \u2013 Injury Infection and Critical Care"},{"key":"10.1016\/j.peptides.2014.01.019_bib0020","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1476-5381.1993.tb13877.x","article-title":"Pharmacological profile of valsartan \u2013 a potent, orally-active, nonpeptide antagonist of the angiotensin II at1-receptor subtype","volume":"110","author":"Criscione","year":"1993","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.peptides.2014.01.019_bib0025","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10741-007-9061-y","article-title":"Aminopeptidase N in arterial hypertension","volume":"13","author":"Danziger","year":"2008","journal-title":"Heart Failure Reviews"},{"key":"10.1016\/j.peptides.2014.01.019_bib0030","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1743-6109.2008.01186.x","article-title":"The role of opiorphins (endogenous neutral endopeptidase inhibitors) in urogenital smooth muscle biology","volume":"6","author":"Davies","year":"2009","journal-title":"Journal of Sexual Medicine"},{"key":"10.1016\/j.peptides.2014.01.019_bib0035","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1046\/j.1440-1681.2000.03262.x","article-title":"Brain versus peripheral angiotensin II receptors in hypovolaemia: behavioural and cardiovascular implications","volume":"27","author":"De Luca","year":"2000","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"10.1016\/j.peptides.2014.01.019_bib0040","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.emc.2008.04.001","article-title":"The use of vasopressors and inotropes in the emergency medical treatment of shock","volume":"26","author":"Ellender","year":"2008","journal-title":"Emergency Medicine Clinics of North America"},{"key":"10.1016\/j.peptides.2014.01.019_bib0045","first-page":"24","article-title":"Intermittent activation of peripheral renin-angiotensin system (RAS) elicits sympathetic long term facilitation (LTF)","volume":"26","author":"Fong","year":"2010","journal-title":"FASEB Journal"},{"key":"10.1016\/j.peptides.2014.01.019_bib0050","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1440-1681.1996.tb02594.x","article-title":"Integrative role of the lamina terminals in the regulation of cardiovascular and body fluid homeostasis","volume":"23","author":"Johnson","year":"1996","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"10.1016\/j.peptides.2014.01.019_bib0055","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1440-1681.1998.tb02238.x","article-title":"Central regulation of autonomic function: no brakes","volume":"25","author":"Krukoff","year":"1998","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"10.1016\/j.peptides.2014.01.019_bib0060","doi-asserted-by":"crossref","first-page":"127A","DOI":"10.1016\/S0895-7061(99)80447-6","article-title":"Superior tolerability of valsartan compared to captopril in Asiatic patients","volume":"12","author":"Lee","year":"1999","journal-title":"American Journal of Hypertension"},{"key":"10.1016\/j.peptides.2014.01.019_bib0065","first-page":"39","article-title":"A comparison of valsartan and captopril in Taiwanese patients with essential hypertension","volume":"16","author":"Lee","year":"1999","journal-title":"Advances in Therapy"},{"key":"10.1016\/j.peptides.2014.01.019_bib0070","first-page":"607","article-title":"Identification of metabolic pathways of brain angiotensin II and angiotensin III: predominant role of angiotensin III in the control of vasopressin secretion","volume":"192","author":"Llorens-Cortes","year":"1998","journal-title":"Comptes rendus des seances de la Societe de biologie et de ses filiales"},{"key":"10.1016\/j.peptides.2014.01.019_bib0075","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.peptides.2013.01.018","article-title":"Angiotensin III stimulates high stretch-induced ANP secretion via angiotensin type 2 receptor","volume":"42","author":"Park","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2014.01.019_bib0080","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bbr.2010.04.045","article-title":"Human opiorphin: the lack of physiological dependence, tolerance to antinociceptive effects and abuse liability in laboratory mice","volume":"213","author":"Popik","year":"2010","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.peptides.2014.01.019_bib0085","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1113\/expphysiol.2010.054080","article-title":"Excitatory amino acid receptors in the dorsomedial hypothalamus are involved in the cardiovascular and behavioural chemoreflex responses","volume":"96","author":"Queiroz","year":"2011","journal-title":"Experimental Physiology"},{"key":"10.1016\/j.peptides.2014.01.019_bib0090","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1113\/jphysiol.2009.176693","article-title":"Influence of endogenous angiotensin II on control of sympathetic nerve activity in human dehydration","volume":"587","author":"Rabbitts","year":"2009","journal-title":"Journal of Physiology"},{"key":"10.1016\/j.peptides.2014.01.019_bib0095","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1152\/jappl.1984.56.5.1426","article-title":"Measurement of hormones and blood-gases during hypoxia in conscious cannulated rats","volume":"56","author":"Raff","year":"1984","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.peptides.2014.01.019_bib0100","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000054439","article-title":"PC18, a specific aminopeptidase N inhibitor, induces vasopressin release by increasing the half-life of brain angiotensin III","volume":"69","author":"Reaux","year":"1999","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.peptides.2014.01.019_bib0105","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1432-1033.1994.tb18556.x","article-title":"Selective processing of submandibular rat 1 protein at dibasic cleavage sites \u2013 salivary and blood-stream secretion products","volume":"219","author":"Rougeot","year":"1994","journal-title":"European Journal of Biochemistry"},{"key":"10.1016\/j.peptides.2014.01.019_bib0110","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0033-0620(78)90024-5","article-title":"Captopril (sq 14,225) (d-3-mercapto-2-methylpropanoyl-l-proline) \u2013 novel orally active inhibitor of angiotensin-converting enzyme and antihypertensive agent","volume":"21","author":"Rubin","year":"1978","journal-title":"Progress in Cardiovascular Diseases"},{"key":"10.1016\/j.peptides.2014.01.019_bib0115","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.resuscitation.2004.01.005","article-title":"Influence of selective nitric oxide synthetase inhibitor for treatment of refractory haemorrhagic shock","volume":"61","author":"Shirhan","year":"2004","journal-title":"Resuscitation"},{"key":"10.1016\/j.peptides.2014.01.019_bib0120","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1095\/biolreprod37.3.595","article-title":"Development of a sensitive enzyme-linked-immunosorbent-assay for cattle, sheep, rat, and mouse luteinizing-hormone","volume":"37","author":"Spearow","year":"1987","journal-title":"Biology of Reproduction"},{"key":"10.1016\/j.peptides.2014.01.019_bib0125","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1464-410X.2006.06247.x","article-title":"Variable coding sequence protein A1 as a marker for erectile dysfunction","volume":"98","author":"Tong","year":"2006","journal-title":"BJU International"},{"key":"10.1016\/j.peptides.2014.01.019_bib0130","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1464-410X.2008.07631.x","article-title":"The opiorphin gene (ProL1) and its homologues function in erectile physiology","volume":"102","author":"Tong","year":"2008","journal-title":"BJU International"},{"key":"10.1016\/j.peptides.2014.01.019_bib0135","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/hep.1840150616","article-title":"Effects of vasopressor agents and epoprostenol on systemic hemodynamics and oxygen-transport in fulminant hepatic-failure","volume":"15","author":"Wendon","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.peptides.2014.01.019_bib0140","doi-asserted-by":"crossref","first-page":"17979","DOI":"10.1073\/pnas.0605865103","article-title":"Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways","volume":"103","author":"Wisner","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.peptides.2014.01.019_bib0145","doi-asserted-by":"crossref","first-page":"R1194","DOI":"10.1152\/ajpregu.00849.2010","article-title":"Neuronostatin acts in brain to biphasically increase mean arterial pressure through sympatho-activation followed by vasopressin secretion: the role of melanocortin receptors","volume":"300","author":"Yosten","year":"2011","journal-title":"American Journal of Physiology \u2013 Regulatory Integrative and Comparative Physiology"},{"key":"10.1016\/j.peptides.2014.01.019_bib0150","doi-asserted-by":"crossref","first-page":"11968","DOI":"10.1073\/pnas.93.21.11968","article-title":"Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: Predominant role of angiotensin III in the control of vasopressin release","volume":"93","author":"Zini","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978114000229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978114000229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T02:51:43Z","timestamp":1565146303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978114000229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":30,"alternative-id":["S0196978114000229"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2014.01.019","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Opiorphin increases blood pressure of conscious rats through renin-angiotensin system (RAS)","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2014.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}