{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:55:17Z","timestamp":1789732517801,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.peptides.2014.11.001","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T11:01:52Z","timestamp":1415444512000},"page":"43-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["The protective effect of apelin on ischemia\/reperfusion injury"],"prefix":"10.1016","volume":"63","author":[{"given":"Yanjie","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-Yu","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-Kun","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2014.11.001_bib0005","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10989-013-9374-8","article-title":"Apelin-13 inhibits apoptosis of cortical neurons following brain ischemic reperfusion injury in a transient model of focal cerebral ischemia","volume":"20","author":"Aboutaleb","year":"2014","journal-title":"Int J Pept Res Ther"},{"key":"10.1016\/j.peptides.2014.11.001_bib0010","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.peptides.2013.05.006","article-title":"Post-infarct treatment with [Pyr1]-apelin-13 reduces myocardial damage through reduction of oxidative injury and nitric oxide enhancement in the rat model of myocardial infarction","volume":"46","author":"Azizi","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2014.11.001_bib0015","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1136\/hrt.2009.191122","article-title":"Translational promise of the apelin\u2013APJ system","volume":"96","author":"Barnes","year":"2010","journal-title":"Heart"},{"key":"10.1016\/j.peptides.2014.11.001_bib0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1750-3639.2000.tb00247.x","article-title":"Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia","volume":"10","author":"del Zoppo","year":"2000","journal-title":"Brain Pathol"},{"key":"10.1016\/j.peptides.2014.11.001_bib0025","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/ki.2008.199","article-title":"Effect of apelin on glomerular hemodynamic function in the rat kidney","volume":"74","author":"Hus-Citharel","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.peptides.2014.11.001_bib0030","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0167-4889(00)00143-9","article-title":"Molecular properties of apelin: tissue distribution and receptor binding","volume":"1538","author":"Kawamata","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.peptides.2014.11.001_bib0035","first-page":"4","article-title":"Acute renal failure in the new millennium: time to consider combination therapy","volume":"20","author":"Kelly","year":"2000","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.peptides.2014.11.001_bib0040","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12031-012-9808-3","article-title":"Apelin-13 protects the brain against ischemic reperfusion injury and cerebral edema in a transient model of focal cerebral ischemia","volume":"48","author":"Khaksari","year":"2012","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.peptides.2014.11.001_bib0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.regpep.2007.10.002","article-title":"Apelin reduces myocardial reperfusion injury independently of PI3K\/Akt and P70S6 kinase","volume":"146","author":"Kleinz","year":"2008","journal-title":"Regul Pept"},{"key":"10.1016\/j.peptides.2014.11.001_bib0050","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.regpep.2003.11.002","article-title":"Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells","volume":"118","author":"Kleinz","year":"2004","journal-title":"Regul Pept"},{"key":"10.1016\/j.peptides.2014.11.001_bib0055","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.regpep.2004.10.019","article-title":"Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells","volume":"126","author":"Kleinz","year":"2005","journal-title":"Regul Pept"},{"key":"10.1016\/j.peptides.2014.11.001_bib0060","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0167-4781(00)00183-4","article-title":"Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus","volume":"1493","author":"Lee","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.peptides.2014.11.001_bib0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.peptides.2013.03.024","article-title":"Regulation of feeding behavior, gastrointestinal function and fluid homeostasis by apelin","volume":"44","author":"Lv","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2014.11.001_bib0070","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000092122","article-title":"Apelin and cardiac function in hemodialyzed patients: possible relations","volume":"26","author":"Ma\u0142yszko","year":"2006","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.peptides.2014.11.001_bib0075","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2478\/v10039-008-0024-x","article-title":"Visfatin and apelin, new adipocytokines, and their relation to endothelial function in patients with chronic renal failure","volume":"53","author":"Malyszko","year":"2008","journal-title":"Adv Med Sci"},{"key":"10.1016\/j.peptides.2014.11.001_bib0080","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.yjmcc.2009.10.026","article-title":"ER stress in cardiovascular disease","volume":"48","author":"Minamino","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.peptides.2014.11.001_bib0085","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/351233a0","article-title":"Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor","volume":"351","author":"Murphy","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2014.11.001_bib0090","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0378-1119(93)90495-O","article-title":"A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11","volume":"136","author":"O\u2018Dowd","year":"1993","journal-title":"Gene"},{"key":"10.1016\/j.peptides.2014.11.001_bib0095","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0167-4781(00)00072-5","article-title":"Distribution of mRNA encoding B78\/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues","volume":"1492","author":"O\u2019Carroll","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.peptides.2014.11.001_bib0100","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1111\/j.1471-4159.2007.04645.x","article-title":"Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury","volume":"102","author":"O\u2019Donnell","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.peptides.2014.11.001_bib0105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11010-014-2008-4","article-title":"Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion","volume":"391","author":"Pisarenko","year":"2014","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.peptides.2014.11.001_bib0110","first-page":"52","article-title":"Involvement of NO-dependent mechanisms of apelin action in myocardial protection against ischemia\/reperfusion damage","volume":"52","author":"Pisarenko","year":"2011","journal-title":"Kardiologiia"},{"key":"10.1016\/j.peptides.2014.11.001_bib0115","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10517-011-1459-9","article-title":"In vivo reduction of reperfusion injury to the heart with apelin-12 peptide in rats","volume":"152","author":"Pisarenko","year":"2011","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.peptides.2014.11.001_bib0120","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4103\/0976-500X.114600","article-title":"Effects of structural analogues of apelin-12 in acute myocardial infarction in rats","volume":"4","author":"Pisarenko","year":"2013","journal-title":"J Pharmacol Pharmacother"},{"key":"10.1016\/j.peptides.2014.11.001_bib0125","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1124\/pr.110.002949","article-title":"International union of basic and clinical pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function","volume":"62","author":"Pitkin","year":"2010","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.peptides.2014.11.001_bib0130","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/hep.22467","article-title":"The hepatic apelin system: a new therapeutic target for liver disease","volume":"48","author":"Principe","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.peptides.2014.11.001_bib0135","doi-asserted-by":"crossref","first-page":"H2308","DOI":"10.1152\/ajpheart.01177.2010","article-title":"Apelin-13 limits infarct size and improves cardiac postischemic mechanical recovery only if given after ischemia","volume":"300","author":"Rastaldo","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.peptides.2014.11.001_bib0140","first-page":"469","article-title":"Molecular mechanisms in liver ischemic\u2013reperfusion injury and ischemic preconditioning","volume":"133","author":"Romanque","year":"2005","journal-title":"Rev Med Chile"},{"issue":"2","key":"10.1016\/j.peptides.2014.11.001_bib0145","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12262-012-0676-4","article-title":"Effect of leptin and apelin preconditioning on hepatic ischemia reperfusion injury in rats","volume":"76","author":"Sagiroglu","year":"2014","journal-title":"Indian J Surg"},{"key":"10.1016\/j.peptides.2014.11.001_bib0150","doi-asserted-by":"crossref","first-page":"908","DOI":"10.3892\/etm.2012.499","article-title":"Effects of apelin and leptin on renal functions following renal ischemia\/reperfusion: an experimental study","volume":"3","author":"Sagiroglu","year":"2012","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.peptides.2014.11.001_bib0155","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.yjmcc.2012.05.012","article-title":"Ischemia-reperfusion induces myocardial infarction through mitochondrial Ca2+ overload","volume":"53","author":"Shintani-Ishida","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.peptides.2014.11.001_bib0160","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s00395-007-0671-2","article-title":"Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemiareperfusion injury","volume":"102","author":"Simpkin","year":"2007","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.peptides.2014.11.001_bib0165","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10557-007-6054-y","article-title":"Temporal changes in myocardial salvage kinases during reperfusion following ischemia: studies involving the cardioprotective adipocytokine apelin","volume":"21","author":"Smith","year":"2007","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.peptides.2014.11.001_bib0170","doi-asserted-by":"crossref","first-page":"H1471","DOI":"10.1152\/ajpheart.00097.2011","article-title":"Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion","volume":"301","author":"Tao","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.peptides.2014.11.001_bib0175","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/bbrc.1998.9489","article-title":"Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor","volume":"251","author":"Tatemoto","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.peptides.2014.11.001_bib0180","doi-asserted-by":"crossref","first-page":"e000249","DOI":"10.1161\/JAHA.113.000249","article-title":"Loss of apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic apelin analogues","volume":"2","author":"Wang","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.peptides.2014.11.001_bib0185","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neulet.2014.03.037","article-title":"Apelin-13 protects the brain against ischemia\/reperfusion injury through activating PI3K\/Akt and ERK1\/2 signaling pathways","volume":"568","author":"Yang","year":"2014","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.peptides.2014.11.001_bib0190","first-page":"82","article-title":"Effect and mechanisms of apelin-13 on ischemia\/reperfusion injury in rat heart","volume":"23","author":"Zeng","year":"2007","journal-title":"Chin Pharmacol Bull"},{"key":"10.1016\/j.peptides.2014.11.001_bib0195","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.yexcr.2010.02.005","article-title":"Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons","volume":"316","author":"Zeng","year":"2010","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.peptides.2014.11.001_bib0200","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.peptides.2009.02.010","article-title":"Apelin protects heart against ischemia\/reperfusion injury in rat","volume":"30","author":"Zeng","year":"2009","journal-title":"Peptides"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978114003271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978114003271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T01:13:36Z","timestamp":1566004416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978114003271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":40,"alternative-id":["S0196978114003271"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2014.11.001","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The protective effect of apelin on ischemia\/reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2014.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}