{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:52:44Z","timestamp":1781110364048,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 208803"],"award-info":[{"award-number":["MOP 208803"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.peptides.2015.01.005","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T13:08:51Z","timestamp":1422623331000},"page":"29-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Acylated ghrelin is not required for the surge in pituitary growth hormone observed in pregnant mice"],"prefix":"10.1016","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0348-1888","authenticated-orcid":false,"given":"Arjun","family":"Trivedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Babic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Heiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-402X","authenticated-orcid":false,"given":"William T.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Chanoine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.peptides.2015.01.005_bib0165","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1258\/ebm.2011.011306","article-title":"Nanobiology and physiology of growth hormone secretion","volume":"237","author":"Anderson","year":"2012","journal-title":"Exp Biol Med"},{"issue":"11","key":"10.1016\/j.peptides.2015.01.005_bib0170","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1210\/endo.141.11.7757","article-title":"Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans","volume":"141","author":"Date","year":"2000","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.peptides.2015.01.005_bib0175","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2008.01.017","article-title":"Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone","volume":"132","author":"Yang","year":"2008","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.peptides.2015.01.005_bib0180","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1365-2826.2004.01237.x","article-title":"Ghrelin-induced growth hormone release from isolated rat anterior pituitary cells depends on intracellular and extracellular Ca2+ sources","volume":"16","author":"Yamazaki","year":"2004","journal-title":"J Neuroendocrinol"},{"issue":"6762","key":"10.1016\/j.peptides.2015.01.005_bib0185","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.peptides.2015.01.005_bib0190","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1007\/BF03349259","article-title":"The continuous infusion of acylated ghrelin enhances growth hormone secretion and worsens glucose metabolism in humans","volume":"31","author":"Broglio","year":"2008","journal-title":"J Endocrinol Invest"},{"issue":"1\u20133","key":"10.1016\/j.peptides.2015.01.005_bib0195","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.regpep.2010.10.008","article-title":"The vagus nerve as a regulator of growth hormone secretion","volume":"166","author":"Al-Massadi","year":"2011","journal-title":"Regul Pept"},{"issue":"5","key":"10.1016\/j.peptides.2015.01.005_bib0200","doi-asserted-by":"crossref","first-page":"E1093","DOI":"10.1152\/ajpendo.90866.2008","article-title":"Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: relationship with cholinesterase","volume":"296","author":"Tham","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.peptides.2015.01.005_bib0205","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1365-2265.2005.02257.x","article-title":"Ghrelin and its relationship to growth hormones during normal pregnancy","volume":"62","author":"Fuglsang","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"Suppl. A","key":"10.1016\/j.peptides.2015.01.005_bib0210","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1053\/plac.2002.0811","article-title":"Human placental growth hormone \u2013 a review","volume":"23","author":"Lacroix","year":"2002","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.peptides.2015.01.005_bib0215","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/humupd\/dmg043","article-title":"A comparison of placental development and endocrine functions between the human and mouse model","volume":"9","author":"Malassine","year":"2003","journal-title":"Hum Reprod Update"},{"issue":"2","key":"10.1016\/j.peptides.2015.01.005_bib0220","first-page":"876","article-title":"Expression of the growth hormone receptor and growth hormone-binding protein during pregnancy in the mouse","volume":"131","author":"Cramer","year":"1992","journal-title":"Endocrinology"},{"issue":"17","key":"10.1016\/j.peptides.2015.01.005_bib0225","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1073\/pnas.0800708105","article-title":"Ghrelin octanoylation mediated by an orphan lipid transferase","volume":"105","author":"Gutierrez","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"10.1016\/j.peptides.2015.01.005_bib0230","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.clinbiochem.2011.10.023","article-title":"Pitfalls in the determination of human acylated ghrelin plasma concentrations using a double antibody enzyme immunometric assay","volume":"45","author":"Trivedi","year":"2012","journal-title":"Clin Biochem"},{"issue":"3","key":"10.1016\/j.peptides.2015.01.005_bib0235","first-page":"1169","article-title":"Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone","volume":"86","author":"Arvat","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"22","key":"10.1016\/j.peptides.2015.01.005_bib0240","doi-asserted-by":"crossref","first-page":"7973","DOI":"10.1128\/MCB.23.22.7973-7981.2003","article-title":"Deletion of ghrelin impairs neither growth nor appetite","volume":"23","author":"Sun","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"21","key":"10.1016\/j.peptides.2015.01.005_bib0245","doi-asserted-by":"crossref","first-page":"8227","DOI":"10.1073\/pnas.0402763101","article-title":"Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference","volume":"101","author":"Wortley","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"10.1016\/j.peptides.2015.01.005_bib0250","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1073\/pnas.0305930101","article-title":"Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor","volume":"101","author":"Sun","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.peptides.2015.01.005_bib0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-1809.2008.00484.x","article-title":"A genetic study of the ghrelin and growth hormone secretagogue receptor (GHSR) genes and stature","volume":"73","author":"Gueorguiev","year":"2009","journal-title":"Ann Hum Genet"},{"issue":"11","key":"10.1016\/j.peptides.2015.01.005_bib0260","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1210\/jc.2009-1327","article-title":"Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor","volume":"94","author":"Pantel","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.peptides.2015.01.005_bib0265","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1172\/JCI25303","article-title":"Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature","volume":"116","author":"Pantel","year":"2006","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.peptides.2015.01.005_bib0270","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nm.1997","article-title":"GOAT links dietary lipids with the endocrine control of energy balance","volume":"15","author":"Kirchner","year":"2009","journal-title":"Nat Med"},{"issue":"16","key":"10.1016\/j.peptides.2015.01.005_bib0275","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.1073\/pnas.1002271107","article-title":"Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice","volume":"107","author":"Zhao","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.peptides.2015.01.005_bib0280","doi-asserted-by":"crossref","first-page":"e32100","DOI":"10.1371\/journal.pone.0032100","article-title":"The GOAT\u2013ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction","volume":"7","author":"Yi","year":"2012","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.peptides.2015.01.005_bib0285","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1385\/ENDO:19:1:73","article-title":"Placental growth hormones","volume":"19","author":"Lacroix","year":"2002","journal-title":"Endocrine"},{"issue":"3","key":"10.1016\/j.peptides.2015.01.005_bib0290","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2826.2008.01650.x","article-title":"The pregnancy-induced increase in baseline circulating growth hormone in rats is not induced by ghrelin","volume":"20","author":"El-Kasti","year":"2008","journal-title":"J Neuroendocrinol"},{"issue":"8","key":"10.1016\/j.peptides.2015.01.005_bib0295","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1210\/en.2003-1424","article-title":"The role of pituitary ghrelin in growth hormone (GH) secretion: GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content","volume":"145","author":"Kamegai","year":"2004","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.peptides.2015.01.005_bib0300","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1210\/jcem.86.9.8002","article-title":"A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans","volume":"86","author":"Hataya","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.peptides.2015.01.005_bib0305","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1046\/j.1365-2826.2000.00586.x","article-title":"Intracerebroventricular administration of the rat growth hormone (GH) receptor antagonist G118R stimulates GH secretion: evidence for the existence of short loop negative feedback of GH","volume":"12","author":"Nass","year":"2000","journal-title":"J Neuroendocrinol"},{"issue":"4","key":"10.1016\/j.peptides.2015.01.005_bib0310","first-page":"443","article-title":"Importance of ghrelin in hypothalamus\u2013pituitary axis on growth hormone release during normal pregnancy in the rat","volume":"61","author":"Szczepankiewicz","year":"2010","journal-title":"J Physiol Pharmacol"},{"issue":"3","key":"10.1016\/j.peptides.2015.01.005_bib0315","doi-asserted-by":"crossref","first-page":"E341","DOI":"10.1152\/ajpendo.00057.2010","article-title":"Age, sex, and lactating status regulate ghrelin secretion and GOAT mRNA levels from isolated rat stomach","volume":"299","author":"Al-Massadi","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1\u20132","key":"10.1016\/j.peptides.2015.01.005_bib0320","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.mce.2009.12.023","article-title":"Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach","volume":"317","author":"Gahete","year":"2010","journal-title":"Mol Cell Endocrinol"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978115000212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978115000212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T06:48:52Z","timestamp":1566283732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978115000212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":32,"alternative-id":["S0196978115000212"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2015.01.005","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acylated ghrelin is not required for the surge in pituitary growth hormone observed in pregnant mice","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2015.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}