{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:24:08Z","timestamp":1791321848801,"version":"4.3.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Scientific Research Tunisia"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.peptides.2015.05.015","type":"journal-article","created":{"date-parts":[[2015,6,14]],"date-time":"2015-06-14T13:01:45Z","timestamp":1434286905000},"page":"4-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Kbot55, purified from Buthus occitanus tunetanus venom, represents the first member of a novel \u03b1-KTx subfamily"],"prefix":"10.1016","volume":"80","author":[{"given":"Rym","family":"ElFessi-Magouri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-5702","authenticated-orcid":false,"given":"Steve","family":"Peigneur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oussema","family":"Khamessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najet","family":"Srairi-Abid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"ElAyeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bea Garcia","family":"Mille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Cuypers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tytgat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riadh","family":"Kharrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2015.05.015_bib0130","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3109\/15563650.2010.533679","article-title":"Nosocomial scorpion envenomation: an unusual mode of scorpion sting","volume":"48","author":"Bahloul","year":"2010","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1016\/j.peptides.2015.05.015_bib0135","doi-asserted-by":"crossref","first-page":"e00594","DOI":"10.7554\/eLife.00594","article-title":"Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel","volume":"2","author":"Banerjee","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.peptides.2015.05.015_bib0140","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3390\/toxins4111082","article-title":"Scorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering","volume":"4","author":"Bergeron","year":"2012","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.peptides.2015.05.015_bib0145","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.actatropica.2008.05.021","article-title":"Epidemiology of scorpionism: a global appraisal","volume":"107","author":"Chippaux","year":"2008","journal-title":"Acta Trop"},{"key":"10.1016\/j.peptides.2015.05.015_bib0150","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1749-6632.1999.tb11293.x","article-title":"Molecular diversity of K+ channels","volume":"868","author":"Coetzee","year":"1999","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.peptides.2015.05.015_bib0155","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1097\/00000542-199905000-00012","article-title":"ATX II, a sodium channel toxin, sensitizes skeletal muscle to halothane, caffeine, and ryanodine","volume":"90","author":"Fletcher","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.peptides.2015.05.015_bib0160","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/prot.10341","article-title":"Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels","volume":"52","author":"Gao","year":"2003","journal-title":"Proteins"},{"key":"10.1016\/j.peptides.2015.05.015_bib0165","doi-asserted-by":"crossref","first-page":"6834","DOI":"10.1021\/bi00188a012","article-title":"Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom","volume":"33","author":"Garcia","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.peptides.2015.05.015_bib0170","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1124\/pr.57.4.10","article-title":"International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels","volume":"57","author":"Gutman","year":"2005","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.peptides.2015.05.015_bib0175","doi-asserted-by":"crossref","first-page":"12195","DOI":"10.1074\/jbc.M115.637611","article-title":"Variability of potassium channel blockers in Mesobuthus eupeus scorpion venom with focus on Kv1.1: an integrated transcriptomic and proteomic study","volume":"290","author":"Kuzmenkov","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.peptides.2015.05.015_bib0180","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nature04649","article-title":"Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR","volume":"440","author":"Lange","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2015.05.015_bib0185","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0896-6273(92)90239-A","article-title":"Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs","volume":"9","author":"Liman","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.peptides.2015.05.015_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchemneu.2010.03.003","article-title":"Organisation of potassium channels on the neuronal surface","volume":"40","author":"Lujan","year":"2010","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.peptides.2015.05.015_bib0195","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1126\/science.280.5360.106","article-title":"Structural conservation in prokaryotic and eukaryotic potassium channels","volume":"280","author":"MacKinnon","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.peptides.2015.05.015_bib0200","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0896-6273(90)90335-D","article-title":"Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor","volume":"5","author":"MacKinnon","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.peptides.2015.05.015_bib0205","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.peptides.2004.02.017","article-title":"Kbot1, a three disulfide bridges toxin from Buthus occitanus tunetanus venom highly active on both SK and Kv channels","volume":"25","author":"Mahjoubi-Boubaker","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2015.05.015_bib0210","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1042\/bj20030115","article-title":"The \u2018functional\u2019 dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels","volume":"377","author":"Mouhat","year":"2004","journal-title":"Biochem J"},{"key":"10.1016\/j.peptides.2015.05.015_bib0215","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bcp.2011.03.023","article-title":"A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties","volume":"82","author":"Peigneur","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.peptides.2015.05.015_bib0220","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1432-1327.1999.00625.x","article-title":"Scorpion toxins specific for Na+-channels","volume":"264","author":"Possani","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.peptides.2015.05.015_bib0225","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.toxicon.2004.03.022","article-title":"Current views on scorpion toxins specific for K+-channels","volume":"43","author":"Rodriguez de la Vega","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.peptides.2015.05.015_bib0230","doi-asserted-by":"crossref","first-page":"5614","DOI":"10.1046\/j.1432-1327.2000.01632.x","article-title":"Purification, characterization and molecular modelling of two toxin-like proteins from the Androctonus australis Hector venom","volume":"267","author":"Srairi-Abid","year":"2000","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.peptides.2015.05.015_bib0235","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0165-6147(99)01398-X","article-title":"A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies","volume":"20","author":"Tytgat","year":"1999","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.peptides.2015.05.015_bib0240","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1745-7270.2008.00479.x","article-title":"Structure\u2013function relationship of bifunctional scorpion toxin BmBKTx1","volume":"40","author":"Wang","year":"2008","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.peptides.2015.05.015_bib0245","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1124\/pr.57.4.13","article-title":"Overview of molecular relationships in the voltage-gated ion channel superfamily","volume":"57","author":"Yu","year":"2005","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.peptides.2015.05.015_bib0250","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/molbev\/msu038","article-title":"Experimental conversion of a defensin into a neurotoxin: implications for origin of toxic function","volume":"31","author":"Zhu","year":"2014","journal-title":"Mol Biol Evol"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978115001710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978115001710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T16:21:59Z","timestamp":1537546919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978115001710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":25,"alternative-id":["S0196978115001710"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2015.05.015","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kbot55, purified from Buthus occitanus tunetanus venom, represents the first member of a novel \u03b1-KTx subfamily","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2015.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}