{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T04:09:37Z","timestamp":1748750977504,"version":"3.41.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIDDK, NIH"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.peptides.2015.10.007","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T06:28:28Z","timestamp":1446618508000},"page":"8-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Novel chiral-diazepines function as specific, selective receptor agonists with variable coupling and species variability in human, mouse and rat BRS-3 receptor cells"],"prefix":"10.1016","volume":"75","author":[{"given":"Irene","family":"Ramos-\u00c1lvarez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel A.","family":"Mantey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Nuche-Berenguer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2015.10.007_bib0005","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1124\/mol.52.1.16","article-title":"Nonpeptide mimic of bradykinin with long-acting properties at the bradykinin B2 receptor","volume":"52","author":"Aramori","year":"1997","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0010","doi-asserted-by":"crossref","first-page":"20285","DOI":"10.1016\/S0021-9258(20)80726-1","article-title":"Serines and threonines in the gastrin-releasing peptide receptor carboxyl terminus mediate internalization","volume":"268","author":"Benya","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.peptides.2015.10.007_bib0015","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0026-895X(25)09677-4","article-title":"Gastrin-releasing peptide receptor-induced internalization, down-regulation, desensitization and growth: possible role of cAMP","volume":"46","author":"Benya","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0020","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0026-895X(25)08508-6","article-title":"Expression and characterization of cloned human bombesin receptors","volume":"47","author":"Benya","year":"1995","journal-title":"Mol. Pharmacol."},{"issue":"6","key":"10.1016\/j.peptides.2015.10.007_bib0025","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0026-895X(25)09240-5","volume":"42","author":"Benya","year":"1992","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0030","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S0022-3565(24)38196-0","article-title":"SR. 146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. I. In vitro studies","volume":"289","author":"Bignon","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.peptides.2015.10.007_bib0035","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1124\/jpet.113.208637","article-title":"Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligands","volume":"347","author":"Canal","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1\/2","key":"10.1016\/j.peptides.2015.10.007_bib0040","first-page":"31","article-title":"Short chain bombesin pseudopeptides which are potent and more general bombesin receptor antagonists, Eur","volume":"190","author":"Coy","year":"1990","journal-title":"J. Pharmacol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0167-0115(88)90085-7","article-title":"Parallel bioassay of 27 bombesin-like peptides on 9 smooth muscle preparations, structure-activity relationships and bombesin receptor subtypes","volume":"21","author":"Falconieri Erspamer","year":"1988","journal-title":"Regul. Pept."},{"issue":"8","key":"10.1016\/j.peptides.2015.10.007_bib0050","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.1016\/S0021-9258(18)53415-3","article-title":"BRS-3: novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells","volume":"268","author":"Fathi","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2015.10.007_bib0055","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1210\/en.2011-1440","article-title":"Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species","volume":"152","author":"Feng","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2015.10.007_bib0060","first-page":"33","article-title":"Toward peptide receptor ligand drugs: progress on nonpeptides","volume":"40","author":"Freidinger","year":"1993","journal-title":"Prog. Drug Res."},{"issue":"9","key":"10.1016\/j.peptides.2015.10.007_bib0065","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1517\/14728222.2015.1056154","article-title":"Bombesin receptor\u2014subtype 3 as a potential target for obesity and diabetes","volume":"19","author":"Gonzales","year":"2015","journal-title":"Curr. Opin. Ther. Targets"},{"key":"10.1016\/j.peptides.2015.10.007_bib0070","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.peptides.2009.05.007","article-title":"Characterization of putative GRP- and NMB-receptor antagonist\u2019s interaction with human receptors","volume":"30","author":"Gonzalez","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2015.10.007_bib0075","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/MED.0b013e3282f3709b","article-title":"Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states","volume":"15","author":"Gonzalez","year":"2008","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.peptides.2015.10.007_bib0080","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0014-2999(99)00612-3","article-title":"Contrasting roles of leu(356) in the human CCK(1) receptor for antagonist SR. 27897 and agonist SR. 146131 binding","volume":"383","author":"Gouldson","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0085","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cmet.2009.12.008","article-title":"Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity","volume":"11","author":"Guan","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2015.10.007_bib0090","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1124\/jpet.110.174763","article-title":"Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist","volume":"336","author":"Guan","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.peptides.2015.10.007_bib0095","first-page":"G439","article-title":"[D-Phe12]bombesin analogues: a new class of bombesin receptor antagonists","volume":"252","author":"Heinz-Erian","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0100","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1002\/cbdv.201200288","article-title":"Neuropeptides and neuropeptide receptors: drug targets, and peptide and non-peptide ligands: a tribute to Prof. Dieter Seebach","volume":"9","author":"Hoyer","year":"2012","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.peptides.2015.10.007_bib0105","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0306-4522(03)00260-4","article-title":"The distribution of the orphan bombesin receptor subtype-3 in the rat CNS","volume":"120","author":"Jennings","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.peptides.2015.10.007_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.107.07108","article-title":"International union of pharmacology LVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling and functions in normal and disease states","volume":"60","author":"Jensen","year":"2008","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.peptides.2015.10.007_bib0115","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1056\/NEJMe1013903","article-title":"Promising advances in the treatment of malignant pancreatic endocrine tumors","volume":"364","author":"Jensen","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.peptides.2015.10.007_bib0120","series-title":"Handbook of Biologically Active Peptides","first-page":"1188","article-title":"Bombesin-related peptides","author":"Jensen","year":"2013"},{"key":"10.1016\/j.peptides.2015.10.007_bib0125","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1210\/en.2007-1319","article-title":"Factors contributing to obesity in bombesin receptor subtype-3-deficient mice","volume":"149","author":"Ladenheim","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2015.10.007_bib0130","doi-asserted-by":"crossref","first-page":"E681","DOI":"10.1152\/ajpendo.00615.2013","article-title":"Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3","volume":"306","author":"Lateef","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2015.10.007_bib0135","doi-asserted-by":"crossref","first-page":"8954","DOI":"10.1021\/bi0202777","article-title":"Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3)","volume":"41","author":"Liu","year":"2002","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.peptides.2015.10.007_bib0140","first-page":"823","article-title":"Species differences of bombesin analog interactions with GRP-R define the choice of animal models in the development of GRP-R-targeting drugs","volume":"46","author":"Maina","year":"2005","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.peptides.2015.10.007_bib0145","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/978-3-642-24716-3_19","article-title":"Appetite-modifying effects of bombesin receptor subtype-3 agonists","author":"Majumdar","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0150","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/MED.0b013e32834ec77d","article-title":"Biology and pharmacology of bombesin receptor subtype-3","volume":"19","author":"Majumdar","year":"2012","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.peptides.2015.10.007_bib0155","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/S0026-895X(25)13654-7","article-title":"Characterization of bombesin receptors using a novel, potent, radiolabeled antagonist that distinguishes bombesin receptor subtypes","volume":"45","author":"Mantey","year":"1993","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0160","doi-asserted-by":"crossref","first-page":"9219","DOI":"10.1074\/jbc.M008737200","article-title":"Rational design of a peptide agonist that interacts selectively with the orphan receptor, bombesin receptor subtype 3","volume":"276","author":"Mantey","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2015.10.007_bib0165","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1124\/jpet.106.107011","article-title":"Identification of bombesin receptor subtype-specific ligands: effect of N-methyl scanning, truncation, substitution, and evaluation of putative reported selective ligands","volume":"319","author":"Mantey","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"41","key":"10.1016\/j.peptides.2015.10.007_bib0170","doi-asserted-by":"crossref","first-page":"26062","DOI":"10.1074\/jbc.272.41.26062","article-title":"Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates it has a unique pharmacology compared to other mammalian bombesin receptors","volume":"272","author":"Mantey","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2015.10.007_bib0175","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bmc.2014.11.018","article-title":"Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach","volume":"23","author":"Matsufuji","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.peptides.2015.10.007_bib0180","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.bmcl.2013.12.106","article-title":"Discovery of novel chiral-diazepines as bombesin receptor subtype-3 (BRS-3) agonists with low brain penetration","volume":"24","author":"Matsufuji","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.peptides.2015.10.007_bib0185","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.peptides.2011.06.011","article-title":"Bombesin receptor subtype-3 agonists stimulate the growth of lung cancer cells and increase EGF receptor tyrosine phosphorylation","volume":"32","author":"Moody","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2015.10.007_bib0190","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1124\/jpet.113.206896","article-title":"Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors","volume":"347","author":"Moreno","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.peptides.2015.10.007_bib0195","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1038\/sj.bjp.0703221","article-title":"Characterization of a novel nonpeptide vasopressin V(2)-agonist, OPC-51803, in cells transfected human vasopressin receptor subtypes","volume":"129","author":"Nakamura","year":"2000","journal-title":"Br. J. Pharmacol."},{"issue":"6656","key":"10.1016\/j.peptides.2015.10.007_bib0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/36568","article-title":"Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity","volume":"390","author":"Ohki-Hamazaki","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2015.10.007_bib0205","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0014-2999(97)01527-6","article-title":"Identification of a unique ligand which has high affinity for all four bombesin receptor subtypes","volume":"343","author":"Pradhan","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0210","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.peptides.2015.01.009","article-title":"A structure-function study of PACAP using conformationally restricted analogs: identification of PAC1 receptor-selective PACAP agonists","volume":"66","author":"Ramos-Alvarez","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2015.10.007_bib0215","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.peptides.2015.04.026","article-title":"Insights into bombesin receptors and ligands: highlighting recent advances","volume":"72","author":"Ramos-Alvarez","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2015.10.007_bib0220","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1177\/0091270011419854","article-title":"Pharmacokinetics and pharmacodynamics of MK-5046, a bombesin receptor subtype-3 (BRS-3) agonist, in healthy patients","volume":"52","author":"Reitman","year":"2012","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0225","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1006\/bbrc.1995.1530","article-title":"Pharmacological differences between rat and human endothelin B receptors","volume":"209","author":"Reynolds","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.peptides.2015.10.007_bib0230","first-page":"G655","article-title":"Cholecystokinin-induced formation of inositol phosphates in pancreatic acini","volume":"259","author":"Rowley","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0235","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/S0022-3565(24)35024-4","article-title":"Comparative pharmacology of a nonpeptoid neuromedin B antagonist PD 168368","volume":"290","author":"Ryan","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.peptides.2015.10.007_bib0240","doi-asserted-by":"crossref","first-page":"13613","DOI":"10.1074\/jbc.273.22.13613","article-title":"Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3","volume":"273","author":"Ryan","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2015.10.007_bib0245","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0022-3565(24)37799-7","article-title":"Pharmacology and intracellular signaling mechanisms of the native human orphan receptor BRS-3 in lung cancer cells","volume":"287","author":"Ryan","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.peptides.2015.10.007_bib0250","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.peptides.2010.04.023","article-title":"Pharmacology of putative selective h-BRS-3 receptor agonists for human bombesin receptors (BnR): affinities, potencies and selectivity in multiple native and BnR transfected cells","volume":"31","author":"Sancho","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2015.10.007_bib0255","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ygeno.2004.01.008","article-title":"Characterization of the bombesin-like peptide receptor family in primates","volume":"84","author":"Sano","year":"2004","journal-title":"Genomics"},{"key":"10.1016\/j.peptides.2015.10.007_bib0260","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/B978-0-12-386933-3.00010-8","article-title":"The role of bombesin and bombesin-related peptides in the short-term control of food intake","volume":"114","author":"Sayegh","year":"2013","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.peptides.2015.10.007_bib0265","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0014-2999(00)00274-0","article-title":"Characterisation of the effects of SR 146131, a novel non-peptide CCK(1) receptor agonist, on IMR-32 human neuroblastoma cells","volume":"397","author":"Schaeffer","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0270","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1021\/ml100196d","article-title":"Discovery of MK-5046, a potent, selective bombesin recptor subtype-3 agonist for the treatment of obesity","volume":"2","author":"Sebhat","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.peptides.2015.10.007_bib0275","doi-asserted-by":"crossref","first-page":"L165","DOI":"10.1152\/ajplung.00436.2002","article-title":"Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung","volume":"286","author":"Shan","year":"2004","journal-title":"Am. J. Physiol. (Lung Cell. Mol. Physiol.)"},{"key":"10.1016\/j.peptides.2015.10.007_bib0280","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tips.2012.10.004","article-title":"Species-dependent activities of G-protein-coupled receptor ligands: lessons from histamine receptor orthologs","volume":"34","author":"Strasser","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.peptides.2015.10.007_bib0285","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1164\/rccm.200212-1434OC","article-title":"Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasias?","volume":"168","author":"Subramaniam","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.peptides.2015.10.007_bib0290","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000098129","article-title":"In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine","volume":"79","author":"Takanashi","year":"2007","journal-title":"Pharmacology"},{"key":"10.1016\/j.peptides.2015.10.007_bib0295","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.peptides.2005.12.012","article-title":"Wound repair and proliferation of bronchial epithelial cells enhanced by bombesin receptor subtype 3 activation","volume":"27","author":"Tan","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2015.10.007_bib0300","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.bmcl.2014.11.047","article-title":"Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2","volume":"25","author":"Thomas","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.peptides.2015.10.007_bib0305","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.peptides.2011.06.017","article-title":"Pharmacology and selectivity of various natural and synthetic bombesin related peptide agonists for human and rat bombesin receptors differs","volume":"32","author":"Uehara","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2015.10.007_bib0310","first-page":"G468","article-title":"Potent bombesin receptor antagonists distinguish receptor subtypes","volume":"259","author":"von Schrenck","year":"1990","journal-title":"J. Am. Physiol."},{"issue":"3","key":"10.1016\/j.peptides.2015.10.007_bib0315","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1021\/bi00455a004","article-title":"Desmethionine alkylamide bombesin analogues: a new class of bombesin receptor antagonists with a potent antisecretory activity in pancreatic acini and antimitotic activity in Swiss 3T3 cells","volume":"29","author":"Wang","year":"1990","journal-title":"Biochemistry (Mosc.)"},{"issue":"26","key":"10.1016\/j.peptides.2015.10.007_bib0320","doi-asserted-by":"crossref","first-page":"15695","DOI":"10.1016\/S0021-9258(18)55454-5","article-title":"Des-Met carboxyl-terminally modified analogues of bombesin function as potent bombesin receptor antagonists, partial agonists, or agonists","volume":"265","author":"Wang","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2015.10.007_bib0325","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.cellbi.2007.06.016","article-title":"BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts","volume":"31","author":"Wang","year":"2007","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.peptides.2015.10.007_bib0330","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0014-2999(00)00941-9","article-title":"A bombesin receptor subtype-3 peptide increases nuclear oncogene expression in a MEK-1 dependent manner in human lung cancer cells","volume":"412","author":"Weber","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.peptides.2015.10.007_bib0335","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/sj.mp.4000974","article-title":"Role of bombesin (BN)-like peptides\/receptors in emotional behavior by comparison of three strains of BN-like peptide receptor knockout mice","volume":"7","author":"Yamada","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.peptides.2015.10.007_bib0340","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3109\/07853890008998831","article-title":"Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice","volume":"32","author":"Yamada","year":"2000","journal-title":"Ann. Med."},{"key":"10.1016\/j.peptides.2015.10.007_bib0345","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/cne.23216","article-title":"Anatomical characterization of bombesin receptor subtype-3 mRNA expression in the rodent central nervous system","volume":"521","author":"Zhang","year":"2013","journal-title":"J. Comp. Neurol."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978115002892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978115002892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T08:52:43Z","timestamp":1748681563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978115002892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":69,"alternative-id":["S0196978115002892"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2015.10.007","relation":{},"ISSN":["0196-9781"],"issn-type":[{"type":"print","value":"0196-9781"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel chiral-diazepines function as specific, selective receptor agonists with variable coupling and species variability in human, mouse and rat BRS-3 receptor cells","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2015.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}