{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:00:55Z","timestamp":1780459255318,"version":"3.54.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.peptides.2016.07.003","type":"journal-article","created":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T05:31:17Z","timestamp":1469943077000},"page":"38-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["p21 CIP1\/WAF1 -dependent inhibition of cardiac hypertrophy in response to Angiotensin II involves Akt\/Myc and pRb signaling"],"prefix":"10.1016","volume":"83","author":[{"given":"Ludger","family":"Hauck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Grothe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2824-1215","authenticated-orcid":false,"given":"Filio","family":"Billia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2016.07.003_bib0005","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1101\/gad.13.12.1501","article-title":"CDK inhibitors: positive and negative regulators of G1-phase progression","volume":"13","author":"Sherr","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.peptides.2016.07.003_bib0010","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nrd869","article-title":"CDKs and CKIs: molecular targets for tissue remodelling","volume":"1","author":"Nabel","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.peptides.2016.07.003_bib0015","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","article-title":"WAF1, a potential mediator of p53 tumor suppression","volume":"75","author":"el-Deiry","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.peptides.2016.07.003_bib0020","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1038\/sj.onc.1208615","article-title":"The p53 pathway: positive and negative feedback loops","volume":"24","author":"Harris","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.peptides.2016.07.003_bib0025","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrm2147","article-title":"p53 in health and disease","volume":"8","author":"Vousden","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.peptides.2016.07.003_bib0030","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nature01119","article-title":"Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage","volume":"419","author":"Seoane","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2016.07.003_bib0035","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/366707a0","article-title":"Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit","volume":"366","author":"Gu","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2016.07.003_bib0040","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/375159a0","article-title":"Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1","volume":"375","author":"Luo","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2016.07.003_bib0045","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/356215a0","article-title":"Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours","volume":"356","author":"Donehower","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2016.07.003_bib0050","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(95)90039-X","article-title":"Mice lacking p21CIP1\/WAF1 undergo normal development, but are defective in G1 checkpoint control","volume":"82","author":"Deng","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.peptides.2016.07.003_bib0055","first-page":"H1358","article-title":"Downregulation of cyclin-dependent kinase inhibitors p21 and p27 in pressure-overload hypertrophy","volume":"273","author":"Li","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.peptides.2016.07.003_bib0060","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/dbio.1996.0270","article-title":"Human E2F-1 reactivates cell cycle progression in ventricular myocytes and represses cardiac gene transcription","volume":"179","author":"Kirshenbaum","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1016\/j.peptides.2016.07.003_bib0065","first-page":"H2183","article-title":"Cardiomyocyte DNA synthesis and binucleation during murine development","volume":"271","author":"Soonpaa","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.peptides.2016.07.003_bib0070","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1172\/JCI119453","article-title":"Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice","volume":"99","author":"Soonpaa","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.peptides.2016.07.003_bib0075","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/01.RES.85.2.128","article-title":"E2F-1 overexpression in cardiomyocytes induces downregulation of p21CIP1 and p27KIP1 and release of active cyclin-dependent kinases in the presence of insulin-like growth factor I","volume":"85","author":"von Harsdorf","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.peptides.2016.07.003_bib0080","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/cvr\/cvn183","article-title":"Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase","volume":"80","author":"Tamamori-Adachi","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.peptides.2016.07.003_bib0085","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.cell.2015.10.037","article-title":"Cardiomyocyte cell-cycle activity during preadolescence","volume":"163","author":"Soonpaa","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.peptides.2016.07.003_bib0090","first-page":"233","article-title":"Induction of cell-cycle inhibitor p21 in rat ventricular myocytes during early postnatal transition from hyperplasia to hypertrophy","volume":"46","author":"Hork\u00fd","year":"1997","journal-title":"Physiol. Res."},{"key":"10.1016\/j.peptides.2016.07.003_bib0095","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1161\/01.RES.0000020201.44772.67","article-title":"Cardiomyocyte cell cycle regulation","volume":"90","author":"Pasumarthi","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.peptides.2016.07.003_bib0100","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1128\/MCB.25.6.2486-2497.2005","article-title":"Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb","volume":"25","author":"MacLellan","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.peptides.2016.07.003_bib0105","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.201012049","article-title":"Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes","volume":"194","author":"Sdek","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.peptides.2016.07.003_bib0110","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.bbrc.2013.12.109","article-title":"CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes","volume":"443","author":"Tane","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.peptides.2016.07.003_bib0115","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity","volume":"358","author":"Hill","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.peptides.2016.07.003_bib0120","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1056\/NEJM199608153350707","article-title":"The management of chronic heart failure","volume":"335","author":"Cohn","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.peptides.2016.07.003_bib0125","doi-asserted-by":"crossref","first-page":"IV14","DOI":"10.1161\/01.CIR.102.suppl_4.IV-14","article-title":"Congestive heart failure: fifty years of progress","volume":"102","author":"Braunwald","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.peptides.2016.07.003_bib0130","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1056\/NEJMra021498","article-title":"Heart failure","volume":"348","author":"Jessup","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.peptides.2016.07.003_bib0135","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cardiores.2004.09.003","article-title":"Therapeutic opportunities for cell cycle re-entry and cardiac regeneration","volume":"64","author":"Regula","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.peptides.2016.07.003_bib0140","first-page":"4","article-title":"Therapeutic strategies to inhibit MYC","volume":"1","author":"McKeown","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.peptides.2016.07.003_bib0145","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/hh2401.100742","article-title":"Inducible activation of c-Myc in adult myocardium in vivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis","volume":"89","author":"Xiao","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.peptides.2016.07.003_bib0150","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1038\/sj.emboj.7601252","article-title":"Hypertrophic growth in cardiac myocytes is mediated by Myc through a cyclin D2-dependent pathway","volume":"25","author":"Zhong","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.peptides.2016.07.003_bib0155","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1161\/CIRCRESAHA.107.163550","article-title":"A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium","volume":"102","author":"Angelis","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.peptides.2016.07.003_bib0160","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1365-2184.2008.00549.x","article-title":"Phosphorylation of pRb by cyclin D kinase is necessary for development of cardiac hypertrophy","volume":"41","author":"Hinrichsen","year":"2008","journal-title":"Cell Prolif."},{"key":"10.1016\/j.peptides.2016.07.003_bib0165","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/01.RES.0000254704.92532.b9","article-title":"Critical role for FoxO3a-dependent regulation of p21CIP1\/WAF1 in response to statin signaling in cardiac myocytes","volume":"100","author":"Hauck","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.peptides.2016.07.003_bib0170","first-page":"H814","article-title":"Role of G1 phase cyclins and cyclin-dependent kinases during cardiomyocyte hypertrophic growth in rats","volume":"275","author":"Li","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.peptides.2016.07.003_bib0175","first-page":"H2036","article-title":"Essential roles for G1 cyclin-dependent kinase activity in development of cardiomyocyte hypertrophy","volume":"275","author":"Tamamori","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.peptides.2016.07.003_bib0180","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1253\/jcj.64.595","article-title":"G1 cyclins are involved in the mechanism of cardiac myocyte hypertrophy induced by angiotensin II","volume":"64","author":"Nozato","year":"2000","journal-title":"Jpn. Circ. J."},{"key":"10.1016\/j.peptides.2016.07.003_bib0185","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0092-8674(93)90541-W","article-title":"Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro","volume":"75","author":"Sadoshima","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.peptides.2016.07.003_bib0190","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1161\/01.CIR.97.19.1952","article-title":"Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice","volume":"97","author":"Harada","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.peptides.2016.07.003_bib0195","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cardiores.2005.04.030","article-title":"Blockade of NF-kappaB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II","volume":"67","author":"Kawano","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.peptides.2016.07.003_bib0200","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1161\/HYPERTENSIONAHA.110.152207","article-title":"Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice","volume":"56","author":"Sumitomo-Ueda","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2016.07.003_bib0205","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1126\/science.285.5433.1569","article-title":"In vivo protein transduction: delivery of a biologically active protein into the mouse","volume":"285","author":"Schwarze","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.peptides.2016.07.003_bib0210","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nm1729","article-title":"Protein kinase CK2 links extracellular growth factor signaling with the control of p27(Kip1) stability in the heart","volume":"14","author":"Hauck","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.peptides.2016.07.003_bib0215","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1126\/science.1106148","article-title":"Phosphorylation and regulation of Akt\/PKB by the rictor-mTOR complex","volume":"307","author":"Sarbassov","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.peptides.2016.07.003_bib0220","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1161\/01.CIR.0000091403.62293.2B","article-title":"Phosphoinositide 3-kinase \u03b3\u2013deficient mice are protected from isoproterenol-induced heart failure","volume":"108","author":"Oudit","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.peptides.2016.07.003_bib0225","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1161\/HYPERTENSIONAHA.110.156158","article-title":"Negative inotropy by angiotensin II is mediated via phosphoinositide 3-kinase alpha-protein kinase C-coupled signaling pathway","volume":"56","author":"Dhingra","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2016.07.003_bib0230","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1128\/MCB.21.16.5644-5657.2001","article-title":"Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells","volume":"21","author":"R\u00f6ssig","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.peptides.2016.07.003_bib0235","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1523\/JNEUROSCI.5110-06.2007","article-title":"Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1\/Cip1) as a novel mechanism of neuroprotection by glucocorticoids","volume":"27","author":"Harms","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.peptides.2016.07.003_bib0240","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1091\/mbc.8.2.287","article-title":"Cyclin Dl\/Cdk4 regulates retinoblastoma protein mediated cell cycle arrest by site-specific phosphorylation","volume":"8","author":"Connell-Crowley","year":"1997","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.peptides.2016.07.003_bib0245","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1006\/jmcc.1996.0163","article-title":"Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development","volume":"28","author":"Li","year":"1996","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.peptides.2016.07.003_bib0250","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1053\/euhj.1998.1231","article-title":"Cyclin-dependent kinase inhibitor expression in human heart failure: a comparison with fetal development","volume":"20","author":"Burton","year":"1999","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.peptides.2016.07.003_bib0255","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1023\/A:1009640124029","article-title":"Apoptosis in ventricular myocytes: the role of tumor suppressor proteins","volume":"4","author":"Regula","year":"1999","journal-title":"Apoptosis"},{"key":"10.1016\/j.peptides.2016.07.003_bib0260","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/01.RES.88.4.408","article-title":"Cyclin A\/cdk2 activation is involved in hypoxia-induced apoptosis in cardiomyocytes","volume":"88","author":"Adachi","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.peptides.2016.07.003_bib0265","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/01.RES.0000041030.98642.41","article-title":"Inhibition of hypoxia-induced apoptosis by modulation of retinoblastoma protein-dependent signaling in cardiomyocytes","volume":"91","author":"Hauck","year":"2002","journal-title":"Circ. Res."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978116301413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978116301413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T23:59:18Z","timestamp":1536537558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978116301413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":53,"alternative-id":["S0196978116301413"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2016.07.003","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"p21CIP1\/WAF1-dependent inhibition of cardiac hypertrophy in response to Angiotensin II involves Akt\/Myc and pRb signaling","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2016.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}