{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:29:47Z","timestamp":1773797387970,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki and Sakari Sohlberg Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Professor Naoyuki Yamamoto, Nagoya University for providing us with the tripeptides used in this study and Dr"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.peptides.2016.09.001","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T19:38:40Z","timestamp":1473709120000},"page":"46-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Bradykinin \u2013induced vasodilatation: Role of age, ACE1-inhibitory peptide, mas- and bradykinin receptors"],"prefix":"10.1016","volume":"85","author":[{"given":"A.","family":"Siltari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Korpela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Vapaatalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2016.09.001_bib0005","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/(SICI)1097-4644(19961201)63:3<292::AID-JCB4>3.0.CO;2-S","article-title":"Calcium-calmodulin plays a major role in bradykinin-induced arachidonic acid release by bovine aortic endothelial cells","volume":"63","author":"Briand","year":"1996","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.peptides.2016.09.001_bib0010","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1161\/01.HYP.31.1.362","article-title":"Metabolism of angiotensin-(1-7) by angiotensin-converting enzyme","volume":"31","author":"Chappell","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2016.09.001_bib0015","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/jhh.2010.85","article-title":"Blood pressure lowering effects of lactotripeptides assumed as functional food: a meta-analysis of current available clinical trials","volume":"25","author":"Cicero","year":"2011","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.peptides.2016.09.001_bib0020","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.peptides.2012.03.022","article-title":"The cardiac expression of Mas receptor is responsive to different physiological and pathological stimuli","volume":"35","author":"Dias-Peixoto","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2016.09.001_bib0025","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.lfs.2010.11.001","article-title":"Casein-derived tripeptide Ile-Pro-Pro improves angiotensin-(1-7)- and bradykinin-induced rat mesenteric artery relaxation","volume":"88","author":"Ehlers","year":"2011","journal-title":"Life Sci."},{"key":"10.1016\/j.peptides.2016.09.001_bib0030","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.freeradbiomed.2013.07.003","article-title":"Oxidative stress and vascular inflammation in aging","volume":"65","author":"El Assar","year":"2013","journal-title":"Free Radic Biol. Med."},{"key":"10.1016\/j.peptides.2016.09.001_bib0035","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1042\/CS20110181","article-title":"Low doses of ethanol decrease the activity of the angiotensin-converting enzyme in the aorta of aging rats and rats treated with a nitric oxide synthase inhibitor and dexamethasone","volume":"122","author":"Emel\u2019yanov","year":"2012","journal-title":"Clin. Sci."},{"key":"10.1016\/j.peptides.2016.09.001_bib0040","first-page":"1760","article-title":"The angiotensin I converting enzyme","volume":"36","author":"Erd\u00f6s","year":"1977","journal-title":"Fed. Proc."},{"key":"10.1016\/j.peptides.2016.09.001_bib0045","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1476-5381.1990.tb12712.x","article-title":"Bradykinin-induced vasoconstriction of rat mesenteric arteries precontracted with noradrenaline","volume":"101","author":"Fasciolo","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.peptides.2016.09.001_bib0050","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/01.HYP.37.2.703","article-title":"Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo","volume":"37","author":"Fernandes","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2016.09.001_bib0055","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.regpep.2004.12.006","article-title":"Role of PGI2 and effect of ACE inhibition on the bradykinin potentiation by angiotensin(1-7) in resistance vessels of SHR","volume":"127","author":"Fernandes","year":"2005","journal-title":"Regul. Pept."},{"key":"10.1016\/j.peptides.2016.09.001_bib0060","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1021\/bi00815a005","article-title":"Isolation of bradykinin potentiating peptides from Bothrops jararaca venom","volume":"9","author":"Ferreira","year":"1970","journal-title":"Biochemistry"},{"key":"10.1016\/j.peptides.2016.09.001_bib0065","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11010-008-9884-4","article-title":"Angiotensin metabolites can stimulate receptors of the Mas-related genes family","volume":"319","author":"Gembardt","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.peptides.2016.09.001_bib0070","article-title":"Changes in angiotensin receptor distribution and in aortic morpholody are associated with blood pressure control in aged metabolic syndrome rats","volume":"2016","author":"Guarner-Lans","year":"2016","journal-title":"Int. J. Hyper."},{"key":"10.1016\/j.peptides.2016.09.001_bib0075","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.yjmcc.2015.04.011","article-title":"Vascular biology of ageing-Implications in hypertension","volume":"83","author":"Harvey","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.peptides.2016.09.001_bib0080","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jff.2009.03.002","article-title":"Milk protein-derived bioactive tripeptides Ile-Pro-Pro and Val-Pro-Pro protect endothelial function in vitro in hypertensive rats","volume":"1","author":"J\u00e4k\u00e4l\u00e4","year":"2009","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.peptides.2016.09.001_bib0085","doi-asserted-by":"crossref","first-page":"H948","DOI":"10.1152\/ajpheart.00868.2005","article-title":"Positive cooperativity between the thrombin and bradykinin B2 receptors enhances arachidonic acid release","volume":"290","author":"Hecquet","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.peptides.2016.09.001_bib0090","first-page":"11","article-title":"Cardiovascular activity of milk casein-derived tripeptides and plant sterols in spontaneously hypertensive rats","volume":"60","author":"J\u00e4k\u00e4l\u00e4","year":"2009","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.peptides.2016.09.001_bib0095","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3390\/ph3010251","article-title":"Antihypertensive peptides from milk proteins","volume":"3","author":"J\u00e4k\u00e4l\u00e4","year":"2010","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.peptides.2016.09.001_bib0100","first-page":"142","article-title":"Comparison of cumulative and non-cumulative administration of vasoactive agents in arterial smooth muscle responses in vitro. Pharmacol","volume":"73","author":"K\u00e4h\u00f6nen","year":"1993","journal-title":"Toxicol"},{"key":"10.1016\/j.peptides.2016.09.001_bib0105","doi-asserted-by":"crossref","first-page":"H202","DOI":"10.1152\/ajpheart.01287.2004","article-title":"Age-related changes of bradykinin B1 and B2 receptors in rat heart","volume":"289","author":"Kintsurashvili","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.peptides.2016.09.001_bib0110","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s11357-011-9282-9","article-title":"Distribution of the activity of the angiotensin-converting enzyme in the rat aorta and changes in the activity with aging and by the action of L-NAME","volume":"34","author":"Korystova","year":"2012","journal-title":"AGE"},{"key":"10.1016\/j.peptides.2016.09.001_bib0115","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1097\/00004872-200309000-00023","article-title":"Expression of bradykinin receptors in the left ventricles of rats with pressure overload hypertrophy and heart failure","volume":"21","author":"Kuoppala","year":"2003","journal-title":"J. Hypertens."},{"key":"10.1016\/j.peptides.2016.09.001_bib0120","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/CIRCRESAHA.113.301077","article-title":"Discovery and characterization of alamandine. A novel component of the renin\u2013angiotensin system","volume":"112","author":"Lautner","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.peptides.2016.09.001_bib0125","first-page":"182","article-title":"Effects of milk casein-derived tripeptides Ile-Pro-Pro Val-Pro-Pro, and Leu-Pro-Pro on enzymes processing vasoactive precursors in vitro","volume":"60","author":"Lehtinen","year":"2010","journal-title":"Azneimittelforschung. (Drug Research)"},{"key":"10.1016\/j.peptides.2016.09.001_bib0130","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.regpep.2003.10.001","article-title":"PLA2\/PGE2 are involved in the inhibitory effect of bradykinin on the angiotensin(1-7)-stimulated NA(+)-ATPase activity of the proximal tubule","volume":"117","author":"Lopes","year":"2004","journal-title":"Regul. Pept."},{"key":"10.1016\/j.peptides.2016.09.001_bib0135","first-page":"H1250","article-title":"Reversal of hypertension and endothelial dysfunction in deoxycorticosterone-NaCl-treated rats by high-Ca2+ diet","volume":"270","author":"M\u00e4kynen","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.peptides.2016.09.001_bib0140","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/BF01793215","article-title":"Bradykinin-induced vasodilation is changed to a vasoconstrictor response in vessels of aged normotensive and hypertensive rats","volume":"44","author":"Mantelli","year":"1995","journal-title":"Inflammation Res."},{"key":"10.1016\/j.peptides.2016.09.001_bib0145","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0008-6363(00)00184-X","article-title":"Kinin B1 receptor and the cardiovascular system: regulation of expression and function","volume":"48","author":"McLean","year":"2000","journal-title":"Cardiovascul. Res."},{"key":"10.1016\/j.peptides.2016.09.001_bib0150","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1161\/01.HYP.37.2.414","article-title":"Endothelial dysfunction and xanthine oxidoreductase avtivity in rats with human renin and angiotensin genes","volume":"37","author":"Mervaala","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2016.09.001_bib0155","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3168\/jds.S0022-0302(95)76689-9","article-title":"Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk","volume":"78","author":"Nakamura","year":"1995","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.peptides.2016.09.001_bib0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000329615","article-title":"Downregulation of bradykinin type 2 receptor expression in cardiac endothelial cells during senescence","volume":"49","author":"Nurmi","year":"2012","journal-title":"J Vascul Res"},{"key":"10.1016\/j.peptides.2016.09.001_bib0165","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0196-9781(99)00123-0","article-title":"Synergistic effect of angiotensin-(1-7) on bradykinin arteriolar dilation in vivo","volume":"20","author":"Oliveira","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2016.09.001_bib0170","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1161\/01.HYP.26.6.1154","article-title":"Angiotensin-(1-7) potentiates the hypotensive effect of bradykinin in conscious rats","volume":"26","author":"Paula","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2016.09.001_bib0175","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/gerona\/60.8.984","article-title":"Increased kinin levels and decreased responsiveness to kinins during aging","volume":"60A","author":"P\u00e9rez","year":"2005","journal-title":"J. Gerontol."},{"key":"10.1016\/j.peptides.2016.09.001_bib0180","article-title":"Effect of peptides derived from food proteins on blood pressure: a meta-analysis of randomized controlled trials","volume":"32","author":"Pripp","year":"2008","journal-title":"Food Nutr Res"},{"key":"10.1016\/j.peptides.2016.09.001_bib0185","first-page":"1","article-title":"Pharmacology of bradykinin and related kinins","volume":"32","author":"Regoli","year":"1980","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.peptides.2016.09.001_bib0190","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1152\/ajplegacy.1949.156.2.261","article-title":"a hypotensive and smooth muscle stimulating factor realized from plasma globulin by snake venoms and by trypsin","volume":"156","author":"Rocha e Silva","year":"1949","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.peptides.2016.09.001_bib0195","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.peptides.2014.04.021","article-title":"Angiotensin II and 1-7 during aging in metabolic syndrome rats Expression of AT1, AT2 and Mas receptors in abdominal white adipose tissue","volume":"57","author":"Rubio-Ru\u00edz","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2016.09.001_bib0200","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/ejn.13133","article-title":"Opposite roles of bradykinin B1 and B2 receptors during cerebral ischaemia\u2013reperfusion injury in experimental diabetic rats","volume":"43","author":"Sang","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.peptides.2016.09.001_bib0205","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-12-0341","article-title":"Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system","volume":"216","author":"Santos","year":"2013","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.peptides.2016.09.001_bib0210","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cardiores.2004.11.005","article-title":"Aging decreases vasoconstrictor responses of coronary resistance arterioles through endothelium-dependent mechanism","volume":"66","author":"Shipley","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.peptides.2016.09.001_bib0215","first-page":"91","article-title":"Age-dependency of acetylcholine- and bradykinin-induced vascular relaxation in vitro","author":"Siltari","year":"2013","journal-title":"Proceedings of the 6th European Congress of Pharmacology 17\u201320 2012 \u2212 Granada (Spain)"},{"key":"10.1016\/j.peptides.2016.09.001_bib0220","first-page":"59","article-title":"Does the cis\/trans configuration of peptide bonds in bioactive tripeptides play a role in ACE-1 enzyme inhibition","volume":"8","author":"Siltari","year":"2014","journal-title":"Biol Targets Ther"},{"key":"10.1016\/j.peptides.2016.09.001_bib0225","first-page":"745","article-title":"Long-term intake of milk peptide attenuates development of hypertension in spontaneously hypertensive rats","volume":"52","author":"Sipola","year":"2001","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.peptides.2016.09.001_bib0230","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3109\/07853890.2012.663926","article-title":"Antihypertensive effects of bioactive tripeptides \u2212a random effects meta-analysis","volume":"45","author":"Turpeinen","year":"2013","journal-title":"Ann. Med."},{"key":"10.1016\/j.peptides.2016.09.001_bib0235","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1097\/00004872-200111000-00010","article-title":"Angiotensin(1-7) potentiates bradykinin-induced vasodilatation in man","volume":"19","author":"Ueda","year":"2001","journal-title":"J. Hypertens."},{"issue":"7","key":"10.1016\/j.peptides.2016.09.001_bib0240","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genom biol"},{"key":"10.1016\/j.peptides.2016.09.001_bib0245","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1365-2605.2010.01052.x","article-title":"Age-related changes in kallikreins- kinins system in rat corpus cavernosum","volume":"34","author":"Wang","year":"2010","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.peptides.2016.09.001_bib0250","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.nut.2008.04.004","article-title":"Effects of milk tripeptides on blood pressure: a meta-analysis of randomized controlled trials","volume":"24","author":"Xu","year":"2008","journal-title":"Nutrition"},{"key":"10.1016\/j.peptides.2016.09.001_bib0255","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.regpep.2012.04.002","article-title":"Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells","volume":"177","author":"Xue","year":"2012","journal-title":"Regul. Pept."},{"key":"10.1016\/j.peptides.2016.09.001_bib0260","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/2181224a0","article-title":"New enzymatic route for the inactivation of angiotensin","volume":"218","author":"Yang","year":"1968","journal-title":"Nature"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978116301693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978116301693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T07:56:36Z","timestamp":1568361396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978116301693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":52,"alternative-id":["S0196978116301693"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2016.09.001","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bradykinin \u2013induced vasodilatation: Role of age, ACE1-inhibitory peptide, mas- and bradykinin receptors","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2016.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}