{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:32:54Z","timestamp":1790105574168,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.peptides.2016.12.002","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T18:00:35Z","timestamp":1481220035000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice"],"prefix":"10.1016","volume":"88","author":[{"given":"J.B.","family":"Pawlak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.E.","family":"Wetzel-Strong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.K.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Caron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.peptides.2016.12.002_bib0005","first-page":"138","article-title":"Adrenomedullin: a multifunctional regulatory peptide","volume":"21","author":"Hinson","year":"2000","journal-title":"Endocr. Rev."},{"issue":"5","key":"10.1016\/j.peptides.2016.12.002_bib0010","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1210\/edrv-17-5-533","article-title":"Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials","volume":"17","author":"Wimalawansa","year":"1996","journal-title":"Endocr. Rev."},{"issue":"Suppl","key":"10.1016\/j.peptides.2016.12.002_bib0015","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1291\/hypres.26.S33","article-title":"Immunohistological localization and possible functions of adrenomedullin","volume":"26","author":"Marutsuka","year":"2003","journal-title":"Hypertens. Res."},{"issue":"5","key":"10.1016\/j.peptides.2016.12.002_bib0020","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1161\/01.HYP.0000097604.64716.D2","article-title":"Chronic administration of adrenomedullin attenuates transition from left ventricular hypertrophy to heart failure in rats","volume":"42","author":"Nishikimi","year":"2003","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.peptides.2016.12.002_bib0025","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1161\/01.CIR.96.6.1983","article-title":"Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure","volume":"96","author":"Rademaker","year":"1997","journal-title":"Circulation"},{"issue":"1 Pt 2","key":"10.1016\/j.peptides.2016.12.002_bib0030","first-page":"R213","article-title":"Cardiovascular and renal effects of adrenomedullin in rats with heart failure","volume":"276","author":"Nagaya","year":"1999","journal-title":"Am. J. Physiol."},{"issue":"5","key":"10.1016\/j.peptides.2016.12.002_bib0035","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1161\/01.CIR.101.5.498","article-title":"Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure","volume":"101","author":"Nagaya","year":"2000","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.peptides.2016.12.002_bib0040","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/01.HYP.34.1.70","article-title":"Bioactivity and interactions of adrenomedullin and brain natriuretic peptide in patients with heart failure","volume":"34","author":"Lainchbury","year":"1999","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.peptides.2016.12.002_bib0045","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1136\/thx.2010.135996","article-title":"Adrenomedullin attenuates ventilator-induced lung injury in mice","volume":"65","author":"Muller","year":"2010","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.peptides.2016.12.002_bib0050","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00134-007-0561-y","article-title":"Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock","volume":"33","author":"Temmesfeld-Wollbruck","year":"2007","journal-title":"Intensive Care Med."},{"issue":"6683","key":"10.1016\/j.peptides.2016.12.002_bib0055","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/30666","article-title":"RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor","volume":"393","author":"McLatchie","year":"1998","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.peptides.2016.12.002_bib0060","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1124\/pr.54.2.233","article-title":"International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides: adrenomedullin, amylin, and calcitonin receptors","volume":"54","author":"Poyner","year":"2002","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.peptides.2016.12.002_bib0065","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1476-5381.2011.01530.x","article-title":"The pharmacology of adrenomedullin 2\/intermedin","volume":"166","author":"Hong","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.peptides.2016.12.002_bib0070","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1073\/pnas.0611365104","article-title":"Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males","volume":"104","author":"Caron","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.peptides.2016.12.002_bib0075","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1042\/cs0920467","article-title":"Adrenomedullin: a hypotensive hormone in man","volume":"92","author":"Lainchbury","year":"1997","journal-title":"Clin. Sci. (Lond.)"},{"issue":"42","key":"10.1016\/j.peptides.2016.12.002_bib0080","doi-asserted-by":"crossref","first-page":"16702","DOI":"10.1073\/pnas.0705974104","article-title":"Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice","volume":"104","author":"Tsujikawa","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.peptides.2016.12.002_bib0085","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1161\/01.RES.0000200737.63865.58","article-title":"Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2","volume":"98","author":"Tam","year":"2006","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.peptides.2016.12.002_bib0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1172\/JCI33022","article-title":"The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity","volume":"118","author":"Ichikawa-Shindo","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.peptides.2016.12.002_bib0095","first-page":"PL19","article-title":"Adrenomedullin mediates vasodilation via CGRP1 receptors","volume":"56","author":"Entzeroth","year":"1995","journal-title":"Life Sci."},{"issue":"7","key":"10.1016\/j.peptides.2016.12.002_bib0100","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/sj.bjp.0705824","article-title":"The calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS blocks CGRP and adrenomedullin vasoactive responses in the microvasculature","volume":"142","author":"Grant","year":"2004","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.peptides.2016.12.002_bib0105","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1139\/y95-154","article-title":"Rat adrenomedullin induces a selective arterial vasodilation via CGRP1 receptors in the double-perfused mesenteric bed of the rat","volume":"73","author":"Berthiaume","year":"1995","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"7","key":"10.1016\/j.peptides.2016.12.002_bib0110","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1128\/MCB.26.7.2511-2518.2006","article-title":"Hydrops fetalis: cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene","volume":"26","author":"Dackor","year":"2006","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.peptides.2016.12.002_bib0115","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1172\/JCI33302","article-title":"Adrenomedullin signaling is necessary for murine lymphatic vascular development","volume":"118","author":"Fritz-Six","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"25","key":"10.1016\/j.peptides.2016.12.002_bib0120","doi-asserted-by":"crossref","first-page":"18094","DOI":"10.1074\/jbc.M703544200","article-title":"Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age","volume":"282","author":"Dackor","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.peptides.2016.12.002_bib0125","doi-asserted-by":"crossref","first-page":"e102356","DOI":"10.1371\/journal.pone.0102356","article-title":"Deficiency of RAM attenuates antigen-induced airway hyperresponsiveness in mice","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.peptides.2016.12.002_bib0130","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1073\/pnas.0307333101","article-title":"Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene","volume":"101","author":"Caron","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.peptides.2016.12.002_bib0135","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.yjmcc.2011.10.021","article-title":"Loss of receptor activity-modifying protein 3 exacerbates cardiac hypertrophy and transition to heart failure in a sex-dependent manner","volume":"52","author":"Barrick","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.peptides.2016.12.002_bib0140","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/mcne.1999.0767","article-title":"Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development","volume":"14","author":"Lu","year":"1999","journal-title":"Mol. Cell. Neurosci."},{"issue":"11","key":"10.1016\/j.peptides.2016.12.002_bib0145","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/hh2301.100812","article-title":"Elevated sympathetic nervous activity in mice deficient in alphaCGRP","volume":"89","author":"Oh-hashi","year":"2001","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.peptides.2016.12.002_bib0150","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1152\/japplphysiol.00073.2004","article-title":"Characterization of blood pressure and morphological traits in cardiovascular-related organs in 13 different inbred mouse strains","volume":"97","author":"Deschepper","year":"2004","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"2","key":"10.1016\/j.peptides.2016.12.002_bib0155","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1468-2982.2004.00830.x","article-title":"The CGRP-antagonist: BIBN4096BS does not affect cerebral or systemic haemodynamics in healthy volunteers","volume":"25","author":"Petersen","year":"2005","journal-title":"Cephalalgia"},{"issue":"2","key":"10.1016\/j.peptides.2016.12.002_bib0160","doi-asserted-by":"crossref","first-page":"R531","DOI":"10.1152\/ajpregu.00337.2002","article-title":"Responses to human CGRP: ADM, and PAMP in human thymic arteries","volume":"284","author":"Champion","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"8","key":"10.1016\/j.peptides.2016.12.002_bib0165","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/sj.bjp.0705572","article-title":"Direct coronary vasodilator action of adrenomedullin is mediated by nitric oxide","volume":"140","author":"De Matteo","year":"2003","journal-title":"Br. J. Pharmacol."},{"issue":"38","key":"10.1016\/j.peptides.2016.12.002_bib0170","doi-asserted-by":"crossref","first-page":"29602","DOI":"10.1074\/jbc.M004534200","article-title":"Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling","volume":"275","author":"Kuwasako","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.peptides.2016.12.002_bib0175","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/bph.12508","article-title":"Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology","volume":"171","author":"Watkins","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.peptides.2016.12.002_bib0180","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0303-7207(00)00212-4","article-title":"Mouse receptor-activity-modifying proteins 1, \u22122 and \u22123: amino acid sequence, expression and function","volume":"162","author":"Husmann","year":"2000","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.peptides.2016.12.002_bib0185","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1161\/HYPERTENSIONAHA.116.07191","article-title":"Endothelial restoration of receptor activity-modifying protein 2 is sufficient to rescue lethality: but survivors develop dilated cardiomyopathy","volume":"68","author":"Kechele","year":"2016","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.peptides.2016.12.002_bib0190","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/01.HYP.0000151130.34874.fa","article-title":"Calcitonin gene-related peptide protects against hypertension-induced heart and kidney damage","volume":"45","author":"Supowit","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2016.12.002_bib0195","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.regpep.2013.06.008","article-title":"Alpha-calcitonin gene-related peptide is protective against pressure overload-induced heart failure","volume":"185","author":"Li","year":"2013","journal-title":"Regul. Pept."},{"issue":"3","key":"10.1016\/j.peptides.2016.12.002_bib0200","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/cvr\/24.3.239","article-title":"Improved cardiac performance with human calcitonin gene related peptide in patients with congestive heart failure","volume":"24","author":"Gennari","year":"1990","journal-title":"Cardiovasc. Res."},{"issue":"3","key":"10.1016\/j.peptides.2016.12.002_bib0205","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0167-5273(92)90274-7","article-title":"Calcitonin gene-related peptide: a haemodynamic study of a novel vasodilator in patients with severe chronic heart failure","volume":"37","author":"Stevenson","year":"1992","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.peptides.2016.12.002_bib0210","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/hc0102.101399","article-title":"Adrenomedullin: an endogenous peptide, counteracts cardiovascular damage","volume":"105","author":"Shimosawa","year":"2002","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.peptides.2016.12.002_bib0215","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.peptides.2010.03.005","article-title":"Adrenomedullin ameliorates the development of atherosclerosis in apoE-\/- mice","volume":"31","author":"Pan","year":"2010","journal-title":"Peptides"},{"issue":"10","key":"10.1016\/j.peptides.2016.12.002_bib0220","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1172\/JCI28462","article-title":"Reduced maternal expression of adrenomedullin disrupts fertility: placentation, and fetal growth in mice","volume":"116","author":"Li","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.peptides.2016.12.002_bib0225","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1152\/physrev.00034.2013","article-title":"Calcitonin gene-related peptide: physiology and pathophysiology","volume":"94","author":"Russell","year":"2014","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.peptides.2016.12.002_bib0230","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1468-2982.2002.00310.x","article-title":"CGRP may play a causative role in migraine","volume":"22","author":"Lassen","year":"2002","journal-title":"Cephalalgia"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978116302388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978116302388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T23:56:58Z","timestamp":1536191818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978116302388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":46,"alternative-id":["S0196978116302388"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2016.12.002","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2016.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}