{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:17:41Z","timestamp":1759936661567,"version":"build-2065373602"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.peptides.2017.08.002","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T06:00:30Z","timestamp":1503381630000},"page":"3-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Rebirth of the Incretin Concept: Its conception and early development"],"prefix":"10.1016","volume":"100","author":[{"given":"Vincent","family":"Marks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.peptides.2017.08.002_bib0005","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1001\/jama.1955.02960280020005","article-title":"Studies with glucagon in patients with insulin sensitivity","volume":"159","author":"Alivisatos","year":"1955","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.peptides.2017.08.002_bib0010","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0140-6736(65)90898-6","article-title":"Glucagon antibodies","volume":"286","author":"Assan","year":"1965","journal-title":"Lancet"},{"key":"10.1016\/j.peptides.2017.08.002_bib0015","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0014-5793(82)80709-6","article-title":"Isolation of glucagon-37 (bioactive enteroglucagon\/oxyntomodulin) from porcine jejuno-ileum characterization of the peptide","volume":"146","author":"Bataille","year":"1982","journal-title":"FEBS Lett."},{"key":"10.1016\/j.peptides.2017.08.002_bib0020","first-page":"182","article-title":"Immunoassay of plasma insulin","volume":"vol. 14","author":"Berson","year":"1962"},{"year":"1982","series-title":"Gastric Inhibitory Peptide","author":"Brown","key":"10.1016\/j.peptides.2017.08.002_bib0025"},{"key":"10.1016\/j.peptides.2017.08.002_bib0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1139\/y69-020","article-title":"Preparation of highly active enterogastrone","volume":"47","author":"Brown","year":"1969","journal-title":"Can. J. Physiol."},{"key":"10.1016\/j.peptides.2017.08.002_bib0035","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2337\/diab.18.6.381","article-title":"Insulin and glucagon release from isolated islets of Langerhans; effect of enteric factors","volume":"18","author":"Buchanan","year":"1969","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2017.08.002_bib0040","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1210\/jcem-39-2-223","article-title":"Gastric inhibitory polypeptide (GIP) stimulation by oral glucose in man","volume":"39","author":"Catland","year":"1974","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2017.08.002_bib0045","first-page":"391","article-title":"Delayed manifestation of the physiological effects of insulin following the administration of certain pancreatic extracts","volume":"63","author":"Collip","year":"1923","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.peptides.2017.08.002_bib0050","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/jez.a.312","article-title":"Major contributions of comparative endocrinology to the development and exploitation of the incretin concept","volume":"305A","author":"Conlon","year":"2006","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.peptides.2017.08.002_bib0055","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.regpep.2004.08.004","article-title":"The [pre]history of the incretin concept","volume":"128","author":"Creutzfeldt","year":"2005","journal-title":"Regul. Pept."},{"key":"10.1016\/j.peptides.2017.08.002_bib0060","first-page":"952","article-title":"Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide which is a major endogenous metabolite in vivo","volume":"80","author":"Deacon","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2017.08.002_bib0065","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1210\/jcem-37-5-826","article-title":"Stimulation of insulin secretion by gastric inhibitory peptide in man","volume":"37","author":"Dupre","year":"1973","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2017.08.002_bib0070","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0140-6736(64)92481-X","article-title":"An intestinal hormone affecting glucose disposal in man","volume":"284","author":"Dupre","year":"1964","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.peptides.2017.08.002_bib0075","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF00257346","article-title":"Preservation of incretin activity after removal of gastric inhibitory polypeptide (GIP) from rat gut extracts by immunoadsorption","volume":"24","author":"Ebert","year":"1983","journal-title":"Diabetologia"},{"key":"10.1016\/j.peptides.2017.08.002_bib0080","unstructured":"Ellis Samols: http:\/\/munksroll.rcplondon.ac.uk\/Biography\/Details\/5566."},{"issue":"10","key":"10.1016\/j.peptides.2017.08.002_bib0085","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1210\/jcem-24-10-1076","article-title":"Plasma insulin response to oral and intravenous glucose administration","volume":"24","author":"Elrick","year":"1964","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.peptides.2017.08.002_bib0090","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1464-5491.2008.02455.x","article-title":"Dorothy Hodgkin Lecture 2008. Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesity-diabetes?","volume":"25","author":"Flatt","year":"2008","journal-title":"Diabet. Med."},{"year":"1962","series-title":"Glucagon, Chemistry and Function in Health and Disease","author":"Foa","key":"10.1016\/j.peptides.2017.08.002_bib0095"},{"key":"10.1016\/j.peptides.2017.08.002_bib0100","doi-asserted-by":"crossref","first-page":"35581","DOI":"10.1074\/jbc.M113.512046","article-title":"A novel glucagon-like peptide-1 (GLP-1)\/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mice","volume":"288","author":"Gault","year":"2013","journal-title":"JBC"},{"key":"10.1016\/j.peptides.2017.08.002_bib0105","first-page":"549A","article-title":"Proglucagon 78-107, a potent insulinotropic hormone from the lower small intestine","volume":"29","author":"Holst","year":"1986","journal-title":"Diabetologia"},{"key":"10.1016\/j.peptides.2017.08.002_bib0110","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1345\/aph.1E245","article-title":"Incretin mimetics as emerging treatments for type 2 diabetes","volume":"39","author":"Joy","year":"2005","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.peptides.2017.08.002_bib0115","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0021-9258(18)85474-6","article-title":"Aqueous extracts of pancreas III. Some precipitation reactions of insulin","volume":"58","author":"Kimball","year":"1923","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2017.08.002_bib0120","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0016-5085(74)80134-4","article-title":"Radioimmunoassay for gastric inhibitory polypeptide","volume":"66","author":"Kuzio","year":"1974","journal-title":"Gastoenterology"},{"key":"10.1016\/j.peptides.2017.08.002_bib0125","first-page":"620","article-title":"Sur les possibilities d\u2019un traitment du diabete par l\u2019incretine","volume":"12","author":"La Barre","year":"1932","journal-title":"Bull. Acad. R. Med. Belg."},{"key":"10.1016\/j.peptides.2017.08.002_bib0130","first-page":"292","article-title":"Arterio-venous difference of blood sugar in the dog: influence of glucagon","volume":"70","author":"Lefebvre","year":"1962","journal-title":"Arch. Int. Physiol. Biochim."},{"key":"10.1016\/j.peptides.2017.08.002_bib0135","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1152\/ajplegacy.1940.129.3.659","article-title":"Is a duodenal hormone involved in carbohydrate metabolism","volume":"129","author":"Loew","year":"1940","journal-title":"Am. J. Physiol."},{"issue":"January (2)","key":"10.1016\/j.peptides.2017.08.002_bib0140","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1073\/pnas.79.2.345","article-title":"Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem","volume":"79","author":"Lund","year":"1982","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.peptides.2017.08.002_bib0145","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/S0021-9258(18)64673-3","article-title":"Presence of a glucagon-like material in blood of man and dog","volume":"233","author":"Makman","year":"1958","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2017.08.002_bib0150","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000094265","article-title":"Human obesity: its hormonal basis and the role of gastric inhibitory polypeptide","volume":"15","author":"Marks","year":"2006","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.peptides.2017.08.002_bib0155","series-title":"Recent Advances in Endocrinology","first-page":"111","article-title":"Glucose homeostasis","author":"Marks","year":"1968"},{"key":"10.1016\/j.peptides.2017.08.002_bib0160","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1136\/bmj.1.5447.1419","article-title":"Hyperinsulinism and cushing\u2019s syndrome","volume":"1","author":"Marks","year":"1965","journal-title":"Br. Med. J."},{"key":"10.1016\/j.peptides.2017.08.002_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-027304-1.50007-7","article-title":"Intestinal factors in the regulation of insulin secretion","volume":"4","author":"Marks","year":"1970","journal-title":"Adv. Metab. Disord."},{"key":"10.1016\/j.peptides.2017.08.002_bib0170","first-page":"103","article-title":"Glucose assimilation in hyperinsulinism. a critical evaluation of the intravenous glucose tolerance test","volume":"23","author":"Marks","year":"1962","journal-title":"Clin. Sci."},{"key":"10.1016\/j.peptides.2017.08.002_bib0175","series-title":"Obesity: Current Approaches","article-title":"GIP\u2014the obesity hormone","author":"Marks","year":"1988"},{"key":"10.1016\/j.peptides.2017.08.002_bib0180","series-title":"Disorders of Carbohydrate Metabolism","article-title":"Investigations of hypoglycaemia","author":"Marks","year":"1962"},{"key":"10.1016\/j.peptides.2017.08.002_bib0185","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1136\/bmj.1.5185.1539","article-title":"Response to glucagon by subjects with hyperinsulinism from islet cell tumours","volume":"1","author":"Marks","year":"1960","journal-title":"Br. Med. J."},{"key":"10.1016\/j.peptides.2017.08.002_bib0190","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0009-8981(59)90110-X","article-title":"An improved glucose-oxidase method for determining blood, csf and urine glucose levels","volume":"4","author":"Marks","year":"1959","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.peptides.2017.08.002_bib0195","first-page":"750","article-title":"The glucagon and tolbutamide tests in the diagnosis of hyperinsulinism","volume":"54","author":"Marrack","year":"1961","journal-title":"Proc. R. Soc. Med."},{"key":"10.1016\/j.peptides.2017.08.002_bib0200","first-page":"20","article-title":"New interpretation of oral glucose tolerance","volume":"2","author":"McIntyre","year":"1984","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.peptides.2017.08.002_bib0205","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1210\/jcem-25-10-1317","article-title":"Intestinal factors in the control of insulin secretion","volume":"25","author":"Mcintyre","year":"1965","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2017.08.002_bib0210","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0140-6736(67)90334-0","article-title":"Glucose tolerance and diabetes in chronic liver disease","volume":"290","author":"Megyesi","year":"1967","journal-title":"Lancet"},{"key":"10.1016\/j.peptides.2017.08.002_bib0215","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nm727","article-title":"Inhibition of gastric inhibitory polypeptide signalling prevents obesity","volume":"8","author":"Miyawaki","year":"2002","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.peptides.2017.08.002_bib0220","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1172\/JCI112855","article-title":"Insulinotropin: glucagon-like peptide I (7\u201337) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas","volume":"79","author":"Mojsov","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.peptides.2017.08.002_bib0225","series-title":"Glucagon 1","article-title":"Glucagon, glicentin and related peptides","author":"Moody","year":"1983"},{"key":"10.1016\/j.peptides.2017.08.002_bib0230","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0014-5793(84)81114-X","article-title":"The isolation and sequencing of human gastric inhibitory peptide (GIP)","volume":"172","author":"Moody","year":"1984","journal-title":"FEBS Lett."},{"year":"2000","series-title":"Undue Risk: Secret State Experiments On Humans","author":"Moreno","key":"10.1016\/j.peptides.2017.08.002_bib0235"},{"key":"10.1016\/j.peptides.2017.08.002_bib0240","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1177\/000456327801500138","article-title":"Radioimmunoassay of gastric inhibitory polypeptide","volume":"15","author":"Morgan","year":"1978","journal-title":"Ann. Clin. Biochem."},{"issue":"3","key":"10.1016\/j.peptides.2017.08.002_bib0245","doi-asserted-by":"crossref","first-page":"57P","DOI":"10.1042\/bj1250057P","article-title":"Hormonal polypeptides of the upper intestine","volume":"125","author":"Mutt","year":"1971","journal-title":"Biochem. J"},{"issue":"1","key":"10.1016\/j.peptides.2017.08.002_bib0250","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1172\/JCI116186","article-title":"Preserved incretin activity of glucagon-like peptide 1 [7\u201336 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus","volume":"91","author":"Nauck","year":"1993","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.peptides.2017.08.002_bib0255","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1172\/JCI105685","article-title":"Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects","volume":"46","author":"Perley","year":"1967","journal-title":"J. Clin. Invest."},{"year":"1938","series-title":"The Pharmacological Shock Treatment of Schizophrenia","author":"Sakel","key":"10.1016\/j.peptides.2017.08.002_bib0260"},{"key":"10.1016\/j.peptides.2017.08.002_bib0265","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1136\/bmj.1.5329.507","article-title":"Insulin assays in insulinomas","volume":"1","author":"Samols","year":"1963","journal-title":"Br. Med. J."},{"key":"10.1016\/j.peptides.2017.08.002_bib0270","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(65)91592-8","article-title":"Interpretation of the intravenous glucose test","volume":"1","author":"Samols","year":"1965","journal-title":"Lancet"},{"key":"10.1016\/j.peptides.2017.08.002_bib0275","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0140-6736(66)92982-5","article-title":"Immunochemical glucagon in human pancreas, gut and plasma","volume":"2","author":"Samols","year":"1966","journal-title":"Lancet"},{"key":"10.1016\/j.peptides.2017.08.002_bib0280","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2337\/diab.15.12.855","article-title":"Inter-relationship of glucagon, insulin and glucose: the insulinogenic effect of glucagon","volume":"15","author":"Samols","year":"1966","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2017.08.002_bib0285","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S0140-6736(65)92278-6","article-title":"Stimulation of glucagon secretion by oral glucose","volume":"2","author":"Samols","year":"1965","journal-title":"Lancet"},{"key":"10.1016\/j.peptides.2017.08.002_bib0290","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0140-6736(65)90761-0","article-title":"Promotion of insulin secretion by glucagon","volume":"i","author":"Samols","year":"1965","journal-title":"Lancet"},{"key":"10.1016\/j.peptides.2017.08.002_bib0295","unstructured":"E. Samol, V. Marks, Nouvelles conceptions sur la signification fonctionelle du glucagon (pancreatique et extra-pancreatique)\u2014Journees de Diabetologie de 1'Hotel\u2014Dieu, Paris. Editions Medicales Flammarion, 1967, p. 43\u201366."},{"issue":"1","key":"10.1016\/j.peptides.2017.08.002_bib0300","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00253866","article-title":"The effect of glucose-dependent insulinotropic polypeptide infused at physiological concentrations on the release of insulin in man","volume":"22","author":"Sarson","year":"1982","journal-title":"Diabetologia"},{"issue":"9","key":"10.1016\/j.peptides.2017.08.002_bib0305","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/BF00291980","article-title":"Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets","volume":"28","author":"Schmidt","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.peptides.2017.08.002_bib0310","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1172\/JCI103412","article-title":"The effect of glucagon on the blood glucose level and the clinical state in the presence of marked insulin hypoglycemia","volume":"36","author":"Schulman","year":"1957","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.peptides.2017.08.002_bib0315","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2337\/diab.21.9.955","article-title":"Drug-induced hypoglycemia: a review based on 473 cases","volume":"21","author":"Seltzer","year":"1972","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2017.08.002_bib0320","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1073\/pnas.70.8.2321","article-title":"Isolation of a glucagon-containing peptide; primary structure of a possible fragment of proglucagon","volume":"70","author":"Tager","year":"1973","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.peptides.2017.08.002_bib0325","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0021-9258(18)57183-0","article-title":"Origin and distribution of the hyperglycemic-glycogenolytic factor of the pancreas","volume":"175","author":"Sutherland","year":"1948","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2017.08.002_bib0330","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1055\/s-0028-1095149","article-title":"Intestinal hormones and insulin release: in vitro studies using the rabbit pancreas","volume":"1","author":"Turner","year":"1969","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.peptides.2017.08.002_bib0335","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1210\/endo-93-6-1323","article-title":"The effect of an intestinal polypeptide fraction on insulin release in the rat in vitro and in vivo","volume":"93","author":"Turner","year":"1973","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2017.08.002_bib0340","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0140-6736(72)91431-6","article-title":"Enhancement of glucose-stimulated insulin release by an intestinal polypeptide in rats","volume":"1","author":"Turner","year":"1972","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.peptides.2017.08.002_bib0345","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1172\/JCI104525","article-title":"Measurements of endogenous glucagon in plasma and the influence of blood glucose concentration upon its secretion","volume":"41","author":"Unger","year":"1962","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.peptides.2017.08.002_bib0350","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1001\/archinte.1969.00300130043007","article-title":"Entero-insular axis","volume":"123","author":"Unger","year":"1969","journal-title":"Arch. Intern. Med."},{"issue":"4","key":"10.1016\/j.peptides.2017.08.002_bib0355","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1172\/JCI105565","article-title":"The effects of secretin, pancreozymin, and gastrin on insulin and glucagon secretion in anesthetized dogs","volume":"46","author":"Unger","year":"1967","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.peptides.2017.08.002_bib0360","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/00000441-196806000-00007","article-title":"Demonstration and characterization of a second fraction of glucagon-like immunoreactivity in jejunal extracts","volume":"255","author":"Valverde","year":"1968","journal-title":"Am. J. Med. Sci."},{"issue":"19","key":"10.1016\/j.peptides.2017.08.002_bib0365","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1021\/ja00852a052","article-title":"Synthesis of the tritetracontapeptide corresponding to the entire amino acid sequence of gastric inhibitory polypeptide","volume":"97","author":"Yajima","year":"1975","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.peptides.2017.08.002_bib0370","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1172\/JCI104130","article-title":"Immunoassay of endogenous plasma insulin","volume":"39","author":"Yalow","year":"1960","journal-title":"J. Clin. Invest."},{"issue":"Suppl. 21","key":"10.1016\/j.peptides.2017.08.002_bib0375","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1038\/1841648b0","article-title":"An assay of plasma insulin in human subjects by immunological methods","volume":"84","author":"Yalow","year":"1959","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.peptides.2017.08.002_bib0380","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2337\/diab.10.5.339","article-title":"Immunoassay of plasma insulin in man","volume":"10","author":"Yalow","year":"1961","journal-title":"Diabetes"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978117302528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978117302528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:27:59Z","timestamp":1759310879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978117302528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":76,"alternative-id":["S0196978117302528"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2017.08.002","relation":{},"ISSN":["0196-9781"],"issn-type":[{"type":"print","value":"0196-9781"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rebirth of the Incretin Concept: Its conception and early development","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2017.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}