{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:07:20Z","timestamp":1770044840398,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400298"],"award-info":[{"award-number":["81400298"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570360"],"award-info":[{"award-number":["81570360"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of Science and Technology of Jilin Province","award":["20160101130JC"],"award-info":[{"award-number":["20160101130JC"]}]},{"name":"Project of Science and Technology of Jilin Province","award":["20170622012JC"],"award-info":[{"award-number":["20170622012JC"]}]},{"name":"Program for Development and Reform Commission of Jilin Province","award":["2016C026"],"award-info":[{"award-number":["2016C026"]}]},{"name":"Jilin Provincial Health and Family Planning Commission","award":["20152001"],"award-info":[{"award-number":["20152001"]}]},{"name":"Bethune program of jilin university","award":["2015303"],"award-info":[{"award-number":["2015303"]}]},{"name":"Bethune program of jilin university","award":["2015308"],"award-info":[{"award-number":["2015308"]}]},{"name":"program of First Hospital of jilin university","award":["JDYYZX2015001"],"award-info":[{"award-number":["JDYYZX2015001"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.peptides.2017.10.018","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T22:30:28Z","timestamp":1509834628000},"page":"27-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Ghrelin suppresses cardiac fibrosis of post-myocardial infarction heart failure rats by adjusting the activin A-follistatin imbalance"],"prefix":"10.1016","volume":"99","author":[{"given":"Chunyan","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsha","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beibei","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2017.10.018_bib0005","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.pharmtox.45.120403.095802","article-title":"The cardiac fibroblast: therapeutic target in myocardial remodeling and failure","volume":"45","author":"Brown","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"11","key":"10.1016\/j.peptides.2017.10.018_bib0010","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1253\/circj.CJ-16-1003","article-title":"Defining the cardiac fibroblast","volume":"80","author":"Ivey","year":"2016","journal-title":"Circ. J."},{"issue":"2","key":"10.1016\/j.peptides.2017.10.018_bib0015","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.yexmp.2016.09.002","article-title":"The role of cardiac fibroblasts in post-myocardial heart tissue repair","volume":"101","author":"Chistiakov","year":"2016","journal-title":"Exp. Mol. Pathol."},{"issue":"10","key":"10.1016\/j.peptides.2017.10.018_bib0020","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1253\/circj.CJ-16-0815","article-title":"Heart development, diseases, and regeneration- new approaches from innervation, fibroblasts, and reprogramming","volume":"80","author":"Ieda","year":"2016","journal-title":"Circ. J."},{"key":"10.1016\/j.peptides.2017.10.018_bib0025","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S1043-2760(00)00362-3","article-title":"Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor","volume":"12","author":"Kojima","year":"2001","journal-title":"Trends Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.peptides.2017.10.018_bib0030","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/CRD.0000000000000113","article-title":"Ghrelin and the cardiovascular system","volume":"24","author":"Lilleness","year":"2016","journal-title":"Cardiol. Rev."},{"issue":"6","key":"10.1016\/j.peptides.2017.10.018_bib0035","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00395-003-0434-7","article-title":"Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart","volume":"98","author":"Frascarelli","year":"2003","journal-title":"Basic Res. Cardiol."},{"issue":"3","key":"10.1016\/j.peptides.2017.10.018_bib0040","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/HJH.0b013e328334327c","article-title":"Association of plasma acylated ghrelin with blood pressure and left ventricular mass in patients with metabolic syndrome","volume":"28","author":"Rodr\u00edguez","year":"2010","journal-title":"J. Hypertens."},{"issue":"12","key":"10.1016\/j.peptides.2017.10.018_bib0045","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1161\/hc3601.095575","article-title":"Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure","volume":"104","author":"Nagaya","year":"2001","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.peptides.2017.10.018_bib0050","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1161\/01.CIR.0000149746.62908.BB","article-title":"Effects of ghrelin administration on left ventricular function,exercise capacity, and muscle wasting in patients with chronic heart failure","volume":"110","author":"Nagaya","year":"2004","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.peptides.2017.10.018_bib0055","doi-asserted-by":"crossref","first-page":"e00064","DOI":"10.1002\/prp2.64","article-title":"Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy","volume":"2","author":"Du CK","year":"2014","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.peptides.2017.10.018_bib0060","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1476-7120-9-43","article-title":"The effect of endogenously released glucose, insulin, glucagon-like peptide 1, ghrelin on cardiac output, heart rate, stroke volume, and blood pressure","volume":"9","author":"Hlebowicz","year":"2011","journal-title":"Cardiovasc. Ultrasound"},{"key":"10.1016\/j.peptides.2017.10.018_bib0065","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.peptides.2013.02.003","article-title":"Chronic central ghrelin infusion reduces blood pressure and heart rate despite increasing appetite and promoting weight gain in normotensive and hypertensive rats","volume":"42","author":"John Freeman","year":"2013","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.peptides.2017.10.018_bib0070","doi-asserted-by":"crossref","first-page":"e85785","DOI":"10.1371\/journal.pone.0085785","article-title":"Ping yang mechanisms of ghrelin anti-Heart failure: inhibition of ang II-Induced cardiomyocyte apoptosis by down-Regulating AT1R expression","volume":"9","author":"Yang","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.peptides.2017.10.018_bib0075","first-page":"71","article-title":"attenuates collagen production in lesional fibroblasts from patients with systemic sclerosis","volume":"147","author":"Ota","year":"2013","journal-title":"Immunol"},{"key":"10.1016\/j.peptides.2017.10.018_bib0080","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fnmol.2016.00032","article-title":"Activin signaling in the pathogenesis and therapy of neuropsychiatric diseases","volume":"9","author":"Link","year":"2016","journal-title":"Front. Mol. Neurosci."},{"issue":"10","key":"10.1016\/j.peptides.2017.10.018_bib0085","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/cea.12561","article-title":"The immunoregulatory and fibrotic roles of activin A in allergic asthma","volume":"45","author":"Hardy","year":"2015","journal-title":"Clin. Exp. Allergy"},{"issue":"4944","key":"10.1016\/j.peptides.2017.10.018_bib0090","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1126\/science.2106159","article-title":"Activin-binding protein from rat ovary is follistatin","volume":"247","author":"Nakamura","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.peptides.2017.10.018_bib0095","doi-asserted-by":"crossref","first-page":"376191","DOI":"10.1155\/2014\/376191","article-title":"Follistatin, an activin antagonist, ameliorates renal interstitial fibrosis in a rat model of unilateral ureteral obstruction","volume":"2014","author":"Maeshima","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"6","key":"10.1016\/j.peptides.2017.10.018_bib0100","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1586\/17476348.2015.1098537","article-title":"The potential role of activin and follistatin in lung transplant dysfunction","volume":"9","author":"Snell","year":"2015","journal-title":"Expert Rev Respir Med."},{"issue":"1-2","key":"10.1016\/j.peptides.2017.10.018_bib0105","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mce.2011.10.009","article-title":"The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair","volume":"359","author":"de Kretser","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.peptides.2017.10.018_bib0110","doi-asserted-by":"crossref","first-page":"33677","DOI":"10.1038\/srep33677","article-title":"Ramipril attenuates left ventricular remodeling by regulating the expression of activin A-follistatin in a rat model of heart failure","volume":"6","author":"Wei","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.peptides.2017.10.018_bib0115","doi-asserted-by":"crossref","first-page":"E374","DOI":"10.3390\/ijms18020374","article-title":"Effects of the activin A-Follistatin system on myocardial cell apoptosis through the endoplasmic reticulum stress pathway in heart failure","volume":"18","author":"Liu","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2017.10.018_bib0120","first-page":"27","article-title":"Quantitative analysis of orphan G protein-coupled receptor mRNAs by TaqMan Real-Time PCR: G2A and GPR4 lysophospholipid receptor expression in leukocytes and in a rat myocardial infarction-heart failure model","volume":"306","author":"Douglas","year":"2005","journal-title":"Methods Mol. Biol."},{"issue":"6","key":"10.1016\/j.peptides.2017.10.018_bib0125","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","article-title":"Cardiac fibrosis: the fibroblast awakens","volume":"118","author":"Travers","year":"2016","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.peptides.2017.10.018_bib0130","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00109-015-1314-y","article-title":"Cardiac fibroblasts: from development to heart failure","volume":"93","author":"Moore-Morris","year":"2015","journal-title":"J. Mol. Med. (Berl)."},{"key":"10.1016\/j.peptides.2017.10.018_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2015.12.031","article-title":"Origins of cardiac fibroblasts","volume":"91","author":"Moore-Morris","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.peptides.2017.10.018_bib0140","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrcardio.2009.199","article-title":"Myocardial remodeling after infarction: the role of myofibroblasts","volume":"7","author":"Van Den Borne","year":"2010","journal-title":"Nat. Rev. Cardiol."},{"issue":"5","key":"10.1016\/j.peptides.2017.10.018_bib0145","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/FJC.0b013e31824a7b60","article-title":"Ghrelin protects H9c2 cardiomyocytes from angiotensin II-induced apoptosis through the endoplasmic reticulum stress pathway","volume":"59","author":"Yang","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.peptides.2017.10.018_bib0150","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11033-017-4098-z","article-title":"Ghrelin protected neonatal rat cardiomyocyte against hypoxia\/reoxygenation injury by inhibiting apoptosis through Akt-mTOR signal","volume":"44","author":"Wang","year":"2017","journal-title":"Mol. Biol. Rep."},{"issue":"2","key":"10.1016\/j.peptides.2017.10.018_bib0155","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0008-6363(00)00030-4","article-title":"Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis","volume":"46","author":"MacKenna","year":"2000","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.peptides.2017.10.018_bib0160","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2174\/1871529X11313020010","article-title":"Oxidative stress and transforming growth factor-\u03b21-induced cardiac fibrosis","volume":"13","author":"Purnomo","year":"2013","journal-title":"Cardiovasc. Hematol. Disord. Drug Targets"},{"issue":"7","key":"10.1016\/j.peptides.2017.10.018_bib0165","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/CIRCRESAHA.116.305381","article-title":"Getting to the heart of the matter: new insights into cardiac fibrosis","volume":"116","author":"Leask","year":"2015","journal-title":"Circ. Res."},{"issue":"29","key":"10.1016\/j.peptides.2017.10.018_bib0170","doi-asserted-by":"crossref","first-page":"19432","DOI":"10.1016\/S0021-9258(18)55015-8","article-title":"Follistatin, an activin-binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells","volume":"266","author":"Nakamura","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"21","key":"10.1016\/j.peptides.2017.10.018_bib0175","doi-asserted-by":"crossref","first-page":"13835","DOI":"10.1074\/jbc.272.21.13835","article-title":"A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells: endocytotic degradation of activin and its acceleration by Follistatin associated with cell-surface heparan sulfate","volume":"272","author":"Hashimoto","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.peptides.2017.10.018_bib0180","first-page":"2205","article-title":"Lipopolysaccharide induced activin A-follistatin imbalance affects cardiac fibrosis","volume":"125","author":"Zhang","year":"2012","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.peptides.2017.10.018_bib0185","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.peptides.2017.10.018_bib0190","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1242\/jcs.094151","article-title":"The role and mechanism of action of activin A in neurite outgrowth of chicken embryonic dorsal root ganglia","volume":"125","author":"Fang","year":"2012","journal-title":"J. Cell Sci."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978117303315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978117303315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T13:11:03Z","timestamp":1659791463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978117303315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":38,"alternative-id":["S0196978117303315"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2017.10.018","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ghrelin suppresses cardiac fibrosis of post-myocardial infarction heart failure rats by adjusting the activin A-follistatin imbalance","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2017.10.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}