{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:06:31Z","timestamp":1761419191421,"version":"build-2065373602"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"CF Trust","award":["SRC007"],"award-info":[{"award-number":["SRC007"]}]},{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Professor Tony Bjourson from the European Union Regional Development Fund"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.peptides.2017.11.014","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T19:46:35Z","timestamp":1517600795000},"page":"212-218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Role of islet peptides in beta cell regulation and type 2 diabetes therapy"],"prefix":"10.1016","volume":"100","author":[{"given":"Dawood","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte R.","family":"Moffet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Flatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2017.11.014_bib0005","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1113\/expphysiol.2006.034835","article-title":"Physiological regulation of the pancreatic \u03b2-cell: functional insights for understanding and therapy of diabetes","volume":"92","author":"McClenaghan","year":"2007","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.peptides.2017.11.014_bib0010","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4161\/isl.2.3.11815","article-title":"Pancreatic islet plasticity: interspecies comparison of islet architecture and composition","volume":"2","author":"Steiner","year":"2010","journal-title":"Islets"},{"key":"10.1016\/j.peptides.2017.11.014_bib0015","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cmet.2011.06.004","article-title":"Islets have a lot of nerve! or do they","volume":"14","author":"Taborsky","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2017.11.014_bib0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cmet.2011.05.008","article-title":"Innervation patterns of autonomic axons in the human endocrine pancreas","volume":"14","author":"Rodriguez-Diaz","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2017.11.014_bib0025","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s001250051322","article-title":"Autonomic regulation of islet hormone secretion?implications for health and disease","volume":"43","author":"Ahr\u00e9n","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.peptides.2017.11.014_bib0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1463-1326.2009.01102.x","article-title":"Cell\u2013cell interactions in the endocrine pancreas","volume":"11","author":"Jain","year":"2009","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.peptides.2017.11.014_bib0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4161\/isl.3.2.14805","article-title":"Role of islet structure and cellular interactions in the control of insulin secretion","volume":"3","author":"Kelly","year":"2011","journal-title":"Islets"},{"issue":"3","key":"10.1016\/j.peptides.2017.11.014_bib0040","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0092-8674(00)81282-9","article-title":"The gap junction communication channel","volume":"84","author":"Kumar","year":"1996","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.peptides.2017.11.014_bib0045","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1161\/01.RES.0000225911.24228.9c","article-title":"Identification of a novel peptide that interferes with the chemical regulation of connexin43","volume":"98","author":"Shibayama","year":"2006","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.peptides.2017.11.014_bib0050","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1042\/BJ20051922","article-title":"Life cycle of connexins in health and disease","volume":"394","author":"Laird","year":"2006","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.peptides.2017.11.014_bib0055","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nrc1276","article-title":"Cell adhesion and signalling by cadherins and Ig-CAMs in cancer","volume":"4","author":"Cavallaro","year":"2004","journal-title":"Nature Rev. Cancer"},{"issue":"5","key":"10.1016\/j.peptides.2017.11.014_bib0060","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1159\/000107545","article-title":"E-cadherin interactions regulate beta-Cell proliferation in islet-like structures","volume":"20","author":"Carvell","year":"2007","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.peptides.2017.11.014_bib0065","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/bies.20033","article-title":"The cadherin-catenin complex as a focal point of cell adhesion and signalling: new insights from three-dimensional structures","volume":"26","author":"Gooding","year":"2004","journal-title":"Bioessays"},{"issue":"9","key":"10.1016\/j.peptides.2017.11.014_bib0070","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1242\/dev.122.9.2895","article-title":"Cadherins regulate aggregation of pancreatic beta-cells in vivo","volume":"122","author":"Dahl","year":"1996","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.peptides.2017.11.014_bib0075","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2337\/diabetes.51.1.114","article-title":"Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes","volume":"51","author":"Yamagata","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2017.11.014_bib0080","series-title":"Intercellular Communication and Insulin Secretion. In: Contributions of Physiology to the Understanding of Diabetes; Ten Essays in Memory of Albert E. Reynolds","first-page":"24","author":"Meda","year":"1997"},{"issue":"7","key":"10.1016\/j.peptides.2017.11.014_bib0085","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2337\/diab.36.7.783","article-title":"Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets","volume":"36","author":"Halban","year":"1987","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.peptides.2017.11.014_bib0090","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1210\/endo-117-5-2073","article-title":"Structure-function relationships in pancreatic islets: support for intraislet modulation of insulin secretion","volume":"117","author":"Hopcroft","year":"1985","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.peptides.2017.11.014_bib0095","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0014-4827(89)90365-0","article-title":"Homologous but not heterologous contact increases the insulin secretion of individual pancreatic B-cells","volume":"184","author":"Bosco","year":"1989","journal-title":"Exp. Cell Res."},{"issue":"6","key":"10.1016\/j.peptides.2017.11.014_bib0100","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1073\/pnas.062605899","article-title":"Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta","volume":"99","author":"Shih","year":"2002","journal-title":"Proc. National Acad. Sci. U. S. A."},{"issue":"4\u20136","key":"10.1016\/j.peptides.2017.11.014_bib0105","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/cac.10.4-6.431.435","article-title":"Cx36 involvement in insulin secretion: characteristics and mechanism","volume":"10","author":"Meda","year":"2003","journal-title":"Cell Commun. Adhes."},{"issue":"7","key":"10.1016\/j.peptides.2017.11.014_bib0110","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.2337\/diabetes.48.7.1402","article-title":"Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets","volume":"48","author":"Hauge-Evans","year":"1999","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.peptides.2017.11.014_bib0115","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1097\/MPA.0b013e3181dafaa2","article-title":"Comparison of insulinrelease from MIN6 pseudoislets and pancreatic islets of Langerhans reveals importance of homotypic cell interactions","volume":"39","author":"Kelly","year":"2010","journal-title":"Pancreas"},{"key":"10.1016\/j.peptides.2017.11.014_bib0120","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/glia.10350","article-title":"Astrocyte cultures from conditional connexin43-deficient mice","volume":"46","author":"Theis","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.peptides.2017.11.014_bib0125","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1139\/y04-133","article-title":"Co-expression and regulation of connexins 36 and 43 in cultured neonatal rat pancreatic islets","volume":"83","author":"Leite","year":"2005","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.peptides.2017.11.014_bib0130","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.2337\/diabetes.54.6.1789","article-title":"Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells","volume":"54","author":"Ravier","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2017.11.014_bib0135","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/hmg\/ddn370","article-title":"Cx36 makes chan- nels coupling human pancreatic beta-cells, and correlates with insulin expression","volume":"18","author":"Serre-Beinier","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"7","key":"10.1016\/j.peptides.2017.11.014_bib0140","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.2337\/db11-1312","article-title":"Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse","volume":"61","author":"Head","year":"2012","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.peptides.2017.11.014_bib0145","doi-asserted-by":"crossref","first-page":"E144","DOI":"10.1152\/ajpendo.00489.2011","article-title":"Impaired \u03b2-cell-\u03b2-cell coupling mediated by Cx36 gap junctions in prediabetic mice","volume":"303","author":"Carvalho","year":"2012","journal-title":"Am. J. Physiology Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.peptides.2017.11.014_bib0150","doi-asserted-by":"crossref","first-page":"e0150880","DOI":"10.1371\/journal.pone.0150880","article-title":"A variant of GJD2, encoding for connexin 36, alters the function of insulin producing \u03b2-Cells","volume":"11","author":"Cigliola","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2017.11.014_bib0155","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1172\/JCI110464","article-title":"Functional differences between rat islets of ventral and dorsal pancreatic origin","volume":"69","author":"Trimble","year":"1982","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.peptides.2017.11.014_bib0160","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.bbrc.2015.11.028","article-title":"Autocrine insulin increases plasma membrane K(ATP) channel via PI3K-VAMP2 pathway in MIN6 cells","volume":"468","author":"Xu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.peptides.2017.11.014_bib0165","doi-asserted-by":"crossref","first-page":"960","DOI":"10.2337\/db16-1291","article-title":"Reestablishment of glucose inhibition of glucagon secretion in small pseudoislets","volume":"66","author":"Reissaus","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2017.11.014_bib0170","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/B978-0-12-800174-5.00007-7","article-title":"The somatostatin receptor in human pancreatic \u03b2-cells","volume":"95","author":"Braun","year":"2014","journal-title":"Vitamin Hormone"},{"issue":"6","key":"10.1016\/j.peptides.2017.11.014_bib0175","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4161\/isl.2.6.13858","article-title":"A role for islet somatostatin in mediating sympathetic regulation of glucagon secretion","volume":"2","author":"Hauge-Evans","year":"2010","journal-title":"Islets"},{"issue":"2","key":"10.1016\/j.peptides.2017.11.014_bib0180","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3109\/03009734.2016.1156789","article-title":"Glucagon secretion from pancreatic \u03b1-cells","volume":"121","author":"Briant","year":"2016","journal-title":"Ups. J. Med. Sci."},{"key":"10.1016\/j.peptides.2017.11.014_bib0185","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.bbagen.2017.01.005","article-title":"Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival","volume":"4","author":"Khan","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA)-General Subjects"},{"key":"10.1016\/j.peptides.2017.11.014_bib0190","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.peptides.2017.07.011","article-title":"Differential expression of glucagon-like peptide-2 (glp-2) is involved in pancreatic islet cell adaptations to stress and beta-cell survival","volume":"95","author":"Khan","year":"2017","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2017.11.014_bib0195","doi-asserted-by":"crossref","DOI":"10.1515\/hsz-2017-0136","article-title":"Locally produced xenin and the neurotensinergic system in pancreatic islet function and \u03b2 -cell survival","author":"Khan","year":"2017","journal-title":"Biol. Chem."},{"key":"10.1016\/j.peptides.2017.11.014_bib0200","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mce.2016.07.020","article-title":"Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival","volume":"436","author":"Khan","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.peptides.2017.11.014_bib0205","doi-asserted-by":"crossref","first-page":"e96863","DOI":"10.1371\/journal.pone.0096863","article-title":"Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta-cell adaptation to pregnancy","volume":"9","author":"Moffett","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2017.11.014_bib0210","doi-asserted-by":"crossref","first-page":"e101005","DOI":"10.1371\/journal.pone.0101005","article-title":"Role of endogenous GLP-1 and GIP in beta-cell compensatory responses to insulin resistance and cellular stress","volume":"9","author":"Vasu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2017.11.014_bib0215","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF00492251","article-title":"Electronimmunocytochemical evidence for the K cell localization of gastric inhibitory polypeptide (GIP) in man","volume":"56","author":"Buchan","year":"1978","journal-title":"Histochemistry"},{"key":"10.1016\/j.peptides.2017.11.014_bib0220","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1073\/pnas.84.10.3434","article-title":"Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line","volume":"84","author":"Drucker","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.peptides.2017.11.014_bib0225","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1053\/j.gastro.2007.03.054","article-title":"Biology of incretins: GLP-1 and GIP","volume":"132","author":"Baggio","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.peptides.2017.11.014_bib0230","doi-asserted-by":"crossref","first-page":"11050","DOI":"10.1074\/jbc.M601203200","article-title":"Prohormone convertase 1\/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor","volume":"281","author":"Ugleholdt","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2017.11.014_bib0235","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.cmet.2013.04.008","article-title":"Pharmacology, physiology, and mechanisms of incretin hormone action","volume":"17","author":"Campbell","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2017.11.014_bib0240","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.4239\/wjd.v6.i15.1285","article-title":"New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders","volume":"6","author":"Irwin","year":"2015","journal-title":"World J. Diabetes"},{"issue":"3","key":"10.1016\/j.peptides.2017.11.014_bib0245","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejim.2013.01.009","article-title":"Incretin-based therapies in the treatment of type 2 diabetes\u2013more than meets the eye","volume":"24","author":"Labuzek","year":"2013","journal-title":"Eur. J. Internal Med."},{"issue":"7","key":"10.1016\/j.peptides.2017.11.014_bib0250","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1080\/13543776.2016.1192130","article-title":"Exendins and exendin analogs for diabetic therapy: a patent review (2012\u20132015)","volume":"26","author":"Park","year":"2016","journal-title":"Exp. Opin.Ther. Patents"},{"issue":"2","key":"10.1016\/j.peptides.2017.11.014_sbref0255a","doi-asserted-by":"crossref","first-page":"e90093","DOI":"10.1371\/journal.pone.0090093","article-title":"Chronic exposure to GLP-1 increases GLP-1 synthesis and release in a pancreatic alpha cell line (\u03b1-TC1): evidence of a direct effect of GLP-1 on pancreatic alpha cells","volume":"28","author":"Piro","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2017.11.014_sbref0255b","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/BF00400941","article-title":"Mechanisms underlying the insulinostatic effect of peptide YY in mouse pancreatic islets","volume":"37","author":"Nieuwenhuizen","year":"1994","journal-title":"Diabetologia"},{"key":"10.1016\/j.peptides.2017.11.014_bib0260","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF02917449","article-title":"Physiological concentrations of oxytocin powerfully stimulate insulin secretionin vitro","volume":"3","author":"Bobbioni-Harsch","year":"1995","journal-title":"Endocrine"},{"key":"10.1016\/j.peptides.2017.11.014_bib0265","doi-asserted-by":"crossref","first-page":"19420","DOI":"10.1073\/pnas.1310953110","article-title":"Serotonin regulates glucose-stimulated insulin secretion from pancreatic beta cells during pregnancy","volume":"110","author":"Ohara-Imaizumi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.peptides.2017.11.014_bib0270","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nm.3872","article-title":"Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion","volume":"21","author":"Van Der Meulen","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.peptides.2017.11.014_bib0275","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1399-5448.2007.00272.x","article-title":"Effects of beta-cell rest on beta-cell function: a review of clinical and preclinical data","volume":"9","author":"Brown","year":"2008","journal-title":"Pediatr. Diabetes"},{"key":"10.1016\/j.peptides.2017.11.014_bib0280","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/35073601","article-title":"Neuropeptide Y functions as a neuroproliferative factor","volume":"410","author":"Hansel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2017.11.014_bib0285","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.nbd.2006.12.014","article-title":"Laskowski A & Gray WP. Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus","volume":"26","author":"Howell","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.peptides.2017.11.014_bib0290","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1007\/s00125-014-3292-y","article-title":"Peptide YY: More than just an appetite regulator","volume":"57","author":"Persaud","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.peptides.2017.11.014_bib0295","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1021\/cb900038e","article-title":"Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors","volume":"4","author":"Myers","year":"2009","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.peptides.2017.11.014_bib0300","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3390\/cells2010124","article-title":"The anti-apoptotic role of neurotensin","volume":"2","author":"Devader","year":"2013","journal-title":"Cells"},{"key":"10.1016\/j.peptides.2017.11.014_bib0305","doi-asserted-by":"crossref","first-page":"686","DOI":"10.2337\/diabetes.51.3.686","article-title":"Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue","volume":"51","author":"Rooman","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2017.11.014_bib0310","first-page":"464","article-title":"Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats","volume":"5","author":"Kuntz","year":"2004","journal-title":"J. Pancreas"},{"key":"10.1016\/j.peptides.2017.11.014_bib0315","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1749-6632.2010.05802.x","article-title":"Gastrointestinal hormones and the regulation of \u03b2-cell mass","volume":"1212","author":"Lavine","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.peptides.2017.11.014_bib0320","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nm.2173","article-title":"Serotonin regulates pancreatic beta cell mass during pregnancy","volume":"16","author":"Kim","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.peptides.2017.11.014_bib0325","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1053\/j.gastro.2012.04.047","article-title":"Selective ablation of peptide YY cells in adult mice reveals their role in beta cell survival","volume":"143","author":"Sam","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.peptides.2017.11.014_bib0330","doi-asserted-by":"crossref","first-page":"e0140148","DOI":"10.1371\/journal.pone.0140148","article-title":"Beta cell mass restoration in alloxan-diabetic mice treated with EGF and gastrin","volume":"10","author":"Song","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2017.11.014_bib0335","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5115\/acb.2015.48.1.16","article-title":"Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids","volume":"48","author":"Oh","year":"2015","journal-title":"Anatomy Cell Biol."},{"key":"10.1016\/j.peptides.2017.11.014_bib0340","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1177\/193229681000400607","article-title":"The physiology of glucagon","volume":"4","author":"Taborsky","year":"2010","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.peptides.2017.11.014_bib0345","series-title":"Insulin Action: Molecular Basis of Diabetes","first-page":"2001","author":"Najjar","year":"2016"},{"key":"10.1016\/j.peptides.2017.11.014_bib0350","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.2337\/db12-1001","article-title":"Conversion of mature human beta-cells into glucagon-producing alpha-cells","volume":"62","author":"Spijker","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2017.11.014_bib0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/496904","article-title":"Connexins and diabetes","volume":"2012","author":"Wright","year":"2012","journal-title":"Cardiol. Res. Practice"},{"key":"10.1016\/j.peptides.2017.11.014_bib0360","article-title":"\u03b4-cells and \u03b2-cells are electrically coupled and regulate \u03b1-cell activity via somatostatin","author":"Briant","year":"2017","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.peptides.2017.11.014_bib0365","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2298\/JMH0402179K","article-title":"The serum levels somatostatin in type 2 diabetes mellitus","volume":"23","author":"Kosti\u0107","year":"2004","journal-title":"Jugoslovenska Medicinska Biohemija"},{"key":"10.1016\/j.peptides.2017.11.014_bib0370","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.2337\/db13-0164","article-title":"Somatostatin receptor type 2 antagonism improves glucagon counterregulation in biobreeding diabetic rats","volume":"62","author":"Karimian","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2017.11.014_bib0375","first-page":"69","article-title":"Genetics of type 2 diabetes mellitus","volume":"6","author":"So","year":"2000","journal-title":"Hong Kong Med. J."},{"key":"10.1016\/j.peptides.2017.11.014_bib0380","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0002-9149(02)02553-5","article-title":"Insulin resistance as the core defect in type 2 diabetes mellitus","volume":"90","author":"Goldstein","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.peptides.2017.11.014_bib0385","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2337\/diabetes.48.2.241","article-title":"Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes","volume":"48","author":"Kahn","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2017.11.014_bib0390","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2362.32.s3.5.x","article-title":"The evolution of \u03b2-cell dysfunction and insulin resistance in type 2 diabetes","volume":"32","author":"Bergman","year":"2002","journal-title":"Eur. J. Clin. Invest."},{"issue":"Suppl. 2","key":"10.1016\/j.peptides.2017.11.014_bib0395","doi-asserted-by":"crossref","first-page":"S279","DOI":"10.2337\/dc11-s231","article-title":"Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability","volume":"34","author":"Garber","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.peptides.2017.11.014_bib0400","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1365-2796.1996.377740000.x","article-title":"Diabetes mellitus and impaired pancreatic \u03b2-cell proliferation","volume":"239","author":"\u00c5","year":"1996","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.peptides.2017.11.014_bib0405","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.2337\/db12-0018","article-title":"Human beta-cell proliferation and intracellular signaling: driving in the dark without a road map","volume":"61","author":"Kulkarni","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2017.11.014_bib0410","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/jdi.12475","article-title":"\u03b2-Cell regeneration through the transdifferentiation of pancreatic cells: pancreatic progenitor cells in the pancreas","volume":"7","author":"Kim","year":"2016","journal-title":"J. Diabetes Invest."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978117303601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978117303601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:27:00Z","timestamp":1759310820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978117303601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":83,"alternative-id":["S0196978117303601"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2017.11.014","relation":{},"ISSN":["0196-9781"],"issn-type":[{"type":"print","value":"0196-9781"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of islet peptides in beta cell regulation and type 2 diabetes therapy","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2017.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2017 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}