{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:16:34Z","timestamp":1773119794879,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.peptides.2018.08.008","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T12:24:46Z","timestamp":1535804686000},"page":"25-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Effects of angiotensin-(1\u20137) and angiotensin II on vascular tone in human cirrhotic splanchnic vessels"],"prefix":"10.1016","volume":"108","author":[{"given":"Stephen","family":"Casey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandana","family":"Herath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indu","family":"Rajapaksha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Angus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.peptides.2018.08.008_bib0005","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cld.2013.12.001","article-title":"Pathophysiology of portal hypertension","volume":"18","author":"Iwakiri","year":"2014","journal-title":"Clin. Liver Dis."},{"issue":"10","key":"10.1016\/j.peptides.2018.08.008_bib0010","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.3748\/wjg.v20.i10.2555","article-title":"Splanchnic vasodilation and hyperdynamic circulatory syndrome in cirrhosis","volume":"20","author":"Bolognesi","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.peptides.2018.08.008_bib0015","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/hep.1840200635","article-title":"Increased nitric oxide-dependent vasorelaxation in aortic rings of cirrhotic rats with ascites","volume":"20","author":"Claria","year":"1994","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.peptides.2018.08.008_bib0020","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1124\/jpet.106.116665","article-title":"Carbon monoxide-mediated activation of large-conductance calcium-activated potassium channels contributes to mesenteric vasodilatation in cirrhotic rats","volume":"321","author":"Bolognesi","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.peptides.2018.08.008_bib0025","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1042\/cs0910733","article-title":"Vascular hyporesponsiveness in aortic rings from cirrhotic rats: role of nitric oxide and endothelium","volume":"91","author":"Ortiz","year":"1996","journal-title":"Clin. Sci. (Lond.)"},{"issue":"3","key":"10.1016\/j.peptides.2018.08.008_bib0030","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1042\/cs0890227","article-title":"Vasodilatory responses of isolated arteries of cirrhotic rats","volume":"89","author":"Lee","year":"1995","journal-title":"Clin. Sci. (Lond.)"},{"issue":"4","key":"10.1016\/j.peptides.2018.08.008_bib0035","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1042\/cs0950505","article-title":"Contractile response of isolated human hepatic arteries to alpha-adrenoceptor agonists is not impaired in patients with cirrhosis","volume":"95","author":"Hadoke","year":"1998","journal-title":"Clin. Sci. (Lond.)"},{"issue":"8","key":"10.1016\/j.peptides.2018.08.008_bib0040","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1111\/j.1440-1746.2005.03946.x","article-title":"Vasoconstrictor responses are normal but prostanoid-mediated vasodilatation is enhanced in human cirrhotic mesenteric arteries","volume":"20","author":"Vaughan","year":"2005","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"10","key":"10.1016\/j.peptides.2018.08.008_bib0045","first-page":"1544","article-title":"Enhanced vascular responses to noradrenaline in isolated omental arteries from patients with advanced cirrhosis: evidence against intrinsic vascular hyporeactivity in cirrhosis","volume":"53","author":"Vaughan","year":"2004","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.peptides.2018.08.008_bib0050","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1136\/gut.2007.144584","article-title":"Mechanisms of extrahepatic vasodilation in portal hypertension","volume":"57","author":"Hennenberg","year":"2008","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.peptides.2018.08.008_bib0055","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1365-2362.2009.02181.x","article-title":"Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis","volume":"39","author":"Hennenberg","year":"2009","journal-title":"Eur. J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.peptides.2018.08.008_bib0060","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1113\/expphysiol.1995.sp003871","article-title":"The endothelial and non-endothelial mechanism responsible for attenuated vasoconstriction in cirrhotic rats","volume":"80","author":"Van Obbergh","year":"1995","journal-title":"Exp. Physiol."},{"issue":"3","key":"10.1016\/j.peptides.2018.08.008_bib0065","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1042\/cs0970313","article-title":"Relationship between vascular reactivity in vitro and blood flows in rats with cirrhosis","volume":"97","author":"Pateron","year":"1999","journal-title":"Clin. Sci. (Lond.)"},{"issue":"12","key":"10.1016\/j.peptides.2018.08.008_bib0070","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/j.1440-1746.1998.tb00614.x","article-title":"In vitro and in vivo vascular responses to the L-type calcium channel activator, Bay K 8644, in rats with cirrhosis","volume":"13","author":"Moreau","year":"1998","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.peptides.2018.08.008_bib0075","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0168-8278(01)00141-6","article-title":"Role of small-conductance Ca2+-dependent K+ channels in in vitro nitric oxide-mediated aortic hyporeactivity to alpha-adrenergic vasoconstriction in rats with cirrhosis","volume":"35","author":"Barriere","year":"2001","journal-title":"J. Hepatol."},{"issue":"15","key":"10.1016\/j.peptides.2018.08.008_bib0080","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.3748\/wjg.v11.i15.2306","article-title":"Vascular contractile response and signal transduction in endothelium-denuded aorta from cirrhotic rats","volume":"11","author":"Lin","year":"2005","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.peptides.2018.08.008_bib0085","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1053\/j.gastro.2005.11.029","article-title":"Defective RhoA\/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats","volume":"130","author":"Hennenberg","year":"2006","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.peptides.2018.08.008_bib0090","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/hep.21502","article-title":"Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins","volume":"45","author":"Hennenberg","year":"2007","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.peptides.2018.08.008_bib0095","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1053\/jhep.2001.28794","article-title":"Contractile hyporesponsiveness of hepatic arteries in humans with cirrhosis: evidence for a receptor-specific mechanism","volume":"34","author":"Schepke","year":"2001","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.peptides.2018.08.008_bib0100","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0016-5085(00)70263-0","article-title":"Role of angiotensin II in regulation of basal and sympathetically stimulated vascular tone in early and advanced cirrhosis","volume":"118","author":"Helmy","year":"2000","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.peptides.2018.08.008_bib0105","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0168-8278(02)00319-7","article-title":"Nitric oxide mediates the reduced vasoconstrictor response to angiotensin II in patients with preascitic cirrhosis","volume":"38","author":"Helmy","year":"2003","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.peptides.2018.08.008_bib0110","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/01.fjc.0000211727.23304.49","article-title":"Bradykinin does not contribute to peripheral vascular tone in patients with cirrhosis and ascites","volume":"47","author":"Helmy","year":"2006","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.peptides.2018.08.008_bib0115","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1136\/gut.2005.076562","article-title":"Inducible nitric oxide synthase activity contributes to the regulation of peripheral vascular tone in patients with cirrhosis and ascites","volume":"55","author":"Ferguson","year":"2006","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.peptides.2018.08.008_bib0120","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-12-0341","article-title":"Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system","volume":"216","author":"Santos","year":"2013","journal-title":"J. Endocrinol."},{"issue":"6","key":"10.1016\/j.peptides.2018.08.008_bib0125","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1161\/HYPERTENSIONAHA.113.01274","article-title":"Angiotensin-(1-7)","volume":"63","author":"Santos","year":"2014","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.peptides.2018.08.008_bib0130","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1053\/j.gastro.2013.06.036","article-title":"Activation of the mas receptor by angiotensin-(1-7) in the renin-angiotensin system mediates mesenteric vasodilation in cirrhosis","volume":"145","author":"Grace","year":"2013","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.peptides.2018.08.008_bib0135","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1476-5381.2009.00575.x","article-title":"Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats","volume":"159","author":"Bosnyak","year":"2010","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.peptides.2018.08.008_bib0140","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/mt.2015.92","article-title":"ACE2 therapy using adeno-associated viral vector inhibits liver fibrosis in mice","volume":"23","author":"Mak","year":"2015","journal-title":"Mol. Ther."},{"issue":"14","key":"10.1016\/j.peptides.2018.08.008_bib0145","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1161\/01.CIR.0000160867.23556.7D","article-title":"G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor","volume":"111","author":"Kostenis","year":"2005","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.peptides.2018.08.008_bib0150","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1152\/physrev.1990.70.4.921","article-title":"Structure and function of small arteries","volume":"70","author":"Mulvany","year":"1990","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.peptides.2018.08.008_bib0155","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2165\/11593640-000000000-00000","article-title":"How to assess microvascular structure in humans","volume":"18","author":"Rizzoni","year":"2011","journal-title":"High Blood Press. Cardiovasc. Prev."},{"issue":"2","key":"10.1016\/j.peptides.2018.08.008_bib0160","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.pharmthera.2010.11.001","article-title":"Endothelium-derived vasoactive agents, AT1 receptors and inflammation","volume":"131","author":"MacKenzie","year":"2011","journal-title":"Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.peptides.2018.08.008_bib0165","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/01.HYP.0000033224.99806.8A","article-title":"AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade","volume":"40","author":"Widdop","year":"2002","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.peptides.2018.08.008_bib0170","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/01.HYP.34.2.296","article-title":"Angiotensin-(1-7) is a modulator of the human renin-angiotensin system","volume":"34","author":"Roks","year":"1999","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.peptides.2018.08.008_bib0175","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10557-014-6555-4","article-title":"Angiotensin-(1-7) modulates angiotensin II-induced vasoconstriction in human mammary artery","volume":"28","author":"Mendonca","year":"2014","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"3","key":"10.1016\/j.peptides.2018.08.008_bib0180","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0196-9781(03)00062-7","article-title":"Characterization of angiotensin-(1-7) receptor subtype in mesenteric arteries","volume":"24","author":"Neves","year":"2003","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2018.08.008_bib0185","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.peptides.2017.02.001","article-title":"Angiotensin-(1-7)-dependent vasorelaxation of the renal artery exhibits unique angiotensin and bradykinin receptor selectivity","volume":"90","author":"Yousif","year":"2017","journal-title":"Peptides"},{"issue":"3","key":"10.1016\/j.peptides.2018.08.008_bib0190","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.peptides.2006.10.007","article-title":"Evidence for a new angiotensin-(1-7) receptor subtype in the aorta of Sprague-Dawley rats","volume":"28","author":"Silva","year":"2007","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.peptides.2018.08.008_bib0195","doi-asserted-by":"crossref","first-page":"G99","DOI":"10.1152\/ajpgi.00163.2012","article-title":"Angiotensin-(1-7) reduces the perfusion pressure response to angiotensin II and methoxamine via an endothelial nitric oxide-mediated pathway in cirrhotic rat liver","volume":"304","author":"Herath","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"4","key":"10.1016\/j.peptides.2018.08.008_bib0200","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1161\/01.HYP.35.4.998","article-title":"Angiotensin-(1-7) attenuates vasoconstriction evoked by angiotensin II but not by noradrenaline in man","volume":"35","author":"Ueda","year":"2000","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.peptides.2018.08.008_bib0205","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1161\/HYPERTENSIONAHA.106.084848","article-title":"Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells","volume":"50","author":"Sampaio","year":"2007","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.peptides.2018.08.008_bib0210","doi-asserted-by":"crossref","first-page":"11903","DOI":"10.1038\/s41598-017-12074-3","article-title":"Ang-(1-7) is an endogenous beta-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy","volume":"7","author":"Teixeira","year":"2017","journal-title":"Sci. Rep."},{"issue":"3 Pt 2","key":"10.1016\/j.peptides.2018.08.008_bib0215","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/01.HYP.27.3.523","article-title":"Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide","volume":"27","author":"Brosnihan","year":"1996","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.peptides.2018.08.008_bib0220","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1476-5381.1994.tb14787.x","article-title":"Release of nitric oxide by angiotensin-(1-7) from porcine coronary endothelium: implications for a novel angiotensin receptor","volume":"111","author":"Porsti","year":"1994","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.peptides.2018.08.008_bib0225","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1113\/jphysiol.2013.251413","article-title":"Complete blockade of the vasorelaxant effects of Ang-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas","volume":"591","author":"Peiro","year":"2013","journal-title":"J. Physiol."},{"issue":"Pt 9","key":"10.1016\/j.peptides.2018.08.008_bib0230","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1113\/jphysiol.2013.251413","article-title":"Complete blockade of the vasorelaxant effects of angiotensin-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas","volume":"591","author":"Peiro","year":"2013","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.peptides.2018.08.008_bib0235","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1161\/hy1201.096576","article-title":"Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats","volume":"38","author":"Carey","year":"2001","journal-title":"Hypertension"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978118301505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978118301505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T13:54:04Z","timestamp":1573221244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978118301505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":47,"alternative-id":["S0196978118301505"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2018.08.008","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of angiotensin-(1\u20137) and angiotensin II on vascular tone in human cirrhotic splanchnic vessels","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2018.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}