{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:50:41Z","timestamp":1773888641082,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.peptides.2019.170123","type":"journal-article","created":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T10:07:24Z","timestamp":1564826844000},"page":"170123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1\u03b1 and PPAR-\u03b3 pathway"],"prefix":"10.1016","volume":"121","author":[{"given":"Lamei","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Mun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gi-Ja","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhn Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.peptides.2019.170123_bib0005","first-page":"363","article-title":"Interrelation between nitric oxide and endothelin-1 in an experimental acute hypoxia in rats and its intervention","volume":"112","author":"Wang","year":"1999","journal-title":"Chin. Med. J."},{"issue":"2","key":"10.1016\/j.peptides.2019.170123_bib0010","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00005344-200402000-00010","article-title":"The role of endothelin in mediating ischemia\/ hypoxia-induced atrial natriuretic peptide release","volume":"43","author":"Zhang","year":"2004","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"3","key":"10.1016\/j.peptides.2019.170123_bib0015","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s12020-018-1529-0","article-title":"Regulation, signalling and functions of hormonal peptides in pulmonary vascular remodelling during hypoxia","volume":"59","author":"Gaur","year":"2018","journal-title":"Endocrine"},{"issue":"7","key":"10.1016\/j.peptides.2019.170123_bib0020","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2174\/156800910793605857","article-title":"Cancer therapy by targeting hypoxia-inducible factor-1","volume":"10","author":"Li","year":"2010","journal-title":"Curr. Cancer Drug Targets"},{"issue":"6","key":"10.1016\/j.peptides.2019.170123_bib0025","first-page":"393","article-title":"Targeting hypoxia in cancer therapy, nature reviews","volume":"11","author":"Wilson","year":"2011","journal-title":"Cancer"},{"issue":"7","key":"10.1016\/j.peptides.2019.170123_bib0030","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.kjms.2016.05.011","article-title":"Hypoxia-inducible factor-1alpha, vascular endothelial growth factor, inducible nitric oxide synthase, and endothelin-1 expression correlates with angiogenesis in congenital heart disease","volume":"32","author":"Yin","year":"2016","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"10","key":"10.1016\/j.peptides.2019.170123_bib0035","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0024-3205(03)00429-6","article-title":"ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia\/reperfusion injury","volume":"73","author":"Zhu","year":"2003","journal-title":"Life Sci."},{"issue":"5\u20136","key":"10.1016\/j.peptides.2019.170123_bib0040","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/BF00374574","article-title":"Contribution of prostaglandins in hypoxia-induced vasodilation in isolated rabbit hearts. Relation to adenosine and KATP channels","volume":"428","author":"Nakhostine","year":"1994","journal-title":"Pflugers Arch."},{"issue":"12","key":"10.1016\/j.peptides.2019.170123_bib0045","first-page":"919","article-title":"Effect of hypoxia-inducible factor-1alpha, endothelin-1 and inducible nitric oxide synthase in the pathogenesis of hypoxia-induced pulmonary hypertension of the neonatal rats","volume":"50","author":"Sang","year":"2012","journal-title":"Zhonghua Er Ke Za Zhi"},{"issue":"6","key":"10.1016\/j.peptides.2019.170123_bib0050","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.peptides.2004.08.030","article-title":"Atrial natriuretic peptide in hypoxia","volume":"26","author":"Chen","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2019.170123_bib0055","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.abb.2013.12.010","article-title":"Hypoxia induces peroxisome proliferator-activated receptor gamma expression via HIF-1-dependent mechanisms in HepG2 cell line","volume":"543","author":"Zhao","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.peptides.2019.170123_bib0060","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbrc.2010.08.007","article-title":"Hypoxia induces adipogenic differentitation of myoblastic cell lines","volume":"399","author":"Itoigawa","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1 Pt. 2","key":"10.1016\/j.peptides.2019.170123_bib0065","first-page":"R237","article-title":"Mechanism of anoxia-induced atrial natriuretic peptide release in the isolated rat atria","volume":"271","author":"Skvorak","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.peptides.2019.170123_bib0070","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.prostaglandins.2017.12.001","article-title":"HIF-1alpha-l-PGDS-PPARgamma regulates hypoxia-induced ANP secretion in beating rat atria","volume":"134","author":"Li","year":"2018","journal-title":"Prostaglandins Other Lipid Mediat."},{"issue":"3","key":"10.1016\/j.peptides.2019.170123_bib0075","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"issue":"21","key":"10.1016\/j.peptides.2019.170123_bib0080","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.peptides.2019.170123_bib0085","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.peptides.2019.170123_bib0090","first-page":"4","article-title":"Hydrogen sulfide (H2S) - the third gas of interest for pharmacologists","volume":"59","author":"Lowicka","year":"2007","journal-title":"Pharmacol. Rep."},{"issue":"12","key":"10.1016\/j.peptides.2019.170123_bib0095","first-page":"1145","article-title":"Plasma hydrogen sulfide and homocysteine levels in hypertensive patients with different blood pressure levels and complications","volume":"35","author":"Sun","year":"2007","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"issue":"13","key":"10.1016\/j.peptides.2019.170123_bib0100","first-page":"1114","article-title":"Changes and significance of hydrogen sulfide\/cystathionine gamma-lyase system in hypertension: an experimental study with rats","volume":"84","author":"Yan","year":"2004","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"7","key":"10.1016\/j.peptides.2019.170123_bib0105","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1080\/10715760701263265","article-title":"Hydrogen sulphide: a novel physiological inhibitor of LDL atherogenic modification by HOCl","volume":"41","author":"Laggner","year":"2007","journal-title":"Free Radic. Res."},{"issue":"11","key":"10.1016\/j.peptides.2019.170123_bib0110","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1253\/circj.69.1418","article-title":"Down-regulation of endogenous hydrogen sulfide pathway in pulmonary hypertension and pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats","volume":"69","author":"Xiaohui","year":"2005","journal-title":"Circ. J."},{"issue":"5","key":"10.1016\/j.peptides.2019.170123_bib0115","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3760\/cma.j.issn.0366-6999.20132694","article-title":"Potential biomarkers predicting risk of pulmonary hypertension in congenital heart disease: the role of homocysteine and hydrogen sulfide","volume":"127","author":"Sun","year":"2014","journal-title":"Chin. Med. J."},{"issue":"4","key":"10.1016\/j.peptides.2019.170123_bib0120","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.phrs.2010.06.002","article-title":"Hydrogen sulfide and ischemia-reperfusion injury","volume":"62","author":"Nicholson","year":"2010","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.peptides.2019.170123_bib0125","doi-asserted-by":"crossref","first-page":"H415","DOI":"10.1152\/ajpheart.00645.2016","article-title":"The fate of sulfate in chronic heart failure","volume":"312","author":"Koning","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.peptides.2019.170123_bib0130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.peptides.2018.04.005","article-title":"Hydrogen sulfide donor, NaHS, stimulates ANP secretion via the KATP channel and the NOS\/sGC pathway in rat atria","volume":"111","author":"Yu","year":"2019","journal-title":"Peptides"},{"issue":"2 Pt. 2","key":"10.1016\/j.peptides.2019.170123_bib0135","first-page":"H734","article-title":"Hypoxia-induced activation of KATP channels limits energy depletion in the guinea pig heart","volume":"269","author":"Decking","year":"1995","journal-title":"Am. J. Physiol."},{"issue":"4","key":"10.1016\/j.peptides.2019.170123_bib0140","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.peptides.2007.12.003","article-title":"Regulation of stretch-activated ANP secretion by chloride channels","volume":"29","author":"Han","year":"2008","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.peptides.2019.170123_bib0145","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.peptides.2010.10.031","article-title":"Endogenous angiotensin II suppresses stretch-induced ANP secretion via AT1 receptor pathway","volume":"32","author":"Oh","year":"2011","journal-title":"Peptides"},{"issue":"6","key":"10.1016\/j.peptides.2019.170123_bib0150","doi-asserted-by":"crossref","first-page":"H1782","DOI":"10.1152\/ajpheart.00438.2010","article-title":"Urotensin II receptor antagonist attenuates monocrotaline-induced cardiac hypertrophy in rats","volume":"299","author":"Gao","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.peptides.2019.170123_bib0155","doi-asserted-by":"crossref","first-page":"667","DOI":"10.4196\/kjpp.2017.21.6.667","article-title":"Comparative effects of angiotensin II and angiotensin-(4-8) on blood pressure and ANP secretion in rats","volume":"21","author":"Phuong","year":"2017","journal-title":"Korean J. Physiol. Pharmacol."},{"issue":"16","key":"10.1016\/j.peptides.2019.170123_bib0160","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/0024-3205(93)90170-8","article-title":"Single injection of pentobarbital induces long-lasting effects on ANP synthesis and gene expression in the rat atria","volume":"52","author":"Seul","year":"1993","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.peptides.2019.170123_bib0165","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0167-0115(88)90110-3","article-title":"Characteristics of distension-induced release of immunoreactive atrial natriuretic peptide in isolated perfused rabbit atria","volume":"22","author":"Cho","year":"1988","journal-title":"Regul. Pept."},{"issue":"5 Pt. 2","key":"10.1016\/j.peptides.2019.170123_bib0170","first-page":"R1129","article-title":"Mechanical basis of ANP secretion in beating atria: atrial stroke volume and ECF translocation","volume":"268","author":"Cho","year":"1995","journal-title":"Am. J. Physiol."},{"issue":"2","key":"10.1016\/j.peptides.2019.170123_bib0175","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3346\/jkms.1997.12.2.83","article-title":"Mechanisms for the secretion of ANP","volume":"12","author":"Cho","year":"1997","journal-title":"J. Korean Med. Sci."},{"issue":"2","key":"10.1016\/j.peptides.2019.170123_bib0180","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1006\/jmcc.1996.0361","article-title":"KATP channel activation in a rabbit model of chronic myocardial hypoxia","volume":"29","author":"Baker","year":"1997","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"9","key":"10.1016\/j.peptides.2019.170123_bib0185","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1096\/fj.04-1602fje","article-title":"Hypoxia-induced preconditioning in adult stimulated cardiomyocytes is mediated by the opening and trafficking of sarcolemmal KATP channels","volume":"18","author":"Budas","year":"2004","journal-title":"FASEB J."},{"issue":"11","key":"10.1016\/j.peptides.2019.170123_bib0190","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels","volume":"109","author":"Mustafa","year":"2011","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.peptides.2019.170123_bib0195","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1161\/CIRCULATIONAHA.108.833491","article-title":"Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice","volume":"120","author":"Minamishima","year":"2009","journal-title":"Circulation"},{"issue":"23","key":"10.1016\/j.peptides.2019.170123_bib0200","doi-asserted-by":"crossref","first-page":"9161","DOI":"10.1073\/pnas.1202916109","article-title":"Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation","volume":"109","author":"Coletta","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.peptides.2019.170123_bib0205","first-page":"488","article-title":"The regulatory effect of endogenous hydrogen sulfide on hypoxic pulmonary hypertension","volume":"35","author":"Zhang","year":"2003","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"issue":"23","key":"10.1016\/j.peptides.2019.170123_bib0210","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1111\/bph.12900","article-title":"Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseases","volume":"172","author":"Meng","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.peptides.2019.170123_bib0215","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2003.11.081","article-title":"The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats","volume":"313","author":"Yan","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.peptides.2019.170123_bib0220","first-page":"300","article-title":"The relationship between endogenous hydrogen sulfide system and pulmonary hypertension induced by hypoxic hypercapnia","volume":"27","author":"Xu","year":"2011","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"issue":"4","key":"10.1016\/j.peptides.2019.170123_bib0225","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0006-291X(03)00256-0","article-title":"The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats","volume":"302","author":"Chunyu","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978119301019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978119301019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:24:22Z","timestamp":1759310662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978119301019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":45,"alternative-id":["S0196978119301019"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2019.170123","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1\u03b1 and PPAR-\u03b3 pathway","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2019.170123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"170123"}}