{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:47:04Z","timestamp":1780624024356,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013323","name":"Yancheng Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007166","name":"Jiangsu Provincial Department of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.peptides.2019.170171","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T10:37:54Z","timestamp":1570876674000},"page":"170171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Design and evaluation of four novel tripeptides as potent angiotensin converting enzyme (ACE) inhibitors with anti-hypertension activity"],"prefix":"10.1016","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-9596","authenticated-orcid":false,"given":"Bingjun","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongchong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar D.","family":"Villarreal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2019.170171_bib0005","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/CIRCRESAHA.116.303587","article-title":"Hypertension: renin angiotensin aldosterone system alterations","volume":"116","author":"Te Riet","year":"2015","journal-title":"Circ. Res."},{"issue":"13","key":"10.1016\/j.peptides.2019.170171_bib0010","doi-asserted-by":"crossref","first-page":"e693","DOI":"10.1097\/MD.0000000000000693","article-title":"Differential expression of hypertension-associated microRNAs in the plasma of patients with white coat hypertension","volume":"94","author":"Cengiz","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.peptides.2019.170171_bib0015","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.tifs.2016.01.022","article-title":"Strategies for the discovery, identification and validation of milk protein-derived bioactive peptides","volume":"50","author":"Nongonierma","year":"2016","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.peptides.2019.170171_bib0020","series-title":"Essential Biochemistry for Medicine","author":"Fry","year":"2011"},{"issue":"Suppl. 1","key":"10.1016\/j.peptides.2019.170171_bib0025","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1017\/S0007114500002221","article-title":"Milk protein-derived peptide inhibitors of angiotensin I converting enzyme","volume":"84","author":"FitzGerald","year":"2000","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.peptides.2019.170171_bib0030","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1126\/science.191908","article-title":"Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents","volume":"196","author":"Ondetti","year":"1977","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.peptides.2019.170171_bib0035","first-page":"43","article-title":"Effects of Gabaron tea components on angiotension I-converting enzyme activity in rat","volume":"22","author":"Lin","year":"2002","journal-title":"J. Tea Sci. Res."},{"key":"10.1016\/j.peptides.2019.170171_bib0040","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biopsycho.2006.06.006","article-title":"L-theanine reduces psychological and physiological stress responses","volume":"74","author":"Kimura","year":"2007","journal-title":"Biol. Psychol."},{"issue":"3","key":"10.1016\/j.peptides.2019.170171_bib0045","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/biof.5520260305","article-title":"Relaxation and immunity enhancement effects of \u03b3-aminobutyric acid (GABA) administration in humans","volume":"26","author":"Abdou","year":"2006","journal-title":"BioFactors"},{"issue":"3","key":"10.1016\/j.peptides.2019.170171_bib0050","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jnutbio.2012.02.016","article-title":"L-theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation","volume":"24","author":"Siamwala","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.peptides.2019.170171_bib0055","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.fct.2011.10.036","article-title":"L-Theanine prevents alcoholic liver injury through enhancing the antioxidant capability of hepatocytes","volume":"50","author":"Li","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.peptides.2019.170171_bib0060","doi-asserted-by":"crossref","first-page":"H1425","DOI":"10.1152\/ajpheart.00942.2008","article-title":"Angiotensin II upregulates hypothalamic AT1 receptor expression in rats via the mitogen-activated protein kinase pathway","volume":"296","author":"Wei","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.peptides.2019.170171_bib0065","doi-asserted-by":"crossref","first-page":"11190","DOI":"10.3390\/ijms140611190","article-title":"Angiotensin II regulates microRNA-132\/-212 in hypertensive rats and humans","volume":"14","author":"Eskildsen","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.peptides.2019.170171_bib0070","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0006-2952(71)90292-9","article-title":"Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung","volume":"20","author":"Cushman","year":"1971","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.peptides.2019.170171_bib0075","first-page":"219","article-title":"Modified spectrophotometric method for assay of angiotensin I-converting enzyme inhibitory activity of food derived peptides","volume":"37","author":"Gao","year":"2011","journal-title":"J. Zhejiang Univ."},{"issue":"41","key":"10.1016\/j.peptides.2019.170171_bib0080","doi-asserted-by":"crossref","first-page":"13649","DOI":"10.1021\/ja0697875","article-title":"\"ChemDraw Ultra 10.0\"","volume":"128","author":"Mills","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.peptides.2019.170171_bib0085","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"Autodock4 and AutoDockTools4: automated docking with selective receptor flexiblity","volume":"16","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.peptides.2019.170171_bib0090","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.peptides.2019.170171_bib0095","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.lfs.2018.04.041","article-title":"miRNA-150-5p associate with antihypertensive effect of epigallocatechin-3-gallate revealed by aorta miRNome analysis of spontaneously hypertensive rat","volume":"203","author":"Qian","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.peptides.2019.170171_bib0100","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejmech.2012.03.057","article-title":"A variant peptide of buffalo colostrums beta-lactoglobulin inhibits angiotensin I-converting enzyme activity","volume":"53","author":"Rohit","year":"2012","journal-title":"Eur. J Med. Chem."},{"key":"10.1016\/j.peptides.2019.170171_bib0105","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3168\/jds.S0022-0302(95)76689-9","article-title":"Purification and characterization of angiotensin-I-converting enzyme inhibitors from a sour milk","volume":"78","author":"Nakamura","year":"1995","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.peptides.2019.170171_bib0110","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3390\/nu3090765","article-title":"Bioactive peptides from muscle sources: meat and fish","volume":"3","author":"Ryan","year":"2011","journal-title":"Nutrients"},{"key":"10.1016\/j.peptides.2019.170171_bib0115","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.lwt.2018.08.045","article-title":"Optimization of ACE inhibitory peptides from black soybean by microwave-assisted enzymatic method and study on its stability","volume":"98","author":"Li","year":"2018","journal-title":"LWT"},{"key":"10.1016\/j.peptides.2019.170171_bib0120","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.foodchem.2016.10.087","article-title":"Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities","volume":"221","author":"Garcia","year":"2017","journal-title":"Food Chem."},{"issue":"25","key":"10.1016\/j.peptides.2019.170171_bib0125","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1007\/s00216-017-0531-3","article-title":"Rapid screening and identification of ACE inhibitors in snake venoms using at-line nanofractionation LC-MS","volume":"409","author":"Mladic","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.peptides.2019.170171_bib0130","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/srep00717","article-title":"Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides","volume":"2","author":"Masuyer","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/j.peptides.2019.170171_bib0135","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1021\/jf060264q","article-title":"Angiotensin I-converting enzyme inhibitory peptide derived from glycinin, the 11S globulin of soybean (Glycine max)","volume":"54","author":"Mallikarjun Gouda","year":"2006","journal-title":"J. Agric. Food Chem."},{"issue":"11","key":"10.1016\/j.peptides.2019.170171_bib0140","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/psc.789","article-title":"Analysis of novel angiotensin-I-converting enzyme inhibitory peptides from protease-hydrolyzed marine shrimp Acetes chinensis","volume":"12","author":"He","year":"2006","journal-title":"J. Pept. Sci."},{"issue":"6","key":"10.1016\/j.peptides.2019.170171_bib0145","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.peptides.2010.02.022","article-title":"Arachin derived peptides as selective angiotensin I converting enzyme (ACE) inhibitors: structure-activity relationship","volume":"31","author":"Jimsheena","year":"2010","journal-title":"Peptides"},{"issue":"suppl.1","key":"10.1016\/j.peptides.2019.170171_bib0150","first-page":"22","article-title":"In vitro effects of bioactive tripeptides Ile-pro-pro, Val-pro-pro and Leu-pro-pro on ACE1 and ACE2","volume":"102","author":"Lehtinen","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.peptides.2019.170171_bib0155","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1271\/bbb.56.1541","article-title":"Peptide inhibitors for angiotensin I converting enzyme from thermolysin digest of dried bonito","volume":"56","author":"Yokoyama","year":"1992","journal-title":"Biosci. Biotech. Biochem."},{"key":"10.1016\/j.peptides.2019.170171_bib0160","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.foodchem.2013.03.091","article-title":"Nine novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) muscle protein hydrolysates and antihypertensive effect of the potent active peptide in spontaneously hypertensive rats","volume":"170","author":"Balti","year":"2015","journal-title":"Food Chem."},{"issue":"11","key":"10.1016\/j.peptides.2019.170171_bib0165","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.3390\/molecules22111739","article-title":"Design, synthesis, and evaluation of novel phenolic acid\/dipeptide\/borneol hybrids as potent angiotensin converting enzyme (ACE) inhibitors with anti-hypertension activity","volume":"22","author":"Sun","year":"2017","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.peptides.2019.170171_bib0170","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3390\/md16090299","article-title":"Antihypertensive effects of two novel angiotensin I-converting enzyme (ACE) inhibitory peptides from gracilariopsis lemaneiformis (rhodophyta) in spontaneously hypertensive rats (SHRs)","volume":"16","author":"Deng","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.peptides.2019.170171_bib0175","doi-asserted-by":"crossref","first-page":"26996","DOI":"10.1016\/S0021-9258(19)74209-4","article-title":"Regulatory elements that mediate expression of the gene for the angiotensin II type 1a receptor for the rat","volume":"268","author":"Murasawa","year":"1993","journal-title":"J. Biol. Chem."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978119301494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978119301494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:26:09Z","timestamp":1759310769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978119301494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":35,"alternative-id":["S0196978119301494"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2019.170171","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and evaluation of four novel tripeptides as potent angiotensin converting enzyme (ACE) inhibitors with anti-hypertension activity","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2019.170171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"170171"}}