{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:56:51Z","timestamp":1774501011516,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.peptides.2020.170398","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T10:53:01Z","timestamp":1601722381000},"page":"170398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Chronic Oxytocin treatment has long lasting therapeutic potential in a rat model of neonatal hypercapnic-hypoxia injury, through enhanced GABAergic signaling and by reducing hippocampal gliosis with its anti-inflammatory feature"],"prefix":"10.1016","volume":"135","author":[{"given":"Eda","family":"S\u00fcnnet\u00e7i","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-2347","authenticated-orcid":false,"given":"Volkan","family":"Solmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oytun","family":"Erba\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.peptides.2020.170398_bib0005","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pharmthera.2008.07.003","article-title":"Therapeutics for neonatal brain injury","volume":"120","author":"Gonzalez","year":"2008","journal-title":"Pharmacol Ther."},{"issue":"3","key":"10.1016\/j.peptides.2020.170398_bib0010","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3233\/JAD-122011","article-title":"Cerebrovascular reactivity to carbon dioxide in Alzheimer\u2019s disease","volume":"35","author":"Glodzik","year":"2013","journal-title":"J Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.peptides.2020.170398_bib0015","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3340\/jkns.2015.58.1.22","article-title":"Cognitive Dysfunction and Hippocampal Damage Induced by Hypoxic-Ischemic Brain Injury and Prolonged Febrile Convulsions in Immature Rats","volume":"58","author":"Byeon","year":"2015","journal-title":"J Korean Neurosurg Soc."},{"key":"10.1016\/j.peptides.2020.170398_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.107975","article-title":"5-aminolevulinic acid inhibits oxidative stress and ameliorates autistic-like behaviors in prenatal valproic acid-exposed rats","volume":"168","author":"Matsuo","year":"2020","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.peptides.2020.170398_bib0025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-981-32-9705-0_7","article-title":"The Role of the Oxytocin System in Anxiety Disorders","volume":"1191","author":"Yoon","year":"2020","journal-title":"Adv Exp Med Biol."},{"key":"10.1016\/j.peptides.2020.170398_bib0030","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40814-020-0557-8","article-title":"Probiotics and oxytocin nasal spray as neuro-social-behavioral interventions for patients with autism spectrum disorders: a pilot randomized controlled trial protocol","volume":"6","author":"Kong","year":"2020","journal-title":"Pilot Feasibility Stud."},{"key":"10.1016\/j.peptides.2020.170398_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijdevneu.2017.09.002","article-title":"Consequences of perinatal hypoxia in developing brain: Changes in GABA transporter functioning in cortical, hippocampal and thalamic rat nerve terminals","volume":"63","author":"Pozdnyakova","year":"2017","journal-title":"Int J Dev Neurosci."},{"key":"10.1016\/j.peptides.2020.170398_bib0040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pneurobio.2014.10.001","article-title":"Neuropeptides as neuroprotective agents: Oxytocin a forefront developmental player in the mammalian brain","volume":"123","author":"Vargas-Martinez","year":"2014","journal-title":"Prog Neurobiol."},{"key":"10.1016\/j.peptides.2020.170398_bib0045","doi-asserted-by":"crossref","first-page":"35659","DOI":"10.1038\/srep35659","article-title":"Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro","volume":"6","author":"Kaneko","year":"2016","journal-title":"Sci Rep."},{"issue":"8","key":"10.1016\/j.peptides.2020.170398_bib0050","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s11064-015-1645-7","article-title":"Maternal Oxytocin Administration Before Birth Influences the Effects of Birth Anoxia on the Neonatal Rat Brain","volume":"40","author":"Boksa","year":"2015","journal-title":"Neurochem Res."},{"issue":"5806","key":"10.1016\/j.peptides.2020.170398_bib0055","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1126\/science.1133212","article-title":"Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery","volume":"314","author":"Tyzio","year":"2006","journal-title":"Science."},{"issue":"3","key":"10.1016\/j.peptides.2020.170398_bib0060","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4183\/aeb.2018.315","article-title":"Oxytocin Reduces Seizure Burden and Hippocampal Injury in a Rat Model of Perinatal Asphyxia","volume":"14","author":"Panaitescu","year":"2018","journal-title":"Acta Endocrinol (Buchar)."},{"key":"10.1016\/j.peptides.2020.170398_bib0065","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fncel.2018.00002","article-title":"Surge of Peripheral Arginine Vasopressin in a Rat Model of Birth Asphyxia","volume":"12","author":"Summanen","year":"2018","journal-title":"Front Cell Neurosci."},{"issue":"2","key":"10.1016\/j.peptides.2020.170398_bib0070","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1258\/0023677053739747","article-title":"Carbon dioxide for euthanasia: concerns regarding pain and distress, with special reference to mice and rats","volume":"39","author":"Conlee","year":"2005","journal-title":"Lab Anim."},{"key":"10.1016\/j.peptides.2020.170398_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2020.104695","article-title":"Oxytocin and CD38 in the paraventricular nucleus play a critical role in paternal aggression in mice","volume":"120","author":"Shabalova","year":"2020","journal-title":"Horm Behav."},{"key":"10.1016\/j.peptides.2020.170398_bib0080","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.ejphar.2017.11.018","article-title":"Oxytocin inhibited stress induced visceral hypersensitivity, enteric glial cells activation, and release of proinflammatory cytokines in maternal separated rats","volume":"818","author":"Xu","year":"2018","journal-title":"Eur J Pharmacol."},{"issue":"12","key":"10.1016\/j.peptides.2020.170398_bib0085","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1179\/1743132814Y.0000000391","article-title":"Inhibitor effect of dexketoprofen in rat model of pentylenetetrazol-induced seizures","volume":"37","author":"Erbas","year":"2015","journal-title":"Neurol Res."},{"issue":"1","key":"10.1016\/j.peptides.2020.170398_bib0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0006-8993(89)91533-3","article-title":"Glutaminase inhibition and the release of neurotransmitter glutamate from synaptosomes","volume":"476","author":"Bradford","year":"1989","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.peptides.2020.170398_bib0095","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00213-018-5030-5","article-title":"Acute and long-lasting effects of oxytocin in cortico-limbic circuits: consequences for fear recall and extinction","volume":"236","author":"Triana-Del Rio","year":"2019","journal-title":"Psychopharmacology (Berl)."},{"issue":"1","key":"10.1016\/j.peptides.2020.170398_bib0100","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13229-020-0313-1","article-title":"Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up","volume":"11","author":"Bernaerts","year":"2020","journal-title":"Mol Autism."},{"issue":"1","key":"10.1016\/j.peptides.2020.170398_bib0105","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.1038\/s41598-018-24722-3","article-title":"The Role of Kainate Receptors in the Pathophysiology of Hypoxia-Induced Seizures in the Neonatal Mouse","volume":"8","author":"Grosenbaugh","year":"2018","journal-title":"Sci Rep."},{"issue":"1","key":"10.1016\/j.peptides.2020.170398_bib0110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neulet.2010.04.024","article-title":"Oxytocin is neuroprotective against oxygen-glucose deprivation and reoxygenation in immature hippocampal cultures","volume":"477","author":"Ceanga","year":"2010","journal-title":"Neurosci Lett."},{"key":"10.1016\/j.peptides.2020.170398_bib0115","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.toxlet.2016.05.018","article-title":"Oxytocin is involved in the proconvulsant effects of Sildenafil: Possible role of CREB","volume":"256","author":"Khoshneviszadeh","year":"2016","journal-title":"Toxicol Lett."},{"issue":"4","key":"10.1016\/j.peptides.2020.170398_bib0120","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.pharep.2017.03.003","article-title":"Intra-hippocampal microinjection of oxytocin produced antiepileptic effect on the pentylenetetrazol-induced epilepsy in rats","volume":"69","author":"Erfanparast","year":"2017","journal-title":"Pharmacol Rep."},{"issue":"7","key":"10.1016\/j.peptides.2020.170398_bib0125","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrneurol.2009.80","article-title":"Epileptogenesis in the immature brain: emerging mechanisms","volume":"5","author":"Rakhade","year":"2009","journal-title":"Nat Rev Neurol."},{"issue":"6","key":"10.1016\/j.peptides.2020.170398_bib0130","doi-asserted-by":"crossref","DOI":"10.3390\/cells8060527","article-title":"Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia","volume":"8","author":"Inoue","year":"2019","journal-title":"Cells."},{"issue":"12","key":"10.1016\/j.peptides.2020.170398_bib0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123848","article-title":"Effects of Oxytocin on Fear Memory and Neuroinflammation in a Rodent Model of Posttraumatic Stress Disorder","volume":"19","author":"Wang","year":"2018","journal-title":"Int J Mol Sci."},{"issue":"1","key":"10.1016\/j.peptides.2020.170398_bib0140","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12974-016-0541-7","article-title":"Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice","volume":"13","author":"Yuan","year":"2016","journal-title":"J Neuroinflammation."},{"issue":"12","key":"10.1016\/j.peptides.2020.170398_bib0145","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.euroneuro.2019.10.010","article-title":"Methylation in Syn and Psd95 genes underlie the inhibitory effect of oxytocin on oxycodone-induced conditioned place preference","volume":"29","author":"Fan","year":"2019","journal-title":"Eur Neuropsychopharmacol."},{"issue":"5","key":"10.1016\/j.peptides.2020.170398_bib0150","doi-asserted-by":"crossref","first-page":"eaav2244","DOI":"10.1126\/sciadv.aav2244","article-title":"Behavioral and epigenetic consequences of oxytocin treatment at birth","volume":"5","author":"Kenkel","year":"2019","journal-title":"Sci Adv."},{"key":"10.1016\/j.peptides.2020.170398_bib0155","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.neuroscience.2018.05.021","article-title":"Impaired Organization of GABAergic Neurons Following Prenatal Hypoxia","volume":"384","author":"Nisimov","year":"2018","journal-title":"Neuroscience."},{"key":"10.1016\/j.peptides.2020.170398_bib0160","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0079-6123(08)00421-4","article-title":"Effects of oxytocin on GABA signalling in the foetal brain during delivery","volume":"170","author":"Khazipov","year":"2008","journal-title":"Prog Brain Res."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978120301479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978120301479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:27:29Z","timestamp":1759310849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978120301479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":32,"alternative-id":["S0196978120301479"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2020.170398","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic Oxytocin treatment has long lasting therapeutic potential in a rat model of neonatal hypercapnic-hypoxia injury, through enhanced GABAergic signaling and by reducing hippocampal gliosis with its anti-inflammatory feature","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2020.170398","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"170398"}}