{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:21:30Z","timestamp":1790310090380,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":129,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001729","name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.peptides.2020.170445","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T11:20:47Z","timestamp":1605266447000},"page":"170445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["GK-rats respond to gastric bypass surgery with improved glycemia despite unaffected insulin secretion and beta cell mass"],"prefix":"10.1016","volume":"136","author":[{"given":"Michael G.","family":"Miskelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliya","family":"Shcherbina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Helen","family":"Thor\u00e9n Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Abels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Lindqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Wierup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2020.170445_bib0005","series-title":"Diabetes Facts and Figures","author":"International Diabetes Federation","year":"2020"},{"key":"10.1016\/j.peptides.2020.170445_bib0010","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11695-013-1160-3","article-title":"Diabetes and weight in comparative studies of bariatric surgery vs conventional medical therapy: a systematic review and meta-analysis","volume":"24","author":"Ribaric","year":"2014","journal-title":"Obes. Surg."},{"key":"10.1016\/j.peptides.2020.170445_bib0015","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/00000658-199509000-00011","article-title":"Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus","volume":"222","author":"Pories","year":"1995","journal-title":"Ann. Surg."},{"key":"10.1016\/j.peptides.2020.170445_bib0020","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1381\/0960892053723402","article-title":"Loss of insulin resistance after Roux-en-Y gastric bypass surgery: a time course study","volume":"15","author":"Wickremesekera","year":"2005","journal-title":"Obes. Surg."},{"key":"10.1016\/j.peptides.2020.170445_bib0025","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.soard.2016.09.017","article-title":"Roux-en-Y gastric bypass versus calorie restriction: support for surgery <em>per se<\/em> as the direct contributor to altered responses of insulin and incretins to a mixed meal","volume":"13","author":"Berggren","year":"2017","journal-title":"Surg. Obes. Relat. Dis."},{"key":"10.1016\/j.peptides.2020.170445_bib0030","doi-asserted-by":"crossref","DOI":"10.2337\/db20-0131","article-title":"Metabolic effects of gastric bypass surgery - is it all about calories?","author":"Herzog","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2020.170445_bib0035","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.2337\/db12-1762","article-title":"Very low-calorie diet mimics the early beneficial effect of Roux-en-Y gastric bypass on insulin sensitivity and \u03b2-cell Function in type 2 diabetic patients","volume":"62","author":"Jackness","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2020.170445_bib0040","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/00000658-200211000-00003","article-title":"Potential of surgery for curing type 2 diabetes mellitus","volume":"236","author":"Rubino","year":"2002","journal-title":"Ann. Surg."},{"key":"10.1016\/j.peptides.2020.170445_bib0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/MED.0000000000000131","article-title":"Updates in weight loss surgery and gastrointestinal peptides","volume":"22","author":"Svane","year":"2015","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.peptides.2020.170445_bib0050","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1210\/jc.2007-2851","article-title":"Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes","volume":"93","author":"Laferr\u00e8re","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2020.170445_bib0055","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.cmet.2016.01.018","article-title":"Bile diversion in Roux-en-Y gastric bypass modulates sodium-dependent glucose intestinal uptake","volume":"23","author":"Baud","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2020.170445_bib0060","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/ijo.2017.7","article-title":"Roux-en-Y gastric bypass increases systemic but not portal bile acid concentrations by decreasing hepatic bile acid uptake in minipigs","volume":"41","author":"Ch\u00e1vez-Talavera","year":"2017","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.peptides.2020.170445_bib0065","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1530\/EC-18-0234","article-title":"Liver blood dynamics after bariatric surgery: the effects of mixed-meal test and incretin infusions","volume":"7","author":"Honka","year":"2018","journal-title":"Endocr. Connect."},{"key":"10.1016\/j.peptides.2020.170445_bib0070","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cmet.2015.07.009","article-title":"Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation","volume":"22","author":"Tremaroli","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2020.170445_bib0075","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1111\/dme.13257","article-title":"Calorie restriction and not glucagon-like peptide-1 explains the acute improvement in glucose control after gastric bypass in Type 2 diabetes","volume":"33","author":"Steven","year":"2016","journal-title":"Diabet. Med."},{"key":"10.1016\/j.peptides.2020.170445_bib0080","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.2337\/db13-1307","article-title":"Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass","volume":"63","author":"Bojsen-M\u00f8ller","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2020.170445_bib0085","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.coph.2013.09.014","article-title":"Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery","volume":"13","author":"Holst","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.peptides.2020.170445_bib0090","doi-asserted-by":"crossref","first-page":"R352","DOI":"10.1152\/ajpregu.00491.2013","article-title":"GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents","volume":"306","author":"Ye","year":"2014","journal-title":"Am. J. Physiol.-Regul. Integr. Compar. Physiol."},{"key":"10.1016\/j.peptides.2020.170445_bib0095","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.molmet.2013.11.010","article-title":"Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency","volume":"3","author":"Mokadem","year":"2013","journal-title":"Mol. Metab."},{"key":"10.1016\/j.peptides.2020.170445_bib0100","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.2337\/db13-0022","article-title":"Exaggerated glucagon-like peptide 1 response is important for improved \u03b2-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes","volume":"62","author":"J\u00f8rgensen","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2020.170445_bib0105","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2337\/db13-0954","article-title":"Contribution of endogenous glucagon-like peptide 1 to glucose metabolism after Roux-en-Y gastric bypass","volume":"63","author":"Shah","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2020.170445_bib0110","first-page":"84","article-title":"\u03b2-cell function after weight-loss induced by bariatric surgery","volume":"29","author":"Vella","year":"2014","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.peptides.2020.170445_bib0115","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/0026-0495(92)90298-O","article-title":"Genetically obese rats with (SHR\/N-cp) and without diabetes (LA\/N-cp) share abnormal islet responses to glucose","volume":"41","author":"Timmers","year":"1992","journal-title":"Metabolism"},{"key":"10.1016\/j.peptides.2020.170445_bib0120","doi-asserted-by":"crossref","first-page":"E1134","DOI":"10.1152\/ajpendo.00516.2006","article-title":"Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (fa\/fa) rats","volume":"293","author":"Eringa","year":"2007","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2020.170445_bib0125","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cmet.2012.12.007","article-title":"Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice","volume":"17","author":"Parks","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2020.170445_bib0130","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1055\/s-2007-1002165","article-title":"Development of glucose intolerance in obese (fa\/fa) Zucker rats","volume":"25","author":"Apweiler","year":"1993","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.peptides.2020.170445_bib0135","doi-asserted-by":"crossref","first-page":"E500","DOI":"10.1152\/ajpendo.1985.248.5.E500","article-title":"Abnormal oral glucose tolerance in genetically obese (fa\/fa) rats","volume":"248","author":"Ionescu","year":"1985","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2020.170445_bib0140","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1210\/endo-118-2-674","article-title":"Severe hepatic and peripheral insulin resistance as evidenced by euglycemic clamps in genetically obese fa\/fa rats*","volume":"118","author":"Terrettaz","year":"1986","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2020.170445_bib0145","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2337\/diab.28.5.509","article-title":"Lipoproteins in the plasma and hepatic perfusates of the zucker fatty rat","volume":"28","author":"Witztum","year":"1979","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2020.170445_bib0150","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.bone.2010.08.003","article-title":"Genetic loci for bone architecture determined by three-dimensional CT in crosses with the diabetic GK rat","volume":"47","author":"Lagerholm","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.peptides.2020.170445_bib0155","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-0716-0385-7_3","article-title":"Selectively bred diabetes models: GK rats, NSY mice, and ON mice","volume":"2128","author":"Nagao","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.peptides.2020.170445_bib0160","doi-asserted-by":"crossref","DOI":"10.3791\/3940","article-title":"Roux-en-Y gastric bypass operation in rats","author":"Bueter","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.peptides.2020.170445_bib0165","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/ng.288","article-title":"Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion","volume":"41","author":"Lyssenko","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.peptides.2020.170445_bib0170","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.2337\/db13-0969","article-title":"Gastric bypass improves \u03b2-Cell function and increases \u03b2-Cell mass in a porcine model","volume":"63","author":"Lindqvist","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2020.170445_bib0175","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s00424-014-1619-7","article-title":"Localizations of Na+-d-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart","volume":"467","author":"Vrhovac","year":"2015","journal-title":"Pfl\u00fcgers Archiv \u2013 Eur. J. Physiol."},{"issue":"Pt 2","key":"10.1016\/j.peptides.2020.170445_bib0180","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1042\/bj3330359","article-title":"Human mitochondrial phosphoenolpyruvate carboxykinase 2 gene. Structure, chromosomal localization and tissue-specific expression","volume":"333","author":"Modaressi","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.peptides.2020.170445_bib0185","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1074\/jbc.M209105200","article-title":"Tissue-specific Structure\/Function Differentiation of the Liver Isoform of 6-Phosphofructo-2-kinase\/Fructose-2,6-bisphosphatase","volume":"278","author":"Lee","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2020.170445_bib0190","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.nutr.27.061406.093618","article-title":"ChREBP, a Transcriptional Regulator of Glucose and Lipid Metabolism","volume":"27","author":"Postic","year":"2007","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.peptides.2020.170445_bib0195","first-page":"351","article-title":"The polymorphic locus for glycogen storage disease VI (liver glycogen phosphorylase) maps to chromosome 14","volume":"40","author":"Newgard","year":"1987","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.peptides.2020.170445_bib0200","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1172\/JCI2890","article-title":"Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0","volume":"102","author":"Orho","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.peptides.2020.170445_bib0205","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0005-2760(92)90001-C","article-title":"Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase","volume":"1123","author":"Hardie","year":"1992","journal-title":"Biochim. Biophys. Acta (BBA) - Lipids Lipid Metab."},{"key":"10.1016\/j.peptides.2020.170445_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/iub.411","article-title":"Liver glucokinase: an overview on the regulatorymechanisms of its activity","volume":"63","author":"Massa","year":"2011","journal-title":"IUBMB Life"},{"key":"10.1016\/j.peptides.2020.170445_bib0215","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2020.170445_bib0220","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009191","article-title":"Insulin receptor signaling in normal and insulin-resistant states","volume":"6","author":"Boucher","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.peptides.2020.170445_bib0225","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s11695-010-0113-3","article-title":"Metabolic surgery for the treatment of type 2 diabetes in patients with BMI <35 kg\/m2: an integrative review of early studies","volume":"20","author":"Fried","year":"2010","journal-title":"Obes. Surg."},{"key":"10.1016\/j.peptides.2020.170445_bib0230","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.2337\/dc12-1596","article-title":"Metabolic effects of bariatric surgery in patients with moderate obesity and type 2 diabetes: analysis of a randomized control trial comparing surgery with intensive medical treatment","volume":"36","author":"Kashyap","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.peptides.2020.170445_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molmet.2019.08.009","article-title":"Roux-en-Y gastric bypass enhances insulin secretion in type 2 diabetes via FXR-mediated TRPA1 expression","volume":"29","author":"Kong","year":"2019","journal-title":"Mol. Metab."},{"key":"10.1016\/j.peptides.2020.170445_bib0240","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1620\/tjem.225.179","article-title":"Upregulation of IRS-1 expression in Goto-Kakizaki rats following Roux-en-Y gastric bypass surgery: resolution of type 2 diabetes?","volume":"225","author":"Li","year":"2011","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.peptides.2020.170445_bib0245","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11695-015-1730-7","article-title":"Comparing the effectiveness of total gastrectomy and gastric bypass on glucose metabolism in diabetic rats","volume":"26","author":"Zhou","year":"2016","journal-title":"Obes. Surg."},{"key":"10.1016\/j.peptides.2020.170445_bib0250","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.3748\/wjg.v23.i19.3468","article-title":"Diabetes recurrence after metabolic surgeries correlates with re-impaired insulin sensitivity rather than beta-cell function","volume":"23","author":"Liu","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.peptides.2020.170445_bib0255","doi-asserted-by":"crossref","first-page":"E923","DOI":"10.1152\/ajpendo.00422.2010","article-title":"Duodenal-jejunal bypass protects GK rats from \u03b2-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1","volume":"300","author":"Speck","year":"2011","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2020.170445_bib0260","series-title":"The Entire Small Intestine Mediates the Changes in Glucose Homeostasis After Intestinal Surgery in Goto-kakizaki Rats","author":"Liu","year":"2012"},{"key":"10.1016\/j.peptides.2020.170445_bib0265","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1530\/JOE-14-0701","article-title":"Pancreatic hyperplasia after gastric bypass surgery in a GK rat model of non-obese type 2 diabetes","volume":"228","author":"Zhou","year":"2016","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.peptides.2020.170445_bib0270","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.2337\/db14-0935","article-title":"GLP-1 as a mediator in the remission of type 2 diabetes after gastric bypass and sleeve gastrectomy surgery","volume":"63","author":"Madsbad","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2020.170445_bib0275","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1007\/s11695-012-0621-4","article-title":"Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects","volume":"22","author":"Jacobsen","year":"2012","journal-title":"Obes. Surg."},{"key":"10.1016\/j.peptides.2020.170445_bib0280","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1007\/s11695-011-0388-z","article-title":"Roux-en-Y gastric bypass-induced improvement of glucose tolerance and insulin resistance in type 2 diabetic rats are mediated by glucagon-like Peptide-1","volume":"21","author":"Liu","year":"2011","journal-title":"Obes. Surg."},{"key":"10.1016\/j.peptides.2020.170445_bib0285","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.2337\/db13-1307","article-title":"Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass","volume":"63","author":"Bojsen-Moller","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2020.170445_bib0290","series-title":"Roux-en-Y Gastric Bypass Surgery Alters Serum Metabolites and Fatty Acids in Patients With Morbid Obesity","author":"Wijayatunga","year":"2018"},{"key":"10.1016\/j.peptides.2020.170445_bib0295","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.cell.2008.12.040","article-title":"A role of DNA-PK for the metabolic gene regulation in response to insulin","volume":"136","author":"Wong","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.peptides.2020.170445_bib0300","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cmet.2005.04.002","article-title":"\u201cNew\u201d hepatic fat activates PPAR\u03b1 to maintain glucose, lipid, and cholesterol homeostasis","volume":"1","author":"Chakravarthy","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2020.170445_bib0305","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1097\/01.sla.0000224726.61448.1b","article-title":"The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes","volume":"244","author":"Rubino","year":"2006","journal-title":"Ann. Surg."},{"key":"10.1016\/j.peptides.2020.170445_bib0310","doi-asserted-by":"crossref","DOI":"10.1210\/endo.140.11.7143","article-title":"Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine","author":"Hansen","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2020.170445_bib0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.regpep.2006.07.007","article-title":"The elimination rates of intact GIP as well as its primary metabolite, GIP 3-42, are similar in type 2 diabetic patients and healthy subjects","author":"Vilsb\u00f8ll","year":"2006","journal-title":"Regul. Pept."},{"key":"10.1016\/j.peptides.2020.170445_bib0320","series-title":"Etabolic Control (ed Stephan Herzig)","first-page":"137","author":"Wu","year":"2016"},{"key":"10.1016\/j.peptides.2020.170445_bib0325","doi-asserted-by":"crossref","first-page":"E458","DOI":"10.1152\/ajpendo.1996.271.3.E458","article-title":"Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig","volume":"271","author":"Deacon","year":"1996","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2020.170445_bib0330","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/jdi.12065","article-title":"Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: incretin actions beyond the pancreas","volume":"4","author":"Seino","year":"2013","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.peptides.2020.170445_bib0335","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1007\/s11695-018-03663-w","article-title":"Comparison of energy and food intake between gastric bypass and sleeve gastrectomy: a meta-analysis and systematic review","volume":"29","author":"Janmohammadi","year":"2019","journal-title":"Obes. Surg."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978120301947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978120301947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:27:58Z","timestamp":1759310878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978120301947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":67,"alternative-id":["S0196978120301947"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2020.170445","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GK-rats respond to gastric bypass surgery with improved glycemia despite unaffected insulin secretion and beta cell mass","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2020.170445","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"170445"}}