{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:48:29Z","timestamp":1790776109944,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"am","delay-in-days":282,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.peptides.2021.170630","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T01:58:05Z","timestamp":1630547885000},"page":"170630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Long-term protective effect of PACAP in a fetal alcohol syndrome (FAS) model"],"prefix":"10.1016","volume":"146","author":[{"given":"Ilhem","family":"Shili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosra","family":"Hamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"Marouani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakaria","family":"Ben Lasfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoufik","family":"Ghrairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0367-2414","authenticated-orcid":false,"given":"Benjamin","family":"Lefranc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7814-9927","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Leprince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vaudry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masmoudi-Kouki","family":"Olfa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2021.170630_bib0005","first-page":"515","article-title":"Fetal alcohol syndrome and fetal alcohol spectrum disorders","volume":"96","author":"Denny","year":"2017","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.peptides.2021.170630_bib0010","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12724","article-title":"Fetus morphology changes by second-trimester ultrasound in pregnant women drinking alcohol","volume":"25","author":"Ferraguti","year":"2020","journal-title":"Addict. Biol."},{"key":"10.1016\/j.peptides.2021.170630_bib0015","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/acer.12671","article-title":"Verbal learning and memory impairment in children with fetal alcohol spectrum disorders","volume":"39","author":"Lewis","year":"2015","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0020","series-title":"Fetal Alcohol Abuse Syndr.","first-page":"5","article-title":"Why fetal alcohol abuse syndrome?","author":"Abel","year":"1998"},{"key":"10.1016\/j.peptides.2021.170630_bib0025","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2431-11-14","article-title":"Under-reporting of foetal alcohol spectrum disorders: an analysis of hospital episode statistics","volume":"11","author":"Morleo","year":"2011","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.peptides.2021.170630_bib0030","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1096-9926(199711)56:5<317::AID-TERA5>3.0.CO;2-U","article-title":"Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder","volume":"56","author":"Sampson","year":"1997","journal-title":"Teratology"},{"key":"10.1016\/j.peptides.2021.170630_bib0035","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1467-9604.2010.01452.x","article-title":"Shaping the future for children with foetal alcohol spectrum disorders","volume":"25","author":"Blackburn","year":"2010","journal-title":"Support Learn."},{"key":"10.1016\/j.peptides.2021.170630_bib0040","doi-asserted-by":"crossref","first-page":"265","DOI":"10.5014\/ajot.62.3.265","article-title":"Children with fetal alcohol spectrum disorders: problem behaviors and sensory processing","volume":"62","author":"Franklin","year":"2008","journal-title":"Am. J. Occup. Ther."},{"key":"10.1016\/j.peptides.2021.170630_bib0045","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1542\/peds.2014-1915","article-title":"Psychosocial outcomes of fetal alcohol syndrome in adulthood","volume":"135","author":"Rangmar","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.peptides.2021.170630_bib0050","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1037\/0894-4105.12.1.146","article-title":"Neuropsychological comparison of alcohol-exposed children with or without physical features of fetal alcohol syndrome","volume":"12","author":"Mattson","year":"1998","journal-title":"Neuropsychology"},{"key":"10.1016\/j.peptides.2021.170630_bib0055","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0021-9924(92)90017-Q","article-title":"Communication effects of prenatal alcohol exposure","volume":"25","author":"Abkarian","year":"1992","journal-title":"J. Commun. Disord."},{"key":"10.1016\/j.peptides.2021.170630_bib0060","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ddrr.74","article-title":"Psychiatric conditions associated with prenatal alcohol exposure","volume":"15","author":"O\u2019Connor","year":"2009","journal-title":"Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.peptides.2021.170630_bib0065","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3109\/09638237.2011.577113","article-title":"Mental health issues in fetal alcohol spectrum disorder","volume":"20","author":"Pei","year":"2011","journal-title":"J. Ment. Health"},{"key":"10.1016\/j.peptides.2021.170630_bib0070","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.neuropsychologia.2005.07.016","article-title":"Effects of prenatal alcohol exposure on fine motor coordination and balance: a study of two adult samples","volume":"44","author":"Connor","year":"2006","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.peptides.2021.170630_bib0075","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/j.1530-0277.1998.tb03889.x","article-title":"Effect of fetal alcohol exposure on adult symptoms of nicotine, alcohol, and drug dependence","volume":"22","author":"Yates","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0080","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1530-0277.2009.01132.x","article-title":"Prenatal alcohol exposure and chronic mild stress differentially alter depressive- and anxiety-like behaviors in male and female offspring","volume":"34","author":"Hellemans","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0085","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-4256","article-title":"Updated clinical guidelines for diagnosing fetal alcohol spectrum disorders","volume":"138","author":"Hoyme","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.peptides.2021.170630_bib0090","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z","article-title":"Regional differences in synaptogenesis in human cerebral cortex","volume":"387","author":"Huttenlocher","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.peptides.2021.170630_bib0095","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1196\/annals.1317.055","article-title":"Functional splice variants of the type II G protein\u2013coupled receptor (VPAC2) for vasoactive intestinal peptide in mouse and human lymphocytes","volume":"1070","author":"Miller","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.peptides.2021.170630_bib0100","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.expneurol.2007.01.016","article-title":"Time-specific effects of ethanol exposure on cranial nerve nuclei: gastrulation and neuronogenesis","volume":"205","author":"Mooney","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.peptides.2021.170630_bib0105","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.brainresrev.2011.02.001","article-title":"The role of oxidative stress in fetal alcohol spectrum disorders","volume":"67","author":"Brocardo","year":"2011","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.peptides.2021.170630_bib0110","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/alcalc\/agn079","article-title":"Mechanisms of neurodegeneration and regeneration in alcoholism","volume":"44","author":"Crews","year":"2009","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.peptides.2021.170630_bib0115","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/acer.13266","article-title":"The effects of ethanol exposure during distinct periods of brain development on oxidative stress in the adult rat brain","volume":"41","author":"Brocardo","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0120","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1523\/JNEUROSCI.23-03-00876.2003","article-title":"Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits","volume":"23","author":"Jevtovic-Todorovic","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.peptides.2021.170630_bib0125","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0006-291X(89)91757-9","article-title":"Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells","volume":"164","author":"Miyata","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.peptides.2021.170630_bib0130","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1749-6632.2000.tb06980.x","article-title":"PACAP acts as a neurotrophic factor during histogenesis of the rat cerebellar cortex","volume":"921","author":"Vaudry","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.peptides.2021.170630_bib0135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0165-3806(94)90150-3","article-title":"Ontogeny of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the rat cerebellum: a quantitative autoradiographic study","volume":"82","author":"Basille","year":"1994","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0140","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0196-9781(94)90170-8","article-title":"Developmental changes of pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor in the rat brain","volume":"15","author":"Tatsuno","year":"1994","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2021.170630_bib0145","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/cne.1411","article-title":"Embryonic expression of pituitary adenylyl cyclase-activating polypeptide and its selective type I receptor gene in the frog Xenopus laevis neural tube","volume":"441","author":"Hu","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.peptides.2021.170630_bib0150","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1124\/pr.109.001370","article-title":"Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery","volume":"61","author":"Vaudry","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.peptides.2021.170630_bib0155","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0306-4522(96)00617-3","article-title":"Pituitary adenylate cyclase-activating polypeptide promotes cell survival and neurite outgrowth in rat cerebellar neuroblasts","volume":"78","author":"Gonzalez","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.peptides.2021.170630_bib0160","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1523\/JNEUROSCI.17-01-00083.1997","article-title":"Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP Kinase) pathway","volume":"17","author":"Villalba","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.peptides.2021.170630_bib0165","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0006-8993(96)00920-1","article-title":"Pituitary adenylate cyclase-activating polypeptide protects rat-cultured cortical neurons from glutamate-induced cytotoxicity","volume":"741","author":"Morio","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0170","doi-asserted-by":"crossref","first-page":"9630","DOI":"10.1074\/jbc.M209141200","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1","volume":"278","author":"Yaka","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2021.170630_bib0175","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1471-4159.2011.07185.x","article-title":"Pituitary adenylate cyclase-activating polypeptide protects astroglial cells against oxidative stress-induced apoptosis","volume":"117","author":"Masmoudi-Kouki","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.peptides.2021.170630_bib0180","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1046\/j.1460-9568.2002.01981.x","article-title":"PACAP protects cerebellar granule neurons against oxidative stress-induced apoptosis","volume":"15","author":"Vaudry","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.peptides.2021.170630_bib0185","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s12640-010-9186-y","article-title":"Neuroprotective effects of PACAP against ethanol-induced toxicity in the developing rat cerebellum","volume":"19","author":"Botia","year":"2011","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120526","article-title":"PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF","volume":"10","author":"Ogata","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2021.170630_bib0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2014.08.007","article-title":"PACAP induces plasticity at autonomic synapses by nAChR-dependent NOS1 activation and AKAP-mediated PKA targeting","volume":"63","author":"Jayakar","year":"2014","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.peptides.2021.170630_bib0200","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/jnr.20038","article-title":"PACAP promotes neural stem cell proliferation in adult mouse brain","volume":"76","author":"Mercer","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0205","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1073\/pnas.082112699","article-title":"Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death","volume":"99","author":"Vaudry","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.peptides.2021.170630_bib0210","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1016\/j.peptides.2005.05.015","article-title":"Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult","volume":"26","author":"Vaudry","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2021.170630_bib0215","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/jnc.13020","article-title":"Comparison of the deleterious effects of binge drinking-like alcohol exposure in adolescent and adult mice","volume":"132","author":"Lacaille","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.peptides.2021.170630_bib0220","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.1007\/s12035-018-0972-5","article-title":"Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) enhances hippocampal synapticplasticity and improves memory performance in huntington\u2019s disease","volume":"55","author":"Cabezas-Llobet","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.peptides.2021.170630_bib0225","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.peptides.2015.06.010","article-title":"Octadecaneuropeptide ODN prevents hydrogen peroxide-induced oxidative damage of biomolecules in cultured rat astrocytes","volume":"71","author":"Hamdi","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2021.170630_bib0230","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(73)91092-1","article-title":"Recognition of the fetal alcohol syndrome in early infancy","volume":"302","author":"Jones","year":"1973","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.peptides.2021.170630_bib0235","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2018.00200","article-title":"Long-lasting effects of prenatal ethanol exposure on fear learning and development of the amygdala","volume":"12","author":"Kozanian","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.peptides.2021.170630_bib0240","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuint.2019.01.017","article-title":"Therapeutic potential of PACAP in alcohol toxicity","volume":"124","author":"Reglodi","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.peptides.2021.170630_bib0245","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s12640-017-9727-8","article-title":"PACAP protects against ethanol and nicotine toxicity in SH-SY5Y cells: implications fodrinking-smoking co-morbidity","volume":"32","author":"Manavalan","year":"2017","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0250","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/acer.12936","article-title":"The impact of prenatal ethanol exposure on neuroanatomical and behavioral development in mice","volume":"40","author":"Abbott","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0255","doi-asserted-by":"crossref","first-page":"18893","DOI":"10.1523\/JNEUROSCI.3721-13.2013","article-title":"Prenatal ethanol exposure disrupts intraneocortical circuitry, cortical gene expression, and behavior in a mouse model of FASD","volume":"33","author":"El Shawa","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.peptides.2021.170630_bib0260","first-page":"2908","article-title":"Prenatal ethanol exposure and neocortical development: a transgenerational model of FASD","volume":"28","author":"Abbott","year":"2018","journal-title":"Cereb. Cortex N. Y. N 1991"},{"key":"10.1016\/j.peptides.2021.170630_bib0265","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bbr.2011.05.005","article-title":"Maternal voluntary drinking in C57BL\/6J mice: advancing a model for fetal alcohol spectrum disorders","volume":"223","author":"Kleiber","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0270","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.neuropharm.2011.10.006","article-title":"Anxiety- and depression-like behaviors are accompanied by an increase in oxidative stress in a rat model of fetal alcohol spectrum disorders: protective effects of voluntary physical exercise","volume":"62","author":"Brocardo","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.peptides.2021.170630_bib0275","series-title":"Syst. Biol. Free Radic. Antioxid.","first-page":"645","article-title":"Oxidative stress in fetal alcohol spectrum disorders \u2013 insights for the development of antioxidant-based therapies","author":"Patten","year":"2014"},{"key":"10.1016\/j.peptides.2021.170630_bib0280","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/jnc.13614","article-title":"Involvement of endogenous antioxidant systems in the protective activity of pituitary adenylate cyclase-activating polypeptide against hydrogen peroxide-induced oxidative damages in cultured rat astrocytes","volume":"137","author":"Douiri","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.peptides.2021.170630_bib0285","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12031-010-9350-0","article-title":"Regulation of oxidative stress by pituitary adenylate cyclase-activating polypeptide (PACAP) mediated by PACAP receptor","volume":"42","author":"Ohtaki","year":"2010","journal-title":"J. Mol. Neurosci. MN"},{"key":"10.1016\/j.peptides.2021.170630_bib0290","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12031-008-9075-5","article-title":"Peroxiredoxin 2 is involved in the neuroprotective effects of PACAP in cultured cerebellar granule neurons","volume":"36","author":"Botia","year":"2008","journal-title":"J. Mol. Neurosci. MN"},{"key":"10.1016\/j.peptides.2021.170630_bib0295","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.1007\/s12035-016-0204-9","article-title":"PACAP protects the adolescent and adult mice brain from ethanol toxicity and modulates distinct sets of genes regulating similar networks","volume":"54","author":"Lacaille","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.peptides.2021.170630_bib0300","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12972","article-title":"Effects of pituitary adenylate cyclase\u2010activating polypeptide isoforms in nucleus accumbens subregions on ethanol drinking","volume":"26","author":"Gargiulo","year":"2021","journal-title":"Addict. Biol."},{"key":"10.1016\/j.peptides.2021.170630_bib0305","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1111\/acer.13826","article-title":"Pituitary Adenylate Cyclase-Activating Polypeptide-27 (PACAP-27) in the thalamic paraventricular nucleus is stimulated by ethanol drinking","volume":"42","author":"Gupta","year":"2018","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0310","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/dvdy.21048","article-title":"Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome","volume":"236","author":"Green","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.peptides.2021.170630_bib0315","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s11065-011-9163-0","article-title":"Imaging the impact of prenatal alcohol exposure on the structure of the developing human brain","volume":"21","author":"Lebel","year":"2011","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.peptides.2021.170630_bib0320","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/(SICI)1098-1063(2000)10:1<94::AID-HIPO11>3.0.CO;2-T","article-title":"Effects of prenatal alcohol exposure on the hippocampus: spatial behavior, electrophysiology, and neuroanatomy","volume":"10","author":"Berman","year":"2000","journal-title":"Hippocampus."},{"key":"10.1016\/j.peptides.2021.170630_bib0325","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00004703-200408000-00002","article-title":"Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects, J. Dev","volume":"25","author":"Streissguth","year":"2004","journal-title":"Behav. Pediatr. JDBP."},{"key":"10.1016\/j.peptides.2021.170630_bib0330","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1111\/j.1530-0277.2009.01040.x","article-title":"Comparison of adaptive behavior in children with heavy prenatal alcohol exposure or attention-deficit\/hyperactivity disorder","volume":"33","author":"Crocker","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0335","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/j.1530-0277.2001.tb02311.x","article-title":"Comparison of the adaptive functioning of children prenatally exposed to alcohol to a nonexposed clinical sample","volume":"25","author":"Whaley","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.peptides.2021.170630_bib0340","doi-asserted-by":"crossref","first-page":"e192","DOI":"10.1542\/peds.2013-3733","article-title":"Gross motor deficits in children prenatally exposed to alcohol: a meta-analysis","volume":"134","author":"Lucas","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.peptides.2021.170630_bib0345","doi-asserted-by":"crossref","first-page":"9415","DOI":"10.1073\/pnas.96.16.9415","article-title":"Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development","volume":"96","author":"Vaudry","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.peptides.2021.170630_bib0350","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.peptides.2007.04.013","article-title":"Neurotrophic effects of PACAP in the cerebellar cortex","volume":"28","author":"Botia","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2021.170630_bib0355","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41386-020-00904-4","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates dependence-induced alcohol drinking and anxiety-like behavior in male rats","volume":"46","author":"Ferragud","year":"2021","journal-title":"Neuropsychopharmacology"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978121001388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978121001388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:30:50Z","timestamp":1759311050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978121001388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":71,"alternative-id":["S0196978121001388"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2021.170630","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term protective effect of PACAP in a fetal alcohol syndrome (FAS) model","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2021.170630","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"170630"}}