{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:12:56Z","timestamp":1777864376753,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["15\/04194\\u20100"],"award-info":[{"award-number":["15\/04194\\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["18\/03051-9"],"award-info":[{"award-number":["18\/03051-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["15\/04194?"],"award-info":[{"award-number":["15\/04194?"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/03761-9"],"award-info":[{"award-number":["2019\/03761-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["431465\/2016\\u20109"],"award-info":[{"award-number":["431465\/2016\\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["431465\/2016?"],"award-info":[{"award-number":["431465\/2016?"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.peptides.2021.170648","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T11:07:27Z","timestamp":1631790447000},"page":"170648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["The SNX-482 peptide from Hysterocrates gigas spider acts as an immunomodulatory molecule activating macrophages"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3112-3033","authenticated-orcid":false,"given":"Jaqueline","family":"Munhoz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Thom\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdolmohamad","family":"Rostami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3481-2181","authenticated-orcid":false,"given":"Larissa Lumi Watanabe","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liana","family":"Verinaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Rap\u00f4so","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2021.170648_bib0005","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1007\/s11033-018-4427-x","article-title":"Monoclonal antibodies in cancer immunotherapy","volume":"45","author":"Kimiz-Gebologlu","year":"2018","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.peptides.2021.170648_bib0010","doi-asserted-by":"crossref","first-page":"759","DOI":"10.2174\/1389203719666180111150008","article-title":"The potential use of peptides in cancer treatment","volume":"19","author":"Yavari","year":"2018","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.peptides.2021.170648_bib0015","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.coph.2019.01.008","article-title":"The future of peptides in cancer treatment","volume":"47","author":"Kurrikoff","year":"2019","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.peptides.2021.170648_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188486","article-title":"Peptides that immunoactivate the tumor microenvironment","volume":"1875","author":"Furukawa","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.peptides.2021.170648_bib0025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.coph.2019.01.007","article-title":"Peptides as cancer vaccines","volume":"47","author":"Calvo Tard\u00f3n","year":"2019","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.peptides.2021.170648_bib0030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.trecan.2017.07.004","article-title":"Venom peptides: improving specificity in cancer therapy","volume":"3","author":"Mahadevappa","year":"2017","journal-title":"Trends Cancer"},{"key":"10.1016\/j.peptides.2021.170648_bib0035","first-page":"3565","article-title":"Biomimetic peptides for the treatment of cancer","volume":"36","author":"Mine","year":"2016","journal-title":"Anticancer Res."},{"key":"10.1016\/j.peptides.2021.170648_bib0040","first-page":"233","article-title":"Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives","volume":"3","author":"Rap\u00f4so","year":"2017","journal-title":"J. Clin. Transl. Res."},{"key":"10.1016\/j.peptides.2021.170648_bib0045","doi-asserted-by":"crossref","first-page":"9182","DOI":"10.1523\/JNEUROSCI.0339-14.2014","article-title":"Inhibition of A-type potassium current by the peptide toxin SNX-482","volume":"34","author":"Kimm","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.peptides.2021.170648_bib0050","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1460-9568.2006.04640.x","article-title":"Transmitter modulation of spike-evoked calcium transients in arousal related neurons: muscarinic inhibition of SNX-482-sensitive calcium influx","volume":"23","author":"Kohlmeier","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.peptides.2021.170648_bib0055","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1111\/j.1460-9568.2007.05605.x","article-title":"The Ca v 2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain","volume":"25","author":"Matthews","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.peptides.2021.170648_bib0060","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3390\/toxins10120531","article-title":"Acute toxicity of the recombinant and native Ph\u03b11\u03b2 toxin: new analgesic from Phoneutria nigriventer spider venom","volume":"10","author":"Dallegrave","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.peptides.2021.170648_bib0065","doi-asserted-by":"crossref","first-page":"15353","DOI":"10.1021\/bi981255g","article-title":"Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas","volume":"37","author":"Newcomb","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.peptides.2021.170648_bib0070","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1002\/jcp.26935","article-title":"Venom of the Phoneutria nigriventer spider alters the cell cycle, viability, and migration of cancer cells","volume":"234","author":"Barreto dos Santos","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.peptides.2021.170648_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-020-01643-8","article-title":"Spider venom components decrease glioblastoma cell migration and invasion through RhoA-ROCK and Na+\/K+-ATPase \u03b22: potential molecular entities to treat invasive brain cancer","volume":"20","author":"Barreto","year":"2020","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.peptides.2021.170648_bib0080","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.1038\/s41598-020-62620-9","article-title":"Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model","volume":"10","author":"Bonfanti","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.peptides.2021.170648_bib0085","first-page":"vii","article-title":"Components from spider venom activate macrophages against glioblastoma cells: new potential adjuvants for anticancer immunotherapy","volume":"6","author":"Munhoz","year":"2021","journal-title":"J. Biochem."},{"issue":"76","key":"10.1016\/j.peptides.2021.170648_bib0090","first-page":"50323","article-title":"Investigation of macrophage polarization using bone marrow derived macrophages","author":"Ying","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.peptides.2021.170648_bib0095","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01392","article-title":"Induction of peripheral tolerance in ongoing autoimmune inflammation requires interleukin 27 signaling in dendritic cells","volume":"8","author":"Thom\u00e9","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.peptides.2021.170648_bib0100","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.cellsig.2013.11.004","article-title":"Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways","volume":"26","author":"Zhou","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.peptides.2021.170648_bib0105","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.canlet.2017.05.010","article-title":"Melittin, A major peptide component of bee venom, and its conjugates in cancer therapy","volume":"402","author":"Rady","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.peptides.2021.170648_bib0110","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1002\/jcp.26935","article-title":"Venom of the Phoneutria nigriventer spider alters the cell cycle, viability, and migration of cancer cells","volume":"234","author":"Barreto dos Santos","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.peptides.2021.170648_bib0115","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nrd.2018.169","article-title":"Targeting macrophages: therapeutic approaches in cancer","volume":"17","author":"Cassetta","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.peptides.2021.170648_bib0120","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-065X.2009.00771.x","article-title":"Costimulatory and coinhibitory receptors in anti-tumor immunity","volume":"229","author":"Driessens","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.peptides.2021.170648_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/926321","article-title":"Targeting costimulatory molecules to improve antitumor immunity","volume":"2012","author":"Capece","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.peptides.2021.170648_bib0130","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.4049\/jimmunol.176.9.5213","article-title":"Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant","volume":"176","author":"Overwijk","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.peptides.2021.170648_bib0135","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.3390\/ijms19082155","article-title":"Interleukin-1 beta- a friend or foe in malignancies?","volume":"19","author":"Bent","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2021.170648_bib0140","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaut.2011.11.015","article-title":"FAS\/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25\u2212 responder T cells, but not CD4+CD25+ regulatory T cells","volume":"38","author":"Jagger","year":"2012","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.peptides.2021.170648_bib0145","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.15190\/d.2015.29","article-title":"Defective fas expression on bone marrow derived cells alters atherosclerotic plaque morphology in hyperlipidemic mice","volume":"3","author":"Kubo","year":"2015","journal-title":"Discoveries"},{"key":"10.1016\/j.peptides.2021.170648_bib0150","volume":"Series Vol. 1856","author":"Dumitrescu","year":"2018"},{"key":"10.1016\/j.peptides.2021.170648_bib0155","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature22396","article-title":"PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity","volume":"545","author":"Gordon","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2021.170648_bib0160","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1158\/1078-0432.CCR-19-1040","article-title":"Immune cell PD-L1 colocalizes with macrophages and is associated with outcome in PD-1 pathway blockade therapy","volume":"26","author":"Liu","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.peptides.2021.170648_bib0165","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00339","article-title":"Progress and challenges in precise treatment of tumors with PD-1\/PD-L1 blockade","volume":"11","author":"Jiang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.peptides.2021.170648_bib0170","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1038\/s41467-021-22965-9","article-title":"PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.peptides.2021.170648_bib0175","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41577-020-0306-5","article-title":"A guide to cancer immunotherapy: from T cell basic science to clinical practice","volume":"20","author":"Waldman","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.peptides.2021.170648_bib0180","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41590-020-0620-x","article-title":"PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer","volume":"21","author":"Diskin","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.peptides.2021.170648_bib0185","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.canlet.2016.04.039","article-title":"CCR4 is critically involved in effective antitumor immunity in mice bearing intradermal B16 melanoma","volume":"378","author":"Matsuo","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.peptides.2021.170648_bib0190","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00847","article-title":"Interferon-gamma at the crossroads of tumor immune surveillance or evasion","volume":"9","author":"Castro","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.peptides.2021.170648_bib0195","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1002\/cam4.1700","article-title":"Interferon gamma in cancer immunotherapy","volume":"7","author":"Ni","year":"2018","journal-title":"Cancer Med."},{"key":"10.1016\/j.peptides.2021.170648_bib0200","doi-asserted-by":"crossref","first-page":"7616","DOI":"10.7150\/thno.35900","article-title":"A novel Granzyme B nanoparticle delivery system simulates immune cell functions for suppression of solid tumors","volume":"9","author":"Qian","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.peptides.2021.170648_bib0205","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1158\/0008-5472.CAN-16-3346","article-title":"Granzyme B PET imaging as a predictive biomarker of immunotherapy response","volume":"77","author":"Larimer","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.peptides.2021.170648_bib0210","doi-asserted-by":"crossref","DOI":"10.3892\/ijo_00000788","article-title":"Granzyme B-induced apoptosis in cancer cells and its regulation (Review)","volume":"37","author":"Krepela","year":"2010","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.peptides.2021.170648_bib0215","doi-asserted-by":"crossref","first-page":"e000586","DOI":"10.1136\/jitc-2020-000586","article-title":"Granzyme B is correlated with clinical outcome after PD-1 blockade in patients with stage IV non-small-cell lung cancer","volume":"8","author":"Hurkmans","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.peptides.2021.170648_bib0220","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2217\/imt-2018-0156","article-title":"Re-education of macrophages as a therapeutic strategy in cancer","volume":"11","author":"Kowal","year":"2019","journal-title":"Immunotherapy"},{"key":"10.1016\/j.peptides.2021.170648_bib0225","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1002\/cam4.2332","article-title":"Engineering macrophages to phagocytose cancer cells by blocking the CD47\/SIRP\u0251 axis","volume":"8","author":"Yang","year":"2019","journal-title":"Cancer Med."},{"key":"10.1016\/j.peptides.2021.170648_bib0230","series-title":"PubChem Compound Summary for CID 90488787","author":"National Center for Biotechnology Information","year":"2021"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019697812100156X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019697812100156X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:40:52Z","timestamp":1777527652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019697812100156X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":46,"alternative-id":["S019697812100156X"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2021.170648","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The SNX-482 peptide from Hysterocrates gigas spider acts as an immunomodulatory molecule activating macrophages","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2021.170648","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"170648"}}