{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:11:09Z","timestamp":1786554669066,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.peptides.2021.170711","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T11:48:40Z","timestamp":1639482520000},"page":"170711","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Semaglutide early intervention attenuated testicular dysfunction by targeting the GLP-1\u2013PPAR-\u03b1\u2013Kisspeptin\u2013Steroidogenesis signaling pathway in a testicular ischemia-reperfusion rat model"],"prefix":"10.1016","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6409-9079","authenticated-orcid":false,"given":"Doaa M.","family":"Abdullah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5203-0784","authenticated-orcid":false,"given":"Amira Ebrahim","family":"Alsemeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4722-2666","authenticated-orcid":false,"given":"Tarek","family":"Khamis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2021.170711_bib0005","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0198-16.2016","article-title":"GLP-1R signaling directly activates arcuate nucleus kisspeptin action in brain slices but does not rescue luteinizing hormone inhibition in ovariectomized mice during negative energy balance","volume":"4","author":"Heppner","year":"2017","journal-title":"ENeuro"},{"key":"10.1016\/j.peptides.2021.170711_bib0010","doi-asserted-by":"crossref","DOI":"10.1111\/and.13775","article-title":"Effects of myricetin on testicular torsion-detorsion injury in rats","volume":"52","author":"Ek\u015fi","year":"2020","journal-title":"Andrologia"},{"key":"10.1016\/j.peptides.2021.170711_bib0015","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jpurol.2020.08.005","article-title":"Adjuvant pharmacological and surgical therapy for testicular torsion: current state of the art","volume":"16","author":"Thaker","year":"2020","journal-title":"J. Pediatr. Urol."},{"key":"10.1016\/j.peptides.2021.170711_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152439","article-title":"LCZ696 (sacubitril\/valsartan) protects against cyclophosphamide-induced testicular toxicity in rats: role of neprilysin inhibition and lncRNA TUG1 in ameliorating apoptosis","volume":"437","author":"Salama","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.peptides.2021.170711_bib0025","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1590\/S0102-86502013000700007","article-title":"Expression of FAS ligand in the ipsilateral and contralateral testicles of rats subjected to the torsion of the unilateral testicular cord","volume":"28","author":"de Assis","year":"2013","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.peptides.2021.170711_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21082958","article-title":"Kisspeptin and testicular function\u2014is it necessary?","volume":"21","author":"Sharma","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2021.170711_bib0035","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/35079135","article-title":"Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor","volume":"411","author":"Ohtaki","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2021.170711_bib0040","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-2605.2011.01177.x","article-title":"Characterization of the kisspeptin system in human spermatozoa","volume":"35","author":"Pinto","year":"2012","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.peptides.2021.170711_bib0045","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbaexp.2004.02.005","article-title":"Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta","volume":"1678","author":"Terao","year":"2004","journal-title":"Biochim. Biophys. Acta - Gene Struct. Expr."},{"key":"10.1016\/j.peptides.2021.170711_bib0050","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2013.00198","article-title":"Does kisspeptin signaling have a role in the testes?","volume":"4","author":"Mei","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.peptides.2021.170711_bib0055","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1152\/physrev.00037.2010","article-title":"Kisspeptins and reproduction: Physiological roles and regulatory mechanisms","volume":"92","author":"Pinilla","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.peptides.2021.170711_bib0060","doi-asserted-by":"crossref","DOI":"10.1038\/srep19206","article-title":"Direct actions of Kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic Axis activity","volume":"6","author":"Le\u00f3n","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.peptides.2021.170711_bib0065","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s40265-018-0871-0","article-title":"Semaglutide: first global approval","volume":"78","author":"Dhillon","year":"2018","journal-title":"Drugs"},{"key":"10.1016\/j.peptides.2021.170711_bib0070","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s10557-019-06915-8","article-title":"Neuroprotection in rats following ischaemia-reperfusion injury by GLP-1 analogues\u2014liraglutide and semaglutide","volume":"33","author":"Basalay","year":"2019","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.peptides.2021.170711_bib0075","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/biolre\/iox087","article-title":"GLP-1 increases Kiss-1 mRNA expression in kisspeptin-expressing neuronal cells","volume":"97","author":"Oride","year":"2017","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.peptides.2021.170711_bib0080","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1111\/andr.12871","article-title":"Glucagon\u2010like peptide\u20101 receptor is expressed in human and rodent testis","volume":"8","author":"Caltabiano","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.peptides.2021.170711_bib0085","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in vivo experiments: the ARRIVE guidelines","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.peptides.2021.170711_bib0090","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/ilar.38.1.41","article-title":"The 1996 guide for the care and use of laboratory animals","volume":"38","author":"Clark","year":"1997","journal-title":"ILAR J."},{"key":"10.1016\/j.peptides.2021.170711_bib0095","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/cvr\/cvw216","article-title":"Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning","volume":"112","author":"Basalay","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.peptides.2021.170711_bib0100","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jacbts.2018.09.004","article-title":"The GLP-1 analogs liraglutide and semaglutide reduce atherosclerosis in ApoE \u2212\/\u2212 and LDLr \u2212\/\u2212 mice by a mechanism that includes inflammatory pathways","volume":"3","author":"Rakipovski","year":"2018","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.peptides.2021.170711_bib0105","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5424097","article-title":"Probucol reduces testicular torsion\/detorsion-induced ischemia\/reperfusion injury in rats","volume":"2017","author":"Wei","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.peptides.2021.170711_bib0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174188","article-title":"Breast milk MSCs upregulated \u03b2-cells PDX1, Ngn3, and PCNA expression via remodeling ER stress \/inflammatory \/Apoptotic signaling pathways in type 1 diabetic rats","volume":"905","author":"Khamis","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.peptides.2021.170711_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.165577","article-title":"Early intervention with breast milk mesenchymal stem cells attenuates the development of diabetic-induced testicular dysfunction via hypothalamic Kisspeptin\/Kiss1r-GnRH\/GnIH system in male rats","volume":"1866","author":"Khamis","year":"2020","journal-title":"Biochim. Biophys. Acta - Mol. Basis Dis."},{"key":"10.1016\/j.peptides.2021.170711_bib0120","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.peptides.2021.170711_bib0125","series-title":"Bancroft\u2019s Theory and Practice of Histological Techniques","year":"2019"},{"key":"10.1016\/j.peptides.2021.170711_bib0130","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1210\/endo.142.6.8317","article-title":"Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation","volume":"142","author":"Johnston","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2021.170711_bib0135","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.peptides.2021.170711_bib0140","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/ki.2013.427","article-title":"The protective roles of GLP-1R signaling in diabetic nephropathy: Possible mechanism and therapeutic potential","volume":"85","author":"Fujita","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.peptides.2021.170711_bib0145","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1111\/andr.13015","article-title":"Is there a role for glucagon\u2010like peptide\u20101 receptor agonists in the treatment of male infertility?","volume":"9","author":"Cannarella","year":"2021","journal-title":"Andrology"},{"key":"10.1016\/j.peptides.2021.170711_bib0150","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/929285","article-title":"The hypoxic testicle: physiology and pathophysiology","volume":"2012","author":"Reyes","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.peptides.2021.170711_bib0155","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrurol.2014.135","article-title":"Mechanisms of testicular torsion and potential protective agents","volume":"11","author":"Karaguzel","year":"2014","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.peptides.2021.170711_bib0160","first-page":"4349","article-title":"Exenatide reduces oxidative stress and cell death in testis in iron overload rat model","volume":"16","author":"Yesil","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.peptides.2021.170711_bib0165","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1111\/febs.13785","article-title":"Glucagon-like peptide-1 drives energy metabolism on the synaptic highway","volume":"283","author":"Liu","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.peptides.2021.170711_bib0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2020.05.001","article-title":"GLP-1 receptor signaling in astrocytes regulates fatty acid oxidation, mitochondrial integrity, and function","volume":"31","author":"Timper","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2021.170711_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-73630-y","article-title":"Reduced spermatozoa functionality during stress is the consequence of adrenergic-mediated disturbance of mitochondrial dynamics markers","volume":"10","author":"Starovlah","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.peptides.2021.170711_bib0180","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/advan.00052.2006","article-title":"PGC-1\u03b1: A key regulator of energy metabolism","volume":"30","author":"Liang","year":"2006","journal-title":"Am. J. Physiol. - Adv. Physiol. Educ."},{"key":"10.1016\/j.peptides.2021.170711_bib0185","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbrc.2015.08.092","article-title":"GLP-1 contributes to increases in PGC-1\u03b1 expression by downregulating miR-23a to reduce apoptosis","volume":"466","author":"Wang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.peptides.2021.170711_bib0190","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3389\/fendo.2018.00184","article-title":"The emerging role(s) for kisspeptin in metabolism in mammals","volume":"9","author":"Wolfe","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.peptides.2021.170711_bib0195","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.acthis.2016.05.002","article-title":"Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer","volume":"118","author":"Jur\u00edkov\u00e1","year":"2016","journal-title":"Acta Histochem."},{"key":"10.1016\/j.peptides.2021.170711_bib0200","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.2337\/db14-0883","article-title":"Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis","volume":"64","author":"Koehler","year":"2015","journal-title":"Diabetes."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978121002199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978121002199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:30:32Z","timestamp":1759311032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978121002199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":40,"alternative-id":["S0196978121002199"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2021.170711","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Semaglutide early intervention attenuated testicular dysfunction by targeting the GLP-1\u2013PPAR-\u03b1\u2013Kisspeptin\u2013Steroidogenesis signaling pathway in a testicular ischemia-reperfusion rat model","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2021.170711","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"170711"}}