{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:54:00Z","timestamp":1783569240927,"version":"3.55.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.peptides.2021.170716","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T11:23:16Z","timestamp":1640085796000},"page":"170716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity"],"prefix":"10.1016","volume":"150","author":[{"given":"Renzhi","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengjiao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Halmos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9179-0575","authenticated-orcid":false,"given":"Petra","family":"Popovics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4750-0881","authenticated-orcid":false,"given":"Irving","family":"Vidaurre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongxu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Mirsaeidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew V.","family":"Schally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2021.170716_bib0005","first-page":"7","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.peptides.2021.170716_bib0010","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1126\/science.6812220","article-title":"Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly","volume":"218","author":"Guillemin","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.peptides.2021.170716_bib0015","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/300276a0","article-title":"Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour","volume":"300","author":"Rivier","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2021.170716_bib0020","first-page":"259","article-title":"Ectopic production of growth hormone-releasing factor by carcinoid and pancreatic islet tumors associated with acromegaly","volume":"74","author":"Frohman","year":"1981","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.peptides.2021.170716_bib0025","first-page":"4671","article-title":"The discovery of growth hormone-releasing hormone","volume":"84","author":"Thorner","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2021.170716_bib0030","doi-asserted-by":"crossref","first-page":"12298","DOI":"10.1073\/pnas.91.25.12298","article-title":"Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone","volume":"91","author":"Zarandi","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2021.170716_bib0035","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0196-9781(96)00344-0","article-title":"Synthesis and in vitro evaluation of new potent antagonists of growth hormone-releasing hormone (GH-RH)","volume":"18","author":"Zarandi","year":"1997","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2021.170716_bib0040","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1073\/pnas.0511348103","article-title":"Lipopeptide antagonists of growth hormone-releasing hormone with improved antitumor activities","volume":"103","author":"Zarandi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2021.170716_bib0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0014-2999(91)90703-S","article-title":"Human growth hormone-releasing hormone analogues with much improved in vitro growth hormone-releasing potencies in rat pituitary cells","volume":"204","author":"Coy","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.peptides.2021.170716_bib0050","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1210\/endo-117-5-1759","article-title":"Structural requirements for the activation of rat anterior pituitary adenylate cyclase by growth hormone-releasing factor (GRF): discovery of (N-Ac-Tyr1, D-Arg2)-GRF(1-29)-NH2 as a GRF antagonist on membranes","volume":"117","author":"Robberecht","year":"1985","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2021.170716_bib0055","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0006-291X(87)90400-1","article-title":"Synthesis and in vitro bioactivity of human growth hormone-releasing factor analogs substituted with a single D-amino acid","volume":"149","author":"Sato","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.peptides.2021.170716_bib0060","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0006-291X(90)91773-L","article-title":"Synthetic analogs of growth hormone-releasing factor with antagonistic activity in vitro","volume":"167","author":"Sato","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.peptides.2021.170716_bib0065","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.copbio.2006.10.002","article-title":"Therapeutic peptides: technological advances driving peptides into development","volume":"17","author":"Sato","year":"2006","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.peptides.2021.170716_bib0070","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.peptides.2017.01.009","article-title":"Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth","volume":"89","author":"Zarandi","year":"2017","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2021.170716_bib0075","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1073\/pnas.96.2.692","article-title":"Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities","volume":"96","author":"Varga","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2021.170716_bib0080","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1043-2760(99)00209-X","article-title":"Antagonistic analogs of growth hormone-releasing hormone: new potential antitumor agents","volume":"10","author":"Schally","year":"1999","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2021.170716_bib0085","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2174\/138620706776055449","article-title":"Antagonists of growth hormone-releasing hormone in oncology","volume":"9","author":"Schally","year":"2006","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.peptides.2021.170716_bib0090","first-page":"33","article-title":"Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer, Nature clinical practice","volume":"4","author":"Schally","year":"2008","journal-title":"Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2021.170716_bib0095","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/jnci\/87.23.1787","article-title":"Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone","volume":"87","author":"Pinski","year":"1995","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.peptides.2021.170716_bib0100","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3892\/ijo.9.6.1099","article-title":"Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH)","volume":"9","author":"Pinski","year":"1996","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.peptides.2021.170716_bib0105","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.2174\/156802606777951055","article-title":"How C(alpha)-Fluoroalkyl amino acids and peptides interact with enzymes: studies concerning the influence on proteolytic stability, enzymatic resolution and peptide coupling","volume":"6","author":"Smits","year":"2006","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.peptides.2021.170716_bib0110","doi-asserted-by":"crossref","first-page":"18303","DOI":"10.1073\/pnas.1421815112","article-title":"Antagonist of GH-releasing hormone receptors alleviates experimental ocular inflammation","volume":"111","author":"Qin","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2021.170716_bib0115","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00408-019-00257-w","article-title":"Growth hormone-releasing hormone receptor antagonist modulates lung inflammation and fibrosis due to bleomycin","volume":"197","author":"Zhang","year":"2019","journal-title":"Lung"},{"key":"10.1016\/j.peptides.2021.170716_bib0120","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/pros.23655","article-title":"Growth hormone-releasing hormone antagonists reduce prostatic enlargement and inflammation in carrageenan-induced chronic prostatitis","volume":"78","author":"Popovics","year":"2018","journal-title":"Prostate"},{"key":"10.1016\/j.peptides.2021.170716_bib0125","unstructured":"A.V. Schally, R. Cai, X. Zhang, H. Wang, and W. Sha, inventors; Growth hormone-releasing hormone antagonists and uses thereof, US PATENT, Application #62803170, Date of Filing, 2019 Feb 8."},{"key":"10.1016\/j.peptides.2021.170716_bib0130","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.peptides.2013.12.010","article-title":"Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities","volume":"52","author":"Cai","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2021.170716_bib0135","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1002\/ijc.31308","article-title":"Inhibition of experimental small-cell and non-small-cell lung cancers by novel antagonists of growth hormone-releasing hormone","volume":"142","author":"Wang","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.peptides.2021.170716_bib0140","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0003-2697(80)90515-1","article-title":"Ligand: a versatile computerized approach for characterization of ligand-binding systems","volume":"107","author":"Munson","year":"1980","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.peptides.2021.170716_bib0145","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0160-5402(85)90034-8","article-title":"Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC","volume":"14","author":"McPherson","year":"1985","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.peptides.2021.170716_bib0150","doi-asserted-by":"crossref","first-page":"12028","DOI":"10.1073\/pnas.1813375115","article-title":"Agonists of growth hormone-releasing hormone (GHRH) inhibit human experimental cancers in vivo by down-regulating receptors for GHRH","volume":"115","author":"Schally","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2021.170716_bib0155","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.3389\/fimmu.2019.02888","article-title":"Mycobacterium abscessus-bronchial epithelial cells cross-talk through type I interferon signaling","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.peptides.2021.170716_bib0160","doi-asserted-by":"crossref","first-page":"988","DOI":"10.18632\/oncotarget.634","article-title":"Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers","volume":"3","author":"Perez","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.peptides.2021.170716_bib0165","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1073\/pnas.1323102111","article-title":"Preclinical efficacy of growth hormone-releasing hormone antagonists for androgen-dependent and castration-resistant human prostate cancer","volume":"111","author":"Fahrenholtz","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2021.170716_bib0170","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11523-013-0264-y","article-title":"Suppression of the proliferation of human U-87 MG glioblastoma cells by new antagonists of growth hormone-releasing hormone in vivo and in vitro","volume":"8","author":"Jaszberenyi","year":"2013","journal-title":"Target. Oncol."},{"key":"10.1016\/j.peptides.2021.170716_bib0175","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/cncr.26291","article-title":"Novel antagonists of growth hormone-releasing hormone inhibit growth and vascularization of human experimental ovarian cancers","volume":"118","author":"Klukovits","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.peptides.2021.170716_bib0180","doi-asserted-by":"crossref","first-page":"14745","DOI":"10.1073\/pnas.1618582114","article-title":"Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1-STAT3\/NF-kappaB signaling","volume":"113","author":"Gan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2021.170716_bib0185","doi-asserted-by":"crossref","first-page":"6726","DOI":"10.1073\/pnas.1913433117","article-title":"Splice variant of growth hormone-releasing hormone receptor drives esophageal squamous cell carcinoma conferring a therapeutic target","volume":"117","author":"Xiong","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2021.170716_bib0190","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1073\/pnas.1818865116","article-title":"Antagonists of growth hormone-releasing hormone (GHRH) inhibit the growth of human malignant pleural mesothelioma","volume":"116","author":"Villanova","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2021.170716_bib0195","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12672-017-0307-4","article-title":"Inhibitory effects of antagonists of growth hormone-releasing hormone (GHRH) in thyroid cancer","volume":"8","author":"Populo","year":"2017","journal-title":"Horm. Cancer"},{"key":"10.1016\/j.peptides.2021.170716_bib0200","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.4161\/15384101.2015.945879","article-title":"Novel GHRH antagonists suppress the growth of human malignant melanoma by restoring nuclear p27 function","volume":"13","author":"Szalontay","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.peptides.2021.170716_bib0205","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/bjh.15207","article-title":"A new approach to the treatment of acute myeloid leukaemia targeting the receptor for growth hormone-releasing hormone","volume":"181","author":"Jimenez","year":"2018","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.peptides.2021.170716_bib0210","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/pros.23360","article-title":"Discovery of LHRH and development of LHRH analogs for prostate cancer treatment","volume":"77","author":"Schally","year":"2017","journal-title":"Prostate"},{"key":"10.1016\/j.peptides.2021.170716_bib0215","doi-asserted-by":"crossref","first-page":"755","DOI":"10.18632\/aging.100504","article-title":"Beneficial effects of novel antagonists of GHRH in different models of Alzheimer\u2019s disease","volume":"4","author":"Jaszberenyi","year":"2012","journal-title":"Aging"},{"key":"10.1016\/j.peptides.2021.170716_bib0220","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1055\/a-1149-9347","article-title":"GHRH antagonists protect against hydrogen peroxide-induced breakdown of brain microvascular endothelium integrity","volume":"52","author":"Barabutis","year":"2020","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.peptides.2021.170716_bib0225","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev.pharmtox.41.1.443","article-title":"Metabolism of fluorine-containing drugs","volume":"41","author":"Park","year":"2001","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.peptides.2021.170716_bib0230","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/sj.embor.7401099","article-title":"Interleukin 2: from immunostimulation to immunoregulation and back again","volume":"8","author":"Bachmann","year":"2007","journal-title":"EMBO Rep."},{"key":"10.1016\/j.peptides.2021.170716_bib0235","series-title":"Cancer Medicine","first-page":"1067","article-title":"Hypothalamic and other peptide hormones","author":"Schally","year":"1997"},{"key":"10.1016\/j.peptides.2021.170716_bib0240","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ebiom.2018.10.034","article-title":"P53, GHRH, inflammation and cancer","volume":"37","author":"Barabutis","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.peptides.2021.170716_bib0245","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1073\/pnas.1120588109","article-title":"Antagonists of growth hormone-releasing hormone inhibit growth of androgen-independent prostate cancer through inactivation of ERK and Akt kinases","volume":"109","author":"Rick","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2021.170716_bib0250","first-page":"1019","article-title":"Alterations of EGFR\/HER, angiogenesis and apoptosis pathways after therapy with antagonists of growth hormone releasing hormone and bombesin in non-small cell lung cancer","volume":"30","author":"Kanashiro","year":"2007","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.peptides.2021.170716_bib0255","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2174\/157489212798358010","article-title":"Antineoplastic action of growth hormone-releasing hormone (GHRH) antagonists","volume":"7","author":"Siejka","year":"2012","journal-title":"Recent Pat. Anticancer Drug Discov."},{"key":"10.1016\/j.peptides.2021.170716_bib0260","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1038\/sj.onc.1204186","article-title":"G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation","volume":"20","author":"Ram","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.peptides.2021.170716_bib0265","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1073\/pnas.1904532117","article-title":"Signaling mechanisms of growth hormone-releasing hormone receptor in LPS-induced acute ocular inflammation","volume":"117","author":"Liang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2021.170716_bib0270","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.stem.2020.09.013","article-title":"SARS-CoV-2 infection of pluripotent stem cell-derived human lung alveolar type 2 cells elicits a rapid epithelial-intrinsic inflammatory response","volume":"27","author":"Huang","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.peptides.2021.170716_bib0275","doi-asserted-by":"crossref","first-page":"11560","DOI":"10.1074\/jbc.M412914200","article-title":"Distinct conformations of the corticotropin releasing factor type 1 receptor adopted following agonist and antagonist binding are differentially regulated","volume":"280","author":"Perry","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2021.170716_bib0280","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.tibs.2014.10.001","article-title":"Emerging structural insights into biased GPCR signaling","volume":"39","author":"Shukla","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.peptides.2021.170716_bib0285","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1210\/en.2019-00111","article-title":"Actions and potential therapeutic applications of growth hormone-releasing hormone agonists","volume":"160","author":"Schally","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2021.170716_bib0290","first-page":"3590","article-title":"Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women","volume":"82","author":"Khorram","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2021.170716_bib0295","first-page":"1472","article-title":"Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women","volume":"82","author":"Khorram","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2021.170716_bib0300","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ghir.2009.03.001","article-title":"Activation of the GH\/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects","volume":"19","author":"Sackmann-Sala","year":"2009","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.peptides.2021.170716_bib0305","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/jamaneurol.2013.1425","article-title":"Growth hormone-releasing hormone effects on brain gamma-aminobutyric acid levels in mild cognitive impairment and healthy aging","volume":"70","author":"Friedman","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.peptides.2021.170716_bib0310","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1001\/archneurol.2012.1970","article-title":"Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial","volume":"69","author":"Baker","year":"2012","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.peptides.2021.170716_bib0315","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1001\/jama.2014.8334","article-title":"Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial","volume":"312","author":"Stanley","year":"2014","journal-title":"Jama"},{"key":"10.1016\/j.peptides.2021.170716_bib0320","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1097\/QAD.0000000000001614","article-title":"Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV","volume":"31","author":"Fourman","year":"2017","journal-title":"Aids"},{"key":"10.1016\/j.peptides.2021.170716_bib0325","first-page":"4","article-title":"Growth hormone-releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy","author":"Bagno","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.peptides.2021.170716_bib0330","first-page":"118","article-title":"Growth hormone-releasing hormone agonists ameliorate chronic kidney disease-induced heart failure with preserved ejection fraction","author":"Rieger","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2021.170716_bib0335","doi-asserted-by":"crossref","first-page":"925","DOI":"10.4103\/1008-682X.152819","article-title":"New therapies for relapsed castration-resistant prostate cancer based on peptide analogs of hypothalamic hormones","volume":"17","author":"Schally","year":"2015","journal-title":"Asian J. Androl."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978121002242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978121002242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:30:53Z","timestamp":1759311053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978121002242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":67,"alternative-id":["S0196978121002242"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2021.170716","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2021.170716","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"170716"}}