{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:26:57Z","timestamp":1759336017958,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.peptides.2021.170732","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T20:45:19Z","timestamp":1640724319000},"page":"170732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Inhibitors of the MAPK\/ NF-\u03baB pathway attenuate the upregulation of the ETB receptor mediated by high glucose in vascular smooth muscle cells"],"prefix":"10.1016","volume":"150","author":[{"given":"Xia","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaohong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingli","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2021.170732_bib0005","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1001\/jama.287.19.2570","article-title":"Diabetes and atherosclerosis: epidemiology, pathophysiology, and management","volume":"287","author":"Beckman","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.peptides.2021.170732_bib0010","first-page":"85","article-title":"High glucose-induced activation of protein kinase signaling pathways in vascular smooth muscle cells: a potential role in the pathogenesis of vascular dysfunction in diabetes (review)","volume":"9","author":"Srivastava","year":"2002","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.peptides.2021.170732_bib0015","article-title":"Sodium tanshinone IIA silate inhibits high glucose-induced vascular smooth muscle cell proliferation and migration through activation of AMP-activated protein kinase","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2021.170732_bib0020","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1139\/y03-053","article-title":"Endothelins in chronic diabetic complications","volume":"81","author":"Khan","year":"2003","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.peptides.2021.170732_bib0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1124\/jpet.110.175380","article-title":"Endothelial endothelin B receptor-mediated prevention of cerebrovascular remodeling is attenuated in diabetes because of up-regulation of smooth muscle endothelin receptors","volume":"337","author":"Kelly-Cobbs","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.peptides.2021.170732_bib0030","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pharmthera.2010.04.013","article-title":"Cardiovascular risk factors regulate the expression of vascular endothelin receptors","volume":"127","author":"Xu","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.peptides.2021.170732_bib0035","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.pharmthera.2005.11.001","article-title":"Cardiovascular endothelins: essential regulators of cardiovascular homeostasis","volume":"111","author":"Brunner","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.peptides.2021.170732_bib0040","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1139\/Y10-041","article-title":"Endothelial cell-specific ETB receptor knockout: autoradiographic and histological characterisation and crucial role in the clearance of endothelin-1","volume":"88","author":"Kelland","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.peptides.2021.170732_bib0045","doi-asserted-by":"crossref","first-page":"C1295","DOI":"10.1152\/ajpcell.1992.263.6.C1295","article-title":"Endothelin-1 stimulates DNA synthesis and proliferation of pulmonary artery smooth muscle cells","volume":"263","author":"Janakidevi","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.peptides.2021.170732_bib0050","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2261-9-40","article-title":"Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease","volume":"9","author":"Dimitrijevic","year":"2009","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.peptides.2021.170732_bib0055","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bbalip.2011.12.001","article-title":"Minimally modified LDL upregulates endothelin type B receptors in rat coronary artery via ERK1\/2 MAPK and NF-\u03baB pathways","volume":"1821","author":"j","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.peptides.2021.170732_bib0060","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.avsg.2018.02.028","article-title":"High glucose upregulated vascular smooth muscle endothelin subtype B receptors via inhibition of autophagy in rat superior mesenteric arteries","volume":"52","author":"Chen","year":"2018","journal-title":"Ann. Vasc. Surg."},{"key":"10.1016\/j.peptides.2021.170732_bib0065","first-page":"439","article-title":"High glucose upregulates endothelin type B receptors in vascular smooth muscle cells via the downregulation of Sirt1","volume":"41","author":"Lin","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.peptides.2021.170732_bib0070","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/0006-291X(91)91601-8","article-title":"Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes","volume":"175","author":"Williams Jr","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.peptides.2021.170732_bib0075","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.vph.2016.08.011","article-title":"Homocysteine regulates endothelin type B receptors in vascular smooth muscle cells","volume":"87","author":"Chen","year":"2016","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.peptides.2021.170732_bib0080","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.avsg.2017.09.007","article-title":"The curcumin-induced vasorelaxation in rat superior mesenteric arteries","volume":"48","author":"Zhang","year":"2018","journal-title":"Ann. Vasc. Surg."},{"key":"10.1016\/j.peptides.2021.170732_bib0085","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.2147\/DDDT.S261321","article-title":"Synergistic cytotoxic effect from combination of wedelolactone and cisplatin in Hela cell line: A novel finding","volume":"14","author":"Sarwar","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.peptides.2021.170732_bib0090","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.envpol.2015.10.043","article-title":"Airborne fine particulate matter induces an upregulation of endothelin receptors on rat bronchi","volume":"209","author":"Wang","year":"2016","journal-title":"Environ Pollut."},{"key":"10.1016\/j.peptides.2021.170732_bib0095","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/j.biopha.2016.11.011","article-title":"The sirt1\/NF-kB signaling pathway is involved in regulation of endothelin type B receptors mediated by homocysteine in vascular smooth muscle cells","volume":"84","author":"Chen","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.peptides.2021.170732_bib0100","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3892\/ijmm.2014.1920","article-title":"Homocysteine reduces protein S-nitrosylation in the endothelium","volume":"34","author":"Chen","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.peptides.2021.170732_bib0105","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/JIR.S140188","article-title":"Mechanisms of NF-kappaB p65 and strategies for therapeutic manipulation","volume":"11","author":"Giridharan","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.peptides.2021.170732_bib0110","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/HYPERTENSIONAHA.107.094821","article-title":"Chronic activation of endothelin B receptors: new model of experimental hypertension","volume":"50","author":"Fink","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2021.170732_bib0115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.toxlet.2011.12.005","article-title":"Activation of nuclear factor-\u03baB pathway is responsible for tumor necrosis factor-\u03b1-induced up-regulation of endothelin B2 receptor expression in vascular smooth muscle cells in vitro","volume":"209","author":"Zhang","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.peptides.2021.170732_bib0120","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/toxsci\/kfn173","article-title":"Lipid-soluble smoke particles upregulate vascular smooth muscle ETB receptors via activation of mitogen activating protein kinases and NF-kappaB pathways","volume":"106","author":"Xu","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.peptides.2021.170732_bib0125","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mvr.2011.12.001","article-title":"Minimally modified LDL upregulates endothelin type B receptors in rat basilar artery","volume":"83","author":"Li","year":"2012","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.peptides.2021.170732_bib0130","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.vph.2013.11.004","article-title":"Low density lipoprotein induces upregulation of vasoconstrictive endothelin type B receptor expression","volume":"60","author":"Xu","year":"2014","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.peptides.2021.170732_bib0135","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.envpol.2016.07.028","article-title":"Airborne fine particulate matter alters the expression of endothelin receptors in rat coronary arteries","volume":"218","author":"Xiao","year":"2016","journal-title":"Environ Pollut"},{"key":"10.1016\/j.peptides.2021.170732_bib0140","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/toxsci\/kfv229","article-title":"The role of MAPK pathways in airborne fine particulate matter-Induced upregulation ofendothelin receptors in rat basilar arteries","volume":"149","author":"Xiao","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.peptides.2021.170732_bib0145","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrm715","article-title":"MAPK-regulated transcription: a continuously variablegene switch?","volume":"3","author":"Hazzalin","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.peptides.2021.170732_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2015.03.004","article-title":"Cyclosporin A upregulates ETB receptor in vascular smooth muscle via activation of mitogen-activating protein kinases and NF-\u03baB pathways","volume":"235","author":"Zheng","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.peptides.2021.170732_bib0155","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phrs.2013.02.004","article-title":"MAPK\/NF-\u03baB-dependent upregulation of kinin receptors mediates airway hyperreactivity: a new perspective for the treatment","volume":"71","author":"Zhang","year":"2013","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.peptides.2021.170732_bib0160","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejphar.2010.04.006","article-title":"NF-kappaB signaling mediates vascular smooth muscle endothelin type B receptor expression in resistance arteries","volume":"637","author":"Zheng","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.peptides.2021.170732_bib0165","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/bcpt.12123","article-title":"Nuclear factor-kappaB-mediated endothelin receptor up-regulation increases renal artery contractility in rats","volume":"113","author":"Xie","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978121002400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978121002400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:31:19Z","timestamp":1759311079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978121002400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":33,"alternative-id":["S0196978121002400"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2021.170732","relation":{},"ISSN":["0196-9781"],"issn-type":[{"type":"print","value":"0196-9781"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibitors of the MAPK\/ NF-\u03baB pathway attenuate the upregulation of the ETB receptor mediated by high glucose in vascular smooth muscle cells","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2021.170732","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"170732"}}