{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:24:10Z","timestamp":1790522650789,"version":"4.1.0"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["2019-T1\/IND- 13794"],"award-info":[{"award-number":["2019-T1\/IND- 13794"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004593","name":"Universidad Aut\u00f3noma de Madrid","doi-asserted-by":"publisher","award":["SFPI \/ 2020-00053"],"award-info":[{"award-number":["SFPI \/ 2020-00053"]}],"id":[{"id":"10.13039\/501100004593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["496 FPU16\/02612"],"award-info":[{"award-number":["496 FPU16\/02612"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.peptides.2022.170775","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T10:59:47Z","timestamp":1645873187000},"page":"170775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Angiotensin-(1\u22127), a protective peptide against vascular aging"],"prefix":"10.1016","volume":"152","author":[{"suffix":"I","family":"Valencia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Shamoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"De la Cuesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.F.","family":"S\u00e1nchez-Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Peir\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2022.170775_bib1","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1113\/JP270538","article-title":"Ageing, metabolism and cardiovascular disease","volume":"594","author":"Costantino","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.peptides.2022.170775_bib2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/CIRCRESAHA.118.311378","article-title":"Mechanisms of vascular aging","volume":"123","author":"Ungvari","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.peptides.2022.170775_bib3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/01.HYP.0000177474.06749.98","article-title":"Arterial aging: is it an immutable cardiovascular risk factor?","volume":"46","author":"Najjar","year":"2005","journal-title":"Hypertension."},{"key":"10.1016\/j.peptides.2022.170775_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111444","article-title":"Connecting vascular aging and frailty in Alzheimer\u2019s disease","volume":"195","author":"Sabbatinelli","year":"2021","journal-title":"Mech. Ageing"},{"key":"10.1016\/j.peptides.2022.170775_bib5","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1097\/HJH.0b013e32834a4d9f","article-title":"Early vascular aging and the role of central blood pressure","volume":"29","author":"Kotsis","year":"2011","journal-title":"J. Hypertens."},{"key":"10.1016\/j.peptides.2022.170775_bib6","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.peptides.2022.170775_bib7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11906-014-0431-2","article-title":"Angiotensin II and vascular injury","volume":"16","author":"Montezano","year":"2014","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.peptides.2022.170775_bib8","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0002-9149(01)02297-4","article-title":"Effect of losartan in aging-related endothelial impairment","volume":"89","author":"Rajagopalan","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.peptides.2022.170775_bib9","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1161\/01.HYP.0000073843.56046.45","article-title":"Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates","volume":"41","author":"Wang","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2022.170775_bib10","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/ggi.13927","article-title":"Effect of renin-angiotensin system on senescence","volume":"20","author":"Mogi","year":"2020","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.peptides.2022.170775_bib11","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.peptides.2022.170775_bib12","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1161\/HYPERTENSIONAHA.106.084848","article-title":"Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells","volume":"50","author":"Sampaio","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2022.170775_bib13","doi-asserted-by":"crossref","first-page":"H801","DOI":"10.1152\/ajpheart.00908.2011","article-title":"Angiotensin-(1-7) attenuates angiotensin II-induced cardiac remodeling associated with upregulation of dual-specificity phosphatase 1","volume":"302","author":"McCollum","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.peptides.2022.170775_bib14","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.tips.2015.03.001","article-title":"Angiotensins as therapeutic targets beyond heart disease","volume":"36","author":"Passos-Silva","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.peptides.2022.170775_bib15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1152\/physrev.00023.2016","article-title":"The ACE2\/angiotensin-(1-7)\/MAS axis of the renin-angiotensin system: focus on angiotensin-(1-7)","volume":"98","author":"Santos","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.peptides.2022.170775_bib16","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.3390\/ijms21145131","article-title":"Angiotensin-(1-7) improves integrated cardiometabolic function in aged mice","volume":"21","author":"Miller","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2022.170775_bib17","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/j.dsx.2019.04.042","article-title":"Imbalance between Angiotensin II - Angiotensin (1-7) system is associated with vascular endothelial dysfunction and inflammation in type 2 diabetes with newly diagnosed hypertension","volume":"13","author":"Srivastava","year":"2019","journal-title":"Diabetes Metab. Syndr."},{"key":"10.1016\/j.peptides.2022.170775_bib18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.peptides.2014.07.002","article-title":"Angiotensin 1-7: a peptide for preventing and treating metabolic syndrome","volume":"59","author":"Sousa-Santos","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2022.170775_bib19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cger.2009.01.007","article-title":"Renin angiotensin system inhibition in the older person: a review","volume":"25","author":"Mohamed","year":"2009","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.peptides.2022.170775_bib20","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1152\/japplphysiol.91353.2008","article-title":"Vascular endothelial senescence: from mechanisms to pathophysiology","volume":"106","author":"Erusalimsky","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.peptides.2022.170775_bib21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1172\/JCI200420663","article-title":"When cells get stressed: an integrative view of cellular senescence","volume":"113","author":"Ben-Porath","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.peptides.2022.170775_bib22","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.peptides.2022.170775_bib23","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.exger.2005.04.010","article-title":"Cellular senescence in vivo: its relevance in ageing and cardiovascular disease","volume":"40","author":"Erusalimsky","year":"2005","journal-title":"Ex.p Gerontol."},{"key":"10.1016\/j.peptides.2022.170775_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.0000256837.40544.4a","article-title":"Vascular cell senescence: contribution to atherosclerosis","volume":"100","author":"Minamino","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.peptides.2022.170775_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12913","article-title":"The angiotensin-(1-7)\/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation","volume":"18","author":"Romero","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.peptides.2022.170775_bib26","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.dib.2016.12.004","article-title":"Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells","volume":"10","author":"Meinert","year":"2016","journal-title":"Data Brief."},{"key":"10.1016\/j.peptides.2022.170775_bib27","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.peptides.2022.170775_bib28","doi-asserted-by":"crossref","first-page":"284","DOI":"10.14336\/AD.2021.0617","article-title":"Pharmacological blockade of NLRP3 inflammasome\/IL-1\u03b2-positive loop mitigates endothelial cell senescence and dysfunction","volume":"13","author":"Romero","year":"2022","journal-title":"Aging Dis."},{"key":"10.1016\/j.peptides.2022.170775_bib29","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/ATVBAHA.116.307518","article-title":"Vascular actions of angiotensin 1-7 in the human microcirculation: novel role for telomerase","volume":"36","author":"Durand","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.peptides.2022.170775_bib30","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/ATVBAHA.120.315695","article-title":"Telomerase as a therapeutic target in cardiovascular disease","volume":"41","author":"Hoffmann","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.peptides.2022.170775_bib31","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809736","article-title":"Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells","volume":"11","author":"Hamczyk","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.peptides.2022.170775_bib32","doi-asserted-by":"crossref","first-page":"750","DOI":"10.21037\/atm-21-393","article-title":"Effects of anagliptin on the stress induced accelerated senescence of human umbilical vein endothelial cells","volume":"9","author":"Kang","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.peptides.2022.170775_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119919","article-title":"Crosstalk between the renin-angiotensin system and the endoplasmic reticulum stress in the cardiovascular system: lessons learned so far","volume":"284","author":"Sep\u00falveda-Fragoso","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.peptides.2022.170775_bib34","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.020441","article-title":"Aging and Hypercholesterolemia Differentially Affect the Unfolded Protein Response in the Vasculature of ApoE(-\/-) Mice","volume":"10","author":"Zhou","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.peptides.2022.170775_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145413","article-title":"Angiotensin 1-7 protects against angiotensin ii-induced endoplasmic reticulum stress and endothelial dysfunction via mas receptor","volume":"10","author":"Murugan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2022.170775_bib36","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1111\/anae.14349","article-title":"Association between peri-operative angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers and acute kidney injury in major elective non-cardiac surgery: a multicentre, prospective cohort study","volume":"73","author":"STARSurg Collaborative","year":"2018","journal-title":"Anaesthesia."},{"key":"10.1016\/j.peptides.2022.170775_bib37","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.phrs.2012.05.001","article-title":"Characterization of Angiotensin-(1\u20137) effects on the cardiovascular system in an experimental model of Type-1 diabetes","volume":"66","author":"Yousif","year":"2012","journal-title":"Pharmacol Res."},{"key":"10.1016\/j.peptides.2022.170775_bib38","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1161\/CIRCRESAHA.110.219279","article-title":"Genetic Ace2 deficiency accentuates vascular inflammation and atherosclerosis in the ApoE knockout mouse","volume":"107","author":"Thomas","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.peptides.2022.170775_bib39","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41598-020-79902-x","article-title":"Angiotensin-(1\u20137) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats","volume":"11","author":"Tsai","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.peptides.2022.170775_bib40","first-page":"3511","article-title":"Angiotensin 1-7 ameliorates caerulein-induced inflammation in pancreatic acinar cells by downregulating Toll-like receptor 4\/nuclear factor-\u03baB expression","volume":"17","author":"Wang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.peptides.2022.170775_bib41","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1161\/CIRCULATIONAHA.120.047297","article-title":"Substituting angiotensin-(1-7) to prevent lung damage in SARS-CoV-2 infection?","volume":"141","author":"Peir\u00f3","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.peptides.2022.170775_bib42","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3389\/fphys.2020.00730","article-title":"Activation of Ang-(1-7)\/Mas Receptor Is a Possible Strategy to Treat Coronavirus (SARS-CoV-2) Infection","volume":"11","author":"Magalhaes","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.peptides.2022.170775_bib43","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3389\/fphar.2016.00482","article-title":"The angiotensin-(1-7)\/mas axis counteracts angiotensin ii-dependent and -independent pro-inflammatory signaling in human vascular smooth muscle cells","volume":"7","author":"Villalobos","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.peptides.2022.170775_bib44","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/13894501113146660227","article-title":"Inducible nitric oxide synthase as a possible target in hypertension","volume":"15","author":"Oliveira-Paula","year":"2014","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.peptides.2022.170775_bib45","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1474-9726.2009.00466.x","article-title":"Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation","volume":"8","author":"Rodr\u00edguez-Ma\u00f1as","year":"2009","journal-title":"Aging Cell"},{"key":"10.1016\/j.peptides.2022.170775_bib46","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.3389\/fphar.2018.01162","article-title":"Antioxidant and oxidative stress: a mutual interplay in age-related diseases","volume":"16","author":"Tan","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.peptides.2022.170775_bib47","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jash.2008.05.003","article-title":"Ablation of angiotensin (1-7) receptor Mas in C57Bl\/6 mice causes endothelial dysfunction","volume":"2","author":"Rabelo","year":"2008","journal-title":"J. Am. Soc. Hypertens."},{"key":"10.1016\/j.peptides.2022.170775_bib48","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1097\/HJH.0b013e3282f0143c","article-title":"Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function","volume":"25","author":"Peir\u00f3","year":"2007","journal-title":"J. Hypertens."},{"key":"10.1016\/j.peptides.2022.170775_bib49","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.phrs.2007.04.004","article-title":"Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production","volume":"5","author":"Polizio","year":"2007","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.peptides.2022.170775_bib50","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000108758","article-title":"Angiotensin-(1-7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats","volume":"28","author":"Benter","year":"2008","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.peptides.2022.170775_bib51","doi-asserted-by":"crossref","first-page":"994","DOI":"10.3389\/fphys.2017.00994","article-title":"Angiotensin-(1-7) inhibits thrombin-induced endothelial phenotypic changes and reactive oxygen species production via NADPH oxidase 5 downregulation","volume":"8","author":"Pai","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.peptides.2022.170775_bib52","first-page":"3462","article-title":"Angiotensin-(1-7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K\/Akt and MAPK\/ERK signaling pathways","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.peptides.2022.170775_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1841046","article-title":"Long-term administration of angiotensin (1-7) to db\/db mice reduces oxidative stress damage in the kidneys and prevents renal dysfunction","volume":"2018","author":"Papinska","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.peptides.2022.170775_bib54","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1080\/00207454.2020.1713776","article-title":"3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases","volume":"130","author":"Bandookwala","year":"2020","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.peptides.2022.170775_bib55","article-title":"Alteration and association between serum ACE2\/ angiotensin(1-7)\/Mas axis and oxidative stress in chronic kidney disease","volume":"99","author":"Shi","year":"2020","journal-title":"Medicine"},{"key":"10.1016\/j.peptides.2022.170775_bib56","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0002-9343(99)00066-2","article-title":"Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly","volume":"106","author":"Harris","year":"1999","journal-title":"Am. J. Med."},{"key":"10.1016\/j.peptides.2022.170775_bib57","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1161\/01.CIR.103.7.947","article-title":"Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women\u2019s health and aging study","volume":"103","author":"Volpato","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.peptides.2022.170775_bib58","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.peptides.2022.170775_bib59","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.3390\/cells9081808","article-title":"The NLRP3 inflammasome: metabolic regulation and contribution to inflammaging","volume":"9","author":"Meyers","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.peptides.2022.170775_bib60","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3390\/cells9081812","article-title":"The inflammasome in chronic complications of diabetes and related metabolic disorders","volume":"9","author":"Menini","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.peptides.2022.170775_bib61","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1161\/CIRCRESAHA.118.311362","article-title":"NLRP3 inflammasome and the IL-1 pathway in atherosclerosis","volume":"122","author":"Grebe","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.peptides.2022.170775_bib62","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.toxlet.2016.01.014","article-title":"Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells","volume":"246","author":"Chen","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.peptides.2022.170775_bib63","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.tox.2018.09.002","article-title":"Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells","volume":"410","author":"Jiang","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.peptides.2022.170775_bib64","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.2147\/DMSO.S222053","article-title":"NLRP3 inflammasome promotes diabetes-induced endothelial inflammation and atherosclerosis","volume":"12","author":"Wan","year":"2019","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.peptides.2022.170775_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108562","article-title":"The angiotensin-converting enzyme 2\/angiotensin (1-7)\/mas axis protects against pyroptosis in LPS-induced lung injury by inhibiting NLRP3 activation","volume":"693","author":"Huang","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.peptides.2022.170775_bib66","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1089\/ars.2015.6498","article-title":"Angiotensin-(1-7) improves liver fibrosis by regulating the NLRP3 inflammasome via redox balance modulation","volume":"24","author":"Cai","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.peptides.2022.170775_bib67","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1093\/ndt\/gfn736","article-title":"Angiotensin-(1\u20137) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells","volume":"24","author":"Gava","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.peptides.2022.170775_bib68","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.atherosclerosis.2017.02.012","article-title":"Angiotensin-(1-7) regulates angiotensin II-induced matrix metalloproteinase-8 in vascular smooth muscle cells","volume":"261","author":"Zhang","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.peptides.2022.170775_bib69","doi-asserted-by":"crossref","first-page":"H2588","DOI":"10.1152\/ajpheart.00173.2007","article-title":"Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function","volume":"293","author":"Da Costa Gon\u00e7alves","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.peptides.2022.170775_bib70","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.vph.2018.08.009","article-title":"Nrf2 in aging \u2013 focus on the cardiovascular system","volume":"112","author":"Kloska","year":"2019","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.peptides.2022.170775_bib71","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.freeradbiomed.2019.01.016","article-title":"Redox regulation by NRF2 in aging and disease","volume":"134","author":"Schmidlin","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.peptides.2022.170775_bib72","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.peptides.2022.170775_bib73","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.18632\/aging.101506","article-title":"Heme oxygenase\u20101 ameliorates oxidative stress induce endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling","volume":"10","author":"Luo","year":"2018","journal-title":"Aging"},{"key":"10.1016\/j.peptides.2022.170775_bib74","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2022.170775_bib75","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1093\/gerona\/glu170","article-title":"Klotho Prevents NFkB Translocation and Protects Endothelial Cell From Senescence Induced by Uremia","volume":"70","author":"Buend\u00eda","year":"2015","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.peptides.2022.170775_bib76","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/bja\/aeh163","article-title":"Physiology of the endothelium","volume":"93","author":"Galley","year":"2004","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.peptides.2022.170775_bib77","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2165\/00002512-200320070-00005","article-title":"Age-related endothelial dysfunction: potential implications for pharmacotherapy","volume":"20","author":"Matz","year":"2003","journal-title":"Drugs Aging"},{"key":"10.1016\/j.peptides.2022.170775_bib78","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cardiores.2004.12.027","article-title":"Endothelial aging","volume":"66","author":"Brandes","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.peptides.2022.170775_bib79","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.pharmthera.2011.10.004","article-title":"Age-related changes in endothelial function and blood flow regulation","volume":"133","author":"Toda","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.peptides.2022.170775_bib80","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1476-5381.2011.01276.x","article-title":"Endothelium-mediated control of vascular tone: COX-1 and COX-2 products","volume":"164","author":"F\u00e9l\u00e9tou","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.peptides.2022.170775_bib81","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bcp.2017.01.012","article-title":"Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation","volume":"129","author":"Sobrino","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.peptides.2022.170775_bib82","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1124\/pr.113.008136","article-title":"Mas and its related G protein\u2013coupled receptors","volume":"66","author":"Bader","year":"2014","journal-title":"MRGPRS Pharmacol. Rev."},{"key":"10.1016\/j.peptides.2022.170775_bib83","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/bbrc.1998.8943","article-title":"Klotho protein protects against endothelial dysfunction","volume":"248","author":"Saito","year":"1998","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.peptides.2022.170775_bib84","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1007\/s00125-014-3348-z","article-title":"RANKL-OPG and RAGE modulation in vascular calcification and diabetes: novel targets for therapy","volume":"57","author":"Ndip","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.peptides.2022.170775_bib85","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1097\/01.ASN.0000145894.57533.C4","article-title":"Vascular calcification mechanisms","volume":"15","author":"Giachelli","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.peptides.2022.170775_bib86","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1161\/CIRCULATIONAHA..107.181425","volume":"115","author":"Greenland","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.peptides.2022.170775_bib87","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/s11427-014-4693-3","article-title":"ACE2\/Ang-(1-7) signaling and vascular remodeling","volume":"57","author":"Zhang","year":"2014","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.peptides.2022.170775_bib88","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1253\/circj.CJ-13-0805","article-title":"Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway","volume":"77","author":"Song","year":"2013","journal-title":"Circ. J."},{"key":"10.1016\/j.peptides.2022.170775_bib89","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41371-020-0347-z","article-title":"The protective effects of renin-angiotensin system components on vascular calcification","volume":"35","author":"Bai","year":"2021","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.peptides.2022.170775_bib90","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.peptides.2012.12.023","article-title":"Angiotensin-(1-7) inhibits vascular calcification in rats","volume":"42","author":"Sui","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2022.170775_bib91","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s11357-020-00306-w","article-title":"ACE2\/ACE imbalance and impaired vasoreparative functions of stem\/progenitor cells in aging","volume":"43","author":"Joshi","year":"2021","journal-title":"Geroscience"},{"key":"10.1016\/j.peptides.2022.170775_bib92","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1111\/bph.12770","article-title":"Angiotensin-(1-7) induces cerebral ischaemic tolerance by promoting brain angiogenesis in a Mas\/eNOS-dependent pathway","volume":"171","author":"Jiang","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.peptides.2022.170775_bib93","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.yexcr.2015.06.010","article-title":"Angiotensin-(1-7) counteracts angiotensin II-induced dysfunction in cerebral endothelial cells via modulating Nox2\/ROS and PI3K\/NO pathways","volume":"336","author":"Xiao","year":"2015","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.peptides.2022.170775_bib94","doi-asserted-by":"crossref","first-page":"H1171","DOI":"10.1152\/ajpheart.00897.2014","article-title":"Differences in angiotensin (1\u20137) between men and women","volume":"308","author":"Sullivan","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.peptides.2022.170775_bib95","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1177\/1535370217718808","article-title":"Protective regulation of the ACE2\/ACE gene expression by estrogen in human atrial tissue from elderly men","volume":"242","author":"Bukowska","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.peptides.2022.170775_bib96","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrneph.2017.189","article-title":"Sex-specific differences in hypertension and associated cardiovascular disease","volume":"14","author":"Colafella","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.peptides.2022.170775_bib97","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1472-8206.2010.00854.x","article-title":"Gender and the renin-angiotensin-aldosterone system","volume":"24","author":"Komukai","year":"2010","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.peptides.2022.170775_bib98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2015.11.004","article-title":"Estradiol, acting through ER\u03b1, induces endothelial non-classic renin-angiotensin system increasing angiotensin 1-7 production","volume":"422","author":"Mompe\u00f3n","year":"2016","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.peptides.2022.170775_bib99","doi-asserted-by":"crossref","DOI":"10.1177\/1470320318789332","article-title":"Age-related changes in vascular responses to angiotensin-(1-7) in female mice","volume":"19","author":"Costa-Fraga","year":"2018","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.peptides.2022.170775_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2019.154048","article-title":"Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor","volume":"103","author":"Vargas-Castillo","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.peptides.2022.170775_bib101","first-page":"199","article-title":"Age-realted changes in the local intestinal renin-angiotensin system in normotensive and spontaneously hypertesnive rats","volume":"79","author":"Pasanen","year":"2019","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.peptides.2022.170775_bib102","doi-asserted-by":"crossref","first-page":"ID6731093","DOI":"10.1155\/2016\/6731093","article-title":"Age-associated changes in the vascular renin-angiotensin system in mice","volume":"2016","author":"Yoon","year":"2016","journal-title":"Ox. Med. Cell. Longev."},{"key":"10.1016\/j.peptides.2022.170775_bib103","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/HYPERTENSIONAHA.107.089409","article-title":"Proinflammatory prolife within the grossly normal aged human aortic wall","volume":"50","author":"Wang","year":"2007","journal-title":"Hypertesnion"},{"key":"10.1016\/j.peptides.2022.170775_bib104","doi-asserted-by":"crossref","first-page":"H849","DOI":"10.1152\/ajpheart.00422.2016","article-title":"Local renin-angiotensin system mediates endothelial dilator dysfunction in aging arteries","volume":"311","author":"Flavahan","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.peptides.2022.170775_bib105","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.peptides.2016.09.001","article-title":"Bradykinin-induced vasodilatation: role of age, ACE1 inhibitory peptide, mas and bradykinin receptors","volume":"85","author":"Siltari","year":"2016","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2022.170775_bib106","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/ATVBAHA.112.248559","article-title":"Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL\/6 mice","volume":"32","author":"Gupte","year":"2012","journal-title":"Arterioscler Thromb Vasc. Biol."},{"key":"10.1016\/j.peptides.2022.170775_bib107","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/HYPERTENSIONAHA.117.10280","article-title":"Favorable vascular actions of angiotensin-(1-7) in human obesity","volume":"71","author":"Schinzari","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.peptides.2022.170775_bib108","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4592768","article-title":"Phase II trial of Angiotensin-(1-7) for the treatment of patients with metastatic sarcoma","volume":"2016","author":"Savage","year":"2016","journal-title":"Sarcoma"},{"key":"10.1016\/j.peptides.2022.170775_bib109","doi-asserted-by":"crossref","first-page":"72443","DOI":"10.18632\/oncotarget.12494","article-title":"A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence","volume":"7","author":"Asish","year":"2016","journal-title":"Oncotarget"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978122000419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978122000419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:32:31Z","timestamp":1759311151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978122000419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":109,"alternative-id":["S0196978122000419"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2022.170775","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiotensin-(1\u22127), a protective peptide against vascular aging","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2022.170775","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"170775"}}