{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:58:01Z","timestamp":1790776681840,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.peptides.2022.170903","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T11:27:53Z","timestamp":1667993273000},"page":"170903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Human cathelicidin LL-37 exerts amelioration effects against EHEC O157:H7 infection regarding inflammation, enteric dysbacteriosis, and impairment of gut barrier function"],"prefix":"10.1016","volume":"159","author":[{"given":"Xin","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyi","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6775-6695","authenticated-orcid":false,"given":"Haiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2022.170903_bib1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4014\/jmb.0908.08007","article-title":"A brief overview of Escherichia coli O157:H7 and its plasmid O157","volume":"20","author":"Lim","year":"2010","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.peptides.2022.170903_bib2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3201\/eid0505.990502","article-title":"Food-related illness and death in the United States","volume":"5","author":"Mead","year":"1999","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.peptides.2022.170903_bib3","first-page":"67","article-title":"Pathogenesis of Shiga-toxin producing Escherichia coli","volume":"357","author":"Melton-Celsa","year":"2012","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.peptides.2022.170903_bib4","doi-asserted-by":"crossref","first-page":"11265","DOI":"10.1021\/jf103011z","article-title":"Immunomodulating activity of Lactobacillus paracasei subsp. paracasei NTU 101 in enterohemorrhagic Escherichia coli O157H7-infected mice","volume":"58","author":"Tsai","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.peptides.2022.170903_bib5","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/315239","article-title":"Quinolone antibiotics induce Shiga toxin-encoding bacteriophages, toxin production, and death in mice","volume":"181","author":"Zhang","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.peptides.2022.170903_bib6","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1172\/JCI62746","article-title":"A novel murine infection model for Shiga toxin-producing Escherichia coli","volume":"122","author":"Mallick","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.peptides.2022.170903_bib7","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.3748\/wjg.v19.i18.2731","article-title":"Cathelicidin a potential therapeutic peptide for gastrointestinal inflammation and cancer","volume":"19","author":"Chow","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.peptides.2022.170903_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21239126","article-title":"Citrullination-resistant LL-37 is a potent antimicrobial agent in the inflammatory environment high in arginine deiminase activity","volume":"21","author":"Bryzek","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2022.170903_bib9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1615\/CritRevImmunol.2019030225","article-title":"The critical role of the antimicrobial peptide LL-37\/ CRAMP in protection of colon microbiota balance, mucosal homeostasis, anti-inflammatory responses, and resistance to carcinogenesis","volume":"39","author":"Zhang","year":"2019","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.peptides.2022.170903_bib10","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1189\/jlb.0704380","article-title":"Impact of LL-37 on anti-infective immunity","volume":"77","author":"Bowdish","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.peptides.2022.170903_bib11","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.52586\/5029","article-title":"The potentials of short fragments of human anti-microbial peptide LL-37 as a novel therapeutic modality for diseases","volume":"26","author":"Chen","year":"2021","journal-title":"Front Biosci. (Landmark Ed. )"},{"key":"10.1016\/j.peptides.2022.170903_bib12","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/aps.2010.117","article-title":"Cathelicidins in inflammation and tissue repair: potential therapeutic applications for gastrointestinal disorders","volume":"31","author":"Wu","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.peptides.2022.170903_bib13","doi-asserted-by":"crossref","first-page":"9456","DOI":"10.1038\/s41598-019-45913-6","article-title":"Cathelicidin- derived PR39 protects enterohemorrhagic Escherichia coli O157:H7 challenged mice by improving epithelial function and balancing the microbiota in the intestine","volume":"9","author":"Haiwen","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.peptides.2022.170903_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.vetimm.2017.09.005","article-title":"Effects of cathelicidin-derived peptide from reptiles on lipopolysaccharide-induced intestinal inflammation in weaned piglets","volume":"192","author":"Zhang","year":"2017","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.peptides.2022.170903_bib15","doi-asserted-by":"crossref","first-page":"6776956","DOI":"10.1155\/2021\/6776956","article-title":"Vitamin D(3) protects mice from diquat-induced oxidative stress through the NF-\u03baB\/Nrf2\/HO-1 signaling pathway","volume":"2021","author":"Zhang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.peptides.2022.170903_bib16","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1021\/acs.jafc.9b00861","article-title":"Oral administration of bovine lactoferrin-derived lactoferricin (Lfcin) B could attenuate enterohemorrhagic escherichia coli O157:H7 induced intestinal disease through improving intestinal barrier function and microbiota","volume":"67","author":"Haiwen","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.peptides.2022.170903_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1189\/jlb.0609382","article-title":"Human defensins and LL-37 in mucosal immunity","volume":"87","author":"Doss","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.peptides.2022.170903_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tiv.2017.08.011","article-title":"Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state","volume":"45","author":"K\u00e4mpfer","year":"2017","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.peptides.2022.170903_bib19","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/labinvest.3700050","article-title":"A porous defense: the leaky epithelial barrier in intestinal disease","volume":"84","author":"Clayburgh","year":"2004","journal-title":"Lab. Invest."},{"key":"10.1016\/j.peptides.2022.170903_bib20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1440-1746.2002.02769.x","article-title":"Escherichia coli as a cause of diarrhea","volume":"17","author":"Robins-Browne","year":"2002","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.peptides.2022.170903_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1046\/j.1462-5822.2004.00370.x","article-title":"Interaction of Shiga toxin from Escherichia coli with human intestinal epithelial cell lines and explants: Stx2 induces epithelial damage in organ culture","volume":"6","author":"Sch\u00fcller","year":"2004","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.peptides.2022.170903_bib22","first-page":"69","article-title":"Morphologic evaluation of the effects of Shiga toxin and E coli Shiga-like toxin on the rabbit intestine","volume":"125","author":"Keenan","year":"1986","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.peptides.2022.170903_bib23","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1248\/bpb.32.1614","article-title":"Shiga toxin kills epithelial cells isolated from distal but not proximal part of mouse colon","volume":"32","author":"Kashiwamura","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.peptides.2022.170903_bib24","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.regpep.2009.03.009","article-title":"Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity","volume":"156","author":"Otte","year":"2009","journal-title":"Regul. Pept."},{"key":"10.1016\/j.peptides.2022.170903_bib25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/intimm\/dxq471","article-title":"Human anti-microbial cathelicidin peptide LL-37 suppresses the LPS-induced apoptosis of endothelial cells","volume":"23","author":"Suzuki","year":"2011","journal-title":"Int. Immunol."},{"key":"10.1016\/j.peptides.2022.170903_bib26","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.4049\/jimmunol.174.8.4901","article-title":"Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens","volume":"174","author":"Iimura","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.peptides.2022.170903_bib27","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/gt.2012.92","article-title":"Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice","volume":"20","author":"Zhang","year":"2013","journal-title":"Gene Ther."},{"key":"10.1016\/j.peptides.2022.170903_bib28","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1053\/j.gastro.2003.08.028","article-title":"Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori","volume":"125","author":"Hase","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.peptides.2022.170903_bib29","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1097\/MIB.0000000000000804","article-title":"The roles of cathelicidin LL-37 in inflammatory bowel disease","volume":"22","author":"Sun","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.peptides.2022.170903_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.EHEC-0012-2013","article-title":"The inflammatory response during enterohemorrhagic escherichia coli infection","volume":"2","author":"Pearson","year":"2014","journal-title":"Microbiol Spectr."},{"key":"10.1016\/j.peptides.2022.170903_bib31","doi-asserted-by":"crossref","first-page":"G851","DOI":"10.1152\/ajpgi.00327.2009","article-title":"Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier","volume":"298","author":"Karczewski","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.peptides.2022.170903_bib32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fvets.2015.00057","article-title":"Regulation of the intestinal barrier function by host defense peptides","volume":"2","author":"Robinson","year":"2015","journal-title":"Front Vet. Sci."},{"key":"10.1016\/j.peptides.2022.170903_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9020060","article-title":"Enteric pathogens and their toxin-induced disruption of the intestinal barrier through alteration of tight junctions in chickens","volume":"9","author":"Awad","year":"2017","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.peptides.2022.170903_bib34","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00441-018-02984-7","article-title":"Human cathelicidin improves colonic epithelial defenses against Salmonella typhimurium by modulating bacterial invasion, TLR4 and pro-inflammatory cytokines","volume":"376","author":"Marin","year":"2019","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.peptides.2022.170903_bib35","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.EHEC-0015-2013","article-title":"The interplay between the microbiota and enterohemorrhagic escherichia coli","volume":"2","author":"Pifer","year":"2014","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.peptides.2022.170903_bib36","doi-asserted-by":"crossref","first-page":"7402","DOI":"10.3748\/wjg.v27.i43.7402","article-title":"Antimicrobial peptides and the gut microbiome in inflammatory bowel disease","volume":"27","author":"Gubatan","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.peptides.2022.170903_bib37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41385-020-0296-4","article-title":"Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation","volume":"14","author":"Iljazovic","year":"2021","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.peptides.2022.170903_bib38","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/ijc.31559","article-title":"Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice","volume":"143","author":"Koh","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.peptides.2022.170903_bib39","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/carcin\/bgaa018","article-title":"Parabacteroides distasonis attenuates tumorigenesis, modulates inflammatory markers and promotes intestinal barrier integrity in azoxymethane-treated A\/J mice","volume":"41","author":"Koh","year":"2020","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.peptides.2022.170903_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.635","article-title":"Anti-inflammatory and immunomodulatory effects of Lactobacillus spp. as a preservative and therapeutic agent for IBD control","volume":"10","author":"Aghamohammad","year":"2022","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.peptides.2022.170903_bib41","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.pharep.2016.03.015","article-title":"LL-37: cathelicidin-related antimicrobial peptide with pleiotropic activity","volume":"68","author":"Fabisiak","year":"2016","journal-title":"Pharmacol. Rep."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978122001693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978122001693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:33:50Z","timestamp":1759311230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978122001693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":41,"alternative-id":["S0196978122001693"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2022.170903","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human cathelicidin LL-37 exerts amelioration effects against EHEC O157:H7 infection regarding inflammation, enteric dysbacteriosis, and impairment of gut barrier function","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2022.170903","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"170903"}}