{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:35:26Z","timestamp":1781818526805,"version":"3.54.5"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.peptides.2023.171107","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T21:09:48Z","timestamp":1695848988000},"page":"171107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Protective effect of pituitary adenylate cyclase activating polypeptide in diabetic keratopathy"],"prefix":"10.1016","volume":"170","author":[{"given":"Grazia","family":"Maugeri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata Grazia","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Magr\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Giunta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Saccone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Federico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Bucolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Musumeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velia","family":"D\u2019Agata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.peptides.2023.171107_bib1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.survophthal.2020.02.005","article-title":"Diabetic keratopathy: insights and challenges","volume":"65","author":"Priyadarsini","year":"2020","journal-title":"Surv. Ophthalmol."},{"issue":"1","key":"10.1016\/j.peptides.2023.171107_bib2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4239\/wjd.v6.i1.92","article-title":"Ocular complications of diabetes mellitus","volume":"6","author":"Sayin","year":"2015","journal-title":"World J. Diabetes"},{"issue":"2\u20133","key":"10.1016\/j.peptides.2023.171107_bib3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.brainresbull.2009.08.008","article-title":"Diabetic keratopathy and treatment by modulation of the opioid growth factor (OGF)-OGF receptor (OGFr) axis with naltrexone: a review","volume":"81","author":"McLaughlin","year":"2010","journal-title":"Brain Res. Bull."},{"issue":"5","key":"10.1016\/j.peptides.2023.171107_bib4","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2337\/db08-0997","article-title":"High glucose suppresses epidermal growth factor receptor\/phosphatidylinositol 3-kinase\/Akt signaling pathway and attenuates corneal epithelial wound healing","volume":"58","author":"Xu","year":"2009","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.peptides.2023.171107_bib5","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1167\/iovs.10-5670","article-title":"Impaired epithelial wound healing and EGFR signaling pathways in the corneas of diabetic rats","volume":"52","author":"Xu","year":"2011","journal-title":"Invest Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.peptides.2023.171107_bib6","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1006\/exer.1994.1152","article-title":"Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells","volume":"59","author":"Wilson","year":"1994","journal-title":"Exp. Eye Res."},{"issue":"6","key":"10.1016\/j.peptides.2023.171107_bib7","doi-asserted-by":"crossref","first-page":"10097","DOI":"10.1002\/jcb.28293","article-title":"PACAP through EGFR transactivation preserves human corneal endothelial integrity","volume":"120","author":"Maugeri","year":"2019","journal-title":"J. Cell Biochem."},{"issue":"9","key":"10.1016\/j.peptides.2023.171107_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/cells10092409","article-title":"Epidermal growth factor receptor expression in the corneal epithelium","volume":"10","author":"Peterson","year":"2021","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.peptides.2023.171107_bib9","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1167\/iovs.09-3904","article-title":"LL-37 via EGFR transactivation to promote high glucose-attenuated epithelial wound healing in organ-cultured corneas","volume":"51","author":"Yin","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.peptides.2023.171107_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1200\/JCO.2005.04.057","article-title":"Practical management of patients with non-small-cell lung cancer treated with gefitinib","volume":"23","author":"Shah","year":"2005","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.peptides.2023.171107_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1006\/frne.1995.1003","article-title":"Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors: neuroendocrine and endocrine interaction","volume":"16","author":"Arimura","year":"1995","journal-title":"Front Neuroendocr."},{"issue":"3","key":"10.1016\/j.peptides.2023.171107_bib12","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pharmthera.2008.11.006","article-title":"VPAC and PAC receptors: from ligands to function","volume":"121","author":"Dickson","year":"2009","journal-title":"Pharm. Ther."},{"issue":"4","key":"10.1016\/j.peptides.2023.171107_bib13","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1002\/jcp.27328","article-title":"Molecular mechanisms involved in the protective effect of pituitary adenylate cyclase-activating polypeptide in an in vitro model of amyotrophic lateral sclerosis","volume":"234","author":"Maugeri","year":"2019","journal-title":"J. Cell Physiol."},{"issue":"3","key":"10.1016\/j.peptides.2023.171107_bib14","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1124\/jpet.111.190033","article-title":"Pituitary adenylate cyclase-activating polypeptide causes tyrosine phosphorylation of the epidermal growth factor receptor in lung cancer cells","volume":"341","author":"Moody","year":"2012","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.peptides.2023.171107_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2018.09.005","article-title":"PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner","volume":"120","author":"Moody","year":"2019","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2023.171107_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2019.170108","article-title":"Protective effect of PACAP-38 on retinal pigmented epithelium in an in vitro and in vivo model of diabetic retinopathy through EGFR-dependent mechanism","volume":"119","author":"Maugeri","year":"2019","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2023.171107_bib17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3389\/fendo.2020.00377","article-title":"Protective effects of PACAP in peripheral organs","volume":"11","author":"Toth","year":"2020","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"2","key":"10.1016\/j.peptides.2023.171107_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ajo.2006.10.034","article-title":"PACAP induces neurite outgrowth in cultured trigeminal ganglion cells and recovery of corneal sensitivity after flap surgery in rabbits","volume":"143","author":"Fukiage","year":"2007","journal-title":"Am. J. Ophthalmol."},{"issue":"8","key":"10.1016\/j.peptides.2023.171107_bib19","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1167\/iovs.15-17088","article-title":"A new recombinant PACAP-derived peptide efficiently promotes corneal wound repairing and lacrimal secretion","volume":"56","author":"Ma","year":"2015","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.peptides.2023.171107_bib20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.peptides.2017.11.003","article-title":"Trophic effect of PACAP on human corneal endothelium","volume":"99","author":"Maugeri","year":"2018","journal-title":"Peptides"},{"issue":"12","key":"10.1016\/j.peptides.2023.171107_bib21","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.7150\/ijbs.35630","article-title":"The PACAP-derived peptide MPAPO facilitates corneal wound healing by promoting corneal epithelial cell proliferation and trigeminal ganglion cell axon regeneration","volume":"15","author":"Wang","year":"2019","journal-title":"Int J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.peptides.2023.171107_bib22","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1002\/jcp.27331","article-title":"NAP modulates hyperglycemic-inflammatory event of diabetic retina by counteracting outer blood retinal barrier damage","volume":"234","author":"D'Amico","year":"2019","journal-title":"J. Cell Physiol."},{"issue":"3","key":"10.1016\/j.peptides.2023.171107_bib23","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s12031-014-0335-2","article-title":"NAP reduces murine microvascular endothelial cells proliferation induced by hyperglycemia","volume":"54","author":"D'Amico","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.peptides.2023.171107_bib24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tiv.2017.07.003","article-title":"Nicotine promotes blood retinal barrier damage in a model of human diabetic macular edema","volume":"44","author":"Maugeri","year":"2017","journal-title":"Toxicol. Vitr."},{"issue":"8","key":"10.1016\/j.peptides.2023.171107_bib25","article-title":"PACAP modulates the autophagy process in an in vitro model of amyotrophic lateral sclerosis","volume":"21","author":"D'Amico","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.peptides.2023.171107_bib26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/exer.1996.0216","article-title":"Fibronectin facilitates corneal epithelial wound healing in diabetic rats","volume":"64","author":"Nakamura","year":"1997","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.peptides.2023.171107_bib27","doi-asserted-by":"crossref","DOI":"10.1186\/s12917-022-03307-3","article-title":"Pycnogenol a promising remedy for diabetic keratopathy in experimentally induced corneal alkali burns in diabetic rats","volume":"18","author":"Hamed","year":"2022","journal-title":"BMC Vet. Res."},{"issue":"4","key":"10.1016\/j.peptides.2023.171107_bib28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000265202","article-title":"Corneal epithelial changes in diabetic rats","volume":"14","author":"Friend","year":"1982","journal-title":"Ophthalmic Res."},{"issue":"2","key":"10.1016\/j.peptides.2023.171107_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ajo.2006.04.017","article-title":"Autologous serum for the treatment of corneal epithelial abrasions in diabetic patients undergoing vitrectomy","volume":"142","author":"Schulze","year":"2006","journal-title":"Am. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.peptides.2023.171107_bib30","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0195-5616(95)50061-0","article-title":"Ocular manifestations of diabetes mellitus: diabetic cataracts in dogs","volume":"25","author":"Basher","year":"1995","journal-title":"Vet. Clin. North Am. Small Anim. Pr."},{"issue":"9","key":"10.1016\/j.peptides.2023.171107_bib31","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1432-0436.2007.00238.x","article-title":"The epidermal growth factor receptor: from development to tumorigenesis","volume":"75","author":"Sibilia","year":"2007","journal-title":"Differentiation"},{"key":"10.1016\/j.peptides.2023.171107_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2019.101978","article-title":"Protective effect of PACAP against ultraviolet B radiation-induced human corneal endothelial cell injury","volume":"79","author":"Maugeri","year":"2020","journal-title":"Neuropeptides"},{"issue":"1","key":"10.1016\/j.peptides.2023.171107_bib33","article-title":"Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) counteracts UV-B radiation-induced ROS formation in corneal epithelium","volume":"11","author":"Maugeri","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"10.1016\/j.peptides.2023.171107_bib34","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3892\/ijmm.2014.2017","article-title":"Expression, identification and biological effects of the novel recombination protein, PACAP38-NtA, with high bioactivity","volume":"35","author":"Wu","year":"2015","journal-title":"Int. J. Mol. Med."},{"issue":"5","key":"10.1016\/j.peptides.2023.171107_bib35","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2337\/diabetes.52.5.1155","article-title":"Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes","volume":"52","author":"Yamamoto","year":"2003","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.peptides.2023.171107_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123470","article-title":"A promising combination: PACAP and PARP inhibitor have therapeutic potential in models of diabetic and hypertensive retinopathies","volume":"10","author":"P\u00f6sty\u00e9ni","year":"2021","journal-title":"Cells"},{"issue":"19","key":"10.1016\/j.peptides.2023.171107_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910691","article-title":"Protective effects of PACAP in a rat model of diabetic neuropathy","volume":"22","author":"Kiss","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.peptides.2023.171107_bib38","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s12031-020-01769-4","article-title":"PACAP and NAP: effect of two functionally related peptides in diabetic retinopathy","volume":"71","author":"D'Amico","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.peptides.2023.171107_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-800179-0.00001-5","article-title":"Neuropeptides, trophic factors, and other substances providing morphofunctional and metabolic protection in experimental models of diabetic retinopathy","volume":"311","author":"Szabadfi","year":"2014","journal-title":"Int. Rev. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.peptides.2023.171107_bib40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.peptides.2012.06.004","article-title":"Early changes in pituitary adenylate cyclase-activating peptide, vasoactive intestinal peptide and related receptors expression in retina of streptozotocin-induced diabetic rats","volume":"37","author":"Giunta","year":"2012","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.peptides.2023.171107_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00441-012-1349-0","article-title":"Protective effects of the neuropeptide PACAP in diabetic retinopathy","volume":"348","author":"Szabadfi","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.peptides.2023.171107_bib42","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuint.2013.11.005","article-title":"PACAP promotes neuron survival in early experimental diabetic retinopathy","volume":"64","author":"Szabadfi","year":"2014","journal-title":"Neurochem Int."},{"issue":"4","key":"10.1016\/j.peptides.2023.171107_bib43","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.jtos.2019.06.007","article-title":"The impact of hyperglycemia on the corneal epithelium: Molecular mechanisms and insight","volume":"17","author":"Zhu","year":"2019","journal-title":"Ocul. Surf."},{"issue":"21","key":"10.1016\/j.peptides.2023.171107_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218233","article-title":"Effects of Pacap on Schwann cells: focus on nerve injury","volume":"21","author":"Maugeri","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2023.171107_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12034","article-title":"PACAP suppresses dry eye signs by stimulating tear secretion","volume":"7","author":"Nakamachi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.peptides.2023.171107_bib46","doi-asserted-by":"crossref","DOI":"10.1007\/s10989-022-10405-1","article-title":"Effects of pituitary adenylate cyclase activating polypeptide (PACAP) in corneal epithelial regeneration and signal transduction in rats","volume":"28","author":"Kiss","year":"2022","journal-title":"Int. J. Pept. Res Ther."},{"issue":"11","key":"10.1016\/j.peptides.2023.171107_bib47","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1007\/s12031-022-01985-0","article-title":"Distribution of PACAP and PAC1 receptor in the human eye","volume":"72","author":"Patko","year":"2022","journal-title":"J. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.peptides.2023.171107_bib48","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF00414564","article-title":"The effect of the epidermal growth factor (EGF) on the corneal epithelium in humans","volume":"210","author":"Daniele","year":"1979","journal-title":"Albrecht Von. Graefes Arch. Klin. Exp. Ophthalmol."},{"issue":"5","key":"10.1016\/j.peptides.2023.171107_bib49","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/bjo.81.5.391","article-title":"Influence of topical human epidermal growth factor on postkeratoplasty re-epithelialisation","volume":"81","author":"Dellaert","year":"1997","journal-title":"Br. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.peptides.2023.171107_bib50","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0002-9394(84)90121-1","article-title":"The effect of epidermal growth factor on epithelial healing after penetrating keratoplasty in human eyes","volume":"98","author":"Kandarakis","year":"1984","journal-title":"Am. J. Ophthalmol."},{"issue":"7","key":"10.1016\/j.peptides.2023.171107_bib51","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1167\/iovs.09-4386","article-title":"Transforming growth factor-{alpha} enhances corneal epithelial cell migration by promoting EGFR recycling","volume":"51","author":"McClintock","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"8","key":"10.1016\/j.peptides.2023.171107_bib52","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1167\/iovs.14-14133","article-title":"Antagonizing c-Cbl enhances EGFR-dependent corneal epithelial homeostasis","volume":"55","author":"Rush","year":"2014","journal-title":"Invest Ophthalmol. Vis. Sci."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978123001729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978123001729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:34:58Z","timestamp":1759311298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978123001729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":52,"alternative-id":["S0196978123001729"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2023.171107","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of pituitary adenylate cyclase activating polypeptide in diabetic keratopathy","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2023.171107","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"171107"}}