{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:04:34Z","timestamp":1772496274689,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010993","name":"Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010993","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770826"],"award-info":[{"award-number":["31770826"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071261"],"award-info":[{"award-number":["32071261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003472","name":"Harbin Institute of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2020C065"],"award-info":[{"award-number":["LH2020C065"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009007","name":"Guangxi Normal University","doi-asserted-by":"publisher","award":["CMEMR2022-B01"],"award-info":[{"award-number":["CMEMR2022-B01"]}],"id":[{"id":"10.13039\/501100009007","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.peptides.2023.171116","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T05:47:57Z","timestamp":1699595277000},"page":"171116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Endomorphin-2 analogs with C-terminal esterification display potent antinociceptive effects in the formalin pain test in mice"],"prefix":"10.1016","volume":"171","author":[{"given":"Si-yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-han","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-ci","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-tong","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2023.171116_bib1","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1517\/17460441.2010.511473","article-title":"Opioid receptor targeting ligands for pain management: a review and update","volume":"5","author":"Davis","year":"2010","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.peptides.2023.171116_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1568026043451618","article-title":"Opioid receptors and their ligands","volume":"4","author":"Janecka","year":"2004","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.peptides.2023.171116_bib3","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.36076\/ppj.2008\/11\/S105","article-title":"Opioid complications and side effects","author":"Benyamin","year":"2008","journal-title":"Pain. Physician 11"},{"key":"10.1016\/j.peptides.2023.171116_bib4","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1038\/sj.bjp.0706435","article-title":"75 years of opioid research: the exciting but vain quest for the Holy Grail","volume":"147","author":"Corbett","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.peptides.2023.171116_bib5","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.ddtec.2011.07.007","article-title":"Opioid peptides: potential for drug development","volume":"9","author":"Aldrich","year":"2012","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.peptides.2023.171116_bib6","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2174\/138161210790963869","article-title":"Development of opioid peptide analogs for pain relief","volume":"16","author":"Janecka","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.peptides.2023.171116_bib7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/386499a0","article-title":"A potent and selective endogenous agonist for the mu-opiate receptor","volume":"386","author":"Zadina","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2023.171116_bib8","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1097\/00001756-199709290-00025","article-title":"Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2","volume":"8","author":"Stone","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.peptides.2023.171116_bib9","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0022-3565(24)35327-3","article-title":"Differential antinociceptive eeffects of endomorphin-1 and endomorphin-2 in the mouse","volume":"292","author":"Tseng","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.peptides.2023.171116_bib10","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1213\/ANE.0000000000002318","article-title":"Antiallodynic effects of endomorphin-1 and endomorphin-2 in the spared nerve injury model of neuropathic pain in mice","volume":"125","author":"Wang","year":"2017","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.peptides.2023.171116_bib11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/1568026615666150817103635","article-title":"Strategies to improve bioavailability and in vivo efficacy of the endogenous opioid peptides endomorphin-1 and endomorphin-2","volume":"16","author":"De Marco","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.peptides.2023.171116_bib12","doi-asserted-by":"crossref","DOI":"10.1186\/s12987-017-0080-3","article-title":"The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse","volume":"14","author":"Schaefer","year":"2017","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.peptides.2023.171116_bib13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/15734064113099990040","article-title":"Bioavailability of endomorphins and the blood-brain barrier--a review","volume":"10","author":"Perlikowska","year":"2014","journal-title":"Med. Chem."},{"key":"10.1016\/j.peptides.2023.171116_bib14","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.2174\/0929867311320220002","article-title":"Endomorphin derivatives with improved pharmacological properties","volume":"20","author":"Varamini","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.peptides.2023.171116_bib15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3389\/fphar.2013.00155","article-title":"Lipid- and sugar-modified endomorphins: novel targets for the treatment of neuropathic pain","volume":"4","author":"Varamini","year":"2013","journal-title":"Front. Pharm."},{"key":"10.1016\/j.peptides.2023.171116_bib16","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1016\/j.bmc.2008.05.001","article-title":"Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling","volume":"16","author":"Wang","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.peptides.2023.171116_bib17","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/j.1532-2149.2014.00462.x","article-title":"Differential antinociceptive effects of intrathecal administration of C-terminal esterified endomorphin-2 analogues in mice","volume":"18","author":"Wang","year":"2014","journal-title":"Eur. J. Pain."},{"key":"10.1016\/j.peptides.2023.171116_bib18","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuropharm.2016.12.026","article-title":"Endomorphin-2 analogs with C-terminal esterification produce potent systemic antinociception with reduced tolerance and gastrointestinal side effects","volume":"116","author":"Wang","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.peptides.2023.171116_bib19","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.pain.2013.11.015","article-title":"The interphase of the formalin test","volume":"155","author":"Fischer","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.peptides.2023.171116_bib20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/cns.12486","article-title":"Preclinical assessment of inflammatory pain","volume":"22","author":"Muley","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.peptides.2023.171116_bib21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1476-5381.1957.tb01354.x","article-title":"Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse","volume":"12","author":"Haley","year":"1957","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.peptides.2023.171116_bib22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejphar.2018.08.039","article-title":"Systemic administration of the bifunctional opioid\/neuropeptide FF receptors agonist BN-9 produced peripheral antinociception in preclinical mouse models of pain","volume":"837","author":"Li","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.peptides.2023.171116_bib23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jpain.2019.08.016","article-title":"Spinal DN-9, a peptidic multifunctional opioid\/neuropeptide FF agonist produced potent nontolerance forming analgesia with limited side effects","volume":"21","author":"Wang","year":"2020","journal-title":"J. Pain."},{"key":"10.1016\/j.peptides.2023.171116_bib24","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1021\/acschemneuro.7b00097","article-title":"MEL-N16: a series of novel endomorphin analogs with good analgesic activity and a favorable side effect profile","volume":"8","author":"Liu","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.peptides.2023.171116_bib25","doi-asserted-by":"crossref","first-page":"16801","DOI":"10.1021\/acs.jmedchem.1c01631","article-title":"Novel cyclic endomorphin analogues with multiple modifications and oligoarginine vector exhibit potent antinociception with reduced opioid-like side effects","volume":"64","author":"Zhang","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.peptides.2023.171116_bib26","doi-asserted-by":"crossref","first-page":"13394","DOI":"10.1021\/acs.jmedchem.1c00694","article-title":"Development of multifunctional and orally active cyclic peptide agonists of opioid\/neuropeptide FF receptors that produce potent, long-lasting, and peripherally restricted antinociception with diminished side effects","volume":"64","author":"Zhang","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.peptides.2023.171116_bib27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature19112","article-title":"Structure-based discovery of opioid analgesics with reduced side effects","volume":"537","author":"Manglik","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2023.171116_bib28","doi-asserted-by":"crossref","first-page":"E76","DOI":"10.1208\/aapsj080109","article-title":"CNS drug delivery: opioid peptides and the blood-brain barrier","volume":"8","author":"Witt","year":"2006","journal-title":"AAPS J."},{"key":"10.1016\/j.peptides.2023.171116_bib29","first-page":"19","article-title":"Low molecular weight opioid peptide esters could be developed as a new class of analgesics","volume":"5","author":"Goldberg","year":"2011","journal-title":"Perspect. Med. Chem."},{"key":"10.1016\/j.peptides.2023.171116_bib30","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0006-291X(91)91786-C","article-title":"Opioid receptor selectivity reversal in deltorphin tetrapeptide analogues","volume":"178","author":"Lazarus","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.peptides.2023.171116_bib31","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1248\/cpb.51.759","article-title":"Synthesis and antinociceptive activity of orally active opioid peptides: improvement of oral bioavailability by esterification","volume":"51","author":"Ogawa","year":"2003","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.peptides.2023.171116_bib32","doi-asserted-by":"crossref","first-page":"891","DOI":"10.12688\/f1000research.18338.1","article-title":"A refinement to the formalin test in mice","volume":"8","author":"Lopes","year":"2019","journal-title":"F1000Res"},{"key":"10.1016\/j.peptides.2023.171116_bib33","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1124\/jpet.105.098293","article-title":"Possible involvement of dynorphin A-(1-17) release via mu1-opioid receptors in spinal antinociception by endomorphin-2","volume":"317","author":"Mizoguchi","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.peptides.2023.171116_bib34","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/bja\/aep129","article-title":"Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile","volume":"103","author":"Dietis","year":"2009","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.peptides.2023.171116_bib35","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/bph.12663","article-title":"Heteromers of \u03bc-\u03b4 opioid receptors: new pharmacology and novel therapeutic possibilities","volume":"172","author":"Fujita","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.peptides.2023.171116_bib36","doi-asserted-by":"crossref","first-page":"E118","DOI":"10.1208\/aapsj080114","article-title":"Opioid ligands with mixed mu\/delta opioid receptor interactions: an emerging approach to novel analgesics","volume":"8","author":"Ananthan","year":"2006","journal-title":"AAPS J."},{"key":"10.1016\/j.peptides.2023.171116_bib37","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0022-3565(24)37501-9","article-title":"Delta opioid receptor enhancement of mu opioid receptor-induced antinociception in spinal cord","volume":"285","author":"He","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.peptides.2023.171116_bib38","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1021\/jm100982d","article-title":"Development of potent \u03bc and \u03b4 opioid agonists with high lipophilicity","volume":"54","author":"Lee","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.peptides.2023.171116_bib39","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.lfs.2009.02.025","article-title":"Bi- or multifunctional opioid peptide drugs","volume":"86","author":"Schiller","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.peptides.2023.171116_bib40","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.pain.2010.09.009","article-title":"Co-administration of \u03b4- and \u03bc-opioid receptor agonists promotes peripheral opioid receptor function","volume":"151","author":"Schramm","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.peptides.2023.171116_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pbb.2018.07.002","article-title":"Tetrabenazine, a vesicular monoamine transporter-2 inhibitor, attenuates morphine-induced hyperlocomotion in mice through alteration of dopamine and 5-hydroxytryptamine turnover in the cerebral cortex","volume":"172","author":"Kitanaka","year":"2018","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019697812300181X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019697812300181X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T04:11:59Z","timestamp":1736395919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019697812300181X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":41,"alternative-id":["S019697812300181X"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2023.171116","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endomorphin-2 analogs with C-terminal esterification display potent antinociceptive effects in the formalin pain test in mice","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2023.171116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"171116"}}