{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:03:31Z","timestamp":1790129011518,"version":"4.0.1"},"reference-count":138,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.peptides.2024.171220","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T17:33:55Z","timestamp":1713288835000},"page":"171220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Nisin variants: What makes them different and unique?"],"prefix":"10.1016","volume":"177","author":[{"given":"Weslei","family":"da Silva Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar Roberto Viana","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hil\u00e1rio Cuquetto","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio Santana","family":"Dolabella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Andr\u00e9a Teixeira","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2024.171220_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1128\/jb.16.4.211-229.1928","article-title":"Limiting factors in the lactic fermentation","volume":"16","author":"Rogers","year":"1928","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.peptides.2024.171220_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0140-6736(47)90004-4","article-title":"Further observations on an inhibitory substance (nisin) from lactic streptococci","volume":"250","author":"Mattick","year":"1947","journal-title":"Lancet"},{"key":"10.1016\/j.peptides.2024.171220_bib3","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1021\/ja00747a073","article-title":"The structure of nisin","volume":"93","author":"Gross","year":"1971","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.peptides.2024.171220_bib4","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrmicro1273","article-title":"Bacteriocins: Developing innate immunity for food","volume":"3","author":"Cotter","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1605(01)00560-8","article-title":"Bacteriocins: Safe, natural antimicrobials for food preservation","volume":"71","author":"Cleveland","year":"2001","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib6","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1111\/jam.13033","article-title":"Biomedical applications of nisin","volume":"120","author":"Shin","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2020.01007","article-title":"Nisin Damages the Septal Membrane and Triggers DNA Condensation in Methicillin-Resistant Staphylococcus aureus","volume":"11","author":"Jensen","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib8","article-title":"The Synergistic Antimicrobial Effect and Mechanism of Nisin and Oxacillin against Methicillin-Resistant Staphylococcus aureus","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0131008","article-title":"Nisin ZP, a bacteriocin and food preservative, inhibits head and neck cancer tumorigenesis and prolongs survival","volume":"10","author":"Kamarajan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2024.171220_bib10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1631\/jzus.B1500222","article-title":"Efficacy of vaccination and nisin Z treatments to eliminate intramammary Staphylococcus aureus infection in lactating cows","volume":"18","author":"Guan","year":"2017","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.peptides.2024.171220_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220000","article-title":"Diabetic foot infections: Application of a nisin-biogel to complement the activity of conventional antibiotics and antiseptics against Staphylococcus aureus biofilms","volume":"14","author":"Santos","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2024.171220_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/jisp.jisp_326_18","article-title":"The antiplaque efficacy of lantibiotic Nisin extract mouthrinse","volume":"23","author":"Mitra","year":"2019","journal-title":"J. Indian Soc. Periodontol."},{"key":"10.1016\/j.peptides.2024.171220_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.virol.2020.10.002","article-title":"A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2","volume":"552","author":"Bhattacharya","year":"2021","journal-title":"Virology"},{"key":"10.1016\/j.peptides.2024.171220_bib14","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1432-1033.1991.tb16317.x","article-title":"Identification and characterization of the lantibiotic nisin Z, a natural nisin variant","volume":"201","author":"MULDERS","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.peptides.2024.171220_bib15","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1271\/bbb.67.1616","article-title":"Identi\u02c6cation of the Lantibiotic Nisin Q, a New Natural Nisin Variant Produced by Lactococcus lactis 61-14 Isolated from a River in Japan","volume":"67","author":"Zendo","year":"2003","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.peptides.2024.171220_bib16","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1128\/AEM.72.2.1148-1156.2006","article-title":"Molecular and genetic characterization of a novel nisin variant produced by Streptococcus uberis","volume":"72","author":"Wirawan","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib17","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1099\/mic.0.000515","article-title":"Discovery of a novel lantibiotic nisin O from Blautia obeum A2-162, isolated from the human gastrointestinal tract","volume":"163","author":"Hatziioanou","year":"2017","journal-title":"Microbiol. (U. Kingd."},{"key":"10.1016\/j.peptides.2024.171220_bib18","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/AEM.01862-07","article-title":"Characterization of the structural gene encoding nisin F, a new lantibiotic produced by a Lactococcus lactis subsp. lactis isolate from freshwater catfish (Clarias gariepinus)","volume":"74","author":"De Kwaadsteniet","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib19","article-title":"Nisin M: a Bioengineered Nisin A Variant That Retains Full Induction Capacity but Has Significantly Reduced Antimicrobial Activity","volume":"86","author":"O\u2019Connor","year":"2020","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib20","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1365-2958.2008.06279.x","article-title":"The generation of nisin variants with enhanced activity against specific gram-positive pathogens","volume":"69","author":"Field","year":"2008","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1751-7915.2010.00184.x","article-title":"Studies with bioengineered Nisin peptides highlight the broad-spectrum potency of Nisin V","volume":"3","author":"Field","year":"2010","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.peptides.2024.171220_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jgar.2019.04.010","article-title":"A novel bioengineered derivative of nisin displays enhanced antimicrobial activity against clinical Streptococcus agalactiae isolates","volume":"19","author":"Hayes","year":"2019","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"10.1016\/j.peptides.2024.171220_bib23","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3390\/antibiotics9060305","article-title":"Bioengineered Nisin Derivative M17Q Has Enhanced Activity against Staphylococcus epidermidis","volume":"9","author":"Twomey","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.peptides.2024.171220_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.571903","article-title":"Kunkecin A, a New Nisin Variant Bacteriocin Produced by the Fructophilic Lactic Acid Bacterium, Apilactobacillus kunkeei FF30-6 Isolated From Honey Bees","volume":"11","author":"Zendo","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib25","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1111\/jam.15107","article-title":"Nisin variants from Streptococcus and Staphylococcus successfully express in NZ9800","volume":"131","author":"O\u2019Sullivan","year":"2021","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib26","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00639-19","article-title":"Nisin J, a Novel Natural Nisin Variant, Is Produced by Staphylococcus capitis Sourced from the Human Skin Microbiota","volume":"202","author":"O\u2019Sullivan","year":"2020","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.peptides.2024.171220_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.132009","article-title":"Synergistic antibacterial activity and mechanism of action of nisin\/carvacrol combination against Staphylococcus aureus and their application in the infecting pasteurized milk","volume":"380","author":"Li","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.peptides.2024.171220_bib28","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.4315\/0362-028X-58.10.1109","article-title":"Use of Nisaplin\u2122 to Inhibit Spoilage Bacteria in Buttermilk Ranch Dressing \u2020","volume":"58","author":"Muriana","year":"1995","journal-title":"J. Food Prot."},{"key":"10.1016\/j.peptides.2024.171220_bib29","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s42770-019-00080-8","article-title":"Application of nisin as biopreservative of pork meat by dipping and spraying methods","volume":"50","author":"de Souza de Azevedo","year":"2019","journal-title":"Braz. J. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3358\/shokueishi.50.173","article-title":"Effect of nisin (Nisaplin) on the growth of Listeria monocytogenes in Karashi-mentaiko (Red-pepper Seasoned Cod Roe","volume":"50","author":"Hara","year":"2009","journal-title":"Shokuhin Eiseigaku Zasshi"},{"key":"10.1016\/j.peptides.2024.171220_bib31","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/jam.12078","article-title":"Modified agar diffusion bioassay for better quantification of Nisaplin(\u00ae)","volume":"114","author":"Lalpuria","year":"2013","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/v11110977","article-title":"The effect of a commercially available bacteriophage and bacteriocin on Listeria monocytogenes in Coleslaw","volume":"11","author":"Lewis","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.peptides.2024.171220_bib33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0168-1605(00)00464-5","article-title":"Cresol red thallium acetate sucrose inulin (CTSI) agar for the selective recovery of Carnobacterium spp","volume":"64","author":"Wasney","year":"2001","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0168-1605(02)00171-X","article-title":"Interactive inhibition of meat spoilage and pathogenic bacteria by lysozyme, nisin and EDTA in the presence of nitrite and sodium chloride at 24\u00b0C","volume":"80","author":"Gill","year":"2003","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijfoodmicro.2013.04.004","article-title":"Effects of nisin-incorporated films on the microbiological and physicochemical quality of minimally processed mangoes","volume":"164","author":"Barbosa","year":"2013","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2021.106603","article-title":"Studies of the highly potent lantibiotic peptide nisin Z in aqueous solutions of salts and biological buffer components","volume":"274","author":"Travers","year":"2021","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.peptides.2024.171220_bib37","first-page":"2989","article-title":"The structure of nisin","volume":"92","author":"Gross","year":"1970","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.peptides.2024.171220_bib38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0014-5793(96)00638-2","article-title":"Structure-activity relationships in the peptide antibiotic nisin: antibacterial activity of fragments of nisin","volume":"390","author":"Chan","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.peptides.2024.171220_bib39","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1432-1033.1996.00716.x","article-title":"Structure and biological activity of chemically modified nisin A species","volume":"241","author":"Rollema","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.peptides.2024.171220_bib40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1128\/jb.179.1.135-140.1997","article-title":"Role of transmembrane pH gradient and membrane binding in nisin pore formation","volume":"179","author":"Moll","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.peptides.2024.171220_bib41","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1074\/jbc.M006770200","article-title":"Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity","volume":"276","author":"Wiedemann","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"80","key":"10.1016\/j.peptides.2024.171220_bib42","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1126\/science.286.5448.2361","article-title":"Use of the cell wail precursor lipid II by a pore-forming peptide antibiotic","volume":"286","author":"Breukink","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.peptides.2024.171220_bib43","article-title":"Nisin Variants Generated by Protein Engineering and Their Properties","volume":"9","author":"Zheng","year":"2022","journal-title":"Bioeng. (Basel, Switz."},{"key":"10.1016\/j.peptides.2024.171220_bib44","doi-asserted-by":"crossref","first-page":"14572","DOI":"10.1002\/chem.201902814","article-title":"A Chemical Biology Approach to Understanding Molecular Recognition of Lipid II by Nisin(1-12): Synthesis and NMR Ensemble Analysis of Nisin(1-12) and Analogues","volume":"25","author":"Dickman","year":"2019","journal-title":"Chemistry"},{"key":"10.1016\/j.peptides.2024.171220_bib45","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev.micro.61.080706.093501","article-title":"Lantibiotics: peptides of diverse structure and function","volume":"61","author":"Willey","year":"2007","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib46","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1046\/j.1432-1327.2000.01075.x","article-title":"Engineering a disulfide bond and free thiols in the lantibiotic nisin Z","volume":"267","author":"Van Kraaij","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.peptides.2024.171220_bib47","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nature13888","article-title":"Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB","volume":"517","author":"Ortega","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2024.171220_bib48","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1021\/acs.chemrev.6b00591","article-title":"Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes","volume":"117","author":"Repka","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.peptides.2024.171220_bib49","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.bbamem.2015.10.024","article-title":"Hit \u2019em where it hurts: The growing and structurally diverse family of peptides that target lipid-II","volume":"1858","author":"Oppedijk","year":"2016","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.peptides.2024.171220_bib50","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1128\/jb.178.12.3434-3439.1996","article-title":"Functional analysis of promoters in the nisin gene cluster of Lactococcus lactis","volume":"178","author":"De Ruyter","year":"1996","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.peptides.2024.171220_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.00461","article-title":"Bacteriocins: Novel solutions to age old spore-related problems?","volume":"7","author":"Egan","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib52","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1128\/AEM.00212-15","article-title":"Nisin H is a new nisin variant produced by the gut-derived strain Streptococcus hyointestinalis DPC6484","volume":"81","author":"O\u2019Connor","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib53","article-title":"Thermosonication Combined with Natural Antimicrobial Nisin: A Potential Technique Ensuring Microbiological Safety and Improving the Quality Parameters of Orange Juice","volume":"10","author":"Zhao","year":"2021","journal-title":"Foods (Basel, Switz. )"},{"issue":"4","key":"10.1016\/j.peptides.2024.171220_bib54","doi-asserted-by":"crossref","first-page":"898","DOI":"10.3390\/foods10040898","article-title":"Impact of Nisin and Nisin-Producing Lactococcus lactis ssp lactis on Clostridium tyrobutyricum and Bacterial Ecosystem of Cheese Matrices","volume":"10","author":"Hassan","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.peptides.2024.171220_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.fm.2019.103244","article-title":"High pressure sensitization of heat-resistant and pathogenic foodborne spores to nisin","volume":"84","author":"Modugno","year":"2019","journal-title":"Food Microbiol"},{"key":"10.1016\/j.peptides.2024.171220_bib56","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ijbiomac.2018.01.194","article-title":"Characterization and long term antimicrobial activity of the nisin anchored cellulose films","volume":"113","author":"Wu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.peptides.2024.171220_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.meatsci.2022.108821","article-title":"Application of bi-layers active gelatin films for sliced dried-cured Coppa conservation","volume":"189","author":"Luciano","year":"2022","journal-title":"Meat Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0233284","article-title":"Vancomycin and nisin A are effective against biofilms of multi-drug resistant Staphylococcus aureus isolates from human milk","volume":"15","author":"Angelopoulou","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2024.171220_bib59","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/wrr.12743","article-title":"Immunomodulatory potential of Nisin A with application in wound healing","volume":"27","author":"Mouritzen","year":"2019","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.peptides.2024.171220_bib60","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.contraception.2009.03.012","article-title":"Interaction of contraceptive antimicrobial peptide nisin with target cell membranes: implications for use as vaginal microbicide","volume":"80","author":"Gupta","year":"2009","journal-title":"Contraception"},{"key":"10.1016\/j.peptides.2024.171220_bib61","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.3168\/jds.2015-10161","article-title":"Antibacterial activity and immunomodulatory effects on a bovine mammary epithelial cell line exerted by nisin A-producing Lactococcus lactis strains","volume":"99","author":"Malvisi","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib62","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.3168\/jds.S0022-0302(92)78083-7","article-title":"Evaluation of a nisin-based germicidal formulation on teat skin of live cows","volume":"75","author":"Sears","year":"1992","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib63","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.3168\/jds.2007-0153","article-title":"Efficacy of nisin in treatment of clinical mastitis in lactating dairy cows","volume":"90","author":"Cao","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib64","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.3168\/jds.2021-21381","article-title":"Efficacy of bacteriocin-based formula for reducing staphylococci, streptococci, and total bacterial counts on teat skin of dairy cows","volume":"105","author":"Bennett","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib65","doi-asserted-by":"crossref","unstructured":"M.E. Omobhude, O.A. Morenikeji, O.T. Oyeyemi, Molluscicidal activities of curcumin-nisin polylactic acid nanoparticle on Biomphalaria pfeifferi (2017). https:\/\/doi.org\/10.1371\/journal.pntd.0005855.","DOI":"10.1371\/journal.pntd.0005855"},{"key":"10.1016\/j.peptides.2024.171220_bib66","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s11686-021-00436-x","article-title":"Nisin Induces Cell-Cycle Arrest in Free-Living Amoebae Acanthamoeba castellanii","volume":"67","author":"de Carvalho Cl\u00edmaco","year":"2022","journal-title":"Acta Parasitol."},{"key":"10.1016\/j.peptides.2024.171220_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111965","article-title":"Synthesis of silver-nisin nanoparticles with low cytotoxicity as antimicrobials against biofilm-forming pathogens","volume":"206","author":"Zhao","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.peptides.2024.171220_bib68","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/abr.abr_99_21","article-title":"Green Synthesis of Silver Nanoparticles Using Nisin and its Antibacterial Activity against Pseudomonas aeruginosa","volume":"11","author":"Yazdi","year":"2022","journal-title":"Adv. Biomed. Res."},{"key":"10.1016\/j.peptides.2024.171220_bib69","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejpb.2021.12.010","article-title":"Synergistic antimicrobial interactions of nisin A with biopolymers and solubilising agents for oral drug delivery","volume":"171","author":"Flynn","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.peptides.2024.171220_bib70","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.3168\/jds.2019-17396","article-title":"An innovative method to enhance protease tolerance of nisin in endogenous proteases","volume":"103","author":"Pan","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib71","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1128\/aem.61.8.2873-2878.1995","article-title":"Improvement of Solubility and Stability of the Antimicrobial Peptide Nisin by Protein Engineering","volume":"61","author":"Rollema","year":"1995","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib72","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1472-765X.2008.02488.x","article-title":"Nisin F in the treatment of respiratory tract infections caused by Staphylococcus aureus","volume":"48","author":"De Kwaadsteniet","year":"2009","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib73","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1472-765X.2010.02948.x","article-title":"The ability of nisin F to control Staphylococcus aureus infection in the peritoneal cavity, as studied in mice","volume":"51","author":"Brand","year":"2010","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib74","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12602-011-9069-4","article-title":"Development of a Murine Model with Optimal Routes for Bacterial Infection and Treatment, as Determined with Bioluminescent Imaging in C57BL\/6 Mice","volume":"3","author":"Brand","year":"2011","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.peptides.2024.171220_bib75","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12602-009-9017-8","article-title":"Evaluation of nisin F in the treatment of subcutaneous skin infections, as monitored by using a bioluminescent strain of Staphylococcus aureus","volume":"2","author":"de Kwaadsteniet","year":"2010","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.peptides.2024.171220_bib76","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1472-765X.2011.03091.x","article-title":"Nisin F, intraperitoneally injected, may have a stabilizing effect on the bacterial population in the gastro-intestinal tract, as determined in a preliminary study with mice as model","volume":"53","author":"van Staden","year":"2011","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib77","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1365-2672.2012.05241.x","article-title":"Nisin F-loaded brushite bone cement prevented the growth of Staphylococcus aureus in vivo","volume":"112","author":"van Staden","year":"2012","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib78","doi-asserted-by":"crossref","unstructured":"M. Fukao, T. Obita, F. Yoneyama, D. Kohda, T. Zendo, J. Nakayama, K. Sonomoto, Complete Covalent Structure of Nisin Q, New Natural Nisin Variant, Containing Post-Translationally Modified Amino Acids, (n.d.). https:\/\/doi.org\/10.1271\/bbb.80066.","DOI":"10.1271\/bbb.80066"},{"key":"10.1016\/j.peptides.2024.171220_bib79","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1111\/j.1365-2672.2008.03958.x","article-title":"Biosynthetic characterization and biochemical features of the third natural nisin variant, nisin Q, produced by Lactococcus lactis 61-14","volume":"105","author":"Yoneyama","year":"2008","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib80","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1751-7915.2010.00207.x","article-title":"Bioengineering of a Nisin A-producing Lactococcus lactis to create isogenic strains producing the natural variants Nisin F, Q and Z","volume":"4","author":"Piper","year":"2011","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.peptides.2024.171220_bib81","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1271\/bbb.130014","article-title":"Screening and characterization of novel bacteriocins from lactic acid bacteria","volume":"77","author":"Zendo","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.peptides.2024.171220_bib82","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ijantimicag.2005.08.010","article-title":"Dual antibacterial mechanisms of nisin Z against Gram-positive and Gram-negative bacteria","volume":"26","author":"Kuwano","year":"2005","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.peptides.2024.171220_bib83","doi-asserted-by":"crossref","DOI":"10.1007\/s11274-017-2353-z","article-title":"Nisin Z produced by Lactococcus lactis from bullfrog hatchery is active against Citrobacter freundii, a red-leg syndrome related pathogen","volume":"33","author":"Quintana","year":"2017","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.peptides.2024.171220_bib84","doi-asserted-by":"crossref","unstructured":"W.M. De Vos, J.W.M. Mulders, R.J. Siezen, J. Hugenholtz, O.P. Kuipers\u2019, Properties of Nisin Z and Distribution of Its Gene, nisZ, in Lactococcus lactis, 1993. http:\/\/aem.asm.org\/ (accessed June 29, 2020).","DOI":"10.1128\/aem.59.1.213-218.1993"},{"key":"10.1016\/j.peptides.2024.171220_bib85","doi-asserted-by":"crossref","unstructured":"P. Pandey, U.H.E. Hansmann, F. Wang, Altering the Solubility of the Antibiotic Candidate Nisin A Computational Study, (2020). https:\/\/doi.org\/10.1021\/acsomega.0c03594.","DOI":"10.1101\/2020.07.16.206821"},{"key":"10.1016\/j.peptides.2024.171220_bib86","doi-asserted-by":"crossref","first-page":"928","DOI":"10.4315\/0362-028X-67.5.928","article-title":"Inhibition of a methicillin-resistant Staphylococcus aureus strain in Afuega\u2019l Pitu cheese by the nisin Z-producing strain Lactococcus lactis subsp. lactis IPLA 729","volume":"67","author":"Rilla","year":"2004","journal-title":"J. Food Prot."},{"key":"10.1016\/j.peptides.2024.171220_bib87","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2217\/fmb-2019-0153","article-title":"Nisin Z and lacticin 3147 improve efficacy of antibiotics against clinically significant bacteria","volume":"14","author":"Ellis","year":"2019","journal-title":"Future Microbiol"},{"key":"10.1016\/j.peptides.2024.171220_bib88","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijpharm.2017.04.071","article-title":"Interactions of the antimicrobial peptide nisin Z with conventional antibiotics and the use of nanostructured lipid carriers to enhance antimicrobial activity","volume":"526","author":"Lewies","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.peptides.2024.171220_bib89","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijpharm.2017.04.071","article-title":"Interactions of the antimicrobial peptide nisin Z with conventional antibiotics and the use of nanostructured lipid carriers to enhance antimicrobial activity","volume":"526","author":"Lewies","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.peptides.2024.171220_bib90","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1111\/j.1365-2672.2008.03908.x","article-title":"Nisin Z inhibits the growth of Candida albicans and its transition from blastospore to hyphal form","volume":"105","author":"Le Lay","year":"2008","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib91","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.joen.2017.01.034","article-title":"High-purity Nisin Alone or in Combination with Sodium Hypochlorite Is Effective against Planktonic and Biofilm Populations of Enterococcus faecalis","volume":"43","author":"Kajwadkar","year":"2017","journal-title":"J. Endod."},{"key":"10.1016\/j.peptides.2024.171220_bib92","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.biochi.2017.10.009","article-title":"The antimicrobial peptide nisin Z induces selective toxicity and apoptotic cell death in cultured melanoma cells","volume":"144","author":"Lewies","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.peptides.2024.171220_bib93","doi-asserted-by":"crossref","DOI":"10.1007\/s11095-022-03220-2","article-title":"Nisin ZP, an Antimicrobial Peptide, Induces Cell Death and Inhibits Non-Small Cell Lung Cancer (NSCLC) Progression in vitro in 2D and 3D Cell Culture","author":"Patil","year":"2022","journal-title":"Pharm. Res."},{"key":"10.1016\/j.peptides.2024.171220_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122641","article-title":"Pulmonary delivery of spray-dried Nisin ZP antimicrobial peptide for non-small cell lung cancer (NSCLC) treatment","volume":"634","author":"Patil","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.peptides.2024.171220_bib95","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-79702-3","article-title":"Incorporation and antimicrobial activity of nisin Z within carrageenan\/chitosan multilayers","volume":"11","author":"Webber","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.peptides.2024.171220_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112479","article-title":"Dual-functional antibacterial and osteogenic nisin-based layer-by-layer coatings","volume":"131","author":"Roupie","year":"2021","journal-title":"Mater. Sci. Eng. C. Mater. Biol. Appl."},{"key":"10.1016\/j.peptides.2024.171220_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22041930","article-title":"Functionalization of Crosslinked Sodium Alginate\/Gelatin Wet-Spun Porous Fibers with Nisin Z for the Inhibition of Staphylococcus aureus-Induced Infections","volume":"22","author":"Homem","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib98","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.3168\/jds.2021-21356","article-title":"Nisin Z attenuates lipopolysaccharide-induced mastitis by inhibiting the ERK1\/2 and p38 mitogen-activated protein kinase signaling pathways","volume":"105","author":"Huang","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11020427","article-title":"Nisin E Is a Novel Nisin Variant Produced by Multiple Streptococcus equinus Strains","volume":"11","author":"Sugrue","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.peptides.2024.171220_bib100","article-title":"Nisin G is a novel nisin variant produced by a gut-derived Streptococcus salivarius","volume":"2022","author":"Lawrence","year":"2022","journal-title":"BioRxiv"},{"key":"10.1016\/j.peptides.2024.171220_bib101","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-60623-0","article-title":"First evidence of production of the lantibiotic nisin P","volume":"10","author":"Garcia-Gutierrez","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.peptides.2024.171220_bib102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2020.573614","article-title":"Insights in the Antimicrobial Potential of the Natural Nisin Variant Nisin H","volume":"11","author":"Reiners","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib103","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-37532-4","article-title":"Systematic characterization of position one variants within the lantibiotic nisin","volume":"9","author":"Lagedroste","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.peptides.2024.171220_bib104","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1111\/jam.15107","article-title":"Nisin variants from Streptococcus and Staphylococcus successfully express in NZ9800","volume":"131","author":"O\u2019Sullivan","year":"2021","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib105","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.gene.2013.11.044","article-title":"Comparative genomic analysis shows that Streptococcus suis meningitis isolate SC070731 contains a unique 105 K genomic island","volume":"535","author":"Wu","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.peptides.2024.171220_bib106","doi-asserted-by":"crossref","first-page":"18361","DOI":"10.1073\/pnas.1210393109","article-title":"Evolution of lanthipeptide synthetases","volume":"109","author":"Zhang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.peptides.2024.171220_bib107","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1099\/jmm.0.001170","article-title":"Purification and characterization of nisin P produced by a strain of Streptococcus gallolyticus","volume":"69","author":"Aldarhami","year":"2020","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib108","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1128\/AAC.05778-11","article-title":"The spiFEG locus in Streptococcus infantarius subsp. infantarius BAA-102 confers protection against nisin U","volume":"56","author":"Draper","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.peptides.2024.171220_bib109","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1751-7915.2010.00207.x","article-title":"Bioengineering of a Nisin A-producing Lactococcus lactis to create isogenic strains producing the natural variants Nisin F, Q and Z","volume":"4","author":"Piper","year":"2011","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.peptides.2024.171220_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02393","article-title":"Screening of bacteriocin associated genes of Streptococcus uberis strains","volume":"5","author":"Lasagno","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.peptides.2024.171220_bib111","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.3168\/jds.2009-2223","article-title":"Experimentally induced intramammary infection with multiple strains of Streptococcus uberis","volume":"92","author":"Pryor","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib112","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.bbmt.2015.04.016","article-title":"Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease","volume":"21","author":"Jenq","year":"2015","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.peptides.2024.171220_bib113","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1099\/ijs.0.000015","article-title":"Reclassification of Ruminococcus obeum as Blautia obeum comb. nov","volume":"65","author":"Lawson","year":"2015","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib114","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.chom.2017.04.002","article-title":"Cooperating commensals restore colonization resistance to vancomycin-resistant Enterococcus faecium","volume":"21","author":"Caballero","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.peptides.2024.171220_bib115","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41586-019-1501-z","article-title":"Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus","volume":"572","author":"Kim","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2024.171220_bib116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AEM.05576-11","article-title":"Bacteriocin production: A probiotic trait?","volume":"78","author":"Dobson","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms24076813","article-title":"a Novel Nisin Variant Produced by Ligilactobacillus salivarius P1CEA3","volume":"24","author":"Sevillano","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib118","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.01143","article-title":"LAB bacteriocins controlling the food isolated (drug-resistant) staphylococci","volume":"9","author":"Perales-Ad\u00e1n","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib119","article-title":"Biodiversity of Ligilactobacillus salivarius Strains from Poultry and Domestic Pigeons","volume":"11","author":"Dec","year":"2021","journal-title":"Anim. Open Access J. MDPI"},{"key":"10.1016\/j.peptides.2024.171220_bib120","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s40168-018-0489-1","article-title":"The queen\u2019s gut refines with age: longevity phenotypes in a social insect model","volume":"6","author":"Anderson","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.peptides.2024.171220_bib121","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033708","article-title":"Diversity of Melissococcus plutonius from honeybee larvae in Japan and experimental reproduction of European foulbrood with cultured atypical isolates","volume":"7","author":"Arai","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2024.171220_bib122","doi-asserted-by":"crossref","DOI":"10.1021\/acssynbio.3c00612","article-title":"Rombocin, a Short Stable Natural Nisin Variant, Displays Selective Antimicrobial Activity against Listeria monocytogenes and Employs a Dual Mode of Action to Kill Target Bacterial Strains","author":"Guo","year":"2024","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.peptides.2024.171220_bib123","doi-asserted-by":"crossref","unstructured":"Z.J. Zhang, C. Wu, R. Moreira, D. Dorantes, T. Pappas, A. Sundararajan, H. Lin, E.G. Pamer, W.A. Van Der Donk, Activity of Gut-Derived Nisin-like Lantibiotics against Human Gut Pathogens and Commensals, (2024). https:\/\/doi.org\/10.1021\/acschembio.3c00577.","DOI":"10.1021\/acschembio.3c00577"},{"key":"10.1016\/j.peptides.2024.171220_bib124","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.3168\/jds.2020-19350","article-title":"Assessing the ability of nisin A and derivatives thereof to inhibit gram-negative bacteria from the genus Thermus","volume":"104","author":"Yeluri Jonnala","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073480","article-title":"Bio-Engineered Nisin with Increased Anti- Staphylococcus and Selectively Reduced Anti- Lactococcus Activity for Treatment of Bovine Mastitis","volume":"22","author":"Field","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2024.171220_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.fm.2021.103835","article-title":"Investigation of combinations of rationally selected bioengineered nisin derivatives for their ability to inhibit Listeria in broth and model food systems","volume":"99","author":"Nyhan","year":"2021","journal-title":"Food Microbiol"},{"key":"10.1016\/j.peptides.2024.171220_bib127","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/mmi.14183","article-title":"Bioengineering nisin to overcome the nisin resistance protein","volume":"111","author":"Field","year":"2019","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib128","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1128\/AAC.01382-08","article-title":"Novel mechanism for nisin resistance via proteolytic degradation of nisin by the nisin resistance protein NSR","volume":"53","author":"Sun","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.peptides.2024.171220_bib129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AEM.00391-21","article-title":"A bioengineered nisin derivative to control Streptococcus uberis biofilms","volume":"87","author":"P\u00e9rez-Ibarreche","year":"2021","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib130","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.fm.2017.01.020","article-title":"Use of enhanced nisin derivatives in combination with food-grade oils or citric acid to control Cronobacter sakazakii and Escherichia coli O157:H7","volume":"65","author":"Campion","year":"2017","journal-title":"Food Microbiol"},{"key":"10.1016\/j.peptides.2024.171220_bib131","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1128\/AEM.00070-15","article-title":"Efficacies of nisin A and nisin V semipurified preparations alone and in combination with plant essential oils for controlling Listeria monocytogenes","volume":"81","author":"Field","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib132","doi-asserted-by":"crossref","first-page":"408","DOI":"10.4161\/bbug.1.6.13642","article-title":"Gene encoded antimicrobial peptides, a template for the design of novel anti-mycobacterial drugs","volume":"1","author":"Carroll","year":"2010","journal-title":"Bioeng. Bugs"},{"key":"10.1016\/j.peptides.2024.171220_bib133","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2180-13-23","article-title":"In vivo activity of Nisin A and Nisin V against Listeria monocytogenes in mice","volume":"13","author":"Campion","year":"2013","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.peptides.2024.171220_bib134","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.00508","article-title":"In vitro activities of nisin and nisin derivatives alone and in combination with antibiotics against Staphylococcus biofilms","volume":"7","author":"Field","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib135","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/jisp.jisp_326_18","article-title":"The antiplaque efficacy of lantibiotic Nisin extract mouthrinse","volume":"23","author":"Mitra","year":"2019","journal-title":"J. Indian Soc. Periodontol."},{"key":"10.1016\/j.peptides.2024.171220_bib136","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ijfoodmicro.2018.09.015","article-title":"Thermoplastic starch\/polybutylene adipate terephthalate film coated with gelatin containing nisin Z and lauric arginate for control of foodborne pathogens associated with chilled and frozen seafood","volume":"290","author":"Pattanayaiying","year":"2019","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib137","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.573614","article-title":"Insights in the Antimicrobial Potential of the Natural Nisin Variant Nisin H","volume":"11","author":"Reiners","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.peptides.2024.171220_bib138","article-title":"Nisin J, a Novel Natural Nisin Variant, Is Produced by Staphylococcus capitis Sourced from the Human Skin","author":"O\u2019sullivan","year":"2020","journal-title":"Microbiota"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978124000731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978124000731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:37:02Z","timestamp":1717115822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978124000731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":138,"alternative-id":["S0196978124000731"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2024.171220","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nisin variants: What makes them different and unique?","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2024.171220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"171220"}}