{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:56:41Z","timestamp":1784120201119,"version":"3.55.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022690","name":"JDRF","doi-asserted-by":"publisher","award":["1-SRA-2023-1402- M-B"],"award-info":[{"award-number":["1-SRA-2023-1402- M-B"]}],"id":[{"id":"10.13039\/100022690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.peptides.2024.171255","type":"journal-article","created":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T14:06:48Z","timestamp":1717337208000},"page":"171255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Harnessing the melanocortin system in the control of food intake and glucose homeostasis"],"prefix":"10.1016","volume":"179","author":[{"given":"Patrick","family":"Swan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carel W.","family":"le Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Miras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2024.171255_bib1","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-18-0596","article-title":"The melanocortin pathway and control of appetite-progress and therapeutic implications","volume":"241","author":"Baldini","year":"2019","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.peptides.2024.171255_bib2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/s41586-021-04088-9","article-title":"MC3R links nutritional state to childhood growth and the timing of puberty","volume":"599","author":"Lam","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2024.171255_bib3","doi-asserted-by":"crossref","first-page":"11381","DOI":"10.1073\/pnas.172378699","article-title":"A role for the melanocortin 4 receptor in sexual function","volume":"99","author":"Van der Ploeg","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.peptides.2024.171255_bib4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3389\/fendo.2019.00683","article-title":"Melanocortin regulation of inflammation","volume":"10","author":"Wang","year":"2019","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.peptides.2024.171255_bib5","doi-asserted-by":"crossref","first-page":"8246","DOI":"10.1016\/S0021-9258(18)53088-X","article-title":"Molecular cloning of a novel melanocortin receptor","volume":"268","author":"Gantz","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2024.171255_bib6","doi-asserted-by":"crossref","first-page":"15174","DOI":"10.1016\/S0021-9258(18)82452-8","article-title":"Molecular cloning, expression, and gene localization of a fourth melanocortin receptor","volume":"268","author":"Gantz","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2024.171255_bib7","doi-asserted-by":"crossref","first-page":"8856","DOI":"10.1073\/pnas.90.19.8856","article-title":"Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system","volume":"90","author":"Roselli-Rehfuss","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.peptides.2024.171255_bib8","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1126\/science.1325670","article-title":"The cloning of a family of genes that encode the melanocortin receptors","volume":"257","author":"Mountjoy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.peptides.2024.171255_bib9","doi-asserted-by":"crossref","first-page":"1902S","DOI":"10.1093\/jn\/127.9.1902S","article-title":"The Role of the agouti Gene in the Yellow Obese Syndrome","volume":"127","author":"Miltenberger","year":"1997","journal-title":"J. Nutr."},{"key":"10.1016\/j.peptides.2024.171255_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1152\/physiolgenomics.1999.1.3.151","article-title":"Physiological consequences of ectopic agouti gene expression: the yellow obese mouse syndrome","volume":"1","author":"Wolff","year":"1999","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.peptides.2024.171255_bib11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1126\/science.278.5335.135","article-title":"Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein","volume":"278","author":"Ollmann","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.peptides.2024.171255_bib12","first-page":"285","article-title":"Monogenic human obesity: role of the leptin-melanocortin system in the regulation of food intake and body weight in humans","volume":"35","author":"Gonz\u00e1lez-Jim\u00e9nez","year":"2012","journal-title":"Sist. Sanit. Navar."},{"key":"10.1016\/j.peptides.2024.171255_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/2404","article-title":"A frameshift mutation in MC4R associated with dominantly inherited human obesity","volume":"20","author":"Yeo","year":"1998","journal-title":"Nat. Genet"},{"key":"10.1016\/j.peptides.2024.171255_bib14","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1152\/physrev.00024.2017","article-title":"POMC: the physiological power of hormone processing","volume":"98","author":"Harno","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.peptides.2024.171255_bib15","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1677\/joe.0.1720411","article-title":"Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity","volume":"172","author":"Pritchard","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.peptides.2024.171255_bib16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1530\/eje.0.1490079","article-title":"Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions","volume":"149","author":"Raffin-Sanson","year":"2003","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.peptides.2024.171255_bib17","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nn1455","article-title":"Anatomy and regulation of the central melanocortin system","volume":"8","author":"Cone","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.peptides.2024.171255_bib18","first-page":"835","article-title":"Differential release of proopiomelanocortin-derived peptides from the human pituitary: evidence from a panel of two-site immunoradiometric assays","volume":"78","author":"Gibson","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2024.171255_bib19","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.molmet.2016.07.009","article-title":"\u03b1-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors","volume":"5","author":"Enriori","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.peptides.2024.171255_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1471-2377-10-73","article-title":"The increase of alpha-melanocyte-stimulating hormone in the plasma of chronic fatigue syndrome patients","volume":"10","author":"Shishioh-Ikejima","year":"2010","journal-title":"BMC Neurol."},{"key":"10.1016\/j.peptides.2024.171255_bib21","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1210\/jc.2004-1124","article-title":"Circulating melanin-concentrating hormone, agouti-related protein, and \u03b1-melanocyte-stimulating hormone levels in relation to body composition: alterations in response to food deprivation and recombinant human leptin administration","volume":"90","author":"Gavrila","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2024.171255_bib22","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.2337\/db06-0151","article-title":"A glucose sensor role for glucokinase in anterior pituitary cells","volume":"55","author":"Zelent","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2024.171255_bib23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/1082","article-title":"Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons","volume":"1","author":"Hahn","year":"1998","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.peptides.2024.171255_bib24","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1210\/en.2005-1373","article-title":"Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83\u2013132: interaction between AGRP83\u2013132 and melanocortin receptors cannot be influenced by syndecan-3","volume":"147","author":"Creemers","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2024.171255_bib25","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1021\/acschemneuro.8b00346","article-title":"Insights into the allosteric mechanism of setmelanotide (RM-493) as a potent and first-in-class melanocortin-4 receptor (MC4R) agonist to treat rare genetic disorders of obesity through an in silico approach","volume":"10","author":"Falls","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.peptides.2024.171255_bib26","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1021\/bi700125e","article-title":"Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling","volume":"46","author":"Chen","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.peptides.2024.171255_bib27","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/1523-1747.ep12324134","article-title":"Ultraviolet B and Melanocyte-Stimulating Hormone (MSH) Stimulate mRNA Production for \u221dMSH receptors and proopiomelanocortin-derived peptides in mouse melanoma cells and transformed keratinocytes","volume":"105","author":"Chakraborty","year":"1995","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.peptides.2024.171255_bib28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1749-6632.1999.tb08678.x","article-title":"Role of epidermal cell-derived alpha-melanocyte stimulating hormone in ultraviolet light mediated local immunosuppression","volume":"885","author":"Luger","year":"1999","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.peptides.2024.171255_bib29","first-page":"73","article-title":"Distribution of cDNA for melanocortin receptor subtypes in human tissues","volume":"38","author":"Chhajlani","year":"1996","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.peptides.2024.171255_bib30","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1210\/endo.137.5.8612494","article-title":"Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis","volume":"137","author":"Suzuki","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2024.171255_bib31","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/PL00000868","article-title":"Melanocortin receptors: their functions and regulation by physiological agonists and antagonists","volume":"58","author":"Abdel-Malek","year":"2001","journal-title":"CMLS Cell. Mol. Life Sci."},{"key":"10.1016\/j.peptides.2024.171255_bib32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejphar.2010.12.020","article-title":"Structure, function and regulation of the melanocortin receptors","volume":"660","author":"Yang","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.peptides.2024.171255_bib33","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.cmet.2014.10.004","article-title":"The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo","volume":"20","author":"Panaro","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2024.171255_bib34","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3389\/fendo.2021.690387","article-title":"L-cell expression of melanocortin-4-receptor is marginal in most of the small intestine in mice and humans and direct stimulation of small intestinal melanocortin-4-receptors in mice and rats does not affect GLP-1 secretion","volume":"12","author":"Kuhre","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.peptides.2024.171255_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000342556","article-title":"Treatment options for children with monogenic forms of obesity","volume":"106","author":"Hainerov\u00e1","year":"2013","journal-title":"World Rev. Nutr. Diet."},{"key":"10.1016\/j.peptides.2024.171255_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF00995160","article-title":"Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype","volume":"20","author":"Fathi","year":"1995","journal-title":"Neurochem Res."},{"key":"10.1016\/j.peptides.2024.171255_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01475","article-title":"The melanocortin MC5R as a new target for treatment of high glucose-induced hypertrophy of the cardiac H9c2 cells","volume":"9","author":"Trotta","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.peptides.2024.171255_bib38","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.peptides.2005.05.030","article-title":"Melanocortin-5 receptor: a marker of human sebocyte differentiation","volume":"27","author":"Zhang","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2024.171255_bib39","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ejphar.2010.10.100","article-title":"Melanocortin-5 receptor and sebogenesis","volume":"660","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.peptides.2024.171255_bib40","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1046\/j.1523-1747.2000.00094.x","article-title":"The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells","volume":"115","author":"Thiboutot","year":"2000","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.peptides.2024.171255_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0157027","article-title":"\u03b1-MSH stimulates glucose uptake in mouse muscle and phosphorylates rab-GTPase-activating protein TBC1D1 independently of AMPK","volume":"11","author":"M\u00f8ller","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.peptides.2024.171255_bib42","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/35078085","article-title":"Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus","volume":"411","author":"Cowley","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2024.171255_bib43","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tem.2004.07.009","article-title":"Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis","volume":"15","author":"Niswender","year":"2004","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2024.171255_bib44","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.arcmed.2008.08.004","article-title":"Metabolic syndrome and insulin resistance significantly correlate with body mass index","volume":"39","author":"Esteghamati","year":"2008","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.peptides.2024.171255_bib45","first-page":"170","article-title":"Effect of body mass index and fat distribution on insulin sensitivity, secretion, and clearance in nonobese healthy men","volume":"75","author":"Walton","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2024.171255_bib46","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1126\/science.289.5487.2122","article-title":"Role of brain insulin receptor in control of body weight and reproduction","volume":"289","author":"Br\u00fcning","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.peptides.2024.171255_bib47","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0896-6273(01)80035-0","article-title":"Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area","volume":"23","author":"Elias","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.peptides.2024.171255_bib48","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1210\/en.2008-1184","article-title":"Brain-derived neurotrophic factor\/tropomyosin-related kinase receptor type b signaling is a downstream effector of the brainstem melanocortin system in food intake control","volume":"150","author":"Bariohay","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2024.171255_bib49","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1523\/JNEUROSCI.5398-07.2008","article-title":"Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons","volume":"28","author":"Wan","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.peptides.2024.171255_bib50","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1210\/endo.141.9.7791","article-title":"A unique metalolic sysdrone causes obesity in the melanocortin-3 receptor-deficient mouse","volume":"141","author":"Butler","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2024.171255_bib51","unstructured":"E.M.A. Imcivree. European Medicines Agency \u3008https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/imcivree\u3009 (2021)."},{"key":"10.1016\/j.peptides.2024.171255_bib52","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S2213-8587(20)30364-8","article-title":"Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials","volume":"8","author":"Cl\u00e9ment","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.peptides.2024.171255_bib53","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41591-018-0015-9","article-title":"MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency","volume":"24","author":"Cl\u00e9ment","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.peptides.2024.171255_bib54","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1056\/NEJMoa1512693","article-title":"Proopiomelanocortin deficiency treated with a melanocortin-4 receptor agonist","volume":"375","author":"K\u00fchnen","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.peptides.2024.171255_bib55","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.molmet.2017.06.015","article-title":"Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency","volume":"6","author":"Collet","year":"2017","journal-title":"Mol. Metab."},{"key":"10.1016\/j.peptides.2024.171255_bib56","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1016\/j.bbadis.2017.04.010","article-title":"Biased signaling at neural melanocortin receptors in regulation of energy homeostasis","volume":"1863","author":"Yang","year":"2017","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.peptides.2024.171255_bib57","doi-asserted-by":"crossref","first-page":"40649","DOI":"10.1074\/jbc.M007577200","article-title":"SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985","volume":"275","author":"Bj\u00f8rb\u00e6k","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2024.171255_bib58","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cmet.2006.06.010","article-title":"Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells","volume":"4","author":"Kievit","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2024.171255_bib59","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1172\/JCI59816","article-title":"Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice","volume":"122","author":"Berglund","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.peptides.2024.171255_bib60","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.cmet.2007.05.004","article-title":"Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production","volume":"5","author":"K\u00f6nner","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2024.171255_bib61","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2337\/db09-1303","article-title":"Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons","volume":"59","author":"Lin","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2024.171255_bib62","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.2337\/db09-0638","article-title":"Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues","volume":"58","author":"Toda","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2024.171255_bib63","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.2337\/db14-1257","article-title":"Regulation of glucose tolerance and sympathetic activity by MC4R signaling in the lateral hypothalamus","volume":"64","author":"Morgan","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2024.171255_bib64","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0024-3205(84)90487-9","article-title":"Alpha-melanocyte stimulating hormone increases plasma levels of glucagon and insulin in rabbits","volume":"34","author":"Knudtzon","year":"1984","journal-title":"Life Sci."},{"key":"10.1016\/j.peptides.2024.171255_bib65","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3844\/ajptsp.2006.5.10","article-title":"Effects of administration of alpha-melanocyte stimulating hormone (\u03b1-MSH) on some hematological values of alloxan-induced diabetic rats","volume":"1","author":"Mansi","year":"2006","journal-title":"Am. J. Pharmacol. Toxicol."},{"key":"10.1016\/j.peptides.2024.171255_bib66","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1055\/s-2007-1012379","article-title":"Effects of pro-opiomelanocortin-derived peptides on plasma levels of glucagon, insulin and glucose","volume":"18","author":"Knudtzon","year":"1986","journal-title":"Horm. Metab. Res"},{"key":"10.1016\/j.peptides.2024.171255_bib67","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.mce.2012.06.013","article-title":"Exercise-induced AMPK activity in skeletal muscle: role in glucose uptake and insulin sensitivity","volume":"366","author":"Friedrichsen","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.peptides.2024.171255_bib68","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1074\/jbc.M603454200","article-title":"Peripheral Effect of \u03b1-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle","volume":"282","author":"An","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2024.171255_bib69","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00125-014-3395-5","article-title":"Roles of TBC1D1 and TBC1D4 in insulin- and exercise-stimulated glucose transport of skeletal muscle","volume":"58","author":"Cartee","year":"2015","journal-title":"Diabetologia"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978124001086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978124001086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T08:12:32Z","timestamp":1728288752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978124001086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":69,"alternative-id":["S0196978124001086"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2024.171255","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Harnessing the melanocortin system in the control of food intake and glucose homeostasis","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2024.171255","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"171255"}}