{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T05:23:28Z","timestamp":1773206608853,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination of Higher Education Personnel Improvement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.peptides.2024.171294","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T07:32:39Z","timestamp":1725953559000},"page":"171294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["R-954, a bradykinin B1 receptor antagonist, as a potential therapy in a preclinical endometriosis model"],"prefix":"10.1016","volume":"181","author":[{"given":"Patricia Ribeiro de Carvalho","family":"Fran\u00e7a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Pedro Barros de","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosangela Ribeiro de","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Pinto","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Sirois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Dias","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2024.171294_bib1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ogc.2012.10.002","article-title":"Endometriosis and Infertility: a Review of the pathogenesis and treatment of endometriosis-associated infertility","volume":"39","author":"Macer","year":"2012","journal-title":"Obst Gynecol. Clin. North Am."},{"key":"10.1016\/j.peptides.2024.171294_bib2","first-page":"1","article-title":"Inflammation to infertility: panoramic view on endometriosis","volume":"12","author":"Rasheed","year":"2020","journal-title":"Cureus"},{"key":"10.1016\/j.peptides.2024.171294_bib3","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1530\/REP-19-0106","article-title":"Endometriosis in MRKH cases as a proof for the coelomic metaplasia hypothesis?","volume":"158","author":"Konrad","year":"2019","journal-title":"Reproduction"},{"key":"10.1016\/j.peptides.2024.171294_bib4","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.fertnstert.2017.08.036","article-title":"Pathogenesis of deep endometriosis","volume":"108","author":"Gordts","year":"2017","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.peptides.2024.171294_bib5","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.2741\/e589","article-title":"Stem cell theory for the pathogenesis of endometriosis","volume":"4","author":"Maruyama","year":"2012","journal-title":"Front. Biosci."},{"key":"10.1016\/j.peptides.2024.171294_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: pathogenesis and treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nat. Rev. \u2013Endocrinol."},{"key":"10.1016\/j.peptides.2024.171294_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-pathmechdis-012419-032654","article-title":"The origin and pathogenesis of endometriosis","volume":"15","author":"Wang","year":"2020","journal-title":"Ann. Rev. Pathol: Mech. Dis."},{"key":"10.1016\/j.peptides.2024.171294_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-020-02471-0","article-title":"Endometriosis: current challenges in modeling a multifactorial disease of unknown etiology","volume":"18","author":"Malvezzi","year":"2020","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.peptides.2024.171294_bib9","first-page":"1","article-title":"NK cells as potential targets for immunotherapy in endometriosis","volume":"8","author":"\u015acien\u017cy\u0144ska","year":"2019","journal-title":"J. Clin. Med"},{"key":"10.1016\/j.peptides.2024.171294_bib10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.rbmo.2018.12.025","article-title":"Pro-endometriotic niche in endometriosis","volume":"38","author":"Liang","year":"2019","journal-title":"Rep. Biomed. Online"},{"key":"10.1016\/j.peptides.2024.171294_bib11","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41574-019-0245-z","article-title":"Rethinking mechanisms, diagnosis and management of endometriosis","volume":"15","author":"Chapron","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.peptides.2024.171294_bib12","first-page":"995","article-title":"Current and emerging therapeutics for the management of endometriosis","volume":"78","author":"Ferrero","year":"2018","journal-title":"Adis"},{"key":"10.1016\/j.peptides.2024.171294_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106305","article-title":"Bradykinin receptors: agonists, antagonists, expression, signaling, and adaptation to sustained stimulation","volume":"82","author":"Marceau","year":"2020","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.peptides.2024.171294_bib14","first-page":"1849","volume":"32","author":"Prat","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2024.171294_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.canlet.2013.12.009","article-title":"The role of kinin receptors in cancer and therapeutic opportunities","volume":"345","author":"Costa","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.peptides.2024.171294_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/1721727X15577736","article-title":"A primary role for kinin B1 receptor in inflammation, organ damage, and lethal thrombosis in a rat model of septic shock in diabetes","volume":"13","author":"Tidjane","year":"2015","journal-title":"Eur. J. Inflamm."},{"key":"10.1016\/j.peptides.2024.171294_bib17","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/CCM.0000000000001268","article-title":"Kinin B1 receptor antagonist BI113823 reduces acute lung injury","volume":"43","author":"Nasseri","year":"2015","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.peptides.2024.171294_bib18","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/ejp.1133","article-title":"Bradykinin system is involved in endometriosis-related pain through endothelin-1 production","volume":"22","author":"Yoshino","year":"2017","journal-title":"Eur. J. Pain."},{"key":"10.1016\/j.peptides.2024.171294_bib19","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.peptides.2003.06.003","article-title":"Beneficial effect of chronic treatment with the selective bradykinin B1 receptor antagonists, R-715 and R-954, in attenuating streptozotocin-diabetic thermal hyperalgesia in mice","volume":"24","author":"Gabra","year":"2003","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2024.171294_bib20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.regpep.2004.09.002","article-title":"Enhanced dermal and retinal vascular permeability in streptozotocin-induced type 1 diabetes in Wistar rats: blockade with a selective bradykinin B1 receptor antagonist","volume":"124","author":"Lawson","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2024.171294_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.npep.2009.12.010","article-title":"Antidiabetic efficacy of bradykinin antagonist R-954 on glucose tolerance test in diabetic type 1 mice","volume":"44","author":"Catanzaro","year":"2010","journal-title":"Neuropeptides"},{"key":"10.1016\/j.peptides.2024.171294_bib22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.peptides.2013.12.009","article-title":"Preclinical pharmacology, metabolic stability, pharmacokinetics and toxicology of the peptidic kinin B1 receptor antagonist R-954","volume":"52","author":"Gobeil","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2024.171294_bib23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1139\/y02-053","article-title":"Kinin B1 receptor antagonists with multi-enzymatic resistance properties","volume":"80","author":"Neugebauer","year":"2002","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.peptides.2024.171294_bib24","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0015-0282(16)48988-0","article-title":"Studies on the surgical induction of endometriosis in the rat","volume":"44","author":"Vernon","year":"1985","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.peptides.2024.171294_bib25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF02308461","article-title":"Faerbemethoden zum makroskopischen nachweis von implantationsstellen am uterus der ratte","volume":"247","author":"Salewski","year":"1964","journal-title":"Naunyn-Schmiede Arch. Exp. Pathol. Pharmakol."},{"key":"10.1016\/j.peptides.2024.171294_bib26","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.autrev.2018.03.017","article-title":"The link between immunity, autoimmunity and endometriosis: a literature update","volume":"17","author":"Zang","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.peptides.2024.171294_bib27","first-page":"1","article-title":"Mouse model of surgically-induced endometriosis by auto-transplantation of uterine tissue","volume":"6","author":"Pelch","year":"2012","journal-title":"J. Vis. Exp: JoVE"},{"key":"10.1016\/j.peptides.2024.171294_bib28","first-page":"65","article-title":"Increased levels of human neutrophil peptides 1, 2, and 3 in peritoneal fluid of patients with endometriosis: association with neutrophils, T cells and IL-8","volume":"91","author":"Milewski","year":"2011","journal-title":"J. Rep. Immunol."},{"key":"10.1016\/j.peptides.2024.171294_bib29","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1189\/jlb.0109012","article-title":"Kinin B1 receptor activation turns on exocytosis of matrix metalloprotease-9 and myeloperoxidade in human neutrophils: involvement of mitogen-activated protein kinase Family","volume":"86","author":"Ehrenfeld","year":"2009","journal-title":"J. Leuk. Biol."},{"key":"10.1016\/j.peptides.2024.171294_bib30","doi-asserted-by":"crossref","unstructured":"M. Takamura, K. Koga, G. Izumi, Y. Urata, M. Nagai, A. Hasegawa, M. Harada, T. Hirata, Y. Hirota, O. Wada-Hiraike, T. Fujii, Y. Osuga, Neutrophil depletion reduces endometriotic lesion formation in mice, Am. J. Rep. Immunol. 76 (2016) 193\u2013198.","DOI":"10.1111\/aji.12540"},{"key":"10.1016\/j.peptides.2024.171294_bib31","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1172\/JCI1359","article-title":"The B1-agonist [des-Arg10]-kallidin activates transcription factor nf-kb and induces homologous upregulation of the bradykinin B1\u2013receptor in cultured human lung fibroblasts","volume":"101","author":"Schanstra","year":"1998","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.peptides.2024.171294_bib32","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1189\/jlb.68.5.587","article-title":"Kinins and kinin receptors: importance for the activation of leukocytes","volume":"68","author":"B\u00f6ckmann","year":"2000","journal-title":"J. Leuk. Biol."},{"key":"10.1016\/j.peptides.2024.171294_bib33","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1111\/bph.14962","article-title":"The effects of anti-VEGF and kinin B1 receptor blockade on retinal inflammation in laser-induced choroidal neovascularization","volume":"177","author":"Hachana","year":"2019","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.peptides.2024.171294_bib34","first-page":"1","article-title":"Endometriosis with infertility: a comprehensive review on the role of immune deregulation and immunomodulation therapy","volume":"85","author":"Kolanska","year":"2020","journal-title":"Am. J. Rep. Immunol."},{"key":"10.1016\/j.peptides.2024.171294_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2012.05.004","article-title":"Interleukin-6 in pregnancy and gestational disorders","volume":"95","author":"Prins","year":"2012","journal-title":"J. Rep. Immunol."},{"key":"10.1016\/j.peptides.2024.171294_bib36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yrtph.2007.05.006","article-title":"Developmental toxicity of triphenyltin hidroxide in mice.","volume":"49","author":"Sarpa","year":"2007","journal-title":"Reg. Toxicol. Pharm."},{"key":"10.1016\/j.peptides.2024.171294_bib37","first-page":"1","article-title":"Progesterone alleviates endometriosis via inhibition of uterine cell proliferation, inflammation and angiogenesis in an immunocompetent mouse model","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978124001475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978124001475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T16:57:14Z","timestamp":1728406634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978124001475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":37,"alternative-id":["S0196978124001475"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2024.171294","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"R-954, a bradykinin B1 receptor antagonist, as a potential therapy in a preclinical endometriosis model","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2024.171294","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"171294"}}