{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:35:13Z","timestamp":1791999313557,"version":"4.4.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003790","name":"Hiroshima University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.peptides.2025.171376","type":"journal-article","created":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T06:45:27Z","timestamp":1740293127000},"page":"171376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["A murine model of obesity with hyperinsulinemia and hepatic steatosis involving neurosecretory protein GL gene and a low-fat\/medium-sucrose diet"],"prefix":"10.1016","volume":"186","author":[{"given":"Yuki","family":"Narimatsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiko","family":"Iwakoshi-Ukena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Furumitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Ukena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2025.171376_bib1","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1097\/HEP.0000000000000520","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"78","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.peptides.2025.171376_bib2","first-page":"691","article-title":"MASLD: a systemic metabolic disorder with cardiovascular and malignant complications","author":"Targher","year":"2024","journal-title":"Gut 73"},{"key":"10.1016\/j.peptides.2025.171376_bib3","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.tem.2024.02.007","article-title":"Current status and future trends of the global burden of MASLD","volume":"35","author":"Miao","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2025.171376_bib4","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1016\/j.jhep.2023.08.026","article-title":"99% of patients with NAFLD meet MASLD criteria and natural history is therefore identical","volume":"80","author":"Hagstr\u00f6m","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.peptides.2025.171376_bib5","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1016\/j.jhep.2023.07.021","article-title":"Can we use old NAFLD data under the new MASLD definition?","volume":"80","author":"Song","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.peptides.2025.171376_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6613827","article-title":"NAFLD, insulin resistance, and diabetes mellitus type 2","volume":"2021","author":"Maru\u0161i\u0107","year":"2021","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.peptides.2025.171376_bib7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1872-034X.2012.01031.x","article-title":"Liver and diabetes. A vicious circle: Liver and T2D","volume":"43","author":"Loria","year":"2013","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.peptides.2025.171376_bib8","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1210\/jc.2006-0587","article-title":"The role of insulin resistance in nonalcoholic fatty liver disease","volume":"91","author":"Utzschneider","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2025.171376_bib9","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbrc.2014.02.090","article-title":"Identification of a cDNA encoding a novel small secretory protein, neurosecretory protein GL, in the chicken hypothalamic infundibulum","volume":"446","author":"Ukena","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.peptides.2025.171376_bib10","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28527","article-title":"Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity","volume":"6","author":"Iwakoshi-Ukena","year":"2017","journal-title":"ELife"},{"key":"10.1016\/j.peptides.2025.171376_bib11","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1210\/en.2017-00064","article-title":"Neurosecretory protein GL, a hypothalamic small secretory protein, participates in energy homeostasis in male mice","volume":"158","author":"Matsuura","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2025.171376_bib12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ygcen.2017.09.019","article-title":"Avian and murine neurosecretory protein GL participates in the regulation of feeding and energy metabolism","volume":"260","author":"Ukena","year":"2018","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.peptides.2025.171376_bib13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ygcen.2017.05.016","article-title":"Effects of chronic intracerebroventricular infusion of neurosecretory protein GL on body mass and food and water intake in chicks","volume":"256","author":"Shikano","year":"2018","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.peptides.2025.171376_bib14","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3389\/fendo.2019.00392","article-title":"Neurosecretory protein GL induces fat accumulation in chicks","volume":"10","author":"Shikano","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.peptides.2025.171376_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JOE-19-0112","article-title":"Neurosecretory protein GL induces fat accumulation in mice","volume":"244","author":"Shikano","year":"2020","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.peptides.2025.171376_bib16","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1159\/000518969","article-title":"Hypothalamic Overexpression of Neurosecretory Protein GL Leads to Obesity in Male C57BL\/6J Mice","volume":"112","author":"Narimatsu","year":"2022","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.peptides.2025.171376_bib17","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.3390\/ijms23042071","article-title":"Neurosecretory Protein GL Accelerates Liver Steatosis in Mice Fed Medium-Fat\/Medium-Fructose Diet","volume":"23","author":"Narimatsu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2025.171376_bib18","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.3390\/molecules26196006","article-title":"Overexpression of the Gene Encoding Neurosecretory Protein GL Precursor Prevents Excessive Fat Accumulation in the Adipose Tissue of Mice Fed a Long-Term High-Fat Diet","volume":"26","author":"Fukumura","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.peptides.2025.171376_bib19","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1194\/jlr.M052308","article-title":"A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice","volume":"55","author":"Duarte","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.peptides.2025.171376_bib20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jhep.2021.02.027","article-title":"Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial","volume":"75","author":"Geidl-Flueck","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.peptides.2025.171376_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3390\/cells12010169","article-title":"Exosomes from short-term high-fat or high-sucrose fed mice induce hepatic steatosis through different pathways","volume":"12","author":"Casta\u00f1o","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.peptides.2025.171376_bib22","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1538\/expanim.19-0148","article-title":"High fat diet induced obesity model using four strains of mice: Kunming, C57BL\/6, BALB\/c and ICR","volume":"69","author":"Li","year":"2020","journal-title":"Exp. Anim."},{"key":"10.1016\/j.peptides.2025.171376_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2220\/biomedres.33.63","article-title":"Difference in glucose intolerance between C57BL\/6J and ICR strain mice with streptozotocin\/nicotinamide-induced diabetes","volume":"33","author":"Shimizu","year":"2012","journal-title":"Biomed. Res."},{"key":"10.1016\/j.peptides.2025.171376_bib24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1538\/expanim.14-0086","article-title":"A novel mice model of metabolic syndrome: the high-fat-high-fructose diet-fed ICR mice","volume":"64","author":"Zhuhua","year":"2015","journal-title":"Exp. Anim."},{"key":"10.1016\/j.peptides.2025.171376_bib25","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3390\/biomedicines9050541","article-title":"Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance","volume":"9","author":"Hattori","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.peptides.2025.171376_bib26","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.apjtb.2016.08.010","article-title":"Pandanus amaryllifolius leaf extract increases insulin sensitivity in high-fat diet-induced obese mice","volume":"6","author":"Saenthaweesuk","year":"2016","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.peptides.2025.171376_bib27","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.3390\/biomedicines11123230","article-title":"Neurosecretory Protein GM-Expressing Neurons Participate in Lipid Storage and Inflammation in Newly Developed Cre Driver Male Mice","volume":"11","author":"Narimatsu","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.peptides.2025.171376_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.peptides.2025.171376_bib29","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.2337\/db11-1152","article-title":"Sex-specific effect of estrogen sulfotransferase on mouse models of type 2 diabetes","volume":"61","author":"Gao","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2025.171376_bib30","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.3390\/ijms22115851","article-title":"One week of cdahfd induces steatohepatitis and mitochondrial dysfunction with oxidative stress in liver","volume":"22","author":"Sugasawa","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2025.171376_bib31","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/liv.15571","article-title":"Hepatocytic ballooning in non-alcoholic steatohepatitis: Dilemmas and future directions","volume":"43","author":"Li","year":"2023","journal-title":"Liver Int"},{"key":"10.1016\/j.peptides.2025.171376_bib32","doi-asserted-by":"crossref","first-page":"23072","DOI":"10.18632\/oncotarget.8604","article-title":"The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet \u03b2-cell hypertrophy and dysfunction","volume":"7","author":"Guan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.peptides.2025.171376_bib33","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.2337\/db18-0856","article-title":"\u0392-cell fate in human insulin resistance and type 2 diabetes: A perspective on islet plasticity","volume":"68","author":"Mezza","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2025.171376_bib34","doi-asserted-by":"crossref","first-page":"E685","DOI":"10.1152\/ajpendo.00253.2003","article-title":"Novel concepts in insulin regulation of hepatic gluconeogenesis","volume":"285","author":"Barthel","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2025.171376_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1101\/sqb.2011.76.010942","article-title":"Regulation of glycolysis and gluconeogenesis by acetylation of PKM and PEPCK","volume":"76","author":"Xiong","year":"2011","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.peptides.2025.171376_bib36","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/dmrr.217","article-title":"Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis","volume":"17","author":"Radziuk","year":"2001","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.peptides.2025.171376_bib37","doi-asserted-by":"crossref","first-page":"20144","DOI":"10.1074\/jbc.273.32.20144","article-title":"Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin","volume":"273","author":"Dickens","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2025.171376_bib38","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/305549a0","article-title":"Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin","volume":"305","author":"Granner","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.peptides.2025.171376_bib39","doi-asserted-by":"crossref","first-page":"23301","DOI":"10.1074\/jbc.M200964200","article-title":"Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice","volume":"277","author":"Sun","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2025.171376_bib40","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/brv.12178","article-title":"De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose: Hepaticde novolipogenesis and metabolic disease","volume":"91","author":"Sanders","year":"2016","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.peptides.2025.171376_bib41","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1007\/s10620-016-4054-0","article-title":"Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease","volume":"61","author":"Softic","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.peptides.2025.171376_bib42","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1038\/s41366-018-0062-9","article-title":"Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers","volume":"42","author":"Honma","year":"2018","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.peptides.2025.171376_bib43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1097-2765(05)00010-9","article-title":"Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob\/ob mice","volume":"6","author":"Shimomura","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.peptides.2025.171376_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12977","article-title":"Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity","volume":"7","author":"Kubota","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.peptides.2025.171376_bib45","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.peptides.2025.171376_bib46","doi-asserted-by":"crossref","unstructured":"I.J. Goldberg, R.H. Eckel, N.A. Abumrad, Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways, J. Lipid Res. 50 Suppl (2009) S86-S90. https:\/\/doi.org\/10.1194\/jlr.R800085-JLR200.","DOI":"10.1194\/jlr.R800085-JLR200"},{"key":"10.1016\/j.peptides.2025.171376_bib47","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1210\/en.2015-1866","article-title":"Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice","volume":"157","author":"Wilson","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.peptides.2025.171376_bib48","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1136\/gut.2010.222844","article-title":"C. Garc\u00eda-Monz\u00f3n, Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C","volume":"60","author":"Miquilena-Colina","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.peptides.2025.171376_bib49","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.2337\/db07-0907","article-title":"Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity","volume":"56","author":"Koonen","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2025.171376_bib50","doi-asserted-by":"crossref","first-page":"34268","DOI":"10.1074\/jbc.M300043200","article-title":"Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass","volume":"278","author":"Gavrilova","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.peptides.2025.171376_bib51","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1210\/jc.2010-2129","article-title":"Up-regulation of PPAR-gamma mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction","volume":"96","author":"Pettinelli","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.peptides.2025.171376_bib52","first-page":"351","article-title":"Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease","volume":"20","author":"Kohjima","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.peptides.2025.171376_bib53","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.jcmgh.2021.01.003","article-title":"Hepatocyte-specific loss of PPAR\u03b3 protects mice from NASH and increases the therapeutic effects of rosiglitazone in the liver","volume":"11","author":"Lee","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.peptides.2025.171376_bib54","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-22-0155","article-title":"Role of hepatic peroxisome proliferator-activated receptor \u03b3 in non-alcoholic fatty liver disease","volume":"257","author":"Lee","year":"2023","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.peptides.2025.171376_bib55","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbrc.2005.08.070","article-title":"Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice","volume":"336","author":"Inoue","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.peptides.2025.171376_bib56","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.2337\/db18-1055","article-title":"Osteoprotegerin promotes liver steatosis by targeting the ERK-PPAR-\u03b3-CD36 pathway","volume":"68","author":"Zhang","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2025.171376_bib57","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3390\/toxins13110802","article-title":"Ochratoxin A Induces Steatosis via PPAR\u03b3-CD36 Axis","volume":"13","author":"Zheng","year":"2021","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.peptides.2025.171376_bib58","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.3390\/ijms22094681","article-title":"Effects of Overexpression of Neurosecretory Protein GL-Precursor Gene on Glucose Homeostasis and Insulin Sensitivity in Mice","volume":"22","author":"Fukumura","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2025.171376_bib59","doi-asserted-by":"crossref","first-page":"6488","DOI":"10.3390\/ijms23126488","article-title":"Neurosecretory Protein GL Promotes Normotopic Fat Accumulation in Male ICR Mice","volume":"23","author":"Narimatsu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2025.171376_bib60","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1038\/s41467-023-40039-w","article-title":"Determining the metabolic effects of dietary fat, sugars and fat-sugar interaction using nutritional geometry in a dietary challenge study with male mice","volume":"14","author":"Wali","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.peptides.2025.171376_bib61","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jnutbio.2009.11.009","article-title":"Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease","volume":"22","author":"Kirpich","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.peptides.2025.171376_bib62","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-22-0270","article-title":"Fructose drives de novo lipogenesis affecting metabolic health","volume":"257","author":"Geidl-Flueck","year":"2023","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.peptides.2025.171376_bib63","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jhep.2003.09.020","article-title":"The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance","volume":"40","author":"Rinella","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.peptides.2025.171376_bib64","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1194\/jlr.M600198-JLR200","article-title":"Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1","volume":"47","author":"Rizki","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.peptides.2025.171376_bib65","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.drudis.2017.06.007","article-title":"Mouse models of nonalcoholic steatohepatitis in preclinical drug development","volume":"22","author":"Hansen","year":"2017","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.peptides.2025.171376_bib66","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.bbadis.2018.06.023","article-title":"Animal models of NAFLD from a hepatologist\u2019s point of view","volume":"1865","author":"Jahn","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.peptides.2025.171376_bib67","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.2337\/db15-0629","article-title":"The brain-to-pancreatic islet neuronal map reveals differential glucose regulation from distinct hypothalamic regions","volume":"65","author":"Rosario","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.peptides.2025.171376_bib68","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cmet.2021.12.020","article-title":"A distinct hypothalamus-to-\u03b2 cell circuit modulates insulin secretion","volume":"34","author":"Papazoglou","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.peptides.2025.171376_bib69","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fendo.2017.00060","article-title":"Lipid processing in the brain: A key regulator of systemic metabolism","volume":"8","author":"Bruce","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.peptides.2025.171376_bib70","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3390\/nu5051544","article-title":"Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease","volume":"5","author":"Gaggini","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.peptides.2025.171376_bib71","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adi0759","article-title":"Found in translation-Fibrosis in metabolic dysfunction-associated steatohepatitis (MASH)","volume":"15","author":"Wang","year":"2023","journal-title":"Sci. Transl. Med."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978125000373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978125000373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T13:04:37Z","timestamp":1742130277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978125000373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":71,"alternative-id":["S0196978125000373"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2025.171376","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A murine model of obesity with hyperinsulinemia and hepatic steatosis involving neurosecretory protein GL gene and a low-fat\/medium-sucrose diet","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2025.171376","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"171376"}}