{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:31:53Z","timestamp":1775626313596,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024370","name":"Governo Italiano Ministero dell&apos;Istruzione dell&apos;Universita e della Ricerca","doi-asserted-by":"publisher","award":["P2022JRBMB"],"award-info":[{"award-number":["P2022JRBMB"]}],"id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell&apos;Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.peptides.2025.171432","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T15:30:43Z","timestamp":1752679843000},"page":"171432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Protective effects of PACAP against high glucose-induced inflammation on air-liquid interface corneal epithelium barrier"],"prefix":"10.1016","volume":"192","author":[{"given":"Grazia","family":"Maugeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata Grazia","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Palmeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Pricoco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desiree","family":"Brancato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Federico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velia","family":"D\u2019Agata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2025.171432_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2023.110945","article-title":"Erratum to \"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045\" [Diabetes Res. Clin. Pract. 183 (2022) 109119]","volume":"204","author":"Sun","year":"2023","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.peptides.2025.171432_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res Clin. Pract."},{"issue":"8","key":"10.1016\/j.peptides.2025.171432_bib3","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.2337\/dc20-1295","article-title":"Diabetes epidemiology in the COVID-19 pandemic","volume":"43","author":"Selvin","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.peptides.2025.171432_bib4","doi-asserted-by":"crossref","unstructured":"Diagnosis and classification of diabetes mellitus. Diabetes Care, 2009. 32 Suppl 1(Suppl 1): p. S62-7.","DOI":"10.2337\/dc09-S062"},{"issue":"3","key":"10.1016\/j.peptides.2025.171432_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nutd.2017.4","article-title":"A systematic review on the impact of diabetes mellitus on the ocular surface","volume":"7","author":"Shih","year":"2017","journal-title":"Nutr. Diabetes"},{"issue":"12","key":"10.1016\/j.peptides.2025.171432_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9123956","article-title":"Diabetic corneal neuropathy","volume":"9","author":"Mansoor","year":"2020","journal-title":"J. Clin. Med"},{"issue":"5","key":"10.1016\/j.peptides.2025.171432_bib7","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.survophthal.2020.02.005","article-title":"Diabetic keratopathy: insights and challenges","volume":"65","author":"Priyadarsini","year":"2020","journal-title":"Surv. Ophthalmol."},{"issue":"9","key":"10.1016\/j.peptides.2025.171432_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105127","article-title":"rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice","volume":"299","author":"Li","year":"2023","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.peptides.2025.171432_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24086895","article-title":"Regulation of UV-B-induced inflammatory mediators by activity-dependent neuroprotective protein (ADNP)-derived peptide (NAP) in corneal epithelium","volume":"24","author":"Maugeri","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.peptides.2025.171432_bib10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"issue":"3","key":"10.1016\/j.peptides.2025.171432_bib11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.peptides.2025.171432_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2023.171107","article-title":"Protective effect of pituitary adenylate cyclase activating polypeptide in diabetic keratopathy","volume":"170","author":"Maugeri","year":"2023","journal-title":"Peptides"},{"issue":"12","key":"10.1016\/j.peptides.2025.171432_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123470","article-title":"A promising combination: PACAP and PARP inhibitor have therapeutic potential in models of diabetic and hypertensive retinopathies","volume":"10","author":"P\u00f6sty\u00e9ni","year":"2021","journal-title":"Cells"},{"issue":"19","key":"10.1016\/j.peptides.2025.171432_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910691","article-title":"Protective effects of PACAP in a rat model of diabetic neuropathy","volume":"22","author":"Kiss","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.peptides.2025.171432_bib15","article-title":"PACAP-ADNP axis prevents outer retinal barrier breakdown and choroidal neovascularization by interfering with VEGF secreted from retinal pigmented epitelium cells","volume":"168","author":"D'Amico","year":"2023","journal-title":"Peptides"},{"issue":"8","key":"10.1016\/j.peptides.2025.171432_bib16","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s12031-020-01769-4","article-title":"PACAP and NAP: effect of two functionally related peptides in diabetic retinopathy","volume":"71","author":"D'Amico","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.peptides.2025.171432_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2019.170108","article-title":"Protective effect of PACAP-38 on retinal pigmented epithelium in an in vitro and in vivo model of diabetic retinopathy through EGFR-dependent mechanism","volume":"119","author":"Maugeri","year":"2019","journal-title":"Peptides"},{"issue":"5","key":"10.1016\/j.peptides.2025.171432_bib18","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/jcp.25616","article-title":"PACAP and VIP inhibit HIF-1\u03b1-mediated VEGF expression in a model of diabetic macular edema","volume":"232","author":"Maugeri","year":"2017","journal-title":"J. Cell Physiol."},{"issue":"1","key":"10.1016\/j.peptides.2025.171432_bib19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s10194-018-0855-1","article-title":"Discovery of PACAP and its receptors in the brain","volume":"19","author":"Hirabayashi","year":"2018","journal-title":"J. Headache Pain."},{"issue":"1-3","key":"10.1016\/j.peptides.2025.171432_bib20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.regpep.2007.09.025","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) co-localizes with activity-dependent neuroprotective protein (ADNP) in the mouse brains","volume":"145","author":"Nakamachi","year":"2008","journal-title":"Regul. Pept."},{"key":"10.1016\/j.peptides.2025.171432_bib21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3389\/fendo.2020.00377","article-title":"Protective effects of PACAP in peripheral organs","volume":"11","author":"Toth","year":"2020","journal-title":"Front Endocrinol."},{"issue":"23","key":"10.1016\/j.peptides.2025.171432_bib22","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.2174\/1381612043383548","article-title":"Pituitary adenylate cyclase activating polypeptide: a potential neuroprotective peptide","volume":"10","author":"Somogyv\u00e1ri-Vigh","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.peptides.2025.171432_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neuro.2018.03.010","article-title":"Protective effects of pituitary adenylate cyclase activating polypeptide against neurotoxic agents","volume":"66","author":"Reglodi","year":"2018","journal-title":"Neurotoxicology"},{"issue":"7","key":"10.1016\/j.peptides.2025.171432_bib24","doi-asserted-by":"crossref","first-page":"8430","DOI":"10.3390\/ijms13078430","article-title":"Effect of PACAP in central and peripheral nerve injuries","volume":"13","author":"Tamas","year":"2012","journal-title":"Int J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.peptides.2025.171432_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100782","article-title":"Isolation, expansion, differentiation, and histological processing of human nasal epithelial cells","volume":"2","author":"Manna","year":"2021","journal-title":"STAR Protoc."},{"issue":"1","key":"10.1016\/j.peptides.2025.171432_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11010128","article-title":"Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) Counteracts UV-B Radiation-Induced ROS Formation in Corneal Epithelium","volume":"11","author":"Maugeri","year":"2022","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.peptides.2025.171432_bib27","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1007\/s13277-015-3166-z","article-title":"Expression pattern of parkin isoforms in lung adenocarcinomas","volume":"36","author":"D'Amico","year":"2015","journal-title":"Tumour Biol."},{"issue":"7","key":"10.1016\/j.peptides.2025.171432_bib28","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/cdd.2015.176","article-title":"Inflammasome-dependent IL-1\u03b2 release depends upon membrane permeabilisation","volume":"23","author":"Mart\u00edn-S\u00e1nchez","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.peptides.2025.171432_bib29","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3389\/fimmu.2019.00926","article-title":"PACAP is lethal to flavobacterium psychrophilum through either direct membrane permeabilization or indirectly, by priming the immune response in rainbow trout macrophages","volume":"10","author":"Semple","year":"2019","journal-title":"Front Immunol."},{"issue":"4","key":"10.1016\/j.peptides.2025.171432_bib30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00417-010-1573-9","article-title":"Involvement of advanced glycation end products, oxidative stress and nuclear factor-kappaB in the development of diabetic keratopathy","volume":"249","author":"Kim","year":"2011","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"2","key":"10.1016\/j.peptides.2025.171432_bib31","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1167\/iovs.08-2606","article-title":"Interleukin-1beta-induced disruption of barrier function in cultured human corneal epithelial cells","volume":"50","author":"Kimura","year":"2009","journal-title":"Invest Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.peptides.2025.171432_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.disamonth.2021.101135","article-title":"Diabetic keratopathy","volume":"67","author":"Yeung","year":"2021","journal-title":"Dis. Mon."},{"issue":"4","key":"10.1016\/j.peptides.2025.171432_bib33","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.jtos.2019.06.007","article-title":"The impact of hyperglycemia on the corneal epithelium: molecular mechanisms and insight","volume":"17","author":"Zhu","year":"2019","journal-title":"Ocul. Surf."},{"issue":"6","key":"10.1016\/j.peptides.2025.171432_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12061303","article-title":"Immune-mediated ocular surface disease in diabetes mellitus-clinical perspectives and treatment: a narrative review","volume":"12","author":"Ghenciu","year":"2024","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.peptides.2025.171432_bib35","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1586\/17469899.2015.1049157","article-title":"Sensory nerve regeneration after epithelium wounding in normal and diabetic cornea","volume":"10","author":"Yu","year":"2015","journal-title":"Expert Rev. Ophthalmol."},{"issue":"12","key":"10.1016\/j.peptides.2025.171432_bib36","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.18240\/ijo.2019.12.17","article-title":"Corneal alteration and pathogenesis in diabetes mellitus","volume":"12","author":"Zhao","year":"2019","journal-title":"Int J. Ophthalmol."},{"key":"10.1016\/j.peptides.2025.171432_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109233","article-title":"Assessment of tear inflammatory cytokines concentration in patients with diabetes with varying severity of involvement","volume":"224","author":"Sorkhabi","year":"2022","journal-title":"Exp. Eye Res"},{"issue":"6","key":"10.1016\/j.peptides.2025.171432_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/cells13060532","article-title":"Effects of diabetes mellitus on corneal immune cell activation and the development of keratopathy","volume":"13","author":"Surico","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.peptides.2025.171432_bib39","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1749-6632.2003.tb03145.x","article-title":"PACAP in immunity and inflammation","volume":"992","author":"Delgado","year":"2003","journal-title":"Ann. N. Y Acad. Sci."},{"issue":"30","key":"10.1016\/j.peptides.2025.171432_bib40","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.2174\/1381612824666180924141407","article-title":"Protective Role of Endogenous PACAP in Inflammation-induced Retinal Degeneration","volume":"24","author":"Vaczy","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.peptides.2025.171432_bib41","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target Ther."},{"issue":"17","key":"10.1016\/j.peptides.2025.171432_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179453","article-title":"Increased expression of the neuropeptides PACAP\/VIP in the brain of mice with CNS targeted production of IL-6 is mediated in part by trans-signalling","volume":"25","author":"Castorina","year":"2024","journal-title":"Int J. Mol. Sci."},{"issue":"47","key":"10.1016\/j.peptides.2025.171432_bib43","doi-asserted-by":"crossref","first-page":"31427","DOI":"10.1074\/jbc.273.47.31427","article-title":"Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit tumor necrosis factor alpha transcriptional activation by regulating nuclear factor-kB and cAMP response element-binding protein\/c-Jun","volume":"273","author":"Delgado","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.peptides.2025.171432_bib44","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.4049\/jimmunol.162.3.1707","article-title":"Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide enhance IL-10 production by murine macrophages: in vitro and in vivo studies","volume":"162","author":"Delgado","year":"1999","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.peptides.2025.171432_bib45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ajo.2006.10.034","article-title":"PACAP induces neurite outgrowth in cultured trigeminal ganglion cells and recovery of corneal sensitivity after flap surgery in rabbits","volume":"143","author":"Fukiage","year":"2007","journal-title":"Am. J. Ophthalmol."},{"issue":"8","key":"10.1016\/j.peptides.2025.171432_bib46","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1167\/iovs.15-17088","article-title":"A new recombinant PACAP-derived peptide efficiently promotes corneal wound repairing and lacrimal secretion","volume":"56","author":"Ma","year":"2015","journal-title":"Invest Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.peptides.2025.171432_bib47","doi-asserted-by":"crossref","first-page":"12034","DOI":"10.1038\/ncomms12034","article-title":"PACAP suppresses dry eye signs by stimulating tear secretion","volume":"7","author":"Nakamachi","year":"2016","journal-title":"Nat. Commun."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978125000932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978125000932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:41:05Z","timestamp":1772750465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978125000932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":47,"alternative-id":["S0196978125000932"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2025.171432","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of PACAP against high glucose-induced inflammation on air-liquid interface corneal epithelium barrier","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2025.171432","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"171432"}}