{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:49:35Z","timestamp":1788922175895,"version":"build-2803163510"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016321","name":"Lanzhou University First Hospital","doi-asserted-by":"publisher","award":["ldyyyn2023-29"],"award-info":[{"award-number":["ldyyyn2023-29"]}],"id":[{"id":"10.13039\/501100016321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Gansu Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["25JRRA1246"],"award-info":[{"award-number":["25JRRA1246"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Gansu Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["24JRRA411"],"award-info":[{"award-number":["24JRRA411"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Gansu Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["24JRRA312"],"award-info":[{"award-number":["24JRRA312"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271307"],"award-info":[{"award-number":["32271307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.peptides.2025.171453","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:05:19Z","timestamp":1761869119000},"page":"171453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["MPN-12-NH2 shows potent antinociception effects by targeting opioid, cannabinoid, and neuropeptide FF receptors"],"prefix":"10.1016","volume":"194","author":[{"given":"Lanxia","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanyu","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaofeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingnian","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-7797","authenticated-orcid":false,"given":"Shouliang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2025.171453_bib1","unstructured":"Mark Abraham, Andrey Alekseenko, Brian Andrews, Vladimir Basov, Paul Bauer, Hugh Bird, Eliane Briand, Ania Brown, Mahesh Doijade, Giacomo Fiorin, Stefan Fleischmann, Sergey Gorelov, Gilles Gouaillardet, Alan Gray, M. Eric Irrgang, Farzaneh Jalalypour, Petter Johansson, Carsten Kutzner, Grzegorz \u0141azarski, Justin A. Lemkul, Magnus Lundborg, Pascal Merz, Vedran Mileti\u0107, Dmitry Morozov, Lukas M\u00fcllender, Julien Nabet, Szil\u00e1rd P\u00e1ll, Andrea Pasquadibisceglie, Michele Pellegrino, Nicola Piasentin, Daniele Rapetti, Muhammad Umair Sadiq, Hubert Santuz, Roland Schulz, Michael Shirts, Tatiana Shugaeva, Alexey Shvetsov, Philip Turner, Alessandra Villa, Sebastian Wingberm\u00fchle, Berk Hess, Erik Lindahl, GROMACS 2025.2 manual, in: Zenodo, 2025."},{"key":"10.1016\/j.peptides.2025.171453_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.peptides.2025.171453_bib3","doi-asserted-by":"crossref","first-page":"W530","DOI":"10.1093\/nar\/gkab294","article-title":"PLIP 2021: expanding the scope of the protein\u2013ligand interaction profiler to DNA and RNA","volume":"49","author":"Adasme","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.peptides.2025.171453_bib4","doi-asserted-by":"crossref","first-page":"eaao4227","DOI":"10.1126\/science.aao4227","article-title":"Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice","author":"Albrengues","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.peptides.2025.171453_bib5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/sj.bjp.0706315","article-title":"Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine","volume":"146","author":"Bagley","year":"2005","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.peptides.2025.171453_bib6","doi-asserted-by":"crossref","first-page":"e1427","DOI":"10.1002\/wnan.1427","article-title":"Challenges to develop novel anti-inflammatory and analgesic drugs","author":"Botz","year":"2017","journal-title":"Wiley Inter. Rev. Nanomed. Nanobiotechnol."},{"issue":"14","key":"10.1016\/j.peptides.2025.171453_bib7","first-page":"e1","article-title":"Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse","volume":"122","author":"Bourquin","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.peptides.2025.171453_bib8","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/bioinformatics\/btq007","article-title":"PyRosetta: a script-based interface for implementing molecular modeling algorithms using Rosetta","volume":"26","author":"Chaudhury","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.peptides.2025.171453_bib9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.peptides.2004.10.026","article-title":"Antinociceptive action of hemopressin in experimental hyperalgesia","volume":"26","author":"Dale","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2025.171453_bib10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3390\/biom9040150","article-title":"Intracellular peptides in cell biology and pharmacology","volume":"9","author":"de Araujo","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.peptides.2025.171453_bib11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ejphar.2014.07.013","article-title":"Neuropeptide FF receptors exhibit direct and anti-opioid effects on mice dorsal raphe nucleus neurons","volume":"740","author":"Ding","year":"2014","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.peptides.2025.171453_bib12","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.neuropharm.2011.09.013","article-title":"Effects of neuropeptide FF system on CB\u2081 and CB\u2082 receptors mediated antinociception in mice","volume":"62","author":"Fang","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.peptides.2025.171453_bib13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2174\/092986611794654012","article-title":"Central administration of neuropeptide FF and related peptides attenuate systemic morphine analgesia in mice","volume":"18","author":"Fang","year":"2011","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.peptides.2025.171453_bib14","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nprot.2016.051","article-title":"Computational protein\u2013ligand docking and virtual drug screening with the AutoDock suite","volume":"11","author":"Forli","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.peptides.2025.171453_bib15","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1096\/fj.09-132142","article-title":"Novel endogenous peptide agonists of cannabinoid receptors","volume":"23","author":"Gomes","year":"2009","journal-title":"Faseb J."},{"key":"10.1016\/j.peptides.2025.171453_bib16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2011.07.031","article-title":"Activation of spinal and supraspinal cannabinoid-1 receptors leads to antinociception in a rat model of neuropathic spinal cord injury pain","volume":"1412","author":"Hama","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.peptides.2025.171453_bib17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1124\/jpet.113.209866","article-title":"Antinociceptive effects of central administration of the endogenous cannabinoid receptor type 1 agonist VDPVNFKLLSH-OH [(m)VD-hemopressin(\u03b1)], an N-terminally extended hemopressin peptide","volume":"348","author":"Han","year":"2014","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.peptides.2025.171453_bib18","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1213\/ANE.0000000000000921","article-title":"Neuropeptide VF enhances cannabinoid agonist WIN55,212-2-induced antinociception in mice","volume":"121","author":"Han","year":"2015","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.peptides.2025.171453_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbr.2013.03.046","article-title":"Neuropeptide FF attenuates the acquisition and the expression of conditioned place aversion to endomorphin-2 in mice","volume":"248","author":"Han","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.peptides.2025.171453_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1758-2946-4-17","article-title":"Avogadro: an advanced semantic chemical editor, visualization, and analysis platform","volume":"4","author":"Hanwell","year":"2012","journal-title":"J. Cheminf."},{"key":"10.1016\/j.peptides.2025.171453_bib21","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/jphp.12761","article-title":"Supraspinal inhibitory effects of chimeric peptide MCRT on gastrointestinal motility in mice","volume":"69","author":"He","year":"2017","journal-title":"J. Pharm. Pharm."},{"key":"10.1016\/j.peptides.2025.171453_bib22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.npep.2019.01.006","article-title":"In vitro and in vivo characterization of the bifunctional mu- and delta- opioid receptors ligand MCRT on mouse gastrointestinal motility","volume":"74","author":"He","year":"2019","journal-title":"Neuropeptides"},{"key":"10.1016\/j.peptides.2025.171453_bib23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.npep.2019.01.006","article-title":"In vitro and in vivo characterization of the bifunctional \u03bc- and \u03b4- opioid receptors ligand MCRT on mouse gastrointestinal motility","volume":"74","author":"He","year":"2019","journal-title":"Neuropeptides"},{"key":"10.1016\/j.peptides.2025.171453_bib24","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/bcpt.13566","article-title":"MCRT, a multifunctional ligand of opioid and neuropeptide FF receptors, attenuates neuropathic pain in spared nerve injury model","volume":"128","author":"He","year":"2021","journal-title":"Basic Clin. Pharm. Toxicol."},{"key":"10.1016\/j.peptides.2025.171453_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108406","article-title":"Hemopressin as a breakthrough for the cannabinoid field","volume":"183","author":"Heimann","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.peptides.2025.171453_bib26","doi-asserted-by":"crossref","first-page":"20588","DOI":"10.1073\/pnas.0706980105","article-title":"Hemopressin is an inverse agonist of CB1 cannabinoid receptors","volume":"104","author":"Heimann","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.peptides.2025.171453_bib27","doi-asserted-by":"crossref","first-page":"13619","DOI":"10.3390\/ijms222413619","article-title":"Non-opioid peptides targeting opioid effects","author":"Kaczy\u0144ska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2025.171453_bib28","doi-asserted-by":"crossref","first-page":"7435","DOI":"10.2174\/138161281942140105165646","article-title":"Hybrid opioid\/non-opioid ligands in pain research","volume":"19","author":"Kleczkowska","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.peptides.2025.171453_bib29","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1021\/ci200227u","article-title":"LigPlot+: multiple ligand\u2013protein interaction diagrams for drug discovery","volume":"51","author":"Laskowski","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.peptides.2025.171453_bib30","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/jm4005219","article-title":"Bivalent ligands that target mu opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance","volume":"56","author":"Le Naour","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.peptides.2025.171453_bib31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.peptides.2012.10.014","article-title":"The cardiovascular effects of a chimeric opioid peptide based on morphiceptin and PFRTic-NH2","volume":"39","author":"Li","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2025.171453_bib32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.regpep.2012.08.008","article-title":"Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide","volume":"179","author":"Li","year":"2012","journal-title":"Regul. Pept."},{"key":"10.1016\/j.peptides.2025.171453_bib33","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1111\/bph.13489","article-title":"BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice","volume":"173","author":"Li","year":"2016","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.peptides.2025.171453_bib34","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/nmo.12789","article-title":"Central administrations of hemopressin and related peptides inhibit gastrointestinal motility in mice","volume":"28","author":"Li","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.peptides.2025.171453_bib35","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.5858\/arpa.2020-0055-RA","article-title":"Point-of-care drug of abuse testing in the opioid epidemic","volume":"144","author":"Li","year":"2020","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.peptides.2025.171453_bib36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neulet.2014.10.018","article-title":"Reversal of morphine tolerance by a compound with NPFF receptor subtype-selective actions","volume":"584","author":"Malin","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.peptides.2025.171453_bib37","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.peptides.2005.07.023","article-title":"A neuropeptide FF agonist blocks the acquisition of conditioned place preference to morphine in C57Bl\/6J mice","volume":"27","author":"Marchand","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2025.171453_bib38","doi-asserted-by":"crossref","first-page":"102440","DOI":"10.1016\/j.npep.2024.102440","article-title":"MP-13, a novel chimeric peptide of morphiceptin and pepcan-9, produces potent antinociception with limited side effects","author":"Mei","year":"2024","journal-title":"Neuropeptides"},{"key":"10.1016\/j.peptides.2025.171453_bib39","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1002\/jcc.21787","article-title":"MDAnalysis: a toolkit for the analysis of molecular dynamics simulations","volume":"32","author":"Michaud-Agrawal","year":"2011","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.peptides.2025.171453_bib40","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1007\/s13311-021-01069-8","article-title":"Pain relieving and neuroprotective effects of non-opioid compound, DDD-028, in the rat model of paclitaxel-induced neuropathy","volume":"18","author":"Micheli","year":"2021","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.peptides.2025.171453_bib41","doi-asserted-by":"crossref","first-page":"1050884","DOI":"10.3389\/fvets.2022.1050884","article-title":"The role of cannabinoids in pain modulation in companion animals","volume":"9","author":"Miranda-Cort\u00e9s","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.peptides.2025.171453_bib42","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.peptides.2025.171453_bib43","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/biof.116","article-title":"Opioid-modulating properties of the neuropeptide FF system","volume":"36","author":"Moul\u00e9dous","year":"2010","journal-title":"Biofactors"},{"key":"10.1016\/j.peptides.2025.171453_bib44","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neulet.2014.06.058","article-title":"Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(\u03b1) and WIN55,212-2 at the supraspinal level in mice","volume":"578","author":"Pan","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.peptides.2025.171453_bib45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ejphar.2015.10.016","article-title":"Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(\u03b1) in naive and cannabinoid-tolerant mice","volume":"767","author":"Pan","year":"2015","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.peptides.2025.171453_bib46","first-page":"3092","article-title":"The spared nerve injury (SNI) model of induced mechanical allodynia in mice","author":"Richner","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.peptides.2025.171453_bib47","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1021\/acs.jctc.0c01006","article-title":"Accelerating AutoDock4 with GPUs and gradient-based local search","volume":"17","author":"Santos-Martins","year":"2021","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.peptides.2025.171453_bib48","series-title":"The PyMOL Molecular Graphics System, Version 3.1.4.1","author":"Schrodinger","year":"2015"},{"key":"10.1016\/j.peptides.2025.171453_bib49","doi-asserted-by":"crossref","first-page":"16201","DOI":"10.3390\/ijms232416201","article-title":"Dysmenorrhoea: can medicinal cannabis bring new hope for a collective group of women suffering in pain, globally?","volume":"23","author":"Seifalian","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.peptides.2025.171453_bib50","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0196-9781(99)00125-4","article-title":"Modulation of naloxone-precipitated morphine withdrawal syndromes in rats by neuropeptide FF analogs","volume":"20","author":"Tan","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.peptides.2025.171453_bib51","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1021\/acs.jctc.1c00645","article-title":"gmx_MMPBSA: a new tool to perform end-state free energy calculations with GROMACS","volume":"17","author":"Vald\u00e9s-Tresanco","year":"2021","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.peptides.2025.171453_bib52","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jcc.21367","article-title":"CHARMM general force field: a force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields","volume":"31","author":"Vanommeslaeghe","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.peptides.2025.171453_bib53","article-title":"Structure-based evolution of G protein-biased \u03bc-opioid receptor agonists","volume":"61","author":"Wang","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.peptides.2025.171453_bib54","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.neuropharm.2016.03.017","article-title":"Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited tolerance","volume":"108","author":"Wang","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.peptides.2025.171453_bib55","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.peptides.2025.171453_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2019.101998","article-title":"Signaling molecules targeting cannabinoid receptors: hemopressin and related peptides","volume":"79","author":"Wei","year":"2020","journal-title":"Neuropeptides"},{"key":"10.1016\/j.peptides.2025.171453_bib57","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.tips.2022.06.010","article-title":"Developing the cannabinoid receptor 2 (CB2) pharmacopoeia: past, present, and future","volume":"43","author":"Whiting","year":"2022","journal-title":"Trends Pharm. Sci."},{"key":"10.1016\/j.peptides.2025.171453_bib58","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.neuropharm.2017.06.015","article-title":"The cannabinoid system and pain","volume":"124","author":"Woodhams","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.peptides.2025.171453_bib59","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neulet.2004.03.093","article-title":"Opposite conditioned place preference responses to endomorphin-1 and endomorphin-2 in the mouse","volume":"365","author":"Wu","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.peptides.2025.171453_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108178","article-title":"VF-13, a chimeric peptide of VD-hemopressin(\u03b1) and neuropeptide VF, produces potent antinociception with reduced cannabinoid-related side effects","volume":"175","author":"Xu","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.peptides.2025.171453_bib61","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1213\/ANE.0000000000006266","article-title":"OCP002, a mixed agonist of opioid and cannabinoid receptors, produces potent antinociception with minimized side effects","volume":"136","author":"Xu","year":"2023","journal-title":"Anesth. Analg."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978125001147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978125001147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:01:16Z","timestamp":1773921676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978125001147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":61,"alternative-id":["S0196978125001147"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2025.171453","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MPN-12-NH2 shows potent antinociception effects by targeting opioid, cannabinoid, and neuropeptide FF receptors","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2025.171453","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"171453"}}