{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:48:53Z","timestamp":1785876533295,"version":"3.56.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007322","name":"Binzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.peptides.2026.171496","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:59:34Z","timestamp":1781135974000},"page":"171496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Neuregulin 4 improves white adipose tissue inflammation in mice with polycystic ovary syndrome"],"prefix":"10.1016","volume":"198","author":[{"given":"Xi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingshan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sili","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9640-711X","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.peptides.2026.171496_bib1","doi-asserted-by":"crossref","first-page":"G43","DOI":"10.1093\/ejendo\/lvad096","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome","author":"Teede","year":"2023","journal-title":"Eur. J. Endocrinol. Engl."},{"key":"10.1016\/j.peptides.2026.171496_bib2","first-page":"1","article-title":"Cardiometabolic Syndromes and Associated Cardiovascular Risks: A Narrative Review","author":"Ruiz-Saavedra","year":"2026","journal-title":"J. Vasc. Res. Switz."},{"key":"10.1016\/j.peptides.2026.171496_bib3","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/humupd\/dmaa029","article-title":"Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis","author":"Wekker","year":"2020","journal-title":"Hum. Reprod. Update Engl."},{"issue":"2","key":"10.1016\/j.peptides.2026.171496_bib4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/humrep\/dey363","article-title":"Erratum. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"34","author":"Teede","year":"2019","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.peptides.2026.171496_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1210\/clinem\/dgaf527","article-title":"On the Intimate Relationship of Adiposity to Polycystic Ovary Syndrome","volume":"111","author":"Rosenfield","year":"2025","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.peptides.2026.171496_bib6","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/humupd\/dmab004","article-title":"Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome","volume":"27","author":"de Medeiros","year":"2021","journal-title":"Hum. Reprod. Update"},{"issue":"2","key":"10.1016\/j.peptides.2026.171496_bib7","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jcp.29912","article-title":"Pathophysiological roles of chronic low-grade inflammation mediators in polycystic ovary syndrome","volume":"236","author":"Rostamtabar","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.peptides.2026.171496_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5894768","article-title":"Immunophenotypic Profiles in Polycystic Ovary Syndrome","author":"Hu","year":"2020","journal-title":"Mediat. Inflamm. 2020"},{"issue":"5","key":"10.1016\/j.peptides.2026.171496_bib9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.peptides.2026.171496_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115470","article-title":"The role of macrophages in polycystic ovarian syndrome and its typical pathological features: A narrative review","volume":"167","author":"Feng","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.peptides.2026.171496_bib11","article-title":"Analysis of macrophage polarization and regulation characteristics in ovarian tissues of polycystic ovary syndrome","volume":"11","author":"Yuan","year":"2024","journal-title":"Front. Med. (Lausanne)"},{"issue":"5","key":"10.1016\/j.peptides.2026.171496_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2024.104693","article-title":"Adipokines level in plasma, hypothalamus, ovaries and adipose tissue of rats with polycystic ovary syndrome","volume":"50","author":"Pich","year":"2025","journal-title":"Reprod. Biomed. Online"},{"issue":"2","key":"10.1016\/j.peptides.2026.171496_bib13","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2012.09.010","article-title":"Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria","volume":"151","author":"Fedorenko","year":"2012","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.peptides.2026.171496_bib14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1530\/EJE-19-0505","article-title":"Brown adipose tissue activity is reduced in women with polycystic ovary syndrome","volume":"181","author":"Oliveira","year":"2019","journal-title":"Eur. J. Endocrinol."},{"issue":"5","key":"10.1016\/j.peptides.2026.171496_bib15","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00125-025-06385-8","article-title":"Brown adipose tissue alleviates podocyte apoptosis through NRG4 in a male mouse model of diabetic kidney disease","volume":"68","author":"Ding","year":"2025","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.peptides.2026.171496_bib16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.bbrc.2018.08.197","article-title":"Activation of neuregulin-4 in adipocytes improves metabolic health by enhancing adipose tissue angiogenesis","volume":"504","author":"Nugroho","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.peptides.2026.171496_bib17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.5603\/GP.a2017.0095","article-title":"Increased serum neuregulin 4 levels in women with polycystic ovary syndrome: A case-control study","volume":"88","author":"Temur","year":"2017","journal-title":"Ginekol. Pol."},{"issue":"7","key":"10.1016\/j.peptides.2026.171496_bib18","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1080\/01443615.2019.1581754","article-title":"Association between circulating neuregulin 4 levels and metabolic, aterogenic, and AMH profile of polycystic ovary syndrome","volume":"39","author":"Kurek Eken","year":"2019","journal-title":"J. Obstet. Gynaecol."},{"issue":"11","key":"10.1016\/j.peptides.2026.171496_bib19","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.2174\/1871530321666210119115527","article-title":"Negative Correlation between Neuregulin-4 and IL-9 Serum Levels in Patients with Coronary Artery Disease","volume":"21","author":"Farshidi","year":"2021","journal-title":"Endocr. Metab. Immune Disord. Drug. Targets"},{"key":"10.1016\/j.peptides.2026.171496_bib20","doi-asserted-by":"crossref","first-page":"26242","DOI":"10.1038\/srep26242","article-title":"Preventing High Fat Diet-induced Obesity and Improving Insulin Sensitivity through Neuregulin 4 Gene Transfer","volume":"6","author":"Ma","year":"2016","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.peptides.2026.171496_bib21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2010.217","article-title":"Polycystic ovary syndrome: etiology, pathogenesis and diagnosis","volume":"7","author":"Goodarzi","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.peptides.2026.171496_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jnutbio.2017.04.012","article-title":"Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat","volume":"47","author":"Hu","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.peptides.2026.171496_bib23","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.mam.2019.06.004","article-title":"The beneficial effects of brown adipose tissue transplantation","volume":"68","author":"White","year":"2019","journal-title":"Mol. Asp. Med."},{"issue":"10","key":"10.1016\/j.peptides.2026.171496_bib24","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1073\/pnas.1523236113","article-title":"Brown adipose tissue transplantation ameliorates polycystic ovary syndrome","volume":"113","author":"Yuan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.peptides.2026.171496_bib25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mce.2017.03.025","article-title":"Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome","volume":"448","author":"Marcondes","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.peptides.2026.171496_bib26","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/biolre\/ioad032","article-title":"Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue","author":"Zhang","year":"2023","journal-title":"Dagger Biol. Reprod. U. S."},{"key":"10.1016\/j.peptides.2026.171496_bib27","article-title":"The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis","author":"Schuler-Toprak","year":"2022","journal-title":"Biomed. Switz."},{"issue":"12","key":"10.1016\/j.peptides.2026.171496_bib28","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/nm.3713","article-title":"The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis","volume":"20","author":"Wang","year":"2014","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.peptides.2026.171496_bib29","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1080\/01443615.2019.1581754","article-title":"Association between circulating neuregulin 4 levels and metabolic, aterogenic, and AMH profile of polycystic ovary syndrome","volume":"39","author":"Kurek Eken","year":"2019","journal-title":"J. Obstet. Gynaecol."},{"key":"10.1016\/j.peptides.2026.171496_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092358","article-title":"Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications","author":"Longo","year":"2019","journal-title":"Int. J. Mol. Sci. Switz."},{"key":"10.1016\/j.peptides.2026.171496_bib31","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/humupd\/dmab004","article-title":"Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome","author":"de Medeiros","year":"2021","journal-title":"Hum. Reprod. Update Engl."},{"key":"10.1016\/j.peptides.2026.171496_bib32","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.2147\/DDDT.S468147","article-title":"Impact of Lipids on Insulin Resistance: Insights from Human and Animal Studies","volume":"18","author":"Elkanawati","year":"2024","journal-title":"Drug. Des. Devel Ther."},{"issue":"9","key":"10.1016\/j.peptides.2026.171496_bib33","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41574-019-0230-6","article-title":"The endocrine function of adipose tissues in health and cardiometabolic disease","volume":"15","author":"Scheja","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.peptides.2026.171496_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115824","article-title":"Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS mouse model through the Nrf2\/HO-1\/Cyp1b1 pathway: Integrating network pharmacology and experimental validation in vivo","volume":"301","author":"Zheng","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.peptides.2026.171496_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176742","article-title":"Dapagliflozin attenuates fat accumulation and insulin resistance in obese mice with polycystic ovary syndrome","volume":"977","author":"Lin","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.peptides.2026.171496_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157329","article-title":"Angelica sinensis and Scutellaria baicalensis synergistically alleviates metabolic dysfunction-associated steatohepatitis via promoting adipose tissue-to-liver tissue communication","volume":"148","author":"Zhao","year":"2025","journal-title":"Phytomedicine"}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978126000331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978126000331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:11:12Z","timestamp":1785874272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978126000331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":36,"alternative-id":["S0196978126000331"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2026.171496","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuregulin 4 improves white adipose tissue inflammation in mice with polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2026.171496","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"171496"}}