{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:15:04Z","timestamp":1788552904469,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272209"],"award-info":[{"award-number":["82272209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["NMUB20230136"],"award-info":[{"award-number":["NMUB20230136"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Peptides"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.peptides.2026.171499","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:53:46Z","timestamp":1781308426000},"page":"171499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["[Gly2]-GLP-2(1\u20135): An ultra-short GLP-2 peptide for intestinal mucosal protection in inflammatory bowel disease"],"prefix":"10.1016","volume":"199","author":[{"given":"Haiqing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chujun","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songqi","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.peptides.2026.171499_bib1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: from 2015 to 2025","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.peptides.2026.171499_bib2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gtc.2020.07.005","article-title":"Epidemiology and pathogenesis of ulcerative colitis","volume":"49","author":"Du","year":"2020","journal-title":"Gastroenterol. Clin. North. Am."},{"key":"10.1016\/j.peptides.2026.171499_bib3","article-title":"A potential therapeutic approach for ulcerative colitis: targeted regulation of macrophage polarization through phytochemicals","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"issue":"10080","key":"10.1016\/j.peptides.2026.171499_bib4","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.peptides.2026.171499_bib5","article-title":"Paeonol alleviates ulcerative colitis by modulating PPAR-gamma and nuclear factor-kappaB activation","volume":"14","author":"Cheng","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.peptides.2026.171499_bib6","article-title":"Identification and exploration of pharmacological pyroptosis-related biomarkers of ulcerative colitis","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.peptides.2026.171499_bib7","doi-asserted-by":"crossref","first-page":"E281","DOI":"10.1152\/ajpendo.00129.2006","article-title":"GLP-2 rapidly activates divergent intracellular signaling pathways involved in intestinal cell survival and proliferation in neonatal piglets","volume":"292","author":"Burrin","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.peptides.2026.171499_bib8","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.7150\/thno.96038","article-title":"Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K\/AKT\/mTOR signaling pathway to alleviate ulcerative colitis","volume":"14","author":"Li","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.peptides.2026.171499_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116758","article-title":"Evolution and therapeutic potential of glucagon-like peptide 2 analogs","volume":"233","author":"Gong","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.peptides.2026.171499_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.688715","article-title":"Glucagon-like peptide-2 modulates enteric paneth cells immune response and alleviates gut inflammation during intravenous fluid infusion in mice with a central catheter","volume":"8","author":"Deng","year":"2021","journal-title":"Front. Nutr."},{"issue":"2","key":"10.1016\/j.peptides.2026.171499_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1210\/me.2002-0306","article-title":"Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis","volume":"17","author":"Drucker","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.peptides.2026.171499_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.688715","article-title":"Glucagon-like peptide-2 modulates enteric paneth cells immune response and alleviates gut inflammation during intravenous fluid infusion in mice with a central catheter","volume":"8","author":"Deng","year":"2021","journal-title":"Front. Nutr."},{"issue":"3","key":"10.1016\/j.peptides.2026.171499_bib13","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1021\/acs.jmedchem.9b00835","article-title":"Recent developments in therapeutic peptides for the glucagon-like peptide 1 and 2 receptors","volume":"63","author":"Suzuki","year":"2020","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.peptides.2026.171499_bib14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s40265-017-0703-7","article-title":"Teduglutide: a review in short bowel syndrome","volume":"77","author":"Kim","year":"2017","journal-title":"Drugs"},{"key":"10.1016\/j.peptides.2026.171499_bib15","article-title":"A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment","volume":"32","author":"Marotti","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.peptides.2026.171499_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1439781","article-title":"The real-world analysis of adverse events with teduglutide: a pharmacovigilance study based on the FAERS database","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.peptides.2026.171499_bib17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1124\/jpet.119.262238","article-title":"Pharmacological characterization of apraglutide, a novel long-acting peptidic glucagon-like peptide-2 agonist, for the treatment of short bowel syndrome","volume":"373","author":"Hargrove","year":"2020","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.peptides.2026.171499_bib18","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/s13668-022-00433-0","article-title":"Therapeutic potential of GLP-2 analogs in gastrointestinal disorders: current knowledge, nutritional aspects, and future perspectives","volume":"11","author":"Kounatidis","year":"2022","journal-title":"Curr. Nutr. Rep."},{"issue":"12","key":"10.1016\/j.peptides.2026.171499_bib19","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/s41422-020-00442-0","article-title":"A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor","volume":"30","author":"Sun","year":"2020","journal-title":"Cell. Res."},{"issue":"18","key":"10.1016\/j.peptides.2026.171499_bib20","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1111\/bph.15866","article-title":"N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction","volume":"179","author":"Gabe","year":"2022","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.peptides.2026.171499_bib21","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1021\/acs.jmedchem.7b00768","article-title":"Stapled, long-acting glucagon-like peptide 2 analog with efficacy in dextran sodium sulfate induced mouse colitis models","volume":"61","author":"Yang","year":"2018","journal-title":"J. Med. Chem."},{"issue":"8","key":"10.1016\/j.peptides.2026.171499_bib22","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1136\/gutjnl-2013-305005","article-title":"Palmitoylethanolamide improves colon inflammation through an enteric glia\/toll like receptor 4-dependent PPAR-\u03b1 activation","volume":"63","author":"Esposito","year":"2014","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.peptides.2026.171499_bib23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.15252\/embj.201592649","article-title":"Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis","volume":"35","author":"Shmuel-Galia","year":"2016","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.peptides.2026.171499_bib24","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jcmgh.2015.01.006","article-title":"Experimental models of inflammatory bowel diseases","volume":"1","author":"Kiesler","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.peptides.2026.171499_bib25","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1038\/s41467-022-32505-8","article-title":"Mannose ameliorates experimental colitis by protecting intestinal barrier integrity","volume":"13","author":"Dong","year":"2022","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.peptides.2026.171499_bib26","doi-asserted-by":"crossref","first-page":"s1","DOI":"10.1136\/gutjnl-2024-334395","article-title":"British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025","volume":"74","author":"Moran","year":"2025","journal-title":"Gut"},{"issue":"23","key":"10.1016\/j.peptides.2026.171499_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262311611","article-title":"Special Issue \u201cDrugs in Inflammatory Bowel Diseases\u201d","volume":"26","author":"D\u2019Antongiovanni","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.peptides.2026.171499_bib28","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1111\/bph.16040","article-title":"Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice","volume":"180","author":"Gabe","year":"2023","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.peptides.2026.171499_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10102061","article-title":"GLP-1 and GLP-2 orchestrate intestine integrity, gut microbiota, and immune system crosstalk","volume":"10","author":"Abdalqadir","year":"2022","journal-title":"Microorganisms"},{"issue":"6","key":"10.1016\/j.peptides.2026.171499_bib30","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.ajcnut.2023.04.009","article-title":"Teduglutide for the treatment of short bowel syndrome: a double-edged sword?","volume":"117","author":"Oliveira","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.peptides.2026.171499_bib31","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/ajcn\/nqaa278","article-title":"Cost-effectiveness of teduglutide in pediatric patients with short bowel syndrome: Markov modeling using traditional cost-effectiveness criteria","volume":"113","author":"Raghu","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.peptides.2026.171499_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1439781","article-title":"The real-world analysis of adverse events with teduglutide: a pharmacovigilance study based on the FAERS database","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.peptides.2026.171499_bib33","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.2337\/db14-1708","article-title":"GLP-1(32-36)amide pentapeptide increases basal energy expenditure and inhibits weight gain in obese mice","volume":"64","author":"Eva Tomas","year":"2015","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.peptides.2026.171499_bib34","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.2337\/db13-0140","article-title":"Direct Effects of Exendin-(9,39) and GLP-1-(9,36)amide on Insulin Action, \u03b2-Cell Function, and Glucose Metabolism in Nondiabetic Subjects","volume":"62","author":"Sathananthan","year":"2013","journal-title":"Diabetes"},{"issue":"18","key":"10.1016\/j.peptides.2026.171499_bib35","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1111\/bph.15866","article-title":"N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction","volume":"179","author":"Gabe","year":"2022","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.peptides.2026.171499_bib36","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.ajcnut.2023.02.019","article-title":"Long-term treatment with teduglutide: a 48-week open-label single-center clinical trial in children with short bowel syndrome","volume":"117","author":"Lambe","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.peptides.2026.171499_bib37","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S2468-1253(24)00390-X","article-title":"The intestinal barrier: a pivotal role in health, inflammation, and cancer","volume":"10","author":"Neurath","year":"2025","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.peptides.2026.171499_bib38","doi-asserted-by":"crossref","DOI":"10.1007\/s00281-024-01026-5","article-title":"The role of the mucosal barrier system in maintaining gut symbiosis to prevent intestinal inflammation","volume":"47","author":"Okumura","year":"2024","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.peptides.2026.171499_bib39","doi-asserted-by":"crossref","DOI":"10.3892\/or_00000932","article-title":"Increased apoptosis and decreased proliferation of colonic epithelium in dextran sulfate sodium-induced colitis in mice","author":"Araki","year":"2010","journal-title":"Oncol. Rep."},{"issue":"5","key":"10.1016\/j.peptides.2026.171499_bib40","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1053\/j.gastro.2019.07.058","article-title":"Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression","volume":"157","author":"Kuo","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.peptides.2026.171499_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2016.09.010","article-title":"Influence of glucagon-like peptide 2 on energy homeostasis","volume":"86","author":"Baldassano","year":"2016","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.peptides.2026.171499_bib42","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s10787-024-01607-8","article-title":"Polyphenols mitigating inflammatory mechanisms in inflammatory bowel disease (IBD): focus on the NF-\u0199B and JAK\/STAT pathways","volume":"33","author":"Ismail","year":"2024","journal-title":"Inflammopharmacology"},{"issue":"14","key":"10.1016\/j.peptides.2026.171499_bib43","doi-asserted-by":"crossref","first-page":"7882","DOI":"10.1021\/acs.jafc.3c09396","article-title":"Geraniin alleviates inflammation in caco-2 cells and dextran sulfate sodium-induced colitis mice by targeting IL-1\u03b2","volume":"72","author":"Lee","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.peptides.2026.171499_bib44","doi-asserted-by":"crossref","DOI":"10.1186\/s13018-025-06119-x","article-title":"GLP-2-carrying exosomes alleviate osteoporosis by upregulating miR-378a-3p to inhibit osteoclastic differentiation and NF-\u03baB-MAPK pathway","volume":"20","author":"Shen","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"issue":"2","key":"10.1016\/j.peptides.2026.171499_bib45","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1159\/000363025","article-title":"GLP-2 suppresses LPS-induced inflammation in macrophages by inhibiting ERK phosphorylation and NF-\u03baB activation","volume":"34","author":"Xie","year":"2014","journal-title":"Cell. Physiol. Biochem."}],"container-title":["Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978126000367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196978126000367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:46:38Z","timestamp":1788551198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196978126000367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":45,"alternative-id":["S0196978126000367"],"URL":"https:\/\/doi.org\/10.1016\/j.peptides.2026.171499","relation":{},"ISSN":["0196-9781"],"issn-type":[{"value":"0196-9781","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"[Gly2]-GLP-2(1\u20135): An ultra-short GLP-2 peptide for intestinal mucosal protection in inflammatory bowel disease","name":"articletitle","label":"Article Title"},{"value":"Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.peptides.2026.171499","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"171499"}}